POLX - BACSU - GREMLIN Contacts

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POLX - DNA polymerase/3'-5' exonuclease PolX

UniProt:	P94544	Sequences: MHKKDIIRLLETIAVYMELKGDNPFKVSAFRKAAAALEQDDRSLSEMDDMMSLSGIGKGTYSVIKEYIDEGKSSTLESLQKEVPEGLVPLLKLPGLGGKKIAKLYKELGVHDAESLKEACEQQKVQGLAGFGKKSEEKILQALGEAGKQPERFPIGYALRIAREIEEHLSQFTHIIKFSRAGSLRRARETVKDLDYIIATDHPAEVREQLLELPNIKSVIASGDTKVSVILSFEYETSVDFRLVTEEQFPTTLHHFTGSKDHNIKMRQIAKERGERISEYGVETVETGEIKTFPSEREFYAHFGLPLIPPEIRESGQEVETYSDSIELIELGQIKGDLHMHSTWSDGAFSIREMAEACIKKGYQYMAITDHSQYLKVANGLTAERLKQQAKEIDALNAEFENFRILKGVEMDILPDGTLDYDDDVLAEMDIVIASIHSSFNQPEHVIMKRLETALTNKHVDIIAHPTGRLIGRRAGYEIDIDQLIELARKTNTALELNANPARLDLRTEHLMKANEQGVTLVINTDAHNIEMLDDMKTGVTAARKGWTETKNVLNARSLKDVEAFLKRND	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	570 (562)
Sequences:	695 (530)
Seq/√Len:	22.3

BACSU - POLX

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
352_R	399_E	5.645	1.00
126_Q	136_E	4.211	1.00
394_D	407_K	4.133	1.00
387_K	428_E	4.127	1.00
444_E	480_D	4.056	1.00
111_H	115_S	3.583	1.00
444_E	478_E	3.490	1.00
72_K	77_E	3.410	1.00
117_K	121_E	3.403	1.00
435_S	464_A	3.315	1.00
434_A	460_V	3.295	1.00
494_A	554_L	3.266	1.00
431_I	462_I	3.192	1.00
311_E	544_R	3.100	1.00
442_Q	447_I	3.086	1.00
373_Q	383_A	2.975	0.99
443_P	446_V	2.963	0.99
265_K	315_S	2.940	0.99
363_Y	536_M	2.877	0.99
118_E	122_Q	2.864	0.99
277_I	282_V	2.782	0.99
66_E	74_S	2.716	0.99
20_K	82_E	2.685	0.99
179_S	249_F	2.681	0.99
117_K	147_G	2.654	0.99
497_L	511_L	2.629	0.99
515_N	552_N	2.621	0.99
359_I	402_N	2.618	0.99
352_R	392_E	2.559	0.98
152_R	190_T	2.554	0.98
383_A	422_D	2.554	0.98
558_S	561_D	2.514	0.98
112_D	115_S	2.499	0.98
168_H	213_L	2.496	0.98
390_A	407_K	2.493	0.98
511_L	546_G	2.484	0.98
451_L	479_I	2.477	0.98
335_K	364_Q	2.466	0.98
486_E	517_Q	2.312	0.97
254_H	300_Y	2.263	0.97
9_L	67_Y	2.261	0.96
349_F	353_E	2.254	0.96
515_N	548_T	2.230	0.96
269_I	323_S	2.202	0.96
266_M	303_F	2.199	0.96
497_L	521_L	2.198	0.96
15_V	31_R	2.193	0.96
200_T	243_L	2.157	0.95
294_P	298_E	2.156	0.95
361_K	534_D	2.131	0.95
200_T	203_P	2.124	0.95
123_Q	136_E	2.098	0.95
396_L	405_I	2.027	0.94
187_A	541_T	1.998	0.93
390_A	429_M	1.977	0.93
216_I	229_V	1.972	0.93
532_M	535_D	1.947	0.92
113_A	143_L	1.933	0.92
340_M	366_M	1.932	0.92
499_A	539_G	1.922	0.92
90_L	104_L	1.921	0.92
397_N	403_F	1.914	0.91
481_I	510_H	1.908	0.91
282_V	303_F	1.900	0.91
386_L	429_M	1.886	0.91
379_N	385_R	1.868	0.90
162_A	184_L	1.841	0.90
468_G	477_Y	1.806	0.89
452_E	487_L	1.782	0.88
366_M	405_I	1.777	0.88
406_L	562_V	1.766	0.88
494_A	565_F	1.763	0.88
273_R	304_G	1.759	0.87
100_K	135_S	1.759	0.87
515_N	549_E	1.749	0.87
177_K	246_E	1.735	0.87
342_S	354_M	1.732	0.87
207_R	227_V	1.731	0.87
482_D	513_K	1.717	0.86
267_R	279_E	1.715	0.86
276_R	283_E	1.713	0.86
388_Q	391_K	1.703	0.86
338_L	562_V	1.697	0.85
262_H	300_Y	1.697	0.85
120_C	125_V	1.693	0.85
334_I	525_T	1.657	0.84
245_T	248_Q	1.647	0.84
13_I	73_S	1.646	0.84
455_L	493_T	1.633	0.83
329_I	553_V	1.625	0.83
166_E	178_F	1.610	0.82
462_I	494_A	1.603	0.82
333_Q	550_T	1.601	0.82
367_A	431_I	1.598	0.82
436_I	447_I	1.587	0.81
256_F	267_R	1.585	0.81
242_R	280_Y	1.581	0.81
267_R	280_Y	1.568	0.80
427_A	459_H	1.566	0.80
390_A	425_V	1.545	0.79
12_T	80_Q	1.544	0.79
520_T	552_N	1.540	0.79
223_G	267_R	1.537	0.79
520_T	554_L	1.537	0.79
277_I	303_F	1.530	0.79
210_L	241_F	1.527	0.79
183_S	193_D	1.527	0.79
358_C	366_M	1.521	0.78
211_L	216_I	1.513	0.78
321_T	547_W	1.512	0.78
293_F	299_F	1.501	0.77
406_L	563_E	1.488	0.77
485_I	517_Q	1.486	0.77
102_A	106_K	1.484	0.77
197_I	255_H	1.479	0.76
100_K	131_F	1.477	0.76
193_D	240_D	1.467	0.76
372_S	412_D	1.464	0.76
218_S	230_I	1.457	0.75
456_T	491_T	1.449	0.75
117_K	140_L	1.449	0.75
137_E	141_Q	1.447	0.75
67_Y	73_S	1.441	0.74
499_A	536_M	1.440	0.74
154_P	472_G	1.435	0.74
285_V	288_G	1.434	0.74
382_T	421_Y	1.433	0.74
96_L	100_K	1.429	0.74
329_I	540_V	1.429	0.74
183_S	195_D	1.427	0.74
373_Q	382_T	1.425	0.74
240_D	256_F	1.424	0.73
521_L	548_T	1.420	0.73
342_S	351_I	1.418	0.73
282_V	292_T	1.418	0.73
357_A	361_K	1.417	0.73
120_C	139_I	1.416	0.73
404_R	563_E	1.414	0.73
244_V	252_T	1.408	0.73
263_N	267_R	1.408	0.73
485_I	521_L	1.407	0.73
49_D	52_S	1.404	0.72
322_Y	326_I	1.397	0.72
176_I	246_E	1.395	0.72
455_L	463_I	1.392	0.72
152_R	192_K	1.385	0.71
336_G	365_Y	1.383	0.71
557_R	561_D	1.377	0.71
456_T	487_L	1.374	0.71
508_T	545_K	1.369	0.70
210_L	227_V	1.368	0.70
58_K	62_S	1.362	0.70
74_S	78_S	1.361	0.70
240_D	280_Y	1.361	0.70
158_A	191_V	1.361	0.70
123_Q	126_Q	1.361	0.70
256_F	280_Y	1.360	0.70
357_A	360_K	1.358	0.70
455_L	487_L	1.356	0.70
349_F	530_I	1.351	0.69
14_A	31_R	1.349	0.69
263_N	279_E	1.347	0.69
193_D	256_F	1.334	0.68
352_R	356_E	1.332	0.68
523_I	539_G	1.330	0.68
223_G	256_F	1.328	0.68
351_I	396_L	1.321	0.68
367_A	562_V	1.315	0.67
6_I	64_I	1.313	0.67
221_A	226_K	1.305	0.67
175_I	206_V	1.289	0.66
13_I	75_T	1.288	0.66
562_V	566_L	1.288	0.66
223_G	280_Y	1.282	0.65
59_G	63_V	1.278	0.65
198_I	206_V	1.278	0.65
256_F	263_N	1.275	0.65
63_V	73_S	1.274	0.65
110_V	194_L	1.272	0.65
529_N	532_M	1.271	0.65
37_L	64_I	1.270	0.65
447_I	451_L	1.266	0.64
256_F	279_E	1.260	0.64
329_I	556_A	1.258	0.64
455_L	491_T	1.256	0.64
355_A	403_F	1.256	0.64
378_A	420_D	1.254	0.63
240_D	267_R	1.252	0.63
77_E	80_Q	1.247	0.63
242_R	267_R	1.240	0.63
199_A	246_E	1.238	0.62
316_G	508_T	1.236	0.62
372_S	378_A	1.222	0.61
240_D	263_N	1.221	0.61
460_V	493_T	1.220	0.61
121_E	140_L	1.218	0.61
195_D	240_D	1.216	0.61
510_H	521_L	1.214	0.61
520_T	557_R	1.211	0.61
193_D	279_E	1.208	0.61
525_T	536_M	1.208	0.61
316_G	512_M	1.200	0.60
18_E	31_R	1.195	0.60
120_C	143_L	1.195	0.60
423_D	427_A	1.194	0.60
355_A	405_I	1.193	0.60
240_D	279_E	1.192	0.59
193_D	267_R	1.182	0.59
223_G	279_E	1.174	0.58
121_E	124_K	1.174	0.58
451_L	484_L	1.172	0.58
448_M	484_L	1.163	0.58
427_A	445_H	1.161	0.57
554_L	557_R	1.155	0.57
334_I	363_Y	1.154	0.57
406_L	559_L	1.151	0.57
11_E	38_E	1.151	0.57
104_L	131_F	1.150	0.57
193_D	260_K	1.145	0.56
466_P	506_L	1.144	0.56
263_N	280_Y	1.139	0.56
388_Q	392_E	1.136	0.56
448_M	452_E	1.135	0.56
103_K	107_E	1.132	0.55
220_I	228_S	1.128	0.55
114_E	118_E	1.128	0.55
442_Q	460_V	1.128	0.55
117_K	143_L	1.126	0.55
19_L	83_V	1.124	0.55
542_A	546_G	1.123	0.55
337_D	525_T	1.121	0.55
223_G	240_D	1.108	0.54
10_L	63_V	1.107	0.54
22_D	27_V	1.099	0.53
392_E	395_A	1.096	0.53
223_G	263_N	1.094	0.53
264_I	279_E	1.094	0.53
290_I	293_F	1.086	0.52
3_K	15_V	1.085	0.52
162_A	180_R	1.085	0.52
485_I	495_L	1.084	0.52
195_D	267_R	1.078	0.52
183_S	192_K	1.075	0.52
107_E	129_A	1.074	0.51
295_S	298_E	1.067	0.51
99_K	499_A	1.066	0.51
390_A	394_D	1.064	0.51
282_V	299_F	1.062	0.51
338_L	406_L	1.061	0.51
242_R	256_F	1.060	0.51
359_I	401_E	1.058	0.50
120_C	140_L	1.057	0.50
191_V	294_P	1.056	0.50
223_G	242_R	1.055	0.50
463_I	493_T	1.055	0.50
242_R	279_E	1.054	0.50
133_K	137_E	1.051	0.50
23_N	60_T	1.048	0.50
225_T	228_S	1.045	0.50
284_T	289_E	1.044	0.49
104_L	125_V	1.043	0.49
308_I	312_I	1.041	0.49
382_T	385_R	1.040	0.49
240_D	264_I	1.037	0.49
511_L	521_L	1.035	0.49
180_R	184_L	1.034	0.49
264_I	267_R	1.032	0.49
228_S	242_R	1.032	0.49
317_Q	547_W	1.032	0.49
396_L	400_F	1.031	0.49
452_E	456_T	1.024	0.48
159_L	184_L	1.023	0.48
440_F	477_Y	1.021	0.48
486_E	490_K	1.018	0.48
306_P	325_S	1.017	0.48
437_H	528_H	1.017	0.48
53_L	56_I	1.011	0.47
242_R	263_N	1.009	0.47
267_R	278_S	1.001	0.46
452_E	483_Q	1.000	0.46
226_K	256_F	0.997	0.46
2_H	5_D	0.996	0.46
411_M	419_L	0.994	0.46
409_V	421_Y	0.993	0.46
228_S	256_F	0.992	0.46
345_S	374_Y	0.992	0.46
446_V	449_K	0.991	0.46
36_A	56_I	0.989	0.46
387_K	425_V	0.984	0.45
188_R	261_D	0.974	0.45
183_S	240_D	0.972	0.45
340_M	369_T	0.971	0.44
449_K	456_T	0.971	0.44
90_L	101_I	0.969	0.44
91_L	101_I	0.969	0.44
193_D	223_G	0.966	0.44
26_K	376_K	0.965	0.44
305_L	323_S	0.965	0.44
126_Q	133_K	0.963	0.44
251_T	293_F	0.962	0.44
195_D	256_F	0.961	0.44
65_K	69_D	0.955	0.43
37_L	60_T	0.954	0.43
108_L	119_A	0.950	0.43
3_K	7_I	0.949	0.43
155_I	191_V	0.949	0.43
453_T	463_I	0.947	0.43
485_I	519_V	0.942	0.43
334_I	536_M	0.940	0.42
44_L	134_K	0.938	0.42
255_H	263_N	0.936	0.42
359_I	400_F	0.934	0.42
17_M	30_F	0.933	0.42
10_L	37_L	0.931	0.42
16_Y	76_L	0.930	0.42
331_L	540_V	0.929	0.42
184_L	194_L	0.927	0.42
193_D	280_Y	0.927	0.42
373_Q	422_D	0.924	0.41
110_V	119_A	0.924	0.41
103_K	131_F	0.924	0.41
141_Q	144_G	0.921	0.41
391_K	395_A	0.916	0.41
44_L	64_I	0.915	0.41
174_H	200_T	0.915	0.41
123_Q	458_K	0.913	0.41
120_C	136_E	0.911	0.40
251_T	255_H	0.910	0.40
317_Q	321_T	0.906	0.40
30_F	317_Q	0.905	0.40
357_A	530_I	0.904	0.40
560_K	563_E	0.903	0.40
125_V	136_E	0.901	0.40
479_I	484_L	0.900	0.40
208_E	212_E	0.899	0.40
32_K	100_K	0.899	0.40
344_W	385_R	0.897	0.40
378_A	412_D	0.894	0.39
327_E	330_E	0.891	0.39
355_A	397_N	0.891	0.39
104_L	112_D	0.890	0.39
225_T	244_V	0.888	0.39
342_S	355_A	0.888	0.39
355_A	400_F	0.888	0.39
172_F	175_I	0.888	0.39
306_P	322_Y	0.885	0.39
337_D	363_Y	0.885	0.39
30_F	358_C	0.884	0.39
260_K	279_E	0.883	0.39
122_Q	136_E	0.882	0.39
198_I	241_F	0.882	0.39
361_K	533_L	0.881	0.38
322_Y	325_S	0.879	0.38
195_D	260_K	0.876	0.38
415_P	439_S	0.874	0.38
367_A	566_L	0.874	0.38
463_I	491_T	0.872	0.38
226_K	279_E	0.869	0.38
495_L	506_L	0.866	0.38
226_K	267_R	0.866	0.38
225_T	242_R	0.864	0.37
86_G	125_V	0.864	0.37
228_S	263_N	0.863	0.37
497_L	542_A	0.863	0.37
397_N	401_E	0.859	0.37
228_S	264_I	0.855	0.37
43_S	329_I	0.850	0.36
267_R	276_R	0.848	0.36
270_A	303_F	0.848	0.36
240_D	278_S	0.846	0.36
355_A	364_Q	0.845	0.36
386_L	409_V	0.843	0.36
223_G	228_S	0.842	0.36
263_N	278_S	0.839	0.36
256_F	278_S	0.837	0.36
178_F	191_V	0.836	0.36
264_I	278_S	0.835	0.36
387_K	390_A	0.835	0.36
511_L	548_T	0.834	0.35
242_R	276_R	0.833	0.35
507_R	510_H	0.832	0.35
447_I	463_I	0.831	0.35
409_V	429_M	0.831	0.35
299_F	303_F	0.829	0.35
3_K	250_P	0.829	0.35
419_L	423_D	0.827	0.35
262_H	318_E	0.827	0.35
192_K	238_S	0.826	0.35
193_D	263_N	0.825	0.35
223_G	255_H	0.825	0.35
261_D	264_I	0.821	0.35
489_R	519_V	0.819	0.35
226_K	263_N	0.817	0.34
471_I	510_H	0.816	0.34
183_S	263_N	0.816	0.34
459_H	566_L	0.809	0.34
304_G	541_T	0.808	0.34
225_T	267_R	0.806	0.34
240_D	260_K	0.806	0.34
58_K	536_M	0.805	0.34
266_M	277_I	0.805	0.34
381_L	385_R	0.804	0.34
228_S	279_E	0.803	0.34
42_R	47_M	0.802	0.33
304_G	483_Q	0.802	0.33
415_P	442_Q	0.800	0.33
197_I	293_F	0.800	0.33
56_I	60_T	0.798	0.33
312_I	321_T	0.796	0.33
460_V	463_I	0.796	0.33
340_M	354_M	0.795	0.33
78_S	82_E	0.793	0.33
256_F	264_I	0.792	0.33
377_V	381_L	0.791	0.33
344_W	421_Y	0.791	0.33
337_D	472_G	0.788	0.33
64_I	107_E	0.787	0.33
452_E	484_L	0.784	0.32
103_K	129_A	0.784	0.32
400_F	403_F	0.780	0.32
373_Q	378_A	0.777	0.32
368_I	393_I	0.776	0.32
371_H	437_H	0.776	0.32
375_L	438_S	0.775	0.32
255_H	267_R	0.775	0.32
255_H	278_S	0.774	0.32
254_H	307_L	0.773	0.32
317_Q	320_E	0.771	0.32
254_H	277_I	0.770	0.32
283_E	290_I	0.769	0.32
378_A	381_L	0.768	0.31
442_Q	446_V	0.767	0.31
207_R	210_L	0.767	0.31
195_D	263_N	0.766	0.31
344_W	351_I	0.766	0.31
7_I	34_A	0.765	0.31
261_D	315_S	0.765	0.31
498_N	525_T	0.764	0.31
136_E	442_Q	0.763	0.31
76_L	80_Q	0.763	0.31
4_K	348_A	0.762	0.31
228_S	240_D	0.762	0.31
404_R	559_L	0.762	0.31
155_I	541_T	0.761	0.31
372_S	421_Y	0.760	0.31
276_R	280_Y	0.759	0.31
223_G	264_I	0.759	0.31
159_L	213_L	0.758	0.31
269_I	305_L	0.756	0.31
369_T	433_I	0.755	0.31
391_K	394_D	0.753	0.31
345_S	377_V	0.752	0.31
225_T	280_Y	0.752	0.31
275_E	303_F	0.752	0.31
156_G	160_R	0.752	0.31
83_V	424_D	0.752	0.31
255_H	279_E	0.751	0.30
156_G	502_A	0.751	0.30
481_I	485_I	0.750	0.30
433_I	537_K	0.750	0.30
283_E	293_F	0.750	0.30
50_M	312_I	0.749	0.30
67_Y	493_T	0.748	0.30
18_E	381_L	0.748	0.30
36_A	53_L	0.747	0.30
183_S	279_E	0.747	0.30
431_I	562_V	0.747	0.30
255_H	293_F	0.746	0.30
338_L	367_A	0.746	0.30
264_I	280_Y	0.746	0.30
456_T	490_K	0.746	0.30
434_A	491_T	0.745	0.30
96_L	101_I	0.745	0.30
317_Q	358_C	0.745	0.30
255_H	280_Y	0.743	0.30
201_D	399_E	0.743	0.30
271_K	276_R	0.743	0.30
172_F	209_Q	0.742	0.30
242_R	264_I	0.741	0.30
439_S	442_Q	0.740	0.30
226_K	242_R	0.739	0.30
248_Q	251_T	0.739	0.30
65_K	335_K	0.736	0.30
188_R	314_E	0.736	0.30
24_P	28_S	0.736	0.30
346_D	435_S	0.735	0.30
124_K	127_G	0.734	0.29
335_K	548_T	0.732	0.29
77_E	475_A	0.731	0.29
192_K	255_H	0.730	0.29
472_G	525_T	0.730	0.29
175_I	178_F	0.730	0.29
183_S	256_F	0.730	0.29
153_F	158_A	0.727	0.29
551_K	557_R	0.726	0.29
86_G	343_T	0.724	0.29
153_F	237_T	0.723	0.29
359_I	403_F	0.723	0.29
271_K	277_I	0.722	0.29
151_E	500_N	0.719	0.29
390_A	428_E	0.719	0.29
256_F	276_R	0.717	0.29
226_K	264_I	0.715	0.28
413_I	467_T	0.715	0.28
159_L	187_A	0.714	0.28
315_S	566_L	0.714	0.28
341_H	437_H	0.713	0.28
385_R	388_Q	0.712	0.28
476_G	507_R	0.712	0.28
20_K	83_V	0.710	0.28
220_I	238_S	0.710	0.28
101_I	400_F	0.710	0.28
372_S	380_G	0.710	0.28
272_E	300_Y	0.710	0.28
260_K	264_I	0.709	0.28
369_T	431_I	0.708	0.28
460_V	491_T	0.706	0.28
47_M	103_K	0.706	0.28
374_Y	378_A	0.705	0.28
128_L	218_S	0.705	0.28
93_L	143_L	0.702	0.28
250_P	293_F	0.701	0.28
193_D	228_S	0.698	0.27
372_S	409_V	0.698	0.27
337_D	367_A	0.697	0.27
533_L	536_M	0.697	0.27
93_L	142_A	0.696	0.27
275_E	284_T	0.695	0.27
66_E	335_K	0.695	0.27
431_I	566_L	0.693	0.27
412_D	477_Y	0.693	0.27
276_R	281_G	0.692	0.27
338_L	365_Y	0.691	0.27
341_H	528_H	0.690	0.27
212_E	550_T	0.689	0.27
185_R	253_L	0.689	0.27
170_S	199_A	0.689	0.27
413_I	463_I	0.689	0.27
152_R	251_T	0.687	0.27
109_G	567_K	0.687	0.27
195_D	279_E	0.685	0.27
260_K	267_R	0.683	0.27
38_E	59_G	0.683	0.27
278_S	506_L	0.682	0.27
202_H	205_E	0.681	0.27
197_I	252_T	0.681	0.27
340_M	433_I	0.679	0.26
412_D	525_T	0.678	0.26
26_K	545_K	0.678	0.26
274_G	289_E	0.676	0.26
106_K	467_T	0.674	0.26
93_L	113_A	0.673	0.26
227_V	243_L	0.672	0.26
221_A	238_S	0.671	0.26
197_I	256_F	0.670	0.26
344_W	392_E	0.670	0.26
110_V	212_E	0.669	0.26
559_L	566_L	0.668	0.26
22_D	26_K	0.668	0.26
351_I	355_A	0.667	0.26
25_F	36_A	0.667	0.26
335_K	558_S	0.665	0.26
66_E	476_G	0.665	0.26
158_A	184_L	0.665	0.26
242_R	255_H	0.665	0.26
511_L	542_A	0.663	0.26
519_V	559_L	0.663	0.26
411_M	421_Y	0.663	0.26
141_Q	218_S	0.661	0.25
476_G	479_I	0.661	0.25
113_A	117_K	0.661	0.25
442_Q	493_T	0.661	0.25
367_A	514_A	0.660	0.25
193_D	242_R	0.660	0.25
431_I	461_D	0.660	0.25
406_L	461_D	0.660	0.25
371_H	528_H	0.658	0.25
4_K	38_E	0.658	0.25
251_T	292_T	0.655	0.25
316_G	545_K	0.654	0.25
305_L	445_H	0.654	0.25
447_I	477_Y	0.651	0.25
103_K	125_V	0.650	0.25
375_L	411_M	0.650	0.25
487_L	490_K	0.650	0.25
284_T	288_G	0.649	0.25
66_E	72_K	0.648	0.25
72_K	395_A	0.648	0.25
247_E	353_E	0.646	0.25
240_D	255_H	0.644	0.25
19_L	86_G	0.643	0.25
497_L	548_T	0.643	0.25
394_D	398_A	0.643	0.25
306_P	327_E	0.643	0.25
193_D	278_S	0.642	0.25
412_D	419_L	0.642	0.25
462_I	522_V	0.641	0.24
320_E	551_K	0.639	0.24
409_V	544_R	0.638	0.24
297_R	307_L	0.637	0.24
356_E	402_N	0.637	0.24
354_M	527_A	0.636	0.24
363_Y	533_L	0.635	0.24
56_I	414_L	0.634	0.24
406_L	431_I	0.633	0.24
225_T	279_E	0.631	0.24
317_Q	512_M	0.631	0.24
433_I	456_T	0.630	0.24
509_E	517_Q	0.629	0.24
183_S	260_K	0.629	0.24
13_I	76_L	0.628	0.24
22_D	494_A	0.627	0.24
255_H	292_T	0.627	0.24
247_E	398_A	0.627	0.24
312_I	328_L	0.626	0.24
78_S	282_V	0.626	0.24
345_S	421_Y	0.625	0.24
372_S	414_L	0.624	0.24
485_I	510_H	0.623	0.24
125_V	236_E	0.621	0.23
393_I	419_L	0.620	0.23
256_F	260_K	0.620	0.23
254_H	266_M	0.619	0.23
190_T	250_P	0.619	0.23
337_D	495_L	0.618	0.23
37_L	490_K	0.618	0.23
470_L	544_R	0.617	0.23
351_I	368_I	0.617	0.23
125_V	141_Q	0.616	0.23
252_T	276_R	0.615	0.23
434_A	493_T	0.615	0.23
85_E	424_D	0.614	0.23
231_L	239_V	0.614	0.23
223_G	278_S	0.613	0.23
345_S	378_A	0.612	0.23
372_S	420_D	0.612	0.23
226_K	240_D	0.611	0.23
378_A	421_Y	0.611	0.23
375_L	378_A	0.610	0.23
217_K	232_S	0.609	0.23
223_G	276_R	0.609	0.23
378_A	477_Y	0.608	0.23
275_E	299_F	0.608	0.23
154_P	189_E	0.605	0.23
224_D	350_S	0.604	0.23
272_E	358_C	0.604	0.23
471_I	535_D	0.604	0.23
508_T	525_T	0.602	0.23
100_K	226_K	0.602	0.23
399_E	405_I	0.602	0.23
351_I	405_I	0.599	0.22
254_H	303_F	0.598	0.22
192_K	240_D	0.598	0.22
169_L	178_F	0.597	0.22
37_L	92_K	0.595	0.22
461_D	562_V	0.594	0.22
6_I	110_V	0.594	0.22
294_P	564_A	0.594	0.22
375_L	495_L	0.593	0.22
377_V	495_L	0.592	0.22
389_Q	435_S	0.592	0.22
436_I	451_L	0.591	0.22
372_S	397_N	0.590	0.22
82_E	402_N	0.590	0.22
331_L	536_M	0.589	0.22
212_E	298_E	0.588	0.22
369_T	408_G	0.588	0.22
269_I	273_R	0.588	0.22
208_E	282_V	0.587	0.22
346_D	371_H	0.586	0.22
394_D	397_N	0.586	0.22
276_R	279_E	0.586	0.22
189_E	420_D	0.584	0.22
525_T	545_K	0.584	0.22
164_E	215_N	0.584	0.22
404_R	522_V	0.582	0.22
101_I	135_S	0.582	0.22
508_T	542_A	0.581	0.22
56_I	231_L	0.581	0.22
228_S	267_R	0.580	0.22
166_E	170_S	0.579	0.21
447_I	464_A	0.579	0.21
93_L	96_L	0.579	0.21
252_T	278_S	0.578	0.21
455_L	461_D	0.577	0.21
381_L	389_Q	0.574	0.21
170_S	178_F	0.574	0.21
5_D	77_E	0.573	0.21
407_K	542_A	0.573	0.21
48_D	103_K	0.573	0.21
407_K	429_M	0.573	0.21
242_R	252_T	0.573	0.21
124_K	403_F	0.572	0.21
472_G	495_L	0.571	0.21
440_F	447_I	0.571	0.21
260_K	263_N	0.570	0.21
192_K	250_P	0.570	0.21
264_I	315_S	0.569	0.21
133_K	516_E	0.569	0.21
183_S	267_R	0.568	0.21
50_M	407_K	0.568	0.21
282_V	302_H	0.567	0.21
351_I	541_T	0.567	0.21
371_H	474_R	0.567	0.21
411_M	429_M	0.566	0.21
7_I	27_V	0.565	0.21
13_I	79_L	0.564	0.21
226_K	379_N	0.564	0.21
412_D	464_A	0.563	0.21
272_E	551_K	0.563	0.21
264_I	353_E	0.563	0.21
498_N	528_H	0.561	0.21
381_L	393_I	0.560	0.21
500_N	535_D	0.560	0.21
395_A	424_D	0.559	0.21
198_I	476_G	0.559	0.21
226_K	229_V	0.558	0.21
163_R	537_K	0.558	0.21
345_S	409_V	0.558	0.21
188_R	473_R	0.556	0.20
397_N	407_K	0.556	0.20
294_P	567_K	0.556	0.20
47_M	275_E	0.556	0.20
190_T	251_T	0.556	0.20
208_E	222_S	0.556	0.20
335_K	567_K	0.555	0.20
542_A	548_T	0.554	0.20
497_L	538_T	0.554	0.20
257_T	310_P	0.553	0.20
226_K	255_H	0.553	0.20
557_R	565_F	0.553	0.20
123_Q	137_E	0.553	0.20
60_T	138_K	0.552	0.20
308_I	550_T	0.552	0.20
210_L	433_I	0.552	0.20
193_D	264_I	0.552	0.20
268_Q	272_E	0.551	0.20
50_M	53_L	0.551	0.20
100_K	494_A	0.549	0.20
85_E	112_D	0.549	0.20
516_E	523_I	0.548	0.20
452_E	523_I	0.547	0.20
155_I	165_I	0.546	0.20
81_K	224_D	0.545	0.20
195_D	223_G	0.545	0.20
104_L	362_G	0.544	0.20
326_I	547_W	0.544	0.20
383_A	421_Y	0.544	0.20
9_L	76_L	0.543	0.20
165_I	196_Y	0.542	0.20
32_K	494_A	0.542	0.20
54_S	300_Y	0.540	0.20
274_G	297_R	0.539	0.20
90_L	190_T	0.539	0.20
433_I	464_A	0.539	0.20
444_E	483_Q	0.539	0.20
314_E	317_Q	0.538	0.20
377_V	525_T	0.538	0.20
76_L	96_L	0.538	0.20
366_M	544_R	0.538	0.20
158_A	326_I	0.537	0.20
472_G	513_K	0.536	0.20
447_I	493_T	0.536	0.20
8_R	246_E	0.535	0.19
183_S	226_K	0.535	0.19
356_E	551_K	0.535	0.19
100_K	545_K	0.533	0.19
33_A	37_L	0.533	0.19
70_E	441_N	0.533	0.19
17_M	22_D	0.532	0.19
374_Y	477_Y	0.531	0.19
168_H	209_Q	0.530	0.19
10_L	65_K	0.529	0.19
120_C	135_S	0.529	0.19
53_L	248_Q	0.529	0.19
136_E	495_L	0.528	0.19
322_Y	545_K	0.528	0.19
79_L	512_M	0.528	0.19
471_I	509_E	0.527	0.19
335_K	519_V	0.527	0.19
89_P	110_V	0.527	0.19
431_I	522_V	0.526	0.19
306_P	315_S	0.524	0.19
7_I	451_L	0.524	0.19
138_K	218_S	0.523	0.19
193_D	255_H	0.523	0.19
256_F	259_S	0.523	0.19
344_W	381_L	0.522	0.19
174_H	202_H	0.522	0.19
352_R	395_A	0.522	0.19
137_E	140_L	0.522	0.19
49_D	124_K	0.522	0.19
122_Q	135_S	0.522	0.19
312_I	547_W	0.521	0.19
225_T	256_F	0.521	0.19
427_A	521_L	0.521	0.19
117_K	144_G	0.520	0.19
507_R	525_T	0.519	0.19
169_L	523_I	0.518	0.19
342_S	406_L	0.518	0.19
43_S	76_L	0.518	0.19
10_L	36_A	0.518	0.19
510_H	513_K	0.517	0.19
67_Y	452_E	0.517	0.19
363_Y	457_N	0.516	0.19
312_I	326_I	0.516	0.19
32_K	60_T	0.516	0.19
420_D	548_T	0.516	0.19
240_D	276_R	0.516	0.19
377_V	380_G	0.515	0.19
93_L	165_I	0.514	0.19
33_A	60_T	0.514	0.19
183_S	264_I	0.514	0.19
319_V	322_Y	0.513	0.19
273_R	323_S	0.513	0.19
59_G	70_E	0.513	0.19
364_Q	558_S	0.512	0.19
372_S	385_R	0.511	0.18
132_G	408_G	0.511	0.18
114_E	470_L	0.510	0.18
460_V	511_L	0.510	0.18
175_I	199_A	0.509	0.18
385_R	421_Y	0.508	0.18
153_F	377_V	0.508	0.18
283_E	292_T	0.507	0.18
463_I	488_A	0.505	0.18
471_I	565_F	0.505	0.18
466_P	495_L	0.505	0.18
7_I	60_T	0.504	0.18
101_I	120_C	0.504	0.18
380_G	412_D	0.503	0.18
200_T	353_E	0.503	0.18
495_L	508_T	0.502	0.18
96_L	420_D	0.502	0.18
191_V	311_E	0.502	0.18
463_I	470_L	0.502	0.18
300_Y	317_Q	0.502	0.18
337_D	545_K	0.501	0.18
26_K	421_Y	0.501	0.18
59_G	429_M	0.501	0.18
131_F	431_I	0.501	0.18
311_E	409_V	0.500	0.18
142_A	146_A	0.500	0.18

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3b0xA	1	0.993	100	0.378	Contact Map
2w9mA	1	0.9614	100	0.43	Contact Map
4kliA	1	0.5298	100	0.659	Contact Map
2bcqA	1	0.5211	100	0.67	Contact Map
4lzgA	1	0.5088	100	0.671	Contact Map
4i2aA	1	0.5263	100	0.674	Contact Map
4p4mA	1	0.3947	100	0.68	Contact Map
1jajA	1	0.2895	100	0.811	Contact Map
3qy7A	1	0.3947	100	0.834	Contact Map
1m65A	3	0.386	100	0.834	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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