GREMLIN Database
POLX - DNA polymerase/3'-5' exonuclease PolX
UniProt: P94544 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 570 (562)
Sequences: 695 (530)
Seq/√Len: 22.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
352_R399_E5.6451.00
126_Q136_E4.2111.00
394_D407_K4.1331.00
387_K428_E4.1271.00
444_E480_D4.0561.00
111_H115_S3.5831.00
444_E478_E3.4901.00
72_K77_E3.4101.00
117_K121_E3.4031.00
435_S464_A3.3151.00
434_A460_V3.2951.00
494_A554_L3.2661.00
431_I462_I3.1921.00
311_E544_R3.1001.00
442_Q447_I3.0861.00
373_Q383_A2.9750.99
443_P446_V2.9630.99
265_K315_S2.9400.99
363_Y536_M2.8770.99
118_E122_Q2.8640.99
277_I282_V2.7820.99
66_E74_S2.7160.99
20_K82_E2.6850.99
179_S249_F2.6810.99
117_K147_G2.6540.99
497_L511_L2.6290.99
515_N552_N2.6210.99
359_I402_N2.6180.99
352_R392_E2.5590.98
152_R190_T2.5540.98
383_A422_D2.5540.98
558_S561_D2.5140.98
112_D115_S2.4990.98
168_H213_L2.4960.98
390_A407_K2.4930.98
511_L546_G2.4840.98
451_L479_I2.4770.98
335_K364_Q2.4660.98
486_E517_Q2.3120.97
254_H300_Y2.2630.97
9_L67_Y2.2610.96
349_F353_E2.2540.96
515_N548_T2.2300.96
269_I323_S2.2020.96
266_M303_F2.1990.96
497_L521_L2.1980.96
15_V31_R2.1930.96
200_T243_L2.1570.95
294_P298_E2.1560.95
361_K534_D2.1310.95
200_T203_P2.1240.95
123_Q136_E2.0980.95
396_L405_I2.0270.94
187_A541_T1.9980.93
390_A429_M1.9770.93
216_I229_V1.9720.93
532_M535_D1.9470.92
113_A143_L1.9330.92
340_M366_M1.9320.92
499_A539_G1.9220.92
90_L104_L1.9210.92
397_N403_F1.9140.91
481_I510_H1.9080.91
282_V303_F1.9000.91
386_L429_M1.8860.91
379_N385_R1.8680.90
162_A184_L1.8410.90
468_G477_Y1.8060.89
452_E487_L1.7820.88
366_M405_I1.7770.88
406_L562_V1.7660.88
494_A565_F1.7630.88
273_R304_G1.7590.87
100_K135_S1.7590.87
515_N549_E1.7490.87
177_K246_E1.7350.87
342_S354_M1.7320.87
207_R227_V1.7310.87
482_D513_K1.7170.86
267_R279_E1.7150.86
276_R283_E1.7130.86
388_Q391_K1.7030.86
338_L562_V1.6970.85
262_H300_Y1.6970.85
120_C125_V1.6930.85
334_I525_T1.6570.84
245_T248_Q1.6470.84
13_I73_S1.6460.84
455_L493_T1.6330.83
329_I553_V1.6250.83
166_E178_F1.6100.82
462_I494_A1.6030.82
333_Q550_T1.6010.82
367_A431_I1.5980.82
436_I447_I1.5870.81
256_F267_R1.5850.81
242_R280_Y1.5810.81
267_R280_Y1.5680.80
427_A459_H1.5660.80
390_A425_V1.5450.79
12_T80_Q1.5440.79
520_T552_N1.5400.79
223_G267_R1.5370.79
520_T554_L1.5370.79
277_I303_F1.5300.79
210_L241_F1.5270.79
183_S193_D1.5270.79
358_C366_M1.5210.78
211_L216_I1.5130.78
321_T547_W1.5120.78
293_F299_F1.5010.77
406_L563_E1.4880.77
485_I517_Q1.4860.77
102_A106_K1.4840.77
197_I255_H1.4790.76
100_K131_F1.4770.76
193_D240_D1.4670.76
372_S412_D1.4640.76
218_S230_I1.4570.75
456_T491_T1.4490.75
117_K140_L1.4490.75
137_E141_Q1.4470.75
67_Y73_S1.4410.74
499_A536_M1.4400.74
154_P472_G1.4350.74
285_V288_G1.4340.74
382_T421_Y1.4330.74
96_L100_K1.4290.74
329_I540_V1.4290.74
183_S195_D1.4270.74
373_Q382_T1.4250.74
240_D256_F1.4240.73
521_L548_T1.4200.73
342_S351_I1.4180.73
282_V292_T1.4180.73
357_A361_K1.4170.73
120_C139_I1.4160.73
404_R563_E1.4140.73
244_V252_T1.4080.73
263_N267_R1.4080.73
485_I521_L1.4070.73
49_D52_S1.4040.72
322_Y326_I1.3970.72
176_I246_E1.3950.72
455_L463_I1.3920.72
152_R192_K1.3850.71
336_G365_Y1.3830.71
557_R561_D1.3770.71
456_T487_L1.3740.71
508_T545_K1.3690.70
210_L227_V1.3680.70
58_K62_S1.3620.70
74_S78_S1.3610.70
240_D280_Y1.3610.70
158_A191_V1.3610.70
123_Q126_Q1.3610.70
256_F280_Y1.3600.70
357_A360_K1.3580.70
455_L487_L1.3560.70
349_F530_I1.3510.69
14_A31_R1.3490.69
263_N279_E1.3470.69
193_D256_F1.3340.68
352_R356_E1.3320.68
523_I539_G1.3300.68
223_G256_F1.3280.68
351_I396_L1.3210.68
367_A562_V1.3150.67
6_I64_I1.3130.67
221_A226_K1.3050.67
175_I206_V1.2890.66
13_I75_T1.2880.66
562_V566_L1.2880.66
223_G280_Y1.2820.65
59_G63_V1.2780.65
198_I206_V1.2780.65
256_F263_N1.2750.65
63_V73_S1.2740.65
110_V194_L1.2720.65
529_N532_M1.2710.65
37_L64_I1.2700.65
447_I451_L1.2660.64
256_F279_E1.2600.64
329_I556_A1.2580.64
455_L491_T1.2560.64
355_A403_F1.2560.64
378_A420_D1.2540.63
240_D267_R1.2520.63
77_E80_Q1.2470.63
242_R267_R1.2400.63
199_A246_E1.2380.62
316_G508_T1.2360.62
372_S378_A1.2220.61
240_D263_N1.2210.61
460_V493_T1.2200.61
121_E140_L1.2180.61
195_D240_D1.2160.61
510_H521_L1.2140.61
520_T557_R1.2110.61
193_D279_E1.2080.61
525_T536_M1.2080.61
316_G512_M1.2000.60
18_E31_R1.1950.60
120_C143_L1.1950.60
423_D427_A1.1940.60
355_A405_I1.1930.60
240_D279_E1.1920.59
193_D267_R1.1820.59
223_G279_E1.1740.58
121_E124_K1.1740.58
451_L484_L1.1720.58
448_M484_L1.1630.58
427_A445_H1.1610.57
554_L557_R1.1550.57
334_I363_Y1.1540.57
406_L559_L1.1510.57
11_E38_E1.1510.57
104_L131_F1.1500.57
193_D260_K1.1450.56
466_P506_L1.1440.56
263_N280_Y1.1390.56
388_Q392_E1.1360.56
448_M452_E1.1350.56
103_K107_E1.1320.55
220_I228_S1.1280.55
114_E118_E1.1280.55
442_Q460_V1.1280.55
117_K143_L1.1260.55
19_L83_V1.1240.55
542_A546_G1.1230.55
337_D525_T1.1210.55
223_G240_D1.1080.54
10_L63_V1.1070.54
22_D27_V1.0990.53
392_E395_A1.0960.53
223_G263_N1.0940.53
264_I279_E1.0940.53
290_I293_F1.0860.52
3_K15_V1.0850.52
162_A180_R1.0850.52
485_I495_L1.0840.52
195_D267_R1.0780.52
183_S192_K1.0750.52
107_E129_A1.0740.51
295_S298_E1.0670.51
99_K499_A1.0660.51
390_A394_D1.0640.51
282_V299_F1.0620.51
338_L406_L1.0610.51
242_R256_F1.0600.51
359_I401_E1.0580.50
120_C140_L1.0570.50
191_V294_P1.0560.50
223_G242_R1.0550.50
463_I493_T1.0550.50
242_R279_E1.0540.50
133_K137_E1.0510.50
23_N60_T1.0480.50
225_T228_S1.0450.50
284_T289_E1.0440.49
104_L125_V1.0430.49
308_I312_I1.0410.49
382_T385_R1.0400.49
240_D264_I1.0370.49
511_L521_L1.0350.49
180_R184_L1.0340.49
264_I267_R1.0320.49
228_S242_R1.0320.49
317_Q547_W1.0320.49
396_L400_F1.0310.49
452_E456_T1.0240.48
159_L184_L1.0230.48
440_F477_Y1.0210.48
486_E490_K1.0180.48
306_P325_S1.0170.48
437_H528_H1.0170.48
53_L56_I1.0110.47
242_R263_N1.0090.47
267_R278_S1.0010.46
452_E483_Q1.0000.46
226_K256_F0.9970.46
2_H5_D0.9960.46
411_M419_L0.9940.46
409_V421_Y0.9930.46
228_S256_F0.9920.46
345_S374_Y0.9920.46
446_V449_K0.9910.46
36_A56_I0.9890.46
387_K425_V0.9840.45
188_R261_D0.9740.45
183_S240_D0.9720.45
340_M369_T0.9710.44
449_K456_T0.9710.44
90_L101_I0.9690.44
91_L101_I0.9690.44
193_D223_G0.9660.44
26_K376_K0.9650.44
305_L323_S0.9650.44
126_Q133_K0.9630.44
251_T293_F0.9620.44
195_D256_F0.9610.44
65_K69_D0.9550.43
37_L60_T0.9540.43
108_L119_A0.9500.43
3_K7_I0.9490.43
155_I191_V0.9490.43
453_T463_I0.9470.43
485_I519_V0.9420.43
334_I536_M0.9400.42
44_L134_K0.9380.42
255_H263_N0.9360.42
359_I400_F0.9340.42
17_M30_F0.9330.42
10_L37_L0.9310.42
16_Y76_L0.9300.42
331_L540_V0.9290.42
184_L194_L0.9270.42
193_D280_Y0.9270.42
373_Q422_D0.9240.41
110_V119_A0.9240.41
103_K131_F0.9240.41
141_Q144_G0.9210.41
391_K395_A0.9160.41
44_L64_I0.9150.41
174_H200_T0.9150.41
123_Q458_K0.9130.41
120_C136_E0.9110.40
251_T255_H0.9100.40
317_Q321_T0.9060.40
30_F317_Q0.9050.40
357_A530_I0.9040.40
560_K563_E0.9030.40
125_V136_E0.9010.40
479_I484_L0.9000.40
208_E212_E0.8990.40
32_K100_K0.8990.40
344_W385_R0.8970.40
378_A412_D0.8940.39
327_E330_E0.8910.39
355_A397_N0.8910.39
104_L112_D0.8900.39
225_T244_V0.8880.39
342_S355_A0.8880.39
355_A400_F0.8880.39
172_F175_I0.8880.39
306_P322_Y0.8850.39
337_D363_Y0.8850.39
30_F358_C0.8840.39
260_K279_E0.8830.39
122_Q136_E0.8820.39
198_I241_F0.8820.39
361_K533_L0.8810.38
322_Y325_S0.8790.38
195_D260_K0.8760.38
415_P439_S0.8740.38
367_A566_L0.8740.38
463_I491_T0.8720.38
226_K279_E0.8690.38
495_L506_L0.8660.38
226_K267_R0.8660.38
225_T242_R0.8640.37
86_G125_V0.8640.37
228_S263_N0.8630.37
497_L542_A0.8630.37
397_N401_E0.8590.37
228_S264_I0.8550.37
43_S329_I0.8500.36
267_R276_R0.8480.36
270_A303_F0.8480.36
240_D278_S0.8460.36
355_A364_Q0.8450.36
386_L409_V0.8430.36
223_G228_S0.8420.36
263_N278_S0.8390.36
256_F278_S0.8370.36
178_F191_V0.8360.36
264_I278_S0.8350.36
387_K390_A0.8350.36
511_L548_T0.8340.35
242_R276_R0.8330.35
507_R510_H0.8320.35
447_I463_I0.8310.35
409_V429_M0.8310.35
299_F303_F0.8290.35
3_K250_P0.8290.35
419_L423_D0.8270.35
262_H318_E0.8270.35
192_K238_S0.8260.35
193_D263_N0.8250.35
223_G255_H0.8250.35
261_D264_I0.8210.35
489_R519_V0.8190.35
226_K263_N0.8170.34
471_I510_H0.8160.34
183_S263_N0.8160.34
459_H566_L0.8090.34
304_G541_T0.8080.34
225_T267_R0.8060.34
240_D260_K0.8060.34
58_K536_M0.8050.34
266_M277_I0.8050.34
381_L385_R0.8040.34
228_S279_E0.8030.34
42_R47_M0.8020.33
304_G483_Q0.8020.33
415_P442_Q0.8000.33
197_I293_F0.8000.33
56_I60_T0.7980.33
312_I321_T0.7960.33
460_V463_I0.7960.33
340_M354_M0.7950.33
78_S82_E0.7930.33
256_F264_I0.7920.33
377_V381_L0.7910.33
344_W421_Y0.7910.33
337_D472_G0.7880.33
64_I107_E0.7870.33
452_E484_L0.7840.32
103_K129_A0.7840.32
400_F403_F0.7800.32
373_Q378_A0.7770.32
368_I393_I0.7760.32
371_H437_H0.7760.32
375_L438_S0.7750.32
255_H267_R0.7750.32
255_H278_S0.7740.32
254_H307_L0.7730.32
317_Q320_E0.7710.32
254_H277_I0.7700.32
283_E290_I0.7690.32
378_A381_L0.7680.31
442_Q446_V0.7670.31
207_R210_L0.7670.31
195_D263_N0.7660.31
344_W351_I0.7660.31
7_I34_A0.7650.31
261_D315_S0.7650.31
498_N525_T0.7640.31
136_E442_Q0.7630.31
76_L80_Q0.7630.31
4_K348_A0.7620.31
228_S240_D0.7620.31
404_R559_L0.7620.31
155_I541_T0.7610.31
372_S421_Y0.7600.31
276_R280_Y0.7590.31
223_G264_I0.7590.31
159_L213_L0.7580.31
269_I305_L0.7560.31
369_T433_I0.7550.31
391_K394_D0.7530.31
345_S377_V0.7520.31
225_T280_Y0.7520.31
275_E303_F0.7520.31
156_G160_R0.7520.31
83_V424_D0.7520.31
255_H279_E0.7510.30
156_G502_A0.7510.30
481_I485_I0.7500.30
433_I537_K0.7500.30
283_E293_F0.7500.30
50_M312_I0.7490.30
67_Y493_T0.7480.30
18_E381_L0.7480.30
36_A53_L0.7470.30
183_S279_E0.7470.30
431_I562_V0.7470.30
255_H293_F0.7460.30
338_L367_A0.7460.30
264_I280_Y0.7460.30
456_T490_K0.7460.30
434_A491_T0.7450.30
96_L101_I0.7450.30
317_Q358_C0.7450.30
255_H280_Y0.7430.30
201_D399_E0.7430.30
271_K276_R0.7430.30
172_F209_Q0.7420.30
242_R264_I0.7410.30
439_S442_Q0.7400.30
226_K242_R0.7390.30
248_Q251_T0.7390.30
65_K335_K0.7360.30
188_R314_E0.7360.30
24_P28_S0.7360.30
346_D435_S0.7350.30
124_K127_G0.7340.29
335_K548_T0.7320.29
77_E475_A0.7310.29
192_K255_H0.7300.29
472_G525_T0.7300.29
175_I178_F0.7300.29
183_S256_F0.7300.29
153_F158_A0.7270.29
551_K557_R0.7260.29
86_G343_T0.7240.29
153_F237_T0.7230.29
359_I403_F0.7230.29
271_K277_I0.7220.29
151_E500_N0.7190.29
390_A428_E0.7190.29
256_F276_R0.7170.29
226_K264_I0.7150.28
413_I467_T0.7150.28
159_L187_A0.7140.28
315_S566_L0.7140.28
341_H437_H0.7130.28
385_R388_Q0.7120.28
476_G507_R0.7120.28
20_K83_V0.7100.28
220_I238_S0.7100.28
101_I400_F0.7100.28
372_S380_G0.7100.28
272_E300_Y0.7100.28
260_K264_I0.7090.28
369_T431_I0.7080.28
460_V491_T0.7060.28
47_M103_K0.7060.28
374_Y378_A0.7050.28
128_L218_S0.7050.28
93_L143_L0.7020.28
250_P293_F0.7010.28
193_D228_S0.6980.27
372_S409_V0.6980.27
337_D367_A0.6970.27
533_L536_M0.6970.27
93_L142_A0.6960.27
275_E284_T0.6950.27
66_E335_K0.6950.27
431_I566_L0.6930.27
412_D477_Y0.6930.27
276_R281_G0.6920.27
338_L365_Y0.6910.27
341_H528_H0.6900.27
212_E550_T0.6890.27
185_R253_L0.6890.27
170_S199_A0.6890.27
413_I463_I0.6890.27
152_R251_T0.6870.27
109_G567_K0.6870.27
195_D279_E0.6850.27
260_K267_R0.6830.27
38_E59_G0.6830.27
278_S506_L0.6820.27
202_H205_E0.6810.27
197_I252_T0.6810.27
340_M433_I0.6790.26
412_D525_T0.6780.26
26_K545_K0.6780.26
274_G289_E0.6760.26
106_K467_T0.6740.26
93_L113_A0.6730.26
227_V243_L0.6720.26
221_A238_S0.6710.26
197_I256_F0.6700.26
344_W392_E0.6700.26
110_V212_E0.6690.26
559_L566_L0.6680.26
22_D26_K0.6680.26
351_I355_A0.6670.26
25_F36_A0.6670.26
335_K558_S0.6650.26
66_E476_G0.6650.26
158_A184_L0.6650.26
242_R255_H0.6650.26
511_L542_A0.6630.26
519_V559_L0.6630.26
411_M421_Y0.6630.26
141_Q218_S0.6610.25
476_G479_I0.6610.25
113_A117_K0.6610.25
442_Q493_T0.6610.25
367_A514_A0.6600.25
193_D242_R0.6600.25
431_I461_D0.6600.25
406_L461_D0.6600.25
371_H528_H0.6580.25
4_K38_E0.6580.25
251_T292_T0.6550.25
316_G545_K0.6540.25
305_L445_H0.6540.25
447_I477_Y0.6510.25
103_K125_V0.6500.25
375_L411_M0.6500.25
487_L490_K0.6500.25
284_T288_G0.6490.25
66_E72_K0.6480.25
72_K395_A0.6480.25
247_E353_E0.6460.25
240_D255_H0.6440.25
19_L86_G0.6430.25
497_L548_T0.6430.25
394_D398_A0.6430.25
306_P327_E0.6430.25
193_D278_S0.6420.25
412_D419_L0.6420.25
462_I522_V0.6410.24
320_E551_K0.6390.24
409_V544_R0.6380.24
297_R307_L0.6370.24
356_E402_N0.6370.24
354_M527_A0.6360.24
363_Y533_L0.6350.24
56_I414_L0.6340.24
406_L431_I0.6330.24
225_T279_E0.6310.24
317_Q512_M0.6310.24
433_I456_T0.6300.24
509_E517_Q0.6290.24
183_S260_K0.6290.24
13_I76_L0.6280.24
22_D494_A0.6270.24
255_H292_T0.6270.24
247_E398_A0.6270.24
312_I328_L0.6260.24
78_S282_V0.6260.24
345_S421_Y0.6250.24
372_S414_L0.6240.24
485_I510_H0.6230.24
125_V236_E0.6210.23
393_I419_L0.6200.23
256_F260_K0.6200.23
254_H266_M0.6190.23
190_T250_P0.6190.23
337_D495_L0.6180.23
37_L490_K0.6180.23
470_L544_R0.6170.23
351_I368_I0.6170.23
125_V141_Q0.6160.23
252_T276_R0.6150.23
434_A493_T0.6150.23
85_E424_D0.6140.23
231_L239_V0.6140.23
223_G278_S0.6130.23
345_S378_A0.6120.23
372_S420_D0.6120.23
226_K240_D0.6110.23
378_A421_Y0.6110.23
375_L378_A0.6100.23
217_K232_S0.6090.23
223_G276_R0.6090.23
378_A477_Y0.6080.23
275_E299_F0.6080.23
154_P189_E0.6050.23
224_D350_S0.6040.23
272_E358_C0.6040.23
471_I535_D0.6040.23
508_T525_T0.6020.23
100_K226_K0.6020.23
399_E405_I0.6020.23
351_I405_I0.5990.22
254_H303_F0.5980.22
192_K240_D0.5980.22
169_L178_F0.5970.22
37_L92_K0.5950.22
461_D562_V0.5940.22
6_I110_V0.5940.22
294_P564_A0.5940.22
375_L495_L0.5930.22
377_V495_L0.5920.22
389_Q435_S0.5920.22
436_I451_L0.5910.22
372_S397_N0.5900.22
82_E402_N0.5900.22
331_L536_M0.5890.22
212_E298_E0.5880.22
369_T408_G0.5880.22
269_I273_R0.5880.22
208_E282_V0.5870.22
346_D371_H0.5860.22
394_D397_N0.5860.22
276_R279_E0.5860.22
189_E420_D0.5840.22
525_T545_K0.5840.22
164_E215_N0.5840.22
404_R522_V0.5820.22
101_I135_S0.5820.22
508_T542_A0.5810.22
56_I231_L0.5810.22
228_S267_R0.5800.22
166_E170_S0.5790.21
447_I464_A0.5790.21
93_L96_L0.5790.21
252_T278_S0.5780.21
455_L461_D0.5770.21
381_L389_Q0.5740.21
170_S178_F0.5740.21
5_D77_E0.5730.21
407_K542_A0.5730.21
48_D103_K0.5730.21
407_K429_M0.5730.21
242_R252_T0.5730.21
124_K403_F0.5720.21
472_G495_L0.5710.21
440_F447_I0.5710.21
260_K263_N0.5700.21
192_K250_P0.5700.21
264_I315_S0.5690.21
133_K516_E0.5690.21
183_S267_R0.5680.21
50_M407_K0.5680.21
282_V302_H0.5670.21
351_I541_T0.5670.21
371_H474_R0.5670.21
411_M429_M0.5660.21
7_I27_V0.5650.21
13_I79_L0.5640.21
226_K379_N0.5640.21
412_D464_A0.5630.21
272_E551_K0.5630.21
264_I353_E0.5630.21
498_N528_H0.5610.21
381_L393_I0.5600.21
500_N535_D0.5600.21
395_A424_D0.5590.21
198_I476_G0.5590.21
226_K229_V0.5580.21
163_R537_K0.5580.21
345_S409_V0.5580.21
188_R473_R0.5560.20
397_N407_K0.5560.20
294_P567_K0.5560.20
47_M275_E0.5560.20
190_T251_T0.5560.20
208_E222_S0.5560.20
335_K567_K0.5550.20
542_A548_T0.5540.20
497_L538_T0.5540.20
257_T310_P0.5530.20
226_K255_H0.5530.20
557_R565_F0.5530.20
123_Q137_E0.5530.20
60_T138_K0.5520.20
308_I550_T0.5520.20
210_L433_I0.5520.20
193_D264_I0.5520.20
268_Q272_E0.5510.20
50_M53_L0.5510.20
100_K494_A0.5490.20
85_E112_D0.5490.20
516_E523_I0.5480.20
452_E523_I0.5470.20
155_I165_I0.5460.20
81_K224_D0.5450.20
195_D223_G0.5450.20
104_L362_G0.5440.20
326_I547_W0.5440.20
383_A421_Y0.5440.20
9_L76_L0.5430.20
165_I196_Y0.5420.20
32_K494_A0.5420.20
54_S300_Y0.5400.20
274_G297_R0.5390.20
90_L190_T0.5390.20
433_I464_A0.5390.20
444_E483_Q0.5390.20
314_E317_Q0.5380.20
377_V525_T0.5380.20
76_L96_L0.5380.20
366_M544_R0.5380.20
158_A326_I0.5370.20
472_G513_K0.5360.20
447_I493_T0.5360.20
8_R246_E0.5350.19
183_S226_K0.5350.19
356_E551_K0.5350.19
100_K545_K0.5330.19
33_A37_L0.5330.19
70_E441_N0.5330.19
17_M22_D0.5320.19
374_Y477_Y0.5310.19
168_H209_Q0.5300.19
10_L65_K0.5290.19
120_C135_S0.5290.19
53_L248_Q0.5290.19
136_E495_L0.5280.19
322_Y545_K0.5280.19
79_L512_M0.5280.19
471_I509_E0.5270.19
335_K519_V0.5270.19
89_P110_V0.5270.19
431_I522_V0.5260.19
306_P315_S0.5240.19
7_I451_L0.5240.19
138_K218_S0.5230.19
193_D255_H0.5230.19
256_F259_S0.5230.19
344_W381_L0.5220.19
174_H202_H0.5220.19
352_R395_A0.5220.19
137_E140_L0.5220.19
49_D124_K0.5220.19
122_Q135_S0.5220.19
312_I547_W0.5210.19
225_T256_F0.5210.19
427_A521_L0.5210.19
117_K144_G0.5200.19
507_R525_T0.5190.19
169_L523_I0.5180.19
342_S406_L0.5180.19
43_S76_L0.5180.19
10_L36_A0.5180.19
510_H513_K0.5170.19
67_Y452_E0.5170.19
363_Y457_N0.5160.19
312_I326_I0.5160.19
32_K60_T0.5160.19
420_D548_T0.5160.19
240_D276_R0.5160.19
377_V380_G0.5150.19
93_L165_I0.5140.19
33_A60_T0.5140.19
183_S264_I0.5140.19
319_V322_Y0.5130.19
273_R323_S0.5130.19
59_G70_E0.5130.19
364_Q558_S0.5120.19
372_S385_R0.5110.18
132_G408_G0.5110.18
114_E470_L0.5100.18
460_V511_L0.5100.18
175_I199_A0.5090.18
385_R421_Y0.5080.18
153_F377_V0.5080.18
283_E292_T0.5070.18
463_I488_A0.5050.18
471_I565_F0.5050.18
466_P495_L0.5050.18
7_I60_T0.5040.18
101_I120_C0.5040.18
380_G412_D0.5030.18
200_T353_E0.5030.18
495_L508_T0.5020.18
96_L420_D0.5020.18
191_V311_E0.5020.18
463_I470_L0.5020.18
300_Y317_Q0.5020.18
337_D545_K0.5010.18
26_K421_Y0.5010.18
59_G429_M0.5010.18
131_F431_I0.5010.18
311_E409_V0.5000.18
142_A146_A0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b0xA 1 0.993 100 0.378 Contact Map
2w9mA 1 0.9614 100 0.43 Contact Map
4kliA 1 0.5298 100 0.659 Contact Map
2bcqA 1 0.5211 100 0.67 Contact Map
4lzgA 1 0.5088 100 0.671 Contact Map
4i2aA 1 0.5263 100 0.674 Contact Map
4p4mA 1 0.3947 100 0.68 Contact Map
1jajA 1 0.2895 100 0.811 Contact Map
3qy7A 1 0.3947 100 0.834 Contact Map
1m65A 3 0.386 100 0.834 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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