GREMLIN Database
YSHB - Uncharacterized transmembrane protein YshB
UniProt: P94543 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 177 (166)
Sequences: 652 (571)
Seq/√Len: 44.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_F116_L5.0651.00
14_T118_A3.9431.00
13_G125_V3.5651.00
38_F89_A3.2491.00
126_Y130_F2.5221.00
107_P113_N2.4951.00
126_Y157_I2.4121.00
126_Y161_T2.3791.00
148_M158_I2.3691.00
46_V85_L2.2991.00
35_S89_A2.2571.00
27_I97_G2.2571.00
151_S154_A2.2371.00
104_A113_N1.9880.99
157_I161_T1.9860.99
13_G121_G1.9740.99
54_P77_Y1.9170.99
9_L13_G1.8720.99
30_T34_L1.8590.99
101_S113_N1.8320.99
14_T122_F1.8320.99
111_Q114_Q1.8260.99
85_L89_A1.7710.98
67_F137_S1.7430.98
85_L88_I1.6440.97
9_L125_V1.6150.97
90_K93_L1.5810.96
31_S93_L1.5110.95
46_V84_V1.4880.95
48_P79_A1.4830.95
6_I153_L1.4760.95
76_Y80_I1.4290.94
130_F164_L1.4280.94
7_L156_V1.4110.93
27_I100_L1.3980.93
3_D153_L1.3950.93
44_K67_F1.3940.93
29_L128_F1.3860.93
104_A110_K1.3790.92
11_L110_K1.3720.92
31_S89_A1.3690.92
7_L83_I1.3680.92
33_I83_I1.3670.92
49_H132_L1.3610.92
106_I109_I1.3300.91
67_F72_L1.3120.90
47_A81_A1.3110.90
100_L123_L1.2940.90
46_V95_I1.2900.90
129_T153_L1.2880.90
3_D154_A1.2810.89
29_L132_L1.2760.89
85_L100_L1.2610.89
130_F161_T1.2540.88
37_A41_L1.2500.88
17_G21_G1.2350.87
28_R101_S1.2330.87
127_L159_N1.2130.86
13_G79_A1.2070.86
133_L157_I1.2040.86
130_F157_I1.2010.86
44_K166_G1.1830.85
23_I104_A1.1780.85
140_P145_Q1.1700.84
113_N117_G1.1640.84
107_P117_G1.1520.83
3_D152_S1.1490.83
132_L155_N1.1450.83
136_A144_L1.1430.83
10_L13_G1.1370.83
68_F135_V1.1340.83
86_F89_A1.1250.82
20_R25_Q1.1190.82
84_V123_L1.1150.81
10_L129_T1.1140.81
33_I37_A1.1140.81
39_A162_P1.1020.81
4_I8_I1.0860.80
29_L32_F1.0860.80
22_F117_G1.0810.79
66_S69_T1.0800.79
25_Q31_S1.0590.78
26_F158_I1.0510.77
93_L115_M1.0510.77
94_R101_S1.0480.77
21_G117_G1.0460.77
30_T96_I1.0390.77
83_I87_I1.0370.76
137_S148_M1.0290.76
42_F45_N1.0280.76
39_A82_F1.0130.75
78_N121_G1.0030.74
27_I93_L0.9990.74
56_P76_Y0.9890.73
16_L119_V0.9800.72
35_S42_F0.9720.72
38_F90_K0.9700.71
112_I116_L0.9660.71
112_I117_G0.9560.70
82_F162_P0.9540.70
25_Q97_G0.9530.70
133_L161_T0.9490.70
27_I31_S0.9480.70
110_K131_V0.9380.69
25_Q120_L0.9340.69
7_L135_V0.9320.68
46_V49_H0.9260.68
162_P165_S0.9160.67
3_D48_P0.9100.67
9_L118_A0.9040.66
111_Q115_M0.9000.66
16_L19_K0.8940.65
95_I99_F0.8860.64
55_A59_S0.8830.64
104_A107_P0.8830.64
9_L76_Y0.8620.62
9_L132_L0.8580.62
45_N48_P0.8390.60
29_L73_E0.8340.60
67_F71_N0.8240.59
4_I31_S0.8230.59
8_I70_G0.8160.58
50_L81_A0.8160.58
156_V160_H0.8120.58
35_S86_F0.7960.56
34_L123_L0.7910.56
5_I30_T0.7880.55
109_I121_G0.7880.55
43_Y78_N0.7840.55
85_L120_L0.7760.54
8_I84_V0.7760.54
90_K94_R0.7730.54
37_A156_V0.7730.54
24_L28_R0.7710.54
22_F107_P0.7600.53
56_P73_E0.7560.52
93_L124_E0.7500.52
32_F93_L0.7490.52
30_T93_L0.7460.51
70_G127_L0.7450.51
54_P81_A0.7430.51
48_P131_V0.7360.50
10_L122_F0.7350.50
61_G157_I0.7340.50
73_E77_Y0.7310.50
130_F133_L0.7310.50
11_L84_V0.7270.49
70_G84_V0.7260.49
132_L136_A0.7220.49
58_F97_G0.7200.49
34_L81_A0.7200.49
3_D14_T0.7190.49
127_L156_V0.7170.49
34_L44_K0.7110.48
136_A148_M0.7100.48
152_S156_V0.7070.48
135_V157_I0.6960.47
28_R90_K0.6940.46
88_I155_N0.6900.46
11_L27_I0.6890.46
22_F136_A0.6820.45
77_Y140_P0.6810.45
107_P111_Q0.6780.45
76_Y165_S0.6760.45
110_K113_N0.6720.44
136_A149_G0.6710.44
123_L163_Y0.6650.44
126_Y164_L0.6640.43
3_D79_A0.6620.43
129_T146_Q0.6580.43
32_F124_E0.6500.42
96_I152_S0.6500.42
103_V139_L0.6350.41
20_R24_L0.6320.40
122_F147_M0.6310.40
38_F135_V0.6240.40
81_A96_I0.6230.40
41_L148_M0.6200.39
46_V134_Y0.6200.39
117_G130_F0.6170.39
13_G124_E0.6160.39
163_Y167_L0.6150.39
59_S63_P0.6140.39
38_F85_L0.6130.39
119_V122_F0.6080.38
72_L155_N0.6080.38
113_N156_V0.6060.38
3_D72_L0.6060.38
86_F90_K0.6000.38
50_L84_V0.6000.38
72_L79_A0.5990.37
12_M16_L0.5970.37
42_F85_L0.5960.37
4_I119_V0.5950.37
92_L164_L0.5950.37
23_I138_V0.5950.37
80_I119_V0.5920.37
151_S165_S0.5910.37
135_V152_S0.5870.36
89_A104_A0.5870.36
67_F164_L0.5850.36
78_N116_L0.5850.36
12_M42_F0.5830.36
6_I29_L0.5810.36
42_F53_I0.5780.36
23_I32_F0.5770.35
87_I132_L0.5740.35
136_A147_M0.5740.35
73_E95_I0.5740.35
26_F150_Q0.5710.35
74_A78_N0.5680.35
14_T18_L0.5660.34
20_R28_R0.5620.34
72_L83_I0.5590.34
37_A159_N0.5570.34
3_D151_S0.5540.33
18_L32_F0.5540.33
41_L92_L0.5530.33
3_D35_S0.5530.33
40_A82_F0.5450.33
24_L130_F0.5440.33
115_M132_L0.5420.32
4_I88_I0.5400.32
12_M127_L0.5310.32
18_L103_V0.5280.31
11_L91_I0.5270.31
35_S127_L0.5240.31
45_N96_I0.5220.31
54_P58_F0.5220.31
135_V148_M0.5210.31
91_I121_G0.5190.31
82_F100_L0.5170.30
5_I129_T0.5150.30
7_L142_D0.5140.30
10_L126_Y0.5140.30
33_I132_L0.5130.30
122_F126_Y0.5130.30
60_A64_A0.5110.30
34_L89_A0.5100.30
43_Y154_A0.5100.30
125_V167_L0.5090.30
84_V163_Y0.5060.29
25_Q140_P0.5050.29
111_Q163_Y0.5050.29
69_T84_V0.5040.29
137_S144_L0.5040.29
132_L141_V0.5030.29
109_I112_I0.5010.29
50_L75_A0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2zy9A 2 0.4802 6.9 0.945 Contact Map
2kluA 1 0.3729 4.7 0.949 Contact Map
3hzqA 3 0.4576 2.1 0.957 Contact Map
3j01B 1 0.548 1.8 0.959 Contact Map
2hi2A 1 0.3107 1.7 0.959 Contact Map
1ji6A 1 0.4237 1.6 0.96 Contact Map
2kwtA 1 0.0847 1.5 0.961 Contact Map
3sokA 1 0.2938 1.4 0.962 Contact Map
3j9pD 4 0.7684 1.2 0.963 Contact Map
4u9nA 2 0.4746 1.1 0.964 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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