GREMLIN Database
ZAPA - Cell division protein ZapA
UniProt: P94542 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 85 (79)
Sequences: 253 (200)
Seq/√Len: 22.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_K42_E3.1031.00
24_E69_K2.6710.99
70_L74_C2.6560.99
30_R51_D2.3300.97
40_M55_L2.1910.96
32_V51_D2.1210.95
11_V33_A2.0160.93
74_C78_E1.9440.92
15_G64_V1.9210.92
30_R81_L1.8700.91
20_I29_M1.8310.90
8_K18_F1.8050.89
28_H65_H1.6320.83
73_K78_E1.6210.83
71_Q75_E1.5260.79
7_T29_M1.5020.78
51_D54_K1.4930.77
25_S29_M1.4680.76
18_F57_V1.4190.73
21_V76_K1.3670.71
14_Y43_I1.3470.69
32_V61_V1.3430.69
54_K61_V1.3350.69
51_D61_V1.2830.66
12_D17_H1.2650.64
35_I64_V1.2340.62
57_V81_L1.2170.61
26_R29_M1.1950.60
40_M57_V1.1880.59
34_G71_Q1.1800.59
22_G37_D1.1800.59
12_D41_R1.1780.59
39_K62_N1.1690.58
66_D80_Q1.1310.56
73_K80_Q1.1190.55
75_E78_E1.0800.52
74_C80_Q1.0760.52
44_N48_P1.0690.51
4_G59_T1.0560.51
7_T25_S1.0470.50
35_I68_V1.0430.50
15_G49_Y1.0330.49
18_F47_N1.0270.49
8_K65_H1.0160.48
9_T55_L1.0150.48
14_Y54_K1.0130.48
79_R82_K1.0060.47
5_K53_N0.9510.43
37_D41_R0.9410.43
33_A60_A0.9330.42
70_L81_L0.9320.42
59_T64_V0.8830.39
63_V66_D0.8780.38
75_E79_R0.8770.38
8_K78_E0.8570.37
14_Y55_L0.8560.37
14_Y40_M0.8320.36
48_P75_E0.8310.35
30_R61_V0.8270.35
16_Q63_V0.8120.34
15_G40_M0.8110.34
63_V69_K0.8080.34
25_S61_V0.8080.34
18_F80_Q0.8080.34
42_E46_K0.8040.34
5_K23_E0.7960.33
20_I45_E0.7910.33
22_G64_V0.7790.32
36_V56_A0.7710.32
34_G54_K0.7600.31
44_N49_Y0.7560.31
17_H29_M0.7540.31
9_T22_G0.7450.30
72_E79_R0.7390.30
49_Y63_V0.7310.29
26_R70_L0.7270.29
57_V67_Y0.7260.29
47_N50_L0.7040.28
67_Y71_Q0.7000.28
24_E72_E0.6910.27
24_E47_N0.6890.27
4_G82_K0.6790.27
31_Y66_D0.6790.27
40_M56_A0.6680.26
16_Q27_A0.6650.26
16_Q51_D0.6530.25
29_M46_K0.6490.25
37_D52_I0.6390.24
5_K35_I0.6250.24
4_G23_E0.6220.24
8_K19_T0.6200.24
41_R47_N0.5990.22
30_R41_R0.5960.22
25_S48_P0.5940.22
31_Y39_K0.5900.22
17_H27_A0.5890.22
67_Y72_E0.5870.22
63_V79_R0.5850.22
36_V66_D0.5770.21
21_V51_D0.5760.21
20_I65_H0.5640.21
30_R67_Y0.5620.21
45_E81_L0.5550.20
8_K54_K0.5530.20
24_E71_Q0.5450.20
6_K52_I0.5440.20
15_G55_L0.5440.20
77_L81_L0.5440.20
28_H69_K0.5330.19
67_Y73_K0.5240.19
10_T20_I0.5210.19
52_I67_Y0.5190.19
44_N65_H0.5140.19
32_V68_V0.5120.19
22_G70_L0.5110.19
6_K82_K0.5110.19
22_G41_R0.5100.19
15_G44_N0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2mmvA 2 0.9765 99.9 0.394 Contact Map
3hnwA 2 0.9176 99.8 0.417 Contact Map
1t3uA 4 0.9412 99.8 0.458 Contact Map
4p1mA 4 0.9529 99.7 0.471 Contact Map
3m4wA 2 0.4588 28.5 0.909 Contact Map
2d9dA 1 0.6235 12.7 0.923 Contact Map
2fe3A 2 0.6235 11.5 0.924 Contact Map
1bgvA 5 0.6235 11.3 0.924 Contact Map
2o03A 2 0.5059 10.9 0.925 Contact Map
1wgkA 1 0.9176 9.9 0.926 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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