GREMLIN Database
SSPI - Small, acid-soluble spore protein I
UniProt: P94537 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 71 (68)
Sequences: 154 (96)
Seq/√Len: 11.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
21_L63_L3.3200.97
47_I59_M3.2580.97
17_N20_Q2.8050.93
3_L7_H1.8940.69
10_I67_L1.8680.68
60_L64_E1.8580.67
16_N47_I1.7680.63
53_E56_K1.7550.63
46_V67_L1.7420.62
47_I63_L1.7220.61
22_E56_K1.7150.61
5_L25_I1.5690.54
24_T28_A1.5360.52
21_L60_L1.5300.52
24_T35_K1.3960.45
16_N63_L1.3920.45
5_L9_V1.3050.41
43_L47_I1.3040.41
46_V50_H1.2810.40
44_F47_I1.2570.39
43_L59_M1.2430.38
21_L59_M1.2200.37
54_S57_N1.2130.37
55_E61_K1.2090.37
57_N61_K1.1920.36
60_L63_L1.1400.33
44_F59_M1.1360.33
21_L64_E1.1220.33
9_V46_V1.0820.31
26_V30_Q1.0710.30
46_V68_K1.0640.30
5_L36_M1.0540.30
53_E58_E0.9980.28
4_N7_H0.9980.28
3_L62_T0.9810.27
4_N25_I0.9690.26
3_L55_E0.9640.26
27_D33_E0.9530.26
13_V17_N0.9510.26
47_I51_A0.9510.26
51_A58_E0.9410.25
50_H65_G0.9320.25
13_V63_L0.9050.24
57_N62_T0.8970.24
15_G60_L0.8890.23
7_H13_V0.8880.23
50_H62_T0.8880.23
36_M66_G0.8830.23
11_A58_E0.8830.23
18_Q54_S0.8590.22
28_A64_E0.8520.22
53_E65_G0.8360.22
11_A23_H0.8250.21
52_S61_K0.8120.21
22_E53_E0.8080.21
46_V66_G0.8040.21
3_L19_E0.7990.20
4_N22_E0.7850.20
56_K68_K0.7730.20
5_L31_S0.7720.20
12_N33_E0.7650.19
4_N35_K0.7620.19
1_M36_M0.7600.19
13_V62_T0.7490.19
30_Q49_Q0.7430.19
50_H57_N0.7430.19
13_V53_E0.7290.18
3_L11_A0.7250.18
19_E57_N0.7240.18
9_V54_S0.7230.18
12_N35_K0.7160.18
11_A26_V0.7160.18
1_M12_N0.7050.18
26_V52_S0.6920.17
21_L47_I0.6850.17
5_L44_F0.6770.17
23_H52_S0.6610.16
61_K65_G0.6560.16
16_N28_A0.6550.16
51_A57_N0.6480.16
23_H66_G0.6480.16
10_I23_H0.6460.16
15_G32_G0.6400.16
49_Q60_L0.6400.16
9_V65_G0.6300.15
28_A35_K0.6210.15
15_G47_I0.6180.15
18_Q57_N0.6180.15
16_N49_Q0.6110.15
10_I52_S0.6090.15
35_K43_L0.6050.15
44_F49_Q0.6040.15
5_L13_V0.5870.14
52_S55_E0.5610.14
16_N24_T0.5610.14
15_G46_V0.5590.14
62_T68_K0.5570.14
31_S65_G0.5540.14
10_I14_T0.5460.13
2_D7_H0.5330.13
33_E36_M0.5030.12
17_N49_Q0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3a5iA 1 0.7746 32.3 0.898 Contact Map
3mydA 1 0.8451 29.2 0.9 Contact Map
3mixA 1 0.7606 23.6 0.905 Contact Map
4qjuA 2 0.9718 20.2 0.908 Contact Map
2x49A 1 0.8451 19.3 0.909 Contact Map
2iieA 1 0.9718 18.7 0.909 Contact Map
2x24A 2 0 18 0.91 Contact Map
4ogdA 2 0.8028 17.8 0.91 Contact Map
1mw7A 1 0.8873 16.9 0.911 Contact Map
1owfA 1 0.9577 16.7 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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