GREMLIN Database
YSFB - Uncharacterized protein YsfB
UniProt: P94536 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 368 (343)
Sequences: 6386 (5317)
Seq/√Len: 287.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
239_G250_S7.0391.00
314_H324_D5.9261.00
340_E346_R3.7161.00
303_E306_N3.6501.00
327_I331_T3.2431.00
349_R352_D3.0961.00
314_H321_T2.8481.00
321_T332_L2.8231.00
327_I332_L2.7891.00
237_G257_A2.7791.00
313_H324_D2.7461.00
306_N310_T2.7071.00
310_T314_H2.5981.00
240_R253_Q2.5681.00
237_G254_A2.5451.00
165_L254_A2.4651.00
308_I339_A2.4641.00
351_E361_Y2.4411.00
167_Q262_L2.4211.00
320_Q323_E2.4111.00
199_R255_E2.3221.00
243_A246_S2.3111.00
329_I333_R2.2971.00
12_I25_I2.2891.00
309_R313_H2.2461.00
114_K117_R2.2031.00
345_L352_D2.1871.00
310_T321_T2.0651.00
340_E347_F2.0461.00
328_H331_T2.0391.00
79_V87_A2.0281.00
9_K13_A2.0211.00
27_N31_L1.9831.00
299_L363_L1.9771.00
135_D149_K1.9741.00
201_L251_Y1.9711.00
166_I236_A1.9591.00
261_S268_I1.9251.00
315_D349_R1.9031.00
163_M250_S1.8981.00
337_A341_Q1.8781.00
237_G258_L1.8621.00
251_Y255_E1.8581.00
307_T321_T1.8221.00
310_T324_D1.8051.00
337_A340_E1.8021.00
316_L353_V1.7851.00
107_K110_E1.7701.00
106_R110_E1.7531.00
338_K341_Q1.7471.00
354_V357_Y1.7371.00
312_F353_V1.7361.00
16_K36_T1.7341.00
164_I238_A1.7231.00
269_F272_D1.7201.00
353_V357_Y1.7161.00
132_F150_A1.6991.00
319_K323_E1.6881.00
345_L355_T1.6811.00
318_L333_R1.6711.00
242_V253_Q1.6631.00
248_T252_E1.6541.00
216_L220_L1.6361.00
134_I196_G1.6311.00
314_H320_Q1.6081.00
307_T332_L1.5811.00
242_V246_S1.5781.00
242_V250_S1.5771.00
256_K281_E1.5581.00
294_V297_K1.5551.00
167_Q258_L1.5391.00
339_A343_T1.5351.00
240_R271_E1.5311.00
162_Q206_V1.5291.00
340_E348_D1.5121.00
307_T335_R1.5111.00
319_K333_R1.5081.00
298_A339_A1.5071.00
167_Q199_R1.4871.00
167_Q235_A1.4751.00
343_T352_D1.4691.00
319_K329_I1.4671.00
246_S249_D1.4641.00
165_L255_E1.4541.00
311_F316_L1.4391.00
105_L109_T1.4391.00
250_S254_A1.4281.00
338_K342_L1.4261.00
320_Q324_D1.4061.00
163_M254_A1.3931.00
161_R247_L1.3901.00
307_T339_A1.3761.00
310_T325_M1.3721.00
311_F318_L1.3721.00
71_V74_G1.3681.00
135_D140_K1.3641.00
142_W145_S1.3581.00
304_L342_L1.3451.00
37_N40_R1.3361.00
312_F316_L1.3331.00
162_Q241_A1.3261.00
163_M239_G1.3151.00
313_H357_Y1.3071.00
317_S320_Q1.3001.00
238_A269_F1.2851.00
316_L321_T1.2791.00
47_G52_A1.2781.00
106_R109_T1.2761.00
177_E181_R1.2661.00
40_R43_Q1.2651.00
304_L307_T1.2591.00
203_N247_L1.2541.00
99_Q102_G1.2511.00
74_G77_L1.2511.00
45_H48_A1.2471.00
311_F336_L1.2451.00
12_I23_V1.2361.00
163_M203_N1.2261.00
274_K277_M1.2211.00
239_G242_V1.2091.00
304_L339_A1.2001.00
309_R363_L1.1961.00
278_C290_F1.1941.00
165_L237_G1.1841.00
134_I138_Q1.1771.00
71_V76_N1.1711.00
217_R221_H1.1601.00
298_A305_M1.1601.00
165_L251_Y1.1571.00
257_A261_S1.1571.00
315_D350_T1.1541.00
57_S60_I1.1541.00
257_A270_E1.1351.00
59_I62_K1.1311.00
334_Y338_K1.1291.00
325_M332_L1.1151.00
50_I54_E1.1071.00
47_G51_C1.1011.00
80_F85_V1.1001.00
317_S332_L1.0961.00
318_L336_L1.0931.00
213_D216_L1.0901.00
217_R220_L1.0891.00
37_N41_V1.0861.00
297_K342_L1.0851.00
98_I102_G1.0821.00
123_Q127_R1.0801.00
123_Q126_E1.0741.00
155_V161_R1.0661.00
14_E17_K1.0611.00
180_A183_W1.0571.00
69_K72_K1.0561.00
330_N333_R1.0471.00
125_R129_L1.0461.00
49_L52_A1.0441.00
294_V355_T1.0441.00
235_A262_L1.0391.00
179_M184_K1.0381.00
165_L258_L1.0351.00
357_Y361_Y1.0321.00
305_M309_R1.0291.00
76_N88_V1.0081.00
143_S245_S1.0011.00
352_D355_T1.0001.00
290_F294_V0.9961.00
283_S287_R0.9961.00
52_A55_R0.9941.00
150_A157_L0.9931.00
164_I204_H0.9921.00
237_G261_S0.9901.00
336_L340_E0.9861.00
254_A257_A0.9831.00
307_T327_I0.9811.00
160_R241_A0.9811.00
305_M360_L0.9801.00
299_L305_M0.9791.00
14_E18_M0.9731.00
317_S329_I0.9721.00
237_G253_Q0.9671.00
16_K22_E0.9641.00
347_F352_D0.9621.00
340_E343_T0.9581.00
25_I79_V0.9491.00
239_G254_A0.9361.00
216_L269_F0.9351.00
242_V247_L0.9351.00
15_V19_Y0.9341.00
312_F357_Y0.9341.00
287_R362_F0.9341.00
329_I337_A0.9281.00
178_Q182_S0.9231.00
276_D351_E0.9231.00
47_G50_I0.9231.00
336_L339_A0.9231.00
70_G73_A0.9171.00
238_A267_P0.9151.00
25_I89_F0.9121.00
277_M293_R0.9111.00
292_Q296_G0.9051.00
231_S234_T0.9011.00
220_L223_C0.8981.00
104_L108_M0.8961.00
24_I30_G0.8931.00
22_E36_T0.8901.00
290_F296_G0.8861.00
150_A153_L0.8841.00
242_V249_D0.8811.00
147_L150_A0.8811.00
70_G78_P0.8801.00
124_W127_R0.8801.00
163_M251_Y0.8751.00
12_I34_A0.8741.00
26_V90_G0.8721.00
139_L248_T0.8721.00
307_T325_M0.8711.00
348_D353_V0.8671.00
220_L224_S0.8631.00
276_D361_Y0.8631.00
127_R131_S0.8561.00
309_R360_L0.8511.00
318_L330_N0.8481.00
275_L358_V0.8461.00
311_F321_T0.8441.00
27_N33_M0.8361.00
51_C54_E0.8361.00
100_P103_E0.8361.00
193_I202_I0.8351.00
310_T313_H0.8341.00
98_I101_F0.8331.00
113_I117_R0.8331.00
176_I180_A0.8321.00
76_N79_V0.8311.00
148_E152_L0.8281.00
130_E134_I0.8271.00
284_P287_R0.8251.00
305_M363_L0.8231.00
45_H51_C0.8231.00
93_G96_A0.8231.00
74_G90_G0.8191.00
79_V82_D0.8191.00
166_I202_I0.8181.00
156_D159_S0.8151.00
164_I202_I0.8131.00
165_L201_L0.8121.00
178_Q181_R0.8000.99
143_S147_L0.7980.99
48_A52_A0.7970.99
314_H332_L0.7950.99
46_E55_R0.7940.99
249_D252_E0.7920.99
82_D87_A0.7910.99
346_R349_R0.7880.99
46_E49_L0.7870.99
334_Y341_Q0.7850.99
290_F359_A0.7830.99
58_V61_T0.7820.99
326_H334_Y0.7790.99
45_H55_R0.7760.99
291_P362_F0.7730.99
117_R121_Q0.7730.99
346_R352_D0.7720.99
47_G55_R0.7700.99
358_V361_Y0.7690.99
288_N292_Q0.7680.99
253_Q270_E0.7650.99
350_T357_Y0.7640.99
74_G80_F0.7630.99
22_E92_T0.7620.99
124_W128_M0.7620.99
132_F149_K0.7610.99
50_I53_K0.7610.99
294_V359_A0.7600.99
293_R297_K0.7590.99
26_V35_G0.7580.99
351_E355_T0.7550.99
354_V358_V0.7520.99
219_I222_I0.7510.99
57_S61_T0.7480.99
105_L108_M0.7450.99
291_P295_L0.7450.99
252_E256_K0.7430.99
72_K76_N0.7420.99
132_F153_L0.7410.99
270_E277_M0.7390.99
308_I312_F0.7390.99
350_T353_V0.7350.99
273_L277_M0.7310.99
347_F353_V0.7310.99
39_E42_G0.7310.99
177_E184_K0.7270.99
274_K290_F0.7270.99
49_L53_K0.7260.99
343_T356_M0.7250.99
257_A273_L0.7240.99
118_H121_Q0.7180.99
145_S148_E0.7170.99
274_K355_T0.7170.99
80_F87_A0.7140.99
26_V30_G0.7080.99
104_L107_K0.7070.99
239_G257_A0.7070.99
279_L358_V0.7050.99
300_E338_K0.7050.99
181_R185_S0.7010.99
169_Y235_A0.6980.99
136_W244_S0.6970.98
133_M203_N0.6970.98
19_Y22_E0.6950.98
55_R59_I0.6940.98
315_D353_V0.6940.98
354_V361_Y0.6940.98
84_D87_A0.6940.98
249_D253_Q0.6910.98
39_E43_Q0.6910.98
340_E344_G0.6910.98
74_G87_A0.6900.98
44_F47_G0.6890.98
88_V91_L0.6860.98
56_R60_I0.6850.98
213_D217_R0.6840.98
85_V88_V0.6830.98
271_E293_R0.6830.98
51_C55_R0.6820.98
317_S333_R0.6800.98
80_F86_I0.6780.98
309_R361_Y0.6780.98
313_H351_E0.6770.98
32_I35_G0.6750.98
218_K223_C0.6750.98
48_A51_C0.6730.98
67_R74_G0.6730.98
44_F49_L0.6720.98
16_K21_R0.6690.98
146_F156_D0.6690.98
144_P148_E0.6690.98
45_H49_L0.6680.98
294_V345_L0.6680.98
329_I357_Y0.6670.98
33_M36_T0.6640.98
284_P288_N0.6610.98
12_I19_Y0.6610.98
201_L255_E0.6600.98
306_N309_R0.6590.98
52_A58_V0.6580.98
236_A267_P0.6570.98
15_V108_M0.6560.98
37_N43_Q0.6560.98
48_A54_E0.6530.98
313_H361_Y0.6530.98
67_R73_A0.6510.98
162_Q271_E0.6490.98
117_R120_E0.6490.98
257_A268_I0.6460.98
102_G106_R0.6420.97
351_E354_V0.6420.97
45_H52_A0.6420.97
22_E37_N0.6410.97
316_L333_R0.6410.97
38_D41_V0.6410.97
30_G35_G0.6390.97
11_I16_K0.6380.97
164_I236_A0.6360.97
275_L355_T0.6360.97
146_F150_A0.6350.97
42_G45_H0.6330.97
88_V92_T0.6330.97
295_L359_A0.6320.97
221_H224_S0.6310.97
321_T329_I0.6290.97
91_L105_L0.6260.97
353_V360_L0.6260.97
89_F109_T0.6250.97
182_S186_S0.6250.97
46_E50_I0.6240.97
55_R58_V0.6240.97
12_I16_K0.6230.97
326_H329_I0.6190.97
71_V79_V0.6170.97
71_V77_L0.6160.97
90_G93_G0.6150.97
132_F136_W0.6100.97
136_W247_L0.6090.96
252_E255_E0.6090.96
143_S146_F0.6080.96
81_F86_I0.6070.96
133_M138_Q0.6060.96
180_A184_K0.6030.96
311_F340_E0.6010.96
326_H331_T0.6000.96
89_F92_T0.6000.96
101_F104_L0.5980.96
83_H87_A0.5980.96
69_K76_N0.5980.96
291_P296_G0.5970.96
164_I219_I0.5970.96
216_L272_D0.5960.96
329_I332_L0.5940.96
223_C236_A0.5920.96
9_K34_A0.5920.96
302_Q305_M0.5900.96
328_H334_Y0.5890.96
103_E106_R0.5880.96
44_F48_A0.5870.96
165_L199_R0.5870.96
25_I37_N0.5870.96
47_G58_V0.5860.96
21_R91_L0.5860.96
28_T31_L0.5850.96
119_L123_Q0.5850.96
283_S290_F0.5840.96
345_L349_R0.5840.96
307_T334_Y0.5830.96
283_S286_T0.5830.96
219_I223_C0.5830.96
294_V298_A0.5820.95
58_V62_K0.5820.95
54_E57_S0.5820.95
113_I124_W0.5800.95
13_A36_T0.5800.95
87_A92_T0.5790.95
177_E182_S0.5770.95
26_V74_G0.5750.95
253_Q289_E0.5740.95
318_L329_I0.5740.95
213_D221_H0.5740.95
72_K79_V0.5740.95
89_F94_E0.5740.95
12_I32_I0.5740.95
10_K14_E0.5720.95
274_K293_R0.5700.95
32_I36_T0.5690.95
27_N30_G0.5680.95
23_V91_L0.5670.95
167_Q198_E0.5660.95
84_D92_T0.5660.95
144_P147_L0.5650.95
67_R70_G0.5630.95
70_G76_N0.5610.94
115_E119_L0.5600.94
40_R45_H0.5590.94
76_N80_F0.5590.94
347_F356_M0.5570.94
289_E293_R0.5560.94
321_T327_I0.5540.94
74_G78_P0.5530.94
115_E118_H0.5530.94
136_W157_L0.5530.94
292_Q359_A0.5530.94
93_G98_I0.5530.94
157_L244_S0.5530.94
77_L106_R0.5520.94
312_F339_A0.5520.94
86_I336_L0.5510.94
316_L350_T0.5510.94
177_E180_A0.5510.94
318_L328_H0.5490.94
22_E26_V0.5470.94
74_G79_V0.5460.94
323_E326_H0.5450.94
26_V32_I0.5450.94
290_F295_L0.5450.94
340_E345_L0.5440.94
129_L133_M0.5430.93
57_S62_K0.5430.93
244_S247_L0.5400.93
291_P294_V0.5400.93
56_R62_K0.5400.93
24_I35_G0.5380.93
127_R130_E0.5380.93
126_E130_E0.5370.93
294_V352_D0.5360.93
121_Q125_R0.5340.93
295_L299_L0.5330.93
56_R59_I0.5320.93
21_R102_G0.5320.93
68_L76_N0.5290.93
276_D279_L0.5290.93
196_G201_L0.5280.93
277_M281_E0.5270.92
260_V277_M0.5260.92
22_E34_A0.5260.92
120_E124_W0.5240.92
26_V31_L0.5230.92
298_A342_L0.5210.92
237_G270_E0.5210.92
119_L122_S0.5210.92
350_T354_V0.5200.92
273_L276_D0.5190.92
74_G86_I0.5190.92
52_A60_I0.5180.92
121_Q124_W0.5180.92
135_D139_L0.5180.92
277_M280_T0.5160.92
30_G88_V0.5150.92
256_K259_A0.5150.92
233_Y264_R0.5150.92
75_I79_V0.5140.92
54_E61_T0.5140.92
308_I356_M0.5120.91
128_M131_S0.5120.91
69_K79_V0.5100.91
125_R128_M0.5090.91
89_F93_G0.5080.91
24_I27_N0.5070.91
240_R269_F0.5060.91
70_G90_G0.5050.91
131_S196_G0.5050.91
46_E54_E0.5050.91
237_G268_I0.5030.91
322_A332_L0.5030.91
330_N354_V0.5020.91
285_G293_R0.5010.90
176_I179_M0.5000.90
235_A261_S0.5000.90
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3onqA 5 0.6712 100 0.445 Contact Map
2gx5A 2 0.3288 95.8 0.902 Contact Map
3hhgA 3 0.1902 95.6 0.903 Contact Map
1al3A 1 0 95.5 0.903 Contact Map
4eu0A 1 0.644 95.5 0.903 Contact Map
2esnA 3 0.2011 95.1 0.906 Contact Map
3szpA 3 0.1848 95.1 0.906 Contact Map
2w1rA 2 0.2908 95 0.906 Contact Map
3mz1A 2 0 95 0.906 Contact Map
3fxqA 3 0.1875 94.5 0.909 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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