YSFB - BACSU - GREMLIN Contacts

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YSFB - Uncharacterized protein YsfB

UniProt:	P94536	Sequences: MFLQPLLAKKIIAEVKKMYEREVIIVNTDGLIMAGTNDERVGQFHEGALICAKERRSVIITKEDETRLKGVKAGINLPVFFDHDVIAVFGLTGEPAEIQPFGELLRKMTELFIKESRHLEQSQWRERMLESFMIDWLQLKEWSPSFLEKAQLLGVDLSSRRQMILIQGYEWSPHDIEQMARSWKSSYPADLFIRWGNERILINHEVPQHEQRDRLLRKILHICSFANTASSQYTAAGAGRAVASSSLTDSYEQAEKALAVSLKRKTPIFEEDLKLDMCLTEISPGTRNEFPQRVLGKALEHQELMNTIRTFFHHDLSLKQTAEDMHIHINTLRYRLAKAEQLTGLRFDRTEDVVTMYVALYFLDQDTK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	368 (343)
Sequences:	6386 (5317)
Seq/√Len:	287.1

ECOLI - CDAR
BACSU - YSFB PUCR ADER YCGP YXKF

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
239_G	250_S	7.039	1.00
314_H	324_D	5.926	1.00
340_E	346_R	3.716	1.00
303_E	306_N	3.650	1.00
327_I	331_T	3.243	1.00
349_R	352_D	3.096	1.00
314_H	321_T	2.848	1.00
321_T	332_L	2.823	1.00
327_I	332_L	2.789	1.00
237_G	257_A	2.779	1.00
313_H	324_D	2.746	1.00
306_N	310_T	2.707	1.00
310_T	314_H	2.598	1.00
240_R	253_Q	2.568	1.00
237_G	254_A	2.545	1.00
165_L	254_A	2.465	1.00
308_I	339_A	2.464	1.00
351_E	361_Y	2.441	1.00
167_Q	262_L	2.421	1.00
320_Q	323_E	2.411	1.00
199_R	255_E	2.322	1.00
243_A	246_S	2.311	1.00
329_I	333_R	2.297	1.00
12_I	25_I	2.289	1.00
309_R	313_H	2.246	1.00
114_K	117_R	2.203	1.00
345_L	352_D	2.187	1.00
310_T	321_T	2.065	1.00
340_E	347_F	2.046	1.00
328_H	331_T	2.039	1.00
79_V	87_A	2.028	1.00
9_K	13_A	2.021	1.00
27_N	31_L	1.983	1.00
299_L	363_L	1.977	1.00
135_D	149_K	1.974	1.00
201_L	251_Y	1.971	1.00
166_I	236_A	1.959	1.00
261_S	268_I	1.925	1.00
315_D	349_R	1.903	1.00
163_M	250_S	1.898	1.00
337_A	341_Q	1.878	1.00
237_G	258_L	1.862	1.00
251_Y	255_E	1.858	1.00
307_T	321_T	1.822	1.00
310_T	324_D	1.805	1.00
337_A	340_E	1.802	1.00
316_L	353_V	1.785	1.00
107_K	110_E	1.770	1.00
106_R	110_E	1.753	1.00
338_K	341_Q	1.747	1.00
354_V	357_Y	1.737	1.00
312_F	353_V	1.736	1.00
16_K	36_T	1.734	1.00
164_I	238_A	1.723	1.00
269_F	272_D	1.720	1.00
353_V	357_Y	1.716	1.00
132_F	150_A	1.699	1.00
319_K	323_E	1.688	1.00
345_L	355_T	1.681	1.00
318_L	333_R	1.671	1.00
242_V	253_Q	1.663	1.00
248_T	252_E	1.654	1.00
216_L	220_L	1.636	1.00
134_I	196_G	1.631	1.00
314_H	320_Q	1.608	1.00
307_T	332_L	1.581	1.00
242_V	246_S	1.578	1.00
242_V	250_S	1.577	1.00
256_K	281_E	1.558	1.00
294_V	297_K	1.555	1.00
167_Q	258_L	1.539	1.00
339_A	343_T	1.535	1.00
240_R	271_E	1.531	1.00
162_Q	206_V	1.529	1.00
340_E	348_D	1.512	1.00
307_T	335_R	1.511	1.00
319_K	333_R	1.508	1.00
298_A	339_A	1.507	1.00
167_Q	199_R	1.487	1.00
167_Q	235_A	1.475	1.00
343_T	352_D	1.469	1.00
319_K	329_I	1.467	1.00
246_S	249_D	1.464	1.00
165_L	255_E	1.454	1.00
311_F	316_L	1.439	1.00
105_L	109_T	1.439	1.00
250_S	254_A	1.428	1.00
338_K	342_L	1.426	1.00
320_Q	324_D	1.406	1.00
163_M	254_A	1.393	1.00
161_R	247_L	1.390	1.00
307_T	339_A	1.376	1.00
310_T	325_M	1.372	1.00
311_F	318_L	1.372	1.00
71_V	74_G	1.368	1.00
135_D	140_K	1.364	1.00
142_W	145_S	1.358	1.00
304_L	342_L	1.345	1.00
37_N	40_R	1.336	1.00
312_F	316_L	1.333	1.00
162_Q	241_A	1.326	1.00
163_M	239_G	1.315	1.00
313_H	357_Y	1.307	1.00
317_S	320_Q	1.300	1.00
238_A	269_F	1.285	1.00
316_L	321_T	1.279	1.00
47_G	52_A	1.278	1.00
106_R	109_T	1.276	1.00
177_E	181_R	1.266	1.00
40_R	43_Q	1.265	1.00
304_L	307_T	1.259	1.00
203_N	247_L	1.254	1.00
99_Q	102_G	1.251	1.00
74_G	77_L	1.251	1.00
45_H	48_A	1.247	1.00
311_F	336_L	1.245	1.00
12_I	23_V	1.236	1.00
163_M	203_N	1.226	1.00
274_K	277_M	1.221	1.00
239_G	242_V	1.209	1.00
304_L	339_A	1.200	1.00
309_R	363_L	1.196	1.00
278_C	290_F	1.194	1.00
165_L	237_G	1.184	1.00
134_I	138_Q	1.177	1.00
71_V	76_N	1.171	1.00
217_R	221_H	1.160	1.00
298_A	305_M	1.160	1.00
165_L	251_Y	1.157	1.00
257_A	261_S	1.157	1.00
315_D	350_T	1.154	1.00
57_S	60_I	1.154	1.00
257_A	270_E	1.135	1.00
59_I	62_K	1.131	1.00
334_Y	338_K	1.129	1.00
325_M	332_L	1.115	1.00
50_I	54_E	1.107	1.00
47_G	51_C	1.101	1.00
80_F	85_V	1.100	1.00
317_S	332_L	1.096	1.00
318_L	336_L	1.093	1.00
213_D	216_L	1.090	1.00
217_R	220_L	1.089	1.00
37_N	41_V	1.086	1.00
297_K	342_L	1.085	1.00
98_I	102_G	1.082	1.00
123_Q	127_R	1.080	1.00
123_Q	126_E	1.074	1.00
155_V	161_R	1.066	1.00
14_E	17_K	1.061	1.00
180_A	183_W	1.057	1.00
69_K	72_K	1.056	1.00
330_N	333_R	1.047	1.00
125_R	129_L	1.046	1.00
49_L	52_A	1.044	1.00
294_V	355_T	1.044	1.00
235_A	262_L	1.039	1.00
179_M	184_K	1.038	1.00
165_L	258_L	1.035	1.00
357_Y	361_Y	1.032	1.00
305_M	309_R	1.029	1.00
76_N	88_V	1.008	1.00
143_S	245_S	1.001	1.00
352_D	355_T	1.000	1.00
290_F	294_V	0.996	1.00
283_S	287_R	0.996	1.00
52_A	55_R	0.994	1.00
150_A	157_L	0.993	1.00
164_I	204_H	0.992	1.00
237_G	261_S	0.990	1.00
336_L	340_E	0.986	1.00
254_A	257_A	0.983	1.00
307_T	327_I	0.981	1.00
160_R	241_A	0.981	1.00
305_M	360_L	0.980	1.00
299_L	305_M	0.979	1.00
14_E	18_M	0.973	1.00
317_S	329_I	0.972	1.00
237_G	253_Q	0.967	1.00
16_K	22_E	0.964	1.00
347_F	352_D	0.962	1.00
340_E	343_T	0.958	1.00
25_I	79_V	0.949	1.00
239_G	254_A	0.936	1.00
216_L	269_F	0.935	1.00
242_V	247_L	0.935	1.00
15_V	19_Y	0.934	1.00
312_F	357_Y	0.934	1.00
287_R	362_F	0.934	1.00
329_I	337_A	0.928	1.00
178_Q	182_S	0.923	1.00
276_D	351_E	0.923	1.00
47_G	50_I	0.923	1.00
336_L	339_A	0.923	1.00
70_G	73_A	0.917	1.00
238_A	267_P	0.915	1.00
25_I	89_F	0.912	1.00
277_M	293_R	0.911	1.00
292_Q	296_G	0.905	1.00
231_S	234_T	0.901	1.00
220_L	223_C	0.898	1.00
104_L	108_M	0.896	1.00
24_I	30_G	0.893	1.00
22_E	36_T	0.890	1.00
290_F	296_G	0.886	1.00
150_A	153_L	0.884	1.00
242_V	249_D	0.881	1.00
147_L	150_A	0.881	1.00
70_G	78_P	0.880	1.00
124_W	127_R	0.880	1.00
163_M	251_Y	0.875	1.00
12_I	34_A	0.874	1.00
26_V	90_G	0.872	1.00
139_L	248_T	0.872	1.00
307_T	325_M	0.871	1.00
348_D	353_V	0.867	1.00
220_L	224_S	0.863	1.00
276_D	361_Y	0.863	1.00
127_R	131_S	0.856	1.00
309_R	360_L	0.851	1.00
318_L	330_N	0.848	1.00
275_L	358_V	0.846	1.00
311_F	321_T	0.844	1.00
27_N	33_M	0.836	1.00
51_C	54_E	0.836	1.00
100_P	103_E	0.836	1.00
193_I	202_I	0.835	1.00
310_T	313_H	0.834	1.00
98_I	101_F	0.833	1.00
113_I	117_R	0.833	1.00
176_I	180_A	0.832	1.00
76_N	79_V	0.831	1.00
148_E	152_L	0.828	1.00
130_E	134_I	0.827	1.00
284_P	287_R	0.825	1.00
305_M	363_L	0.823	1.00
45_H	51_C	0.823	1.00
93_G	96_A	0.823	1.00
74_G	90_G	0.819	1.00
79_V	82_D	0.819	1.00
166_I	202_I	0.818	1.00
156_D	159_S	0.815	1.00
164_I	202_I	0.813	1.00
165_L	201_L	0.812	1.00
178_Q	181_R	0.800	0.99
143_S	147_L	0.798	0.99
48_A	52_A	0.797	0.99
314_H	332_L	0.795	0.99
46_E	55_R	0.794	0.99
249_D	252_E	0.792	0.99
82_D	87_A	0.791	0.99
346_R	349_R	0.788	0.99
46_E	49_L	0.787	0.99
334_Y	341_Q	0.785	0.99
290_F	359_A	0.783	0.99
58_V	61_T	0.782	0.99
326_H	334_Y	0.779	0.99
45_H	55_R	0.776	0.99
291_P	362_F	0.773	0.99
117_R	121_Q	0.773	0.99
346_R	352_D	0.772	0.99
47_G	55_R	0.770	0.99
358_V	361_Y	0.769	0.99
288_N	292_Q	0.768	0.99
253_Q	270_E	0.765	0.99
350_T	357_Y	0.764	0.99
74_G	80_F	0.763	0.99
22_E	92_T	0.762	0.99
124_W	128_M	0.762	0.99
132_F	149_K	0.761	0.99
50_I	53_K	0.761	0.99
294_V	359_A	0.760	0.99
293_R	297_K	0.759	0.99
26_V	35_G	0.758	0.99
351_E	355_T	0.755	0.99
354_V	358_V	0.752	0.99
219_I	222_I	0.751	0.99
57_S	61_T	0.748	0.99
105_L	108_M	0.745	0.99
291_P	295_L	0.745	0.99
252_E	256_K	0.743	0.99
72_K	76_N	0.742	0.99
132_F	153_L	0.741	0.99
270_E	277_M	0.739	0.99
308_I	312_F	0.739	0.99
350_T	353_V	0.735	0.99
273_L	277_M	0.731	0.99
347_F	353_V	0.731	0.99
39_E	42_G	0.731	0.99
177_E	184_K	0.727	0.99
274_K	290_F	0.727	0.99
49_L	53_K	0.726	0.99
343_T	356_M	0.725	0.99
257_A	273_L	0.724	0.99
118_H	121_Q	0.718	0.99
145_S	148_E	0.717	0.99
274_K	355_T	0.717	0.99
80_F	87_A	0.714	0.99
26_V	30_G	0.708	0.99
104_L	107_K	0.707	0.99
239_G	257_A	0.707	0.99
279_L	358_V	0.705	0.99
300_E	338_K	0.705	0.99
181_R	185_S	0.701	0.99
169_Y	235_A	0.698	0.99
136_W	244_S	0.697	0.98
133_M	203_N	0.697	0.98
19_Y	22_E	0.695	0.98
55_R	59_I	0.694	0.98
315_D	353_V	0.694	0.98
354_V	361_Y	0.694	0.98
84_D	87_A	0.694	0.98
249_D	253_Q	0.691	0.98
39_E	43_Q	0.691	0.98
340_E	344_G	0.691	0.98
74_G	87_A	0.690	0.98
44_F	47_G	0.689	0.98
88_V	91_L	0.686	0.98
56_R	60_I	0.685	0.98
213_D	217_R	0.684	0.98
85_V	88_V	0.683	0.98
271_E	293_R	0.683	0.98
51_C	55_R	0.682	0.98
317_S	333_R	0.680	0.98
80_F	86_I	0.678	0.98
309_R	361_Y	0.678	0.98
313_H	351_E	0.677	0.98
32_I	35_G	0.675	0.98
218_K	223_C	0.675	0.98
48_A	51_C	0.673	0.98
67_R	74_G	0.673	0.98
44_F	49_L	0.672	0.98
16_K	21_R	0.669	0.98
146_F	156_D	0.669	0.98
144_P	148_E	0.669	0.98
45_H	49_L	0.668	0.98
294_V	345_L	0.668	0.98
329_I	357_Y	0.667	0.98
33_M	36_T	0.664	0.98
284_P	288_N	0.661	0.98
12_I	19_Y	0.661	0.98
201_L	255_E	0.660	0.98
306_N	309_R	0.659	0.98
52_A	58_V	0.658	0.98
236_A	267_P	0.657	0.98
15_V	108_M	0.656	0.98
37_N	43_Q	0.656	0.98
48_A	54_E	0.653	0.98
313_H	361_Y	0.653	0.98
67_R	73_A	0.651	0.98
162_Q	271_E	0.649	0.98
117_R	120_E	0.649	0.98
257_A	268_I	0.646	0.98
102_G	106_R	0.642	0.97
351_E	354_V	0.642	0.97
45_H	52_A	0.642	0.97
22_E	37_N	0.641	0.97
316_L	333_R	0.641	0.97
38_D	41_V	0.641	0.97
30_G	35_G	0.639	0.97
11_I	16_K	0.638	0.97
164_I	236_A	0.636	0.97
275_L	355_T	0.636	0.97
146_F	150_A	0.635	0.97
42_G	45_H	0.633	0.97
88_V	92_T	0.633	0.97
295_L	359_A	0.632	0.97
221_H	224_S	0.631	0.97
321_T	329_I	0.629	0.97
91_L	105_L	0.626	0.97
353_V	360_L	0.626	0.97
89_F	109_T	0.625	0.97
182_S	186_S	0.625	0.97
46_E	50_I	0.624	0.97
55_R	58_V	0.624	0.97
12_I	16_K	0.623	0.97
326_H	329_I	0.619	0.97
71_V	79_V	0.617	0.97
71_V	77_L	0.616	0.97
90_G	93_G	0.615	0.97
132_F	136_W	0.610	0.97
136_W	247_L	0.609	0.96
252_E	255_E	0.609	0.96
143_S	146_F	0.608	0.96
81_F	86_I	0.607	0.96
133_M	138_Q	0.606	0.96
180_A	184_K	0.603	0.96
311_F	340_E	0.601	0.96
326_H	331_T	0.600	0.96
89_F	92_T	0.600	0.96
101_F	104_L	0.598	0.96
83_H	87_A	0.598	0.96
69_K	76_N	0.598	0.96
291_P	296_G	0.597	0.96
164_I	219_I	0.597	0.96
216_L	272_D	0.596	0.96
329_I	332_L	0.594	0.96
223_C	236_A	0.592	0.96
9_K	34_A	0.592	0.96
302_Q	305_M	0.590	0.96
328_H	334_Y	0.589	0.96
103_E	106_R	0.588	0.96
44_F	48_A	0.587	0.96
165_L	199_R	0.587	0.96
25_I	37_N	0.587	0.96
47_G	58_V	0.586	0.96
21_R	91_L	0.586	0.96
28_T	31_L	0.585	0.96
119_L	123_Q	0.585	0.96
283_S	290_F	0.584	0.96
345_L	349_R	0.584	0.96
307_T	334_Y	0.583	0.96
283_S	286_T	0.583	0.96
219_I	223_C	0.583	0.96
294_V	298_A	0.582	0.95
58_V	62_K	0.582	0.95
54_E	57_S	0.582	0.95
113_I	124_W	0.580	0.95
13_A	36_T	0.580	0.95
87_A	92_T	0.579	0.95
177_E	182_S	0.577	0.95
26_V	74_G	0.575	0.95
253_Q	289_E	0.574	0.95
318_L	329_I	0.574	0.95
213_D	221_H	0.574	0.95
72_K	79_V	0.574	0.95
89_F	94_E	0.574	0.95
12_I	32_I	0.574	0.95
10_K	14_E	0.572	0.95
274_K	293_R	0.570	0.95
32_I	36_T	0.569	0.95
27_N	30_G	0.568	0.95
23_V	91_L	0.567	0.95
167_Q	198_E	0.566	0.95
84_D	92_T	0.566	0.95
144_P	147_L	0.565	0.95
67_R	70_G	0.563	0.95
70_G	76_N	0.561	0.94
115_E	119_L	0.560	0.94
40_R	45_H	0.559	0.94
76_N	80_F	0.559	0.94
347_F	356_M	0.557	0.94
289_E	293_R	0.556	0.94
321_T	327_I	0.554	0.94
74_G	78_P	0.553	0.94
115_E	118_H	0.553	0.94
136_W	157_L	0.553	0.94
292_Q	359_A	0.553	0.94
93_G	98_I	0.553	0.94
157_L	244_S	0.553	0.94
77_L	106_R	0.552	0.94
312_F	339_A	0.552	0.94
86_I	336_L	0.551	0.94
316_L	350_T	0.551	0.94
177_E	180_A	0.551	0.94
318_L	328_H	0.549	0.94
22_E	26_V	0.547	0.94
74_G	79_V	0.546	0.94
323_E	326_H	0.545	0.94
26_V	32_I	0.545	0.94
290_F	295_L	0.545	0.94
340_E	345_L	0.544	0.94
129_L	133_M	0.543	0.93
57_S	62_K	0.543	0.93
244_S	247_L	0.540	0.93
291_P	294_V	0.540	0.93
56_R	62_K	0.540	0.93
24_I	35_G	0.538	0.93
127_R	130_E	0.538	0.93
126_E	130_E	0.537	0.93
294_V	352_D	0.536	0.93
121_Q	125_R	0.534	0.93
295_L	299_L	0.533	0.93
56_R	59_I	0.532	0.93
21_R	102_G	0.532	0.93
68_L	76_N	0.529	0.93
276_D	279_L	0.529	0.93
196_G	201_L	0.528	0.93
277_M	281_E	0.527	0.92
260_V	277_M	0.526	0.92
22_E	34_A	0.526	0.92
120_E	124_W	0.524	0.92
26_V	31_L	0.523	0.92
298_A	342_L	0.521	0.92
237_G	270_E	0.521	0.92
119_L	122_S	0.521	0.92
350_T	354_V	0.520	0.92
273_L	276_D	0.519	0.92
74_G	86_I	0.519	0.92
52_A	60_I	0.518	0.92
121_Q	124_W	0.518	0.92
135_D	139_L	0.518	0.92
277_M	280_T	0.516	0.92
30_G	88_V	0.515	0.92
256_K	259_A	0.515	0.92
233_Y	264_R	0.515	0.92
75_I	79_V	0.514	0.92
54_E	61_T	0.514	0.92
308_I	356_M	0.512	0.91
128_M	131_S	0.512	0.91
69_K	79_V	0.510	0.91
125_R	128_M	0.509	0.91
89_F	93_G	0.508	0.91
24_I	27_N	0.507	0.91
240_R	269_F	0.506	0.91
70_G	90_G	0.505	0.91
131_S	196_G	0.505	0.91
46_E	54_E	0.505	0.91
237_G	268_I	0.503	0.91
322_A	332_L	0.503	0.91
330_N	354_V	0.502	0.91
285_G	293_R	0.501	0.90
176_I	179_M	0.500	0.90
235_A	261_S	0.500	0.90

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3onqA	5	0.6712	100	0.445	Contact Map
2gx5A	2	0.3288	95.8	0.902	Contact Map
3hhgA	3	0.1902	95.6	0.903	Contact Map
1al3A	1	0	95.5	0.903	Contact Map
4eu0A	1	0.644	95.5	0.903	Contact Map
2esnA	3	0.2011	95.1	0.906	Contact Map
3szpA	3	0.1848	95.1	0.906	Contact Map
2w1rA	2	0.2908	95	0.906	Contact Map
3mz1A	2	0	95	0.906	Contact Map
3fxqA	3	0.1875	94.5	0.909	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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