GREMLIN Database
GLCD - Glycolate oxidase subunit GlcD
UniProt: P94535 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 470 (428)
Sequences: 18588 (13786)
Seq/√Len: 666.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
50_T168_E4.2131.00
168_E208_E4.2071.00
61_S449_R3.7671.00
145_I209_A3.7521.00
96_Q110_Q3.3881.00
101_D104_N3.2931.00
165_I212_K3.1751.00
95_N117_D3.0521.00
108_T210_I2.9971.00
64_R449_R2.9941.00
121_A124_S2.9891.00
229_N232_A2.9541.00
168_E178_R2.9041.00
108_T208_E2.8481.00
127_L213_L2.8091.00
45_I56_I2.8051.00
48_R93_H2.7871.00
169_V196_F2.7611.00
113_V118_M2.6821.00
348_E351_N2.6421.00
53_I207_T2.5781.00
171_L175_D2.5491.00
110_Q208_E2.5131.00
54_S176_I2.4751.00
172_A452_L2.4451.00
57_L67_I2.3921.00
166_G178_R2.3201.00
102_E125_K2.2241.00
166_G210_I2.2221.00
355_A408_E2.1871.00
116_L120_R2.1151.00
107_A118_M2.0921.00
122_V213_L2.0491.00
171_L177_I2.0441.00
50_T176_I2.0261.00
114_I117_D2.0211.00
59_I63_H1.9951.00
97_I113_V1.9941.00
231_D354_K1.9911.00
51_D54_S1.9911.00
50_T207_T1.9811.00
94_M110_Q1.9601.00
50_T54_S1.9491.00
146_N199_S1.9431.00
168_E176_I1.9241.00
51_D55_R1.9241.00
169_V204_G1.9211.00
109_V141_I1.9151.00
70_R73_G1.9131.00
89_L205_I1.9001.00
57_L452_L1.8991.00
48_R52_E1.8971.00
166_G180_G1.8961.00
123_E216_K1.8851.00
167_L196_F1.8781.00
91_F205_I1.8601.00
106_T210_I1.8411.00
293_E297_A1.8281.00
195_L442_L1.8181.00
107_A211_V1.8041.00
99_E108_T1.8021.00
54_S58_T1.8001.00
53_I205_I1.7991.00
46_A93_H1.7951.00
168_E207_T1.7901.00
358_D362_K1.7741.00
105_L127_L1.7531.00
106_T165_I1.7521.00
100_I121_A1.7451.00
55_R58_T1.7391.00
49_N52_E1.7291.00
117_D120_R1.7281.00
405_K408_E1.7061.00
69_P205_I1.6971.00
91_F94_M1.6931.00
441_A445_A1.6731.00
145_I164_V1.6701.00
421_E456_K1.6271.00
180_G188_A1.6261.00
105_L215_P1.6181.00
146_N206_V1.6081.00
437_D440_K1.5971.00
404_E429_M1.5931.00
393_E397_Q1.5871.00
404_E408_E1.5851.00
144_N160_T1.5831.00
397_Q401_E1.5781.00
57_L61_S1.5751.00
145_I211_V1.5631.00
60_C87_L1.5621.00
58_T61_S1.5491.00
196_F204_G1.5461.00
170_V207_T1.5391.00
101_D106_T1.5221.00
97_I121_A1.5181.00
59_I65_V1.5101.00
163_Y214_V1.5051.00
96_Q113_V1.5031.00
179_T189_G1.5011.00
45_I87_L1.4941.00
53_I170_V1.4941.00
289_E293_E1.4761.00
239_D243_A1.4741.00
437_D441_A1.4731.00
109_V211_V1.4661.00
232_A235_Q1.4631.00
444_A450_N1.4601.00
164_V167_L1.4541.00
355_A409_L1.4501.00
110_Q113_V1.4491.00
57_L205_I1.4461.00
139_S144_N1.4391.00
440_K444_A1.4381.00
231_D235_Q1.4381.00
179_T193_T1.4361.00
362_K401_E1.4351.00
172_A446_F1.4231.00
53_I89_L1.4181.00
22_S25_G1.4031.00
121_A125_K1.3991.00
355_A358_D1.3971.00
47_P52_E1.3961.00
321_E325_S1.3951.00
443_K450_N1.3811.00
20_D25_G1.3791.00
47_P56_I1.3731.00
130_P163_Y1.3681.00
359_I362_K1.3631.00
176_I207_T1.3481.00
57_L170_V1.3381.00
107_A213_L1.3331.00
400_A404_E1.3331.00
100_I107_A1.3321.00
355_A405_K1.3131.00
438_A441_A1.3111.00
388_N391_E1.3091.00
109_V118_M1.3021.00
95_N110_Q1.2921.00
235_Q239_D1.2841.00
435_G438_A1.2821.00
351_N355_A1.2781.00
170_V176_I1.2741.00
363_Y401_E1.2711.00
293_E296_E1.2691.00
100_I127_L1.2681.00
58_T62_E1.2621.00
52_E55_R1.2531.00
60_C67_I1.2511.00
228_E232_A1.2461.00
396_E400_A1.2421.00
432_K435_G1.2421.00
391_E394_R1.2341.00
120_R124_S1.2261.00
23_N26_R1.2251.00
171_L446_F1.2201.00
107_A122_V1.2181.00
417_H420_G1.2141.00
357_N361_A1.2061.00
251_E254_D1.1971.00
358_D361_A1.1831.00
46_A90_L1.1811.00
312_T315_E1.1701.00
436_I440_K1.1701.00
54_S170_V1.1691.00
345_P348_E1.1581.00
56_I87_L1.1551.00
177_I189_G1.1541.00
70_R88_V1.1501.00
145_I160_T1.1411.00
66_P86_G1.1371.00
359_I405_K1.1321.00
394_R397_Q1.1281.00
441_A444_A1.1271.00
61_S451_I1.1251.00
119_I133_P1.1251.00
186_D190_Y1.1191.00
56_I89_L1.1151.00
313_E317_F1.1131.00
194_R438_A1.1041.00
255_Q259_L1.1031.00
413_I416_E1.0911.00
196_F206_V1.0861.00
71_G140_T1.0861.00
180_G187_V1.0771.00
67_I89_L1.0761.00
390_D393_E1.0611.00
46_A92_K1.0601.00
91_F111_P1.0471.00
43_A87_L1.0461.00
164_V197_V1.0431.00
115_T133_P1.0381.00
158_G162_D1.0371.00
167_L193_T1.0361.00
352_M409_L1.0321.00
239_D242_A1.0261.00
142_G209_A1.0161.00
253_L256_P1.0161.00
371_G374_G1.0151.00
169_V177_I1.0131.00
199_S203_L1.0101.00
294_K297_A1.0061.00
167_L209_A1.0011.00
296_E300_K0.9991.00
26_R30_S0.9971.00
287_T290_R0.9951.00
70_R90_L0.9951.00
42_D85_G0.9951.00
354_K358_D0.9921.00
191_D194_R0.9921.00
64_R451_I0.9901.00
285_F289_E0.9881.00
178_R210_I0.9851.00
315_E318_A0.9841.00
21_D26_R0.9821.00
75_N79_G0.9761.00
115_T144_N0.9761.00
195_L203_L0.9721.00
58_T175_D0.9711.00
95_N113_V0.9711.00
117_D121_A0.9651.00
414_T419_V0.9621.00
50_T170_V0.9551.00
392_M396_E0.9531.00
29_Y46_A0.9521.00
26_R40_M0.9511.00
67_I451_I0.9471.00
320_T323_R0.9441.00
328_S331_A0.9431.00
190_Y202_T0.9371.00
366_S369_T0.9361.00
27_L30_S0.9321.00
254_D257_T0.9311.00
359_I401_E0.9261.00
256_P259_L0.9251.00
20_D46_A0.9241.00
141_I211_V0.9231.00
165_I210_I0.9221.00
50_T110_Q0.9211.00
180_G189_G0.9171.00
141_I209_A0.9171.00
247_P256_P0.9161.00
179_T196_F0.9161.00
397_Q400_A0.9131.00
297_A301_K0.9111.00
53_I94_M0.9051.00
239_D301_K0.9051.00
323_R326_A0.8991.00
320_T324_R0.8981.00
178_R208_E0.8971.00
249_T254_D0.8941.00
113_V117_D0.8871.00
351_N409_L0.8871.00
71_G111_P0.8861.00
163_Y212_K0.8821.00
173_N177_I0.8811.00
71_G91_F0.8811.00
47_P93_H0.8791.00
343_T412_T0.8781.00
405_K409_L0.8771.00
238_S242_A0.8761.00
53_I91_F0.8741.00
314_E318_A0.8731.00
351_N354_K0.8701.00
315_E319_L0.8701.00
164_V209_A0.8691.00
350_A354_K0.8641.00
247_P254_D0.8641.00
115_T118_M0.8641.00
427_L436_I0.8631.00
316_A319_L0.8611.00
27_L40_M0.8611.00
21_D43_A0.8581.00
236_T239_D0.8581.00
404_E407_I0.8561.00
107_A121_A0.8551.00
427_L431_L0.8541.00
296_E299_C0.8531.00
130_P214_V0.8511.00
359_I363_Y0.8501.00
317_F321_E0.8461.00
316_A320_T0.8431.00
223_L227_Y0.8421.00
378_L381_T0.8401.00
142_G146_N0.8391.00
92_K140_T0.8371.00
72_S140_T0.8331.00
50_T94_M0.8321.00
239_D302_G0.8311.00
111_P209_A0.8301.00
327_L330_L0.8281.00
454_P457_M0.8281.00
22_S26_R0.8261.00
66_P453_N0.8261.00
118_M141_I0.8261.00
292_M296_E0.8251.00
116_L137_K0.8251.00
235_Q238_S0.8251.00
55_R59_I0.8231.00
187_V190_Y0.8211.00
416_E420_G0.8211.00
428_E436_I0.8201.00
145_I206_V0.8191.00
319_L323_R0.8181.00
401_E404_E0.8161.00
315_E320_T0.8151.00
313_E316_A0.8151.00
50_T53_I0.8111.00
323_R327_L0.8111.00
115_T139_S0.8101.00
369_T374_G0.8091.00
348_E409_L0.8081.00
47_P91_F0.8081.00
189_G446_F0.8051.00
186_D189_G0.8011.00
416_E419_V0.7991.00
180_G186_D0.7971.00
286_E290_R0.7941.00
191_D442_L0.7931.00
237_V241_I0.7931.00
442_L446_F0.7911.00
65_V87_L0.7911.00
390_D394_R0.7891.00
324_R329_A0.7881.00
352_M356_I0.7861.00
327_L331_A0.7851.00
191_D445_A0.7831.00
389_K393_E0.7811.00
249_T253_L0.7801.00
227_Y236_T0.7791.00
206_V209_A0.7791.00
127_L215_P0.7781.00
323_R329_A0.7771.00
377_N381_T0.7741.00
247_P250_L0.7731.00
126_G216_K0.7721.00
131_P163_Y0.7711.00
42_D86_G0.7711.00
116_L136_M0.7691.00
231_D350_A0.7691.00
255_Q274_K0.7691.00
369_T373_A0.7671.00
389_K392_M0.7671.00
437_D444_A0.7661.00
318_A321_E0.7641.00
159_V162_D0.7621.00
415_G418_G0.7601.00
311_Q315_E0.7591.00
29_Y44_V0.7581.00
25_G28_V0.7571.00
247_P251_E0.7561.00
443_K453_N0.7541.00
297_A300_K0.7521.00
351_N357_N0.7501.00
231_D351_N0.7481.00
288_V292_M0.7481.00
136_M139_S0.7481.00
248_A282_D0.7471.00
414_T417_H0.7471.00
101_D108_T0.7461.00
106_T212_K0.7461.00
423_K426_Y0.7451.00
286_E289_E0.7431.00
248_A251_E0.7431.00
166_G208_E0.7421.00
425_P428_E0.7421.00
167_L206_V0.7411.00
324_R327_L0.7401.00
360_A363_Y0.7391.00
234_A238_S0.7371.00
57_L172_A0.7351.00
323_R330_L0.7331.00
336_T339_L0.7311.00
428_E437_D0.7301.00
300_K303_D0.7261.00
291_D294_K0.7251.00
281_Q295_I0.7241.00
324_R330_L0.7241.00
284_P287_T0.7241.00
249_T256_P0.7231.00
193_T197_V0.7221.00
337_T341_D0.7201.00
104_N347_S0.7201.00
68_V86_G0.7191.00
44_V88_V0.7181.00
168_E210_I0.7151.00
363_Y397_Q0.7131.00
344_V352_M0.7091.00
167_L179_T0.7081.00
251_E255_Q0.7071.00
59_I87_L0.7061.00
355_A359_I0.7051.00
411_G415_G0.7031.00
120_R123_E0.7031.00
295_I299_C0.7031.00
324_R331_A0.7031.00
341_D346_R0.7031.00
223_L226_L0.7021.00
100_I125_K0.7011.00
450_N453_N0.6971.00
148_N159_V0.6951.00
323_R328_S0.6911.00
395_V399_F0.6901.00
100_I213_L0.6881.00
75_N80_T0.6881.00
47_P94_M0.6871.00
290_R293_E0.6871.00
51_D176_I0.6861.00
20_D26_R0.6861.00
115_T141_I0.6831.00
407_I429_M0.6801.00
260_V263_D0.6801.00
257_T326_A0.6781.00
340_E343_T0.6781.00
94_M207_T0.6741.00
339_L342_A0.6731.00
262_E265_A0.6711.00
47_P53_I0.6701.00
122_V125_K0.6661.00
368_C371_G0.6661.00
20_D29_Y0.6651.00
325_S330_L0.6651.00
169_V179_T0.6641.00
282_D285_F0.6641.00
280_E283_G0.6621.00
247_P253_L0.6581.00
287_T291_D0.6581.00
233_A237_V0.6571.00
308_Q315_E0.6561.00
92_K114_I0.6561.00
329_A333_L0.6551.00
23_N27_L0.6541.00
393_E396_E0.6541.00
251_E256_P0.6531.00
26_R29_Y0.6531.00
299_C304_A0.6521.00
172_A451_I0.6521.00
377_N380_P0.6491.00
54_S57_L0.6481.00
252_F257_T0.6471.00
178_R188_A0.6461.00
105_L212_K0.6461.00
259_L263_D0.6451.00
261_I264_Y0.6451.00
335_P339_L0.6431.00
403_F407_I0.6421.00
179_T188_A0.6421.00
382_C386_I0.6411.00
427_L430_K0.6411.00
326_A330_L0.6401.00
128_F216_K0.6401.00
414_T418_G0.6381.00
175_D434_E0.6381.00
253_L257_T0.6381.00
167_L197_V0.6371.00
367_I371_G0.6371.00
192_L446_F0.6361.00
119_I128_F0.6341.00
52_E56_I0.6341.00
61_S173_N0.6331.00
337_T340_E0.6331.00
69_P91_F0.6331.00
330_L333_L0.6301.00
281_Q284_P0.6291.00
41_P88_V0.6291.00
249_T252_F0.6281.00
323_R331_A0.6281.00
238_S241_I0.6281.00
97_I109_V0.6251.00
314_E317_F0.6251.00
254_D259_L0.6241.00
101_D105_L0.6241.00
319_L322_A0.6211.00
419_V427_L0.6211.00
203_L442_L0.6211.00
324_R328_S0.6201.00
299_C302_G0.6171.00
251_E257_T0.6161.00
180_G190_Y0.6151.00
341_D345_P0.6141.00
20_D23_N0.6141.00
119_I122_V0.6121.00
443_K447_D0.6101.00
273_A276_V0.6091.00
386_I392_M0.6091.00
338_I341_D0.6051.00
109_V113_V0.6041.00
262_E266_K0.6041.00
300_K304_A0.6041.00
97_I110_Q0.6031.00
24_A28_V0.6031.00
115_T134_S0.6021.00
72_S114_I0.6021.00
134_S144_N0.6001.00
372_H375_D0.5991.00
304_A307_V0.5981.00
289_E296_E0.5971.00
30_S41_P0.5971.00
315_E322_A0.5961.00
255_Q258_L0.5961.00
194_R197_V0.5941.00
298_I302_G0.5931.00
102_E105_L0.5911.00
368_C373_A0.5901.00
114_I140_T0.5901.00
329_A332_R0.5881.00
336_T340_E0.5881.00
434_E437_D0.5881.00
392_M395_V0.5871.00
359_I398_A0.5871.00
164_V211_V0.5871.00
236_T299_C0.5861.00
426_Y429_M0.5851.00
177_I438_A0.5851.00
320_T327_L0.5851.00
43_A65_V0.5851.00
340_E344_V0.5841.00
156_K282_D0.5841.00
151_G154_G0.5831.00
325_S328_S0.5821.00
316_A323_R0.5821.00
322_A327_L0.5801.00
360_A364_D0.5801.00
336_T341_D0.5791.00
252_F256_P0.5781.00
354_K357_N0.5771.00
311_Q314_E0.5771.00
66_P454_P0.5751.00
317_F320_T0.5741.00
249_T255_Q0.5741.00
96_Q99_E0.5731.00
334_K338_I0.5701.00
172_A449_R0.5681.00
246_I250_L0.5681.00
369_T372_H0.5671.00
279_I282_D0.5661.00
109_V209_A0.5661.00
339_L381_T0.5641.00
67_I87_L0.5641.00
319_L326_A0.5641.00
310_A315_E0.5631.00
379_H383_T0.5621.00
71_G142_G0.5621.00
328_S332_R0.5621.00
229_N233_A0.5611.00
260_V264_Y0.5611.00
295_I298_I0.5601.00
417_H421_E0.5601.00
411_G414_T0.5591.00
177_I204_G0.5581.00
334_K340_E0.5581.00
240_I243_A0.5581.00
353_V357_N0.5571.00
246_I249_T0.5551.00
358_D363_Y0.5551.00
438_A445_A0.5541.00
246_I251_E0.5541.00
412_T415_G0.5521.00
237_V240_I0.5521.00
334_K339_L0.5511.00
90_L93_H0.5501.00
31_Y38_Q0.5501.00
99_E106_T0.5501.00
265_A268_G0.5501.00
54_S171_L0.5481.00
316_A324_R0.5471.00
154_G159_V0.5471.00
223_L279_I0.5451.00
319_L324_R0.5441.00
436_I439_M0.5431.00
25_G29_Y0.5431.00
275_A279_I0.5431.00
312_T320_T0.5431.00
310_A313_E0.5391.00
372_H376_G0.5391.00
283_G287_T0.5391.00
424_A428_E0.5381.00
417_H422_M0.5381.00
50_T208_E0.5381.00
66_P451_I0.5371.00
317_F323_R0.5371.00
116_L138_I0.5371.00
129_Y211_V0.5361.00
156_K248_A0.5361.00
54_S207_T0.5351.00
419_V422_M0.5351.00
202_T443_K0.5341.00
312_T316_A0.5331.00
381_T384_T0.5321.00
30_S38_Q0.5321.00
247_P252_F0.5321.00
322_A329_A0.5311.00
35_P38_Q0.5311.00
431_L435_G0.5311.00
99_E102_E0.5301.00
250_L253_L0.5291.00
337_T342_A0.5291.00
204_G446_F0.5291.00
406_A411_G0.5281.00
134_S139_S0.5281.00
113_V141_I0.5260.99
352_M355_A0.5260.99
41_P44_V0.5240.99
398_A401_E0.5240.99
334_K337_T0.5230.99
414_T420_G0.5230.99
370_F373_A0.5220.99
179_T190_Y0.5210.99
278_L282_D0.5200.99
336_T343_T0.5200.99
382_C385_D0.5200.99
262_E268_G0.5190.99
234_A237_V0.5190.99
252_F258_L0.5190.99
146_N196_F0.5180.99
422_M426_Y0.5180.99
380_P383_T0.5180.99
324_R332_R0.5170.99
148_N198_G0.5160.99
186_D430_K0.5160.99
314_E320_T0.5150.99
320_T326_A0.5150.99
415_G419_V0.5150.99
68_V82_P0.5150.99
280_E284_P0.5140.99
322_A325_S0.5110.99
324_R333_L0.5110.99
313_E318_A0.5080.99
315_E321_E0.5080.99
39_S81_C0.5070.99
23_N40_M0.5060.99
321_E324_R0.5060.99
119_I216_K0.5050.99
322_A331_A0.5040.99
327_L333_L0.5040.99
254_D258_L0.5040.99
431_L456_K0.5030.99
48_R94_M0.5030.99
323_R332_R0.5010.99
453_N456_K0.5010.99
323_R333_L0.5000.99
305_V308_Q0.5000.99
228_E305_V0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3pm9A 5 0.9723 100 0.255 Contact Map
2uuuA 2 0.9128 100 0.3 Contact Map
4xloA 2 0.934 100 0.325 Contact Map
1wvfA 2 0.9702 100 0.331 Contact Map
4o95A 1 0.8745 100 0.336 Contact Map
1w1oA 1 0.8936 100 0.338 Contact Map
1f0xA 1 0.9234 100 0.339 Contact Map
2bvfA 1 0.9064 100 0.349 Contact Map
2exrA 1 0.9021 100 0.35 Contact Map
4bbyA 2 0.9574 100 0.354 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0132 seconds.