GREMLIN Database
GLCF - Probable glycolate oxidase iron-sulfur subunit
UniProt: P94534 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 444 (392)
Sequences: 4429 (3036)
Seq/√Len: 153.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_K436_L4.9181.00
197_R227_D4.9141.00
429_V437_E4.6801.00
328_V358_E4.6301.00
216_A433_D4.5051.00
307_F432_A4.3871.00
305_K313_E4.0351.00
158_L162_P3.5611.00
217_T272_N3.4471.00
262_E296_R3.3311.00
312_V349_Q3.1201.00
328_V360_K3.0941.00
281_T309_S2.9191.00
212_P433_D2.8991.00
226_C310_V2.7401.00
196_K226_C2.6961.00
183_H215_N2.6911.00
271_T277_G2.6461.00
327_Q401_L2.5671.00
129_H132_R2.5241.00
403_V434_L2.5171.00
236_C276_C2.4511.00
197_R229_V2.4041.00
348_R361_E2.3911.00
254_A283_Y2.3661.00
329_V434_L2.3421.00
237_C276_C2.3371.00
246_E249_T2.3091.00
380_V384_M2.3041.00
93_K96_Q2.2301.00
259_A296_R2.1941.00
270_I310_V2.1511.00
206_M214_N2.1431.00
363_E396_A2.1401.00
41_E385_K2.1071.00
224_A439_A2.1011.00
401_L429_V2.0981.00
384_M416_G2.0701.00
348_R352_K2.0501.00
131_N134_R1.9521.00
388_D395_K1.9481.00
329_V401_L1.9301.00
220_L432_A1.9241.00
217_T307_F1.9171.00
213_T433_D1.9121.00
298_A302_Q1.8901.00
300_F304_L1.8851.00
200_F272_N1.8701.00
251_K255_K1.8681.00
349_Q352_K1.8671.00
198_V228_I1.8531.00
329_V357_A1.8501.00
197_R267_D1.7491.00
159_R162_P1.7291.00
284_D301_V1.7071.00
199_A264_L1.6901.00
255_K259_A1.6321.00
48_H77_L1.6201.00
218_L228_I1.6051.00
217_T221_L1.5901.00
241_H249_T1.5901.00
96_Q285_H1.5751.00
107_Q248_N1.5571.00
49_S52_G1.5571.00
199_A267_D1.5541.00
178_S183_H1.5521.00
72_E105_I1.5321.00
204_C236_C1.5291.00
218_L222_Q1.5261.00
235_A256_Q1.5261.00
334_S404_T1.5151.00
387_L416_G1.5121.00
387_L391_M1.5071.00
72_E76_S1.4931.00
46_E51_R1.4911.00
333_D348_R1.4891.00
284_D298_A1.4701.00
140_I143_Y1.4391.00
59_A62_D1.4341.00
239_A275_G1.4291.00
33_L49_S1.4291.00
134_R137_V1.4191.00
394_V413_M1.4081.00
130_Q134_R1.4051.00
204_C276_C1.4041.00
223_L436_L1.4041.00
204_C237_C1.3981.00
180_D214_N1.3971.00
241_H253_L1.3951.00
146_S149_Q1.3931.00
242_G279_F1.3881.00
278_A340_V1.3801.00
137_V140_I1.3751.00
429_V434_L1.3611.00
262_E299_A1.3511.00
380_V415_L1.3461.00
273_A406_N1.3451.00
198_V310_V1.3441.00
41_E382_M1.3431.00
210_F213_T1.3351.00
216_A436_L1.3331.00
38_T53_R1.3321.00
268_A310_V1.3301.00
305_K309_S1.3221.00
391_M416_G1.3181.00
405_A431_L1.3161.00
232_P263_A1.3151.00
327_Q437_E1.3101.00
345_L348_R1.3071.00
313_E346_E1.3001.00
242_G250_G1.2981.00
85_E93_K1.2881.00
143_Y146_S1.2821.00
299_A302_Q1.2811.00
290_D296_R1.2791.00
142_L146_S1.2651.00
271_T280_L1.2501.00
381_E385_K1.2441.00
145_R174_D1.2421.00
184_R218_L1.2381.00
199_A266_V1.2371.00
59_A63_G1.2311.00
194_M227_D1.2311.00
307_F311_L1.2261.00
217_T432_A1.2201.00
242_G247_K1.2201.00
305_K310_V1.2161.00
35_S87_V1.2161.00
220_L435_L1.2141.00
327_Q400_I1.2131.00
135_S139_L1.1961.00
127_F130_Q1.1961.00
30_G51_R1.1891.00
345_L349_Q1.1881.00
210_F407_P1.1861.00
311_L350_L1.1821.00
277_G304_L1.1781.00
255_K290_D1.1761.00
39_Y43_G1.1671.00
289_D296_R1.1671.00
202_S214_N1.1661.00
148_L152_V1.1641.00
309_S346_E1.1611.00
394_V402_I1.1601.00
296_R299_A1.1591.00
171_V176_P1.1591.00
54_I94_Y1.1551.00
329_V403_V1.1541.00
219_K222_Q1.1411.00
330_T397_T1.1391.00
374_I378_V1.1371.00
328_V400_I1.1361.00
383_S412_Q1.1311.00
198_V221_L1.1301.00
40_I389_S1.1281.00
139_L142_L1.1211.00
193_P196_K1.1201.00
384_M388_D1.1201.00
264_L267_D1.1171.00
46_E52_G1.1150.99
49_S53_R1.1150.99
138_S141_G1.1110.99
180_D218_L1.1100.99
299_A303_K1.1070.99
64_M67_P1.1040.99
268_A305_K1.1020.99
181_M207_D1.0970.99
103_D247_K1.0960.99
317_H353_S1.0920.99
180_D184_R1.0890.99
239_A243_H1.0820.99
429_V433_D1.0720.99
388_D392_A1.0720.99
275_G406_N1.0710.99
58_K62_D1.0630.99
221_L307_F1.0600.99
259_A262_E1.0560.99
243_H275_G1.0550.99
191_I194_M1.0510.99
241_H246_E1.0410.99
277_G341_M1.0400.99
195_K227_D1.0380.99
392_A396_A1.0370.99
45_Q48_H1.0300.99
253_L256_Q1.0290.99
142_L145_R1.0250.99
105_I109_K1.0210.99
253_L257_N1.0150.99
231_P234_Q1.0120.99
219_K223_L1.0100.99
220_L436_L1.0080.99
103_D107_Q1.0070.99
222_Q228_I0.9990.99
200_F228_I0.9960.99
331_Y359_F0.9950.99
137_V147_G0.9860.99
258_I296_R0.9840.99
139_L143_Y0.9840.99
309_S343_T0.9810.99
79_L386_I0.9800.99
326_P358_E0.9780.99
85_E95_G0.9780.99
190_S222_Q0.9750.99
413_M417_I0.9720.99
168_M175_V0.9720.99
101_A105_I0.9670.99
366_D390_K0.9660.99
178_S186_R0.9650.99
168_M171_V0.9570.98
113_L116_R0.9570.98
218_L230_I0.9560.98
133_M137_V0.9530.98
226_C314_L0.9480.98
77_L382_M0.9450.98
215_N219_K0.9430.98
193_P227_D0.9430.98
60_V66_E0.9420.98
172_L176_P0.9370.98
404_T410_L0.9370.98
202_S230_I0.9360.98
351_L403_V0.9350.98
387_L417_I0.9350.98
99_E242_G0.9320.98
132_R135_S0.9290.98
72_E109_K0.9290.98
371_S412_Q0.9260.98
115_E119_R0.9250.98
168_M172_L0.9220.98
167_T171_V0.9210.98
318_Q321_L0.9160.98
197_R265_D0.9150.98
82_R85_E0.9140.98
371_S376_N0.9130.98
111_H246_E0.9080.98
151_A168_M0.9060.98
311_L435_L0.9000.98
333_D344_S0.8980.98
338_R344_S0.8940.98
210_F433_D0.8880.97
325_T357_A0.8850.97
223_L439_A0.8830.97
158_L161_L0.8830.97
179_K182_K0.8830.97
173_P176_P0.8830.97
356_G359_F0.8800.97
375_Y379_E0.8790.97
52_G56_L0.8770.97
281_T341_M0.8710.97
176_P179_K0.8710.97
202_S234_Q0.8670.97
387_L412_Q0.8630.97
128_P132_R0.8590.97
48_H74_S0.8530.97
392_A395_K0.8490.97
80_G98_L0.8490.97
312_V350_L0.8480.97
203_G273_A0.8480.97
269_V300_F0.8470.97
18_M21_G0.8450.97
186_R232_P0.8440.97
151_A159_R0.8430.97
211_L215_N0.8380.96
334_S406_N0.8380.96
26_C32_C0.8370.96
200_F217_T0.8370.96
104_I107_Q0.8360.96
213_T216_A0.8360.96
346_E349_Q0.8330.96
359_F431_L0.8330.96
354_I357_A0.8330.96
179_K183_H0.8280.96
106_H111_H0.8280.96
287_L290_D0.8230.96
220_L439_A0.8220.96
41_E389_S0.8190.96
174_D177_K0.8190.96
321_L439_A0.8180.96
250_G279_F0.8170.96
66_E69_E0.8160.96
172_L175_V0.8130.96
271_T304_L0.8080.96
351_L357_A0.8060.96
179_K207_D0.8020.95
325_T328_V0.8000.95
116_R119_R0.8000.95
100_E104_I0.7980.95
249_T253_L0.7970.95
52_G79_L0.7940.95
51_R54_I0.7940.95
330_T394_V0.7920.95
330_T362_M0.7910.95
258_I262_E0.7860.95
189_P194_M0.7860.95
402_I413_M0.7850.95
53_R58_K0.7830.95
42_S382_M0.7820.95
354_I435_L0.7800.95
136_A140_I0.7790.95
330_T402_I0.7780.95
196_K268_A0.7770.95
274_G334_S0.7740.94
41_E386_I0.7740.94
38_T406_N0.7730.94
257_N283_Y0.7710.94
82_R93_K0.7700.94
363_E366_D0.7690.94
48_H51_R0.7680.94
229_V232_P0.7670.94
401_L437_E0.7660.94
199_A231_P0.7650.94
257_N260_A0.7630.94
256_Q260_A0.7600.94
369_C409_C0.7560.94
254_A287_L0.7550.94
117_V120_K0.7530.94
309_S313_E0.7510.94
283_Y297_A0.7510.94
314_L319_M0.7490.93
32_C36_C0.7480.93
33_L46_E0.7480.93
168_M176_P0.7480.93
145_R148_L0.7460.93
104_I108_N0.7440.93
333_D338_R0.7420.93
149_Q152_V0.7410.93
35_S367_S0.7400.93
220_L350_L0.7380.93
254_A286_L0.7380.93
130_Q133_M0.7370.93
210_F411_L0.7370.93
171_V175_V0.7340.93
75_L98_L0.7330.93
99_E247_K0.7310.93
202_S231_P0.7310.93
64_M68_D0.7300.93
53_R406_N0.7300.93
362_M394_V0.7290.93
198_V226_C0.7280.92
143_Y149_Q0.7250.92
215_N218_L0.7250.92
33_L39_Y0.7220.92
110_K113_L0.7220.92
433_D436_L0.7200.92
28_R58_K0.7180.92
182_K186_R0.7180.92
57_M97_L0.7170.92
196_K318_Q0.7170.92
329_V359_F0.7160.92
277_G306_D0.7140.92
167_T176_P0.7120.92
113_L117_V0.7120.92
59_A64_M0.7100.92
273_A407_P0.7090.91
55_A58_K0.7090.91
140_I147_G0.7080.91
206_M272_N0.7070.91
196_K267_D0.7050.91
169_E380_V0.7030.91
391_M395_K0.7030.91
94_Y98_L0.6990.91
162_P166_R0.6970.91
249_T252_E0.6960.91
258_I287_L0.6950.91
150_T158_L0.6920.90
417_I421_G0.6910.90
389_S393_A0.6910.90
222_Q227_D0.6910.90
333_D347_P0.6900.90
140_I144_Q0.6900.90
175_V179_K0.6900.90
128_P131_N0.6880.90
333_D361_E0.6850.90
273_A404_T0.6840.90
118_M121_T0.6830.90
76_S379_E0.6810.90
171_V415_L0.6810.90
55_A59_A0.6800.90
29_C32_C0.6770.89
159_R186_R0.6770.89
22_E25_N0.6770.89
235_A260_A0.6750.89
138_S177_K0.6740.89
213_T410_L0.6720.89
221_L226_C0.6710.89
331_Y347_P0.6700.89
402_I417_I0.6700.89
23_L97_L0.6660.89
306_D405_A0.6660.89
38_T79_L0.6640.89
194_M222_Q0.6630.88
210_F410_L0.6600.88
27_M90_S0.6530.88
82_R95_G0.6500.87
170_A180_D0.6490.87
132_R136_A0.6490.87
197_R228_I0.6490.87
384_M415_L0.6480.87
51_R55_A0.6470.87
258_I297_A0.6450.87
114_G378_V0.6450.87
85_E96_Q0.6440.87
169_E175_V0.6440.87
26_C36_C0.6430.87
393_A396_A0.6420.87
33_L51_R0.6420.87
83_A87_V0.6420.87
312_V346_E0.6400.87
312_V316_F0.6390.87
216_A220_L0.6370.86
199_A261_F0.6370.86
26_C29_C0.6370.86
403_V431_L0.6370.86
176_P211_L0.6360.86
331_Y348_R0.6350.86
48_H53_R0.6350.86
325_T438_A0.6340.86
114_G118_M0.6330.86
224_A354_I0.6320.86
303_K313_E0.6320.86
434_L437_E0.6320.86
269_V304_L0.6320.86
331_Y403_V0.6310.86
312_V353_S0.6290.86
203_G406_N0.6270.86
317_H320_D0.6260.85
281_T343_T0.6240.85
201_F280_L0.6240.85
247_K251_K0.6230.85
30_G54_I0.6210.85
251_K288_K0.6200.85
257_N280_L0.6190.85
61_A64_M0.6190.85
229_V264_L0.6180.85
273_A334_S0.6160.85
169_E176_P0.6160.85
94_Y97_L0.6140.84
144_Q147_G0.6140.84
75_L101_A0.6130.84
278_A282_E0.6120.84
178_S182_K0.6110.84
34_P51_R0.6080.84
201_F257_N0.6070.84
326_P356_G0.6060.84
106_H246_E0.6060.84
360_K397_T0.6060.84
385_K389_S0.6060.84
39_Y49_S0.6050.84
201_F234_Q0.6040.83
34_P87_V0.6030.83
221_L228_I0.6010.83
413_M416_G0.6010.83
42_S45_Q0.6000.83
170_A176_P0.5990.83
358_E361_E0.5990.83
315_D353_S0.5990.83
331_Y405_A0.5970.83
358_E435_L0.5970.83
229_V267_D0.5960.83
234_Q261_F0.5950.82
362_M366_D0.5940.82
114_G117_V0.5920.82
76_S372_A0.5900.82
301_V304_L0.5890.82
308_S405_A0.5860.82
152_V160_V0.5850.81
129_H133_M0.5840.81
120_K249_T0.5840.81
381_E384_M0.5830.81
298_A301_V0.5830.81
66_E108_N0.5820.81
27_M33_L0.5820.81
188_L222_Q0.5820.81
166_R172_L0.5810.81
334_S376_N0.5800.81
166_R170_A0.5790.81
112_S115_E0.5790.81
196_K222_Q0.5770.81
128_P135_S0.5770.81
169_E179_K0.5770.81
40_I367_S0.5760.80
320_D353_S0.5760.80
33_L87_V0.5750.80
144_Q152_V0.5730.80
49_S54_I0.5720.80
172_L177_K0.5720.80
19_D23_L0.5710.80
290_D298_A0.5680.80
178_S215_N0.5680.80
166_R173_P0.5670.79
24_L58_K0.5670.79
70_D74_S0.5670.79
203_G334_S0.5630.79
103_D248_N0.5610.79
337_L404_T0.5610.79
53_R56_L0.5600.79
331_Y344_S0.5580.78
436_L439_A0.5580.78
319_M353_S0.5540.78
306_D337_L0.5540.78
85_E339_N0.5540.78
275_G336_H0.5540.78
71_V75_L0.5530.78
404_T413_M0.5520.78
166_R175_V0.5520.78
274_G337_L0.5510.77
134_R138_S0.5490.77
375_Y382_M0.5470.77
325_T352_K0.5470.77
19_D104_I0.5460.77
147_G151_A0.5450.77
29_C36_C0.5420.76
160_V168_M0.5420.76
410_L431_L0.5420.76
50_P53_R0.5410.76
266_V303_K0.5410.76
395_K417_I0.5400.76
40_I385_K0.5400.76
335_C368_C0.5390.76
47_T51_R0.5390.76
141_G144_Q0.5380.76
256_Q259_A0.5380.76
115_E121_T0.5370.76
144_Q148_L0.5370.76
21_G25_N0.5370.76
152_V158_L0.5360.76
330_T360_K0.5360.76
190_S194_M0.5360.76
134_R208_T0.5360.76
46_E53_R0.5350.75
60_V104_I0.5340.75
272_N307_F0.5330.75
363_E393_A0.5330.75
251_K289_D0.5320.75
38_T334_S0.5300.75
250_G286_L0.5300.75
394_V397_T0.5300.75
325_T437_E0.5300.75
336_H406_N0.5300.75
264_L268_A0.5290.75
183_H218_L0.5290.75
194_M225_G0.5280.74
57_M60_V0.5270.74
244_S378_V0.5270.74
181_M232_P0.5270.74
261_F269_V0.5260.74
187_F195_K0.5260.74
171_V179_K0.5250.74
180_D211_L0.5240.74
127_F137_V0.5240.74
240_L407_P0.5230.74
169_E180_D0.5230.74
169_E381_E0.5220.74
255_K320_D0.5220.74
180_D230_I0.5220.74
131_N147_G0.5200.73
46_E92_V0.5160.73
179_K222_Q0.5150.73
27_M31_F0.5150.73
345_L352_K0.5150.73
202_S271_T0.5150.73
195_K225_G0.5140.72
52_G55_A0.5140.72
350_L435_L0.5130.72
316_F353_S0.5130.72
120_K241_H0.5130.72
230_I234_Q0.5120.72
21_G207_D0.5120.72
60_V64_M0.5110.72
302_Q305_K0.5110.72
394_V416_G0.5110.72
184_R202_S0.5100.72
189_P222_Q0.5100.72
262_E300_F0.5100.72
183_H186_R0.5090.72
259_A290_D0.5090.72
248_N252_E0.5090.72
46_E55_A0.5080.72
132_R161_L0.5070.71
311_L315_D0.5070.71
189_P227_D0.5060.71
372_A409_C0.5060.71
42_S53_R0.5040.71
362_M397_T0.5040.71
149_Q174_D0.5030.71
31_F90_S0.5020.71
35_S86_P0.5010.71
220_L311_L0.5000.70
99_E243_H0.5000.70
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kwlA 1 0.8063 100 0.511 Contact Map
3cf4A 2 0.7748 100 0.61 Contact Map
3c8yA 1 0.7545 99.7 0.842 Contact Map
2h88B 1 0.241 99.5 0.862 Contact Map
2wdqB 1 0.2432 99.4 0.864 Contact Map
4ysxB 1 0.2703 99.4 0.867 Contact Map
1kf6B 1 0.259 99.4 0.867 Contact Map
2bs2B 1 0.241 99.2 0.879 Contact Map
4p6vA 1 0.1667 99.1 0.883 Contact Map
1hfeL 2 0.7005 98 0.92 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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