GREMLIN Database
IABF1 - Intracellular exo-alpha-(1->5)-L-arabinofuranosidase 1
UniProt: P94531 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 500 (457)
Sequences: 2157 (1528)
Seq/√Len: 71.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
155_R160_E4.9331.00
108_N163_Y4.4201.00
108_N157_H3.8031.00
386_L419_L3.6841.00
413_S416_E3.6551.00
133_D137_N3.5811.00
56_S60_E3.5071.00
47_E52_K3.3941.00
77_Y82_G3.2711.00
15_G339_A3.0911.00
48_D112_S2.9391.00
423_A486_F2.9021.00
418_T495_R2.8861.00
57_L365_A2.8771.00
55_Q117_V2.8681.00
114_A121_V2.8611.00
120_E166_K2.8121.00
78_N134_A2.8011.00
115_K159_Y2.7161.00
80_E137_N2.6661.00
153_L156_S2.6611.00
388_P410_V2.6451.00
263_D331_L2.6141.00
432_E485_H2.5091.00
199_M206_I2.4491.00
187_E190_R2.4201.00
464_R467_V2.3921.00
184_T190_R2.3451.00
458_A467_V2.3411.00
29_M316_L2.2981.00
145_P148_S2.2741.00
111_L121_V2.2441.00
48_D116_K2.2211.00
60_E371_F2.2171.00
148_S151_S2.2051.00
60_E375_M2.1901.00
406_V431_M2.1631.00
147_G152_D2.1511.00
375_M449_I2.1291.00
141_Y157_H2.1191.00
159_Y163_Y2.1141.00
200_K237_D2.1111.00
453_H458_A2.0931.00
423_A433_T2.0731.00
60_E367_R2.0591.00
123_M138_L2.0461.00
113_W117_V2.0451.00
146_K151_S1.9881.00
111_L115_K1.9811.00
466_N469_P1.9621.00
83_V157_H1.9431.00
486_F492_N1.9311.00
226_A230_E1.9301.00
241_L288_L1.9261.00
454_Q458_A1.9001.00
430_Q488_P1.8971.00
406_V486_F1.8781.00
36_G39_E1.8711.00
143_N164_G1.8661.00
83_V153_L1.8551.00
450_V492_N1.8111.00
108_N159_Y1.8081.00
430_Q485_H1.7861.00
139_V199_M1.7841.00
152_D156_S1.7671.00
329_G424_V1.7261.00
153_L157_H1.7231.00
461_Q465_K1.7221.00
62_Q379_V1.7211.00
322_F452_E1.6931.00
17_V22_Y1.6911.00
337_Q407_D1.6761.00
38_Y86_V1.6731.00
447_E472_N1.6731.00
385_S409_A1.6561.00
142_C165_I1.6511.00
149_Y153_L1.6420.99
267_K338_H1.6370.99
487_T492_N1.6330.99
372_Y375_M1.6300.99
86_V104_E1.6270.99
364_E463_N1.6240.99
125_V135_A1.6180.99
65_I346_C1.6180.99
455_D458_A1.6100.99
290_L342_V1.6030.99
287_N343_K1.5980.99
394_K402_D1.5940.99
420_T495_R1.5930.99
57_L367_R1.5920.99
448_H492_N1.5830.99
99_T315_I1.5780.99
137_N150_W1.5770.99
413_S418_T1.5710.99
151_S155_R1.5710.99
199_M203_D1.5600.99
339_A385_S1.5520.99
146_K155_R1.5520.99
80_E150_W1.5450.99
284_K340_D1.5370.99
144_H151_S1.5260.99
450_V487_T1.5230.99
112_S116_K1.5140.99
193_A235_H1.5000.99
55_Q116_K1.4990.99
434_E481_G1.4880.99
277_K285_T1.4850.99
422_F493_V1.4790.99
388_P408_A1.4760.99
332_L335_M1.4750.99
108_N141_Y1.4630.99
434_E483_T1.4470.99
42_H45_A1.4430.99
326_L491_W1.4290.99
111_L142_C1.4240.99
168_W199_M1.4220.99
16_E19_K1.4130.98
184_T187_E1.4110.98
223_D226_A1.4090.98
207_E238_Y1.4080.98
133_D136_R1.3960.98
111_L165_I1.3940.98
88_N156_S1.3880.98
14_I385_S1.3870.98
322_F453_H1.3850.98
210_A228_V1.3850.98
150_W153_L1.3830.98
115_K161_Q1.3800.98
46_D116_K1.3780.98
333_I377_A1.3720.98
447_E495_R1.3700.98
263_D334_T1.3560.98
432_E483_T1.3540.98
107_T138_L1.3470.98
155_R159_Y1.3360.98
50_F105_V1.3290.98
185_A227_K1.3240.98
125_V199_M1.3240.98
240_S291_D1.3190.98
47_E116_K1.3140.97
35_E39_E1.3110.97
435_I482_L1.3070.97
112_S159_Y1.3040.97
35_E361_K1.3010.97
17_V385_S1.2930.97
107_T142_C1.2740.97
336_L422_F1.2710.97
186_D227_K1.2710.97
484_A494_I1.2670.97
66_I119_T1.2640.97
44_E52_K1.2630.97
361_K364_E1.2610.97
406_V423_A1.2510.97
191_L194_E1.2490.97
40_P86_V1.2460.97
42_H46_D1.2390.96
330_S424_V1.2380.96
380_Y411_V1.2340.96
43_P46_D1.2340.96
333_I409_A1.2320.96
194_E197_K1.2310.96
267_K334_T1.2250.96
376_H451_L1.2200.96
433_T486_F1.2180.96
20_R65_I1.2160.96
446_A494_I1.2150.96
10_K439_G1.2130.96
295_V327_L1.2100.96
445_I474_S1.2100.96
136_R139_V1.2070.96
366_W461_Q1.1970.96
61_L375_M1.1940.96
376_H493_V1.1930.96
423_A492_N1.1930.96
436_S439_G1.1920.96
11_E438_R1.1910.95
384_E412_Y1.1860.95
405_Y427_A1.1810.95
297_Y321_N1.1680.95
367_R371_F1.1530.95
223_D227_K1.1510.95
123_M142_C1.1400.94
186_D231_H1.1320.94
380_Y495_R1.1260.94
456_I489_L1.1210.94
143_N168_W1.1170.94
372_Y469_P1.1160.94
83_V150_W1.1140.94
421_I435_I1.1080.93
82_G107_T1.1030.93
266_I342_V1.0980.93
152_D155_R1.0950.93
139_V195_T1.0920.93
147_G151_S1.0840.93
375_M379_V1.0830.93
91_R100_T1.0830.93
52_K56_S1.0810.93
64_P378_S1.0770.92
246_G298_H1.0750.92
423_A494_I1.0720.92
125_V168_W1.0710.92
458_A468_V1.0640.92
333_I424_V1.0620.92
222_I268_S1.0600.92
136_R202_V1.0560.92
427_A431_M1.0540.92
31_R317_E1.0520.91
482_L496_L1.0510.91
390_I408_A1.0470.91
322_F489_L1.0460.91
9_D438_R1.0460.91
55_Q113_W1.0440.91
80_E153_L1.0440.91
198_V201_W1.0430.91
196_A208_L1.0400.91
83_V108_N1.0340.91
192_A196_A1.0330.91
373_P491_W1.0310.91
18_D343_K1.0250.90
19_K382_R1.0230.90
267_K271_A1.0180.90
460_N468_V1.0170.90
62_Q378_S1.0130.90
41_D45_A1.0090.90
453_H467_V1.0080.90
106_G109_E1.0060.90
364_E462_H1.0060.90
123_M165_I1.0040.89
274_D341_R1.0000.89
371_F375_M0.9960.89
262_L290_L0.9960.89
72_N75_S0.9950.89
329_G333_I0.9950.89
189_G231_H0.9930.89
121_V166_K0.9910.89
13_K384_E0.9880.89
145_P151_S0.9870.89
452_E487_T0.9850.89
65_I344_I0.9840.88
139_V202_V0.9830.88
197_K201_W0.9820.88
135_A168_W0.9820.88
449_I493_V0.9750.88
386_L412_Y0.9720.88
247_N457_K0.9670.88
322_F326_L0.9660.88
337_Q409_A0.9640.87
321_N457_K0.9600.87
266_I269_V0.9510.87
84_G89_R0.9510.87
142_C163_Y0.9430.86
377_A491_W0.9430.86
376_H449_I0.9410.86
39_E42_H0.9400.86
419_L437_L0.9310.86
20_R167_T0.9290.85
448_H473_G0.9210.85
448_H494_I0.9200.85
89_R106_G0.9180.85
24_S350_L0.9150.85
256_L326_L0.9120.84
129_T133_D0.9100.84
11_E439_G0.9080.84
139_V165_I0.9030.84
78_N133_D0.9020.84
174_M211_C0.9010.84
23_G27_E0.9000.84
31_R36_G0.8930.83
270_A338_H0.8930.83
167_T344_I0.8900.83
73_F101_E0.8900.83
35_E362_G0.8890.83
183_K191_L0.8890.83
132_I195_T0.8880.83
348_A353_V0.8880.83
192_A236_V0.8880.83
165_I168_W0.8790.82
12_Y15_G0.8730.82
245_Y261_D0.8730.82
18_D21_I0.8710.82
266_I290_L0.8710.82
147_G155_R0.8710.82
448_H484_A0.8690.81
31_R35_E0.8660.81
380_Y493_V0.8640.81
111_L163_Y0.8630.81
262_L265_F0.8630.81
64_P381_G0.8630.81
366_W462_H0.8570.80
168_W208_L0.8570.80
264_H267_K0.8560.80
39_E44_E0.8540.80
349_Q353_V0.8530.80
394_K399_D0.8530.80
222_I272_T0.8480.80
209_V240_S0.8470.80
207_E237_D0.8430.79
96_A198_V0.8420.79
115_K163_Y0.8410.79
454_Q467_V0.8400.79
170_L192_A0.8400.79
139_V150_W0.8360.79
380_Y420_T0.8350.79
213_S225_E0.8340.79
50_F55_Q0.8320.78
268_S275_Y0.8310.78
80_E133_D0.8290.78
26_I32_A0.8270.78
65_I167_T0.8270.78
50_F113_W0.8260.78
124_A142_C0.8260.78
84_G106_G0.8250.78
180_I201_W0.8230.78
136_R198_V0.8210.78
296_W349_Q0.8200.77
405_Y431_M0.8200.77
316_L347_L0.8190.77
447_E474_S0.8180.77
134_A137_N0.8160.77
142_C168_W0.8160.77
273_C288_L0.8140.77
449_I470_H0.8080.76
66_I117_V0.8070.76
238_Y287_N0.8050.76
78_N81_D0.8050.76
209_V238_Y0.8040.76
92_R103_N0.8040.76
314_P361_K0.8030.76
336_L409_A0.8010.76
19_K120_E0.8010.76
12_Y387_K0.8000.76
329_G491_W0.7990.76
433_T484_A0.7930.75
202_V206_I0.7900.75
296_W324_D0.7900.75
144_H148_S0.7890.75
332_L336_L0.7850.74
406_V484_A0.7840.74
44_E47_E0.7840.74
349_Q354_I0.7800.74
413_S417_E0.7790.74
289_S344_I0.7770.74
333_I407_D0.7750.73
478_S481_G0.7750.73
56_S59_K0.7740.73
13_K412_Y0.7720.73
109_E140_E0.7700.73
207_E289_S0.7700.73
78_N130_R0.7700.73
448_H475_S0.7670.73
80_E134_A0.7660.73
183_K194_E0.7640.72
376_H470_H0.7630.72
43_P48_D0.7600.72
37_I113_W0.7600.72
73_F103_N0.7570.72
258_R262_L0.7570.72
377_A493_V0.7550.71
445_I496_L0.7540.71
452_E471_S0.7530.71
353_V356_P0.7530.71
255_Y258_R0.7520.71
358_M371_F0.7500.71
472_N475_S0.7450.70
482_L494_I0.7450.70
90_P196_A0.7430.70
461_Q464_R0.7390.70
132_I136_R0.7390.70
72_N96_A0.7380.70
63_V117_V0.7380.70
139_V143_N0.7350.69
83_V107_T0.7350.69
256_L259_S0.7330.69
372_Y470_H0.7310.69
333_I408_A0.7310.69
80_E130_R0.7300.69
430_Q477_V0.7270.69
433_T494_I0.7270.69
39_E45_A0.7270.69
199_M202_V0.7260.68
140_E144_H0.7240.68
23_G65_I0.7240.68
296_W354_I0.7230.68
9_D12_Y0.7200.68
47_E112_S0.7200.68
446_A475_S0.7170.67
150_W217_G0.7170.67
282_S286_I0.7160.67
54_V360_E0.7150.67
375_M378_S0.7140.67
384_E414_E0.7140.67
29_M347_L0.7140.67
256_L263_D0.7130.67
25_F30_G0.7130.67
20_R120_E0.7120.67
76_G95_L0.7110.67
321_N325_A0.7110.67
112_S115_K0.7110.67
460_N465_K0.7100.67
330_S407_D0.7070.66
247_N298_H0.7060.66
451_L470_H0.7060.66
326_L426_K0.7060.66
336_L385_S0.7050.66
479_E482_L0.7040.66
127_L170_L0.7030.66
105_V121_V0.7030.66
193_A197_K0.7030.66
42_H49_G0.7010.66
238_Y289_S0.7000.66
89_R109_E0.7000.66
38_Y41_D0.7000.66
140_E148_S0.6980.65
452_E489_L0.6980.65
290_L335_M0.6970.65
145_P161_Q0.6970.65
225_E239_I0.6960.65
266_I331_L0.6950.65
345_A374_Y0.6940.65
233_Y277_K0.6940.65
144_H147_G0.6910.65
437_L480_N0.6910.65
111_L159_Y0.6880.64
473_G485_H0.6870.64
270_A273_C0.6870.64
196_A200_K0.6840.64
394_K401_T0.6840.64
246_G255_Y0.6830.64
445_I494_I0.6820.64
41_D44_E0.6810.63
392_S404_P0.6760.63
17_V23_G0.6750.63
130_R134_A0.6750.63
256_L456_I0.6740.63
25_F31_R0.6730.63
39_E362_G0.6720.62
97_W106_G0.6710.62
27_E30_G0.6710.62
319_I358_M0.6700.62
288_L451_L0.6700.62
22_Y25_F0.6660.62
332_L373_P0.6660.62
114_A467_V0.6650.62
238_Y343_K0.6650.62
378_S381_G0.6650.62
81_D103_N0.6640.62
122_N209_V0.6630.61
478_S483_T0.6620.61
381_G411_V0.6620.61
472_N494_I0.6620.61
132_I198_V0.6580.61
450_V474_S0.6570.61
78_N137_N0.6560.61
84_G109_E0.6560.61
76_G180_I0.6550.60
230_E280_T0.6550.60
264_H268_S0.6520.60
332_L377_A0.6510.60
271_A274_D0.6510.60
37_I350_L0.6500.60
128_G176_G0.6500.60
316_L349_Q0.6500.60
74_L124_A0.6490.60
377_A409_A0.6490.60
105_V111_L0.6480.60
37_I48_D0.6480.60
108_N112_S0.6470.60
296_W300_N0.6470.60
110_F114_A0.6450.59
335_M345_A0.6440.59
114_A119_T0.6430.59
63_V350_L0.6400.59
111_L114_A0.6390.59
477_V494_I0.6380.58
360_E462_H0.6380.58
66_I121_V0.6360.58
10_K13_K0.6350.58
277_K282_S0.6350.58
180_I198_V0.6340.58
77_Y107_T0.6330.58
412_Y419_L0.6330.58
338_H341_R0.6300.58
282_S285_T0.6290.57
33_V36_G0.6280.57
421_I481_G0.6280.57
141_Y153_L0.6270.57
229_L286_I0.6260.57
269_V272_T0.6250.57
484_A492_N0.6250.57
17_V411_V0.6250.57
210_A236_V0.6240.57
25_F29_M0.6230.57
413_S420_T0.6230.57
154_R162_P0.6220.57
466_N471_S0.6200.56
236_V286_I0.6200.56
23_G28_H0.6180.56
214_S269_V0.6170.56
114_A329_G0.6160.56
378_S382_R0.6160.56
475_S482_L0.6150.56
105_V110_F0.6150.56
135_A199_M0.6150.56
210_A232_T0.6140.56
191_L195_T0.6120.55
125_V195_T0.6120.55
73_F77_Y0.6120.55
439_G476_S0.6120.55
114_A206_I0.6120.55
170_L236_V0.6110.55
22_Y27_E0.6100.55
61_L374_Y0.6080.55
93_L202_V0.6080.55
51_R106_G0.6080.55
126_N176_G0.6070.55
222_I225_E0.6060.55
330_S426_K0.6040.54
10_K440_F0.6020.54
412_Y416_E0.6020.54
89_R97_W0.6010.54
27_E31_R0.6010.54
155_R161_Q0.6010.54
66_I113_W0.6010.54
50_F112_S0.6000.54
182_H197_K0.6000.54
232_T237_D0.5990.54
412_Y417_E0.5990.54
364_E465_K0.5990.54
58_I350_L0.5970.54
143_N166_K0.5970.54
51_R291_D0.5970.54
90_P322_F0.5960.53
454_Q488_P0.5950.53
477_V482_L0.5950.53
161_Q464_R0.5930.53
167_T209_V0.5910.53
44_E48_D0.5900.53
144_H155_R0.5900.53
140_E151_S0.5890.53
267_K270_A0.5870.52
463_N466_N0.5870.52
421_I496_L0.5870.52
383_G414_E0.5860.52
127_L191_L0.5860.52
259_S330_S0.5860.52
92_R149_Y0.5840.52
436_S481_G0.5840.52
154_R158_G0.5830.52
92_R150_W0.5830.52
14_I387_K0.5820.52
173_E292_E0.5820.52
19_K23_G0.5820.52
93_L148_S0.5800.51
146_K160_E0.5790.51
324_D370_I0.5790.51
28_H34_Y0.5780.51
148_S153_L0.5770.51
161_Q469_P0.5740.51
332_L470_H0.5730.51
463_N467_V0.5720.50
83_V138_L0.5720.50
108_N115_K0.5710.50
64_P119_T0.5700.50
319_I459_T0.5680.50
326_L456_I0.5680.50
325_A369_P0.5670.50
84_G97_W0.5660.50
296_W320_Y0.5650.50
39_E46_D0.5640.49
258_R261_D0.5630.49
50_F116_K0.5620.49
211_C215_N0.5620.49
101_E212_G0.5610.49
169_C212_G0.5610.49
226_A275_Y0.5600.49
91_R102_T0.5600.49
40_P45_A0.5590.49
444_Q485_H0.5590.49
28_H31_R0.5570.49
12_Y16_E0.5570.49
255_Y265_F0.5560.49
297_Y324_D0.5550.48
161_Q402_D0.5540.48
316_L353_V0.5540.48
431_M449_I0.5530.48
377_A420_T0.5530.48
384_E430_Q0.5520.48
27_E34_Y0.5520.48
264_H494_I0.5510.48
28_H73_F0.5510.48
352_N368_Q0.5500.48
158_G162_P0.5470.47
29_M32_A0.5460.47
246_G300_N0.5460.47
238_Y344_I0.5450.47
461_Q467_V0.5450.47
403_V426_K0.5440.47
169_C291_D0.5430.47
326_L489_L0.5430.47
216_S268_S0.5430.47
394_K431_M0.5430.47
10_K340_D0.5430.47
271_A406_V0.5420.47
344_I421_I0.5420.47
423_A431_M0.5420.47
51_R89_R0.5420.47
19_K22_Y0.5410.47
66_I466_N0.5410.47
265_F268_S0.5400.47
170_L194_E0.5400.47
385_S388_P0.5390.46
40_P47_E0.5370.46
196_A235_H0.5360.46
382_R414_E0.5360.46
87_E160_E0.5360.46
436_S488_P0.5350.46
72_N368_Q0.5350.46
222_I281_R0.5340.46
336_L493_V0.5340.46
476_S479_E0.5330.46
166_K206_I0.5330.46
272_T276_V0.5330.46
368_Q373_P0.5320.46
353_V370_I0.5320.46
24_S63_V0.5310.45
22_Y381_G0.5300.45
143_N199_M0.5300.45
176_G212_G0.5290.45
75_S174_M0.5290.45
166_K207_E0.5280.45
246_G249_D0.5280.45
440_F485_H0.5260.45
446_A474_S0.5260.45
434_E477_V0.5260.45
316_L348_A0.5250.45
68_Y110_F0.5250.45
148_S157_H0.5240.45
111_L119_T0.5240.45
367_R466_N0.5240.45
59_K62_Q0.5240.45
33_V39_E0.5230.44
58_I113_W0.5230.44
172_N292_E0.5210.44
296_W348_A0.5210.44
408_A423_A0.5210.44
124_A211_C0.5210.44
82_G103_N0.5200.44
12_Y161_Q0.5200.44
25_F36_G0.5200.44
23_G29_M0.5200.44
35_E38_Y0.5190.44
67_R172_N0.5190.44
469_P485_H0.5190.44
71_G79_W0.5180.44
398_S402_D0.5180.44
295_V322_F0.5170.44
24_S33_V0.5160.44
280_T435_I0.5160.44
421_I494_I0.5140.43
105_V113_W0.5140.43
405_Y410_V0.5120.43
107_T111_L0.5120.43
215_N265_F0.5110.43
269_V342_V0.5110.43
326_L424_V0.5110.43
30_G36_G0.5110.43
94_D212_G0.5100.43
263_D267_K0.5100.43
416_E452_E0.5090.43
76_G133_D0.5090.43
256_L262_L0.5090.43
284_K341_R0.5080.43
483_T496_L0.5080.43
20_R207_E0.5080.43
34_Y38_Y0.5080.43
143_N205_S0.5070.43
76_G200_K0.5060.42
176_G352_N0.5050.42
76_G201_W0.5030.42
110_F121_V0.5030.42
203_D206_I0.5030.42
358_M367_R0.5020.42
300_N317_E0.5010.42
100_T148_S0.5000.42
76_G96_A0.5000.42
125_V372_Y0.5000.42
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2c7fA 2 0.99 100 0.213 Contact Map
2y2wA 3 0.988 100 0.224 Contact Map
2vrqA 1 0.952 100 0.227 Contact Map
1qw9A 4 0.99 100 0.228 Contact Map
3ug3A 4 0.934 100 0.243 Contact Map
3ik2A 1 0.818 100 0.397 Contact Map
2e4tA 1 0.804 100 0.404 Contact Map
2yihA 1 0.816 100 0.412 Contact Map
3vnyA 3 0.872 100 0.455 Contact Map
3ii1A 1 0.808 100 0.46 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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