GREMLIN Database
ARAQ - L-arabinose transport system permease protein AraQ
UniProt: P94530 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 281 (252)
Sequences: 68849 (45247)
Seq/√Len: 2850.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
186_G190_R3.9811.00
78_F82_V3.2681.00
178_R187_I3.1851.00
163_R167_L3.0341.00
76_W233_G2.7011.00
75_K78_F2.6651.00
37_S63_Y2.6051.00
183_T186_G2.5611.00
165_Y199_A2.5481.00
104_V174_L2.5421.00
177_A187_I2.5141.00
228_F236_S2.4951.00
64_T68_N2.4741.00
74_F78_F2.4201.00
174_L192_M2.3871.00
61_D64_T2.3501.00
184_E187_I2.3431.00
88_T204_I2.2871.00
90_L153_I2.2521.00
185_F189_F2.2301.00
162_F200_F2.2101.00
244_N247_M2.1691.00
61_D65_F2.1361.00
107_F110_R2.1221.00
182_C186_G2.0601.00
186_G189_F2.0341.00
158_A203_M1.9831.00
96_S188_F1.9471.00
35_L39_K1.9421.00
103_A167_L1.9391.00
173_L195_L1.9141.00
177_A182_C1.9121.00
166_A196_M1.9101.00
31_F35_L1.9011.00
114_F163_R1.8821.00
96_S196_M1.8521.00
92_L204_I1.8261.00
75_K79_N1.7681.00
178_R184_E1.7561.00
87_T211_S1.7351.00
86_F149_I1.7211.00
225_K228_F1.7191.00
174_L187_I1.7181.00
82_V86_F1.7091.00
84_G208_S1.6831.00
95_S158_A1.6461.00
96_S162_F1.6311.00
174_L178_R1.6161.00
65_F247_M1.5991.00
98_I159_V1.5981.00
171_R174_L1.5551.00
16_T20_M1.5521.00
233_G237_L1.5011.00
102_L159_V1.4921.00
65_F68_N1.4911.00
109_G112_I1.4681.00
264_L268_K1.4631.00
158_A207_Q1.4621.00
215_F219_L1.4431.00
28_F32_C1.4371.00
106_D110_R1.4311.00
60_F64_T1.4301.00
34_L253_V1.4191.00
103_A163_R1.4191.00
83_L229_T1.3991.00
32_C36_G1.3561.00
93_F97_M1.3451.00
202_A206_L1.3451.00
99_G162_F1.3381.00
166_A192_M1.3341.00
91_T207_Q1.3321.00
193_A200_F1.3271.00
217_W221_V1.3221.00
162_F203_M1.3091.00
171_R175_D1.3071.00
59_S62_N1.3051.00
104_V171_R1.3021.00
96_S200_F1.2771.00
215_F235_S1.2611.00
228_F233_G1.2521.00
112_I115_V1.2461.00
172_D175_D1.2411.00
222_L227_M1.2361.00
177_A191_I1.2251.00
80_S230_L1.2251.00
10_V14_A1.2251.00
145_Y227_M1.2231.00
89_V93_F1.2171.00
43_E57_V1.2171.00
237_L242_G1.2171.00
224_S227_M1.2161.00
100_Y166_A1.2111.00
237_L244_N1.2081.00
92_L200_F1.2021.00
169_L195_L1.2001.00
136_T147_G1.1891.00
79_N82_V1.1801.00
86_F89_V1.1771.00
71_S75_K1.1761.00
65_F69_G1.1691.00
11_Y15_L1.1641.00
236_S240_P1.1431.00
20_M24_L1.1431.00
197_K201_G1.1341.00
40_P43_E1.1141.00
183_T187_I1.1141.00
112_I116_L1.1001.00
214_N217_W1.0981.00
33_L253_V1.0961.00
141_L146_T1.0931.00
162_F199_A1.0851.00
32_C35_L1.0811.00
13_I17_L1.0741.00
174_L184_E1.0731.00
86_F90_L1.0571.00
155_S159_V1.0531.00
228_F232_I1.0501.00
229_T232_I1.0391.00
268_K271_I1.0361.00
41_S45_L1.0251.00
100_Y188_F1.0231.00
87_T91_T1.0161.00
134_K138_G1.0111.00
103_A166_A1.0101.00
81_L85_L1.0101.00
13_I16_T1.0051.00
100_Y184_E1.0011.00
67_F74_F1.0001.00
187_I190_R0.9991.00
151_P221_V0.9961.00
161_F203_M0.9961.00
195_L198_P0.9911.00
10_V13_I0.9861.00
233_G251_G0.9841.00
97_M101_G0.9821.00
110_R167_L0.9781.00
182_C187_I0.9761.00
89_V204_I0.9691.00
12_R16_T0.9571.00
15_L19_F0.9431.00
259_V263_F0.9391.00
233_G236_S0.9381.00
218_P229_T0.9351.00
63_Y253_V0.9341.00
265_F269_Y0.9321.00
87_T152_F0.9191.00
132_L221_V0.9161.00
99_G103_A0.9141.00
143_D224_S0.9101.00
82_V85_L0.9091.00
149_I153_I0.9031.00
77_F230_L0.8991.00
36_G249_I0.8971.00
214_N218_P0.8951.00
219_L232_I0.8951.00
23_S27_L0.8921.00
36_G39_K0.8831.00
85_L89_V0.8801.00
37_S41_S0.8761.00
91_T95_S0.8741.00
165_Y196_M0.8731.00
238_L248_L0.8671.00
42_S45_L0.8661.00
62_N246_D0.8611.00
197_K200_F0.8581.00
95_S159_V0.8551.00
67_F70_G0.8541.00
133_F137_V0.8501.00
187_I192_M0.8491.00
196_M199_A0.8481.00
102_L114_F0.8471.00
111_N114_F0.8461.00
66_L254_F0.8451.00
38_L58_M0.8441.00
90_L93_F0.8431.00
118_L160_F0.8401.00
99_G159_V0.8371.00
73_Y251_G0.8371.00
158_A162_F0.8361.00
147_G151_P0.8341.00
90_L149_I0.8331.00
235_S239_S0.8331.00
188_F193_A0.8321.00
237_L251_G0.8311.00
78_F81_L0.8261.00
108_K111_N0.8251.00
162_F196_M0.8211.00
39_K43_E0.8191.00
189_F193_A0.8191.00
151_P217_W0.8191.00
237_L247_M0.8181.00
101_G107_F0.8161.00
207_Q211_S0.8091.00
197_K269_Y0.8081.00
77_F81_L0.8081.00
36_G40_P0.8041.00
255_A259_V0.8021.00
152_F211_S0.7991.00
182_C190_R0.7951.00
184_E188_F0.7941.00
261_I265_F0.7901.00
141_L144_S0.7841.00
151_P154_V0.7811.00
137_V142_I0.7571.00
173_L191_I0.7561.00
139_L142_I0.7551.00
91_T158_A0.7551.00
91_T211_S0.7531.00
76_W79_N0.7531.00
58_M61_D0.7531.00
232_I236_S0.7511.00
148_V218_P0.7511.00
33_L249_I0.7481.00
129_M216_L0.7451.00
266_F269_Y0.7421.00
99_G166_A0.7421.00
39_K55_P0.7401.00
102_L163_R0.7401.00
38_L59_S0.7391.00
64_T67_F0.7351.00
125_L216_L0.7311.00
83_L152_F0.7311.00
88_T208_S0.7291.00
59_S63_Y0.7281.00
200_F203_M0.7281.00
129_M220_I0.7261.00
28_F31_F0.7231.00
265_F268_K0.7221.00
84_G88_T0.7181.00
60_F63_Y0.7151.00
43_E46_R0.7131.00
14_A17_L0.7091.00
188_F192_M0.7091.00
95_S162_F0.7091.00
118_L121_M0.7081.00
87_T149_I0.7061.00
92_L162_F0.7011.00
74_F77_F0.6991.00
230_L255_A0.6981.00
40_P57_V0.6981.00
98_I155_S0.6981.00
214_N229_T0.6971.00
249_I253_V0.6941.00
62_N65_F0.6911.00
88_T92_L0.6901.00
169_L196_M0.6861.00
22_L26_Y0.6861.00
176_S180_D0.6831.00
176_S179_M0.6831.00
171_R178_R0.6811.00
65_F244_N0.6801.00
102_L113_I0.6781.00
222_L228_F0.6781.00
148_V152_F0.6771.00
82_V145_Y0.6751.00
247_M251_G0.6741.00
86_F153_I0.6711.00
234_L251_G0.6701.00
162_F166_A0.6651.00
141_L145_Y0.6641.00
23_S26_Y0.6621.00
76_W230_L0.6601.00
192_M195_L0.6591.00
18_F22_L0.6581.00
231_P255_A0.6561.00
19_F23_S0.6561.00
14_A18_F0.6531.00
134_K137_V0.6531.00
33_L252_S0.6511.00
98_I117_V0.6511.00
24_L28_F0.6511.00
260_I264_L0.6481.00
200_F204_I0.6441.00
199_A203_M0.6441.00
40_P56_K0.6421.00
17_L20_M0.6421.00
80_S231_P0.6381.00
263_F267_Q0.6361.00
107_F113_I0.6311.00
70_G75_K0.6231.00
108_K112_I0.6231.00
111_N115_V0.6171.00
109_G113_I0.6161.00
114_F160_F0.6141.00
42_S46_R0.6111.00
70_G74_F0.6081.00
57_V61_D0.6051.00
43_E56_K0.6041.00
210_N213_N0.6041.00
83_L87_T0.6011.00
71_S225_K0.6001.00
101_G105_Y0.5991.00
12_R15_L0.5971.00
246_D249_I0.5951.00
132_L135_L0.5951.00
27_L31_F0.5951.00
189_F192_M0.5921.00
249_I252_S0.5921.00
161_F199_A0.5911.00
142_I145_Y0.5911.00
106_D111_N0.5901.00
245_Y249_I0.5901.00
100_Y192_M0.5891.00
149_I152_F0.5871.00
126_E220_I0.5851.00
204_I207_Q0.5851.00
201_G204_I0.5841.00
187_I191_I0.5841.00
63_Y250_S0.5841.00
84_G211_S0.5821.00
115_V119_I0.5821.00
211_S214_N0.5801.00
92_L96_S0.5801.00
66_L251_G0.5791.00
261_I264_L0.5771.00
139_L144_S0.5761.00
55_P58_M0.5761.00
39_K57_V0.5751.00
94_F155_S0.5741.00
216_L219_L0.5731.00
209_L213_N0.5721.00
16_T19_F0.5721.00
117_V156_P0.5711.00
71_S74_F0.5711.00
36_G41_S0.5701.00
143_D146_T0.5701.00
125_L129_M0.5671.00
68_N71_S0.5661.00
57_V60_F0.5661.00
80_S212_W0.5631.00
140_H143_D0.5631.00
120_I156_P0.5601.00
99_G163_R0.5601.00
264_L267_Q0.5561.00
66_L247_M0.5551.00
237_L240_P0.5531.00
37_S250_S0.5531.00
136_T142_I0.5521.00
121_M157_V0.5501.00
79_N227_M0.5481.00
114_F167_L0.5471.00
84_G212_W0.5431.00
98_I101_G0.5431.00
83_L149_I0.5421.00
121_M156_P0.5411.00
245_Y248_L0.5411.00
95_S155_S0.5391.00
69_G74_F0.5331.00
87_T153_I0.5321.00
147_G221_V0.5301.00
107_F111_N0.5291.00
38_L60_F0.5281.00
247_M250_S0.5271.00
110_R114_F0.5251.00
116_L120_I0.5251.00
132_L151_P0.5241.00
106_D171_R0.5221.00
113_I117_V0.5201.00
218_P222_L0.5191.00
225_K236_S0.5161.00
105_Y184_E0.5141.00
39_K56_K0.5141.00
218_P232_I0.5101.00
192_M196_M0.5101.00
100_Y104_V0.5101.00
169_L174_L0.5091.00
183_T189_F0.5071.00
88_T93_F0.5071.00
114_F159_V0.5051.00
232_I235_S0.5041.00
64_T69_G0.5031.00
96_S193_A0.5031.00
79_N229_T0.5021.00
75_K82_V0.5021.00
258_P261_I0.5011.00
175_D178_R0.5011.00
106_D109_G0.5011.00
129_M133_F0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquN 1 0.9502 100 0.245 Contact Map
3rlfG 1 0.9502 100 0.249 Contact Map
2onkC 2 0.8541 100 0.314 Contact Map
4tquM 1 0.9075 100 0.327 Contact Map
3d31C 2 0.8363 100 0.337 Contact Map
3rlfF 1 0.9253 100 0.389 Contact Map
4ymuD 2 0.7544 99.9 0.498 Contact Map
3tuiA 2 0.7331 99.9 0.527 Contact Map
2cfqA 1 0.9181 4.5 0.955 Contact Map
2k1eA 3 0.3665 4.2 0.955 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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