GREMLIN Database
ARAP - L-arabinose transport system permease protein AraP
UniProt: P94529 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 313 (255)
Sequences: 70589 (45952)
Seq/√Len: 2877.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
219_K223_H3.9681.00
88_W92_E3.2441.00
211_D220_K3.0401.00
196_L200_Q3.0281.00
85_T88_W2.6391.00
114_S207_Y2.5981.00
198_G232_V2.5241.00
207_Y225_T2.5211.00
265_L273_Q2.4991.00
96_W180_V2.4731.00
86_A270_Y2.4711.00
210_A220_K2.4691.00
100_V184_S2.4331.00
73_S76_T2.4001.00
84_Y88_W2.3981.00
58_S75_Y2.3651.00
216_N219_K2.3451.00
98_L237_L2.3061.00
217_T220_K2.2931.00
195_F233_T2.2341.00
218_M222_L2.1411.00
73_S77_A2.1411.00
280_E283_Y2.1311.00
117_V120_R2.1281.00
215_A219_K2.0541.00
106_L221_F2.0371.00
219_K222_L2.0001.00
76_T79_N1.9901.00
191_N236_V1.9781.00
199_L229_L1.9361.00
206_L228_F1.9261.00
56_I60_Q1.9101.00
113_N200_Q1.8981.00
92_E176_M1.8901.00
210_A215_A1.8891.00
106_L229_L1.8121.00
124_K196_L1.7991.00
52_I56_I1.7691.00
300_L304_K1.7601.00
85_T89_N1.7171.00
262_N265_L1.7151.00
207_Y220_K1.7001.00
102_I237_L1.6991.00
211_D217_T1.6941.00
105_P191_N1.6741.00
92_E96_W1.6561.00
97_T244_G1.6561.00
94_T241_I1.6331.00
270_Y274_Q1.6121.00
106_L195_F1.6121.00
108_L192_I1.6031.00
112_L192_I1.5991.00
77_A283_Y1.5891.00
207_Y211_D1.5381.00
37_A41_L1.4991.00
204_K207_Y1.4571.00
176_M264_G1.4571.00
55_F289_I1.4461.00
119_F122_I1.4401.00
53_S57_M1.4131.00
49_Y53_S1.4051.00
191_N240_S1.4031.00
109_A195_F1.3971.00
71_G74_N1.3851.00
235_Y239_I1.3771.00
113_N196_L1.3451.00
199_L225_T1.3421.00
248_F252_Y1.3421.00
116_L120_R1.3421.00
101_L240_S1.3291.00
255_W264_G1.3231.00
226_L233_T1.3191.00
195_F236_V1.3171.00
82_T85_T1.3091.00
265_L270_Y1.2891.00
103_P107_L1.2851.00
72_L76_T1.2851.00
204_K208_E1.2811.00
274_Q278_Y1.2731.00
114_S204_K1.2701.00
182_L254_L1.2691.00
210_A224_I1.2571.00
90_T267_L1.2551.00
205_E208_E1.2391.00
93_Y266_T1.2371.00
110_I199_L1.2291.00
250_E254_L1.2241.00
146_F178_L1.2201.00
41_L45_V1.2011.00
122_I125_S1.1921.00
216_N220_K1.1901.00
106_L233_T1.1851.00
31_A35_F1.1751.00
273_Q277_A1.1721.00
30_A34_L1.1721.00
274_Q280_E1.1651.00
96_W99_I1.1621.00
99_I103_P1.1611.00
64_P69_F1.1511.00
202_V228_F1.1501.00
89_N92_E1.1431.00
248_F272_Y1.1331.00
266_T269_G1.1221.00
179_M251_S1.1201.00
32_P36_T1.1171.00
230_K234_V1.1131.00
102_I233_T1.1071.00
29_K32_P1.1031.00
195_F232_V1.0991.00
261_G264_G1.0981.00
34_L38_P1.0831.00
110_I217_T1.0711.00
304_K307_G1.0671.00
66_E69_F1.0661.00
61_R64_P1.0581.00
53_S56_I1.0551.00
207_Y217_T1.0441.00
228_F231_P1.0341.00
147_G151_T1.0301.00
54_V289_I1.0301.00
144_L148_E1.0261.00
100_V180_V1.0261.00
97_T101_L1.0251.00
194_Y236_V1.0141.00
97_T183_A1.0101.00
75_Y289_I1.0061.00
188_M192_I1.0061.00
180_V184_S1.0021.00
34_L37_A1.0001.00
122_I126_A0.9991.00
107_L111_F0.9961.00
96_W100_V0.9911.00
77_A80_N0.9881.00
110_I221_F0.9871.00
113_N199_L0.9861.00
301_I305_L0.9851.00
247_M250_E0.9831.00
265_L269_G0.9811.00
251_S266_T0.9811.00
177_F181_L0.9681.00
57_M285_A0.9681.00
176_M180_V0.9611.00
31_A34_L0.9541.00
215_A220_K0.9461.00
220_K223_H0.9451.00
275_G284_G0.9441.00
142_F254_L0.9391.00
91_L95_F0.9341.00
183_A244_G0.9331.00
247_M251_S0.9261.00
270_Y273_Q0.9241.00
92_E177_F0.9191.00
87_L267_L0.9171.00
270_Y287_I0.9151.00
99_I237_L0.9041.00
120_R200_Q0.8981.00
33_Y37_A0.8971.00
92_E95_F0.8971.00
109_A113_N0.8971.00
83_F287_I0.8921.00
142_F182_L0.8891.00
153_L177_F0.8881.00
29_K33_Y0.8811.00
89_N176_M0.8771.00
97_T180_V0.8741.00
128_F193_L0.8681.00
60_Q64_P0.8621.00
95_F99_I0.8611.00
118_K121_N0.8601.00
93_Y176_M0.8601.00
78_L290_V0.8581.00
115_K120_R0.8581.00
87_L91_L0.8571.00
230_K233_T0.8551.00
229_L232_V0.8541.00
44_L48_L0.8511.00
182_L250_E0.8481.00
301_I304_K0.8471.00
252_Y269_G0.8441.00
195_F229_L0.8421.00
93_Y183_A0.8411.00
112_L124_K0.8411.00
198_G229_L0.8411.00
100_V103_P0.8411.00
36_T40_V0.8391.00
105_P192_I0.8321.00
221_F226_L0.8301.00
177_F180_V0.8281.00
240_S244_G0.8281.00
222_L226_L0.8271.00
57_M60_Q0.8231.00
121_N124_K0.8181.00
101_L105_P0.8121.00
28_K32_P0.8111.00
72_L75_Y0.8111.00
153_L156_S0.8071.00
135_T186_R0.8021.00
54_V285_A0.8001.00
191_N195_F0.7971.00
274_Q283_Y0.7921.00
111_F117_V0.7911.00
109_A199_L0.7901.00
80_N84_Y0.7881.00
96_W184_S0.7871.00
220_K225_T0.7871.00
82_T262_N0.7861.00
295_I299_S0.7821.00
74_N282_G0.7811.00
109_A192_I0.7781.00
88_W91_L0.7731.00
101_L187_W0.7691.00
215_A223_H0.7691.00
46_F50_P0.7641.00
274_Q287_I0.7641.00
54_V288_G0.7631.00
139_G249_E0.7611.00
283_Y287_I0.7551.00
297_V301_I0.7541.00
285_A289_I0.7501.00
206_L224_I0.7481.00
178_L182_L0.7441.00
143_R147_G0.7401.00
74_N77_A0.7401.00
217_T221_F0.7391.00
101_L191_N0.7351.00
221_F225_T0.7311.00
112_L123_F0.7291.00
49_Y52_I0.7261.00
86_A89_N0.7221.00
139_G253_V0.7181.00
138_A185_W0.7151.00
38_P41_L0.7131.00
59_F70_V0.7131.00
108_L188_M0.7111.00
98_L241_I0.7101.00
302_S305_L0.7081.00
77_A280_E0.7061.00
105_P195_F0.7031.00
61_R68_S0.7021.00
128_F131_A0.7011.00
247_M266_T0.7001.00
255_W265_L0.6991.00
35_F39_F0.6991.00
101_L244_G0.6981.00
102_I195_F0.6981.00
204_K211_D0.6971.00
269_G273_Q0.6931.00
233_T236_V0.6921.00
251_S269_G0.6901.00
135_T249_E0.6891.00
272_Y276_L0.6881.00
179_M255_W0.6861.00
35_F38_P0.6841.00
86_A267_L0.6821.00
209_A213_D0.6811.00
30_A33_Y0.6771.00
195_F199_L0.6751.00
81_P85_T0.6731.00
187_W240_S0.6721.00
84_Y87_L0.6721.00
232_V236_V0.6721.00
43_F47_F0.6721.00
59_F71_G0.6701.00
112_L196_L0.6691.00
94_T98_L0.6681.00
111_F115_K0.6681.00
64_P68_S0.6671.00
69_F72_L0.6631.00
61_R69_F0.6611.00
249_E253_V0.6541.00
60_Q67_V0.6531.00
271_L287_I0.6521.00
71_G75_Y0.6471.00
202_V229_L0.6471.00
69_F73_S0.6471.00
285_A288_G0.6461.00
152_S155_N0.6451.00
230_K305_L0.6451.00
225_T228_F0.6431.00
267_L291_L0.6431.00
104_V184_S0.6421.00
104_V188_M0.6421.00
93_Y179_M0.6401.00
268_V291_L0.6381.00
117_V123_F0.6341.00
79_N82_T0.6331.00
127_L189_G0.6331.00
33_Y36_T0.6331.00
78_L287_I0.6311.00
90_T245_F0.6301.00
44_L47_F0.6231.00
209_A212_I0.6211.00
40_V44_L0.6181.00
151_T154_A0.6171.00
131_A189_G0.6161.00
187_W243_G0.6141.00
60_Q69_F0.6131.00
119_F123_F0.6121.00
144_L147_G0.6121.00
142_F145_I0.6121.00
81_P84_Y0.6101.00
70_V73_S0.6101.00
147_G154_A0.6101.00
233_T237_L0.6071.00
67_V70_V0.6051.00
296_L300_L0.6031.00
101_L184_S0.6031.00
108_L127_L0.6021.00
62_I67_V0.6011.00
242_I246_R0.6001.00
65_G68_S0.5961.00
294_V297_V0.5951.00
178_L254_L0.5921.00
98_L102_I0.5921.00
194_Y232_V0.5921.00
118_K122_I0.5891.00
82_T270_Y0.5881.00
93_Y180_V0.5881.00
291_L295_I0.5871.00
124_K193_L0.5851.00
57_M61_R0.5801.00
28_K31_A0.5791.00
89_N264_G0.5741.00
110_I225_T0.5731.00
136_I253_V0.5721.00
116_L121_N0.5701.00
234_V237_L0.5701.00
148_E151_T0.5681.00
179_M183_A0.5671.00
281_M284_G0.5671.00
121_N125_S0.5661.00
109_A196_L0.5651.00
281_M285_A0.5641.00
94_T244_G0.5611.00
220_K224_I0.5591.00
39_F43_F0.5571.00
90_T268_V0.5561.00
75_Y286_A0.5551.00
102_I106_L0.5531.00
155_N261_G0.5521.00
255_W261_G0.5511.00
299_S303_L0.5511.00
183_A247_M0.5491.00
139_G143_R0.5481.00
243_G246_R0.5481.00
135_T139_G0.5481.00
58_S62_I0.5461.00
130_P189_G0.5451.00
68_S71_G0.5441.00
94_T245_F0.5441.00
78_L283_Y0.5441.00
93_Y97_T0.5431.00
264_G268_V0.5431.00
237_L240_S0.5431.00
216_N222_L0.5421.00
123_F127_L0.5421.00
282_G285_A0.5391.00
125_S129_I0.5381.00
131_A190_I0.5381.00
98_L244_G0.5351.00
186_R189_G0.5291.00
151_T156_S0.5291.00
222_L225_T0.5281.00
249_E252_Y0.5241.00
183_A186_R0.5241.00
58_S286_A0.5231.00
146_F154_A0.5221.00
48_L52_I0.5211.00
97_T184_S0.5211.00
102_I107_L0.5201.00
126_A130_P0.5201.00
108_L111_F0.5151.00
55_F59_F0.5131.00
88_W176_M0.5121.00
202_V207_Y0.5091.00
98_L103_P0.5071.00
58_S289_I0.5071.00
124_K200_Q0.5061.00
133_T137_V0.5021.00
116_L204_K0.5011.00
244_G247_M0.5001.00
138_A186_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tquM 1 0.8946 100 0.33 Contact Map
2onkC 2 0.8019 100 0.345 Contact Map
3d31C 2 0.7891 100 0.357 Contact Map
3rlfF 1 0.9361 100 0.383 Contact Map
3rlfG 1 0.8403 100 0.412 Contact Map
4tquN 1 0.8307 100 0.422 Contact Map
4ymuD 2 0.6869 100 0.527 Contact Map
3tuiA 2 0.6677 99.9 0.541 Contact Map
4j7cI 2 0.8371 13.4 0.951 Contact Map
2kogA 1 0.1821 12.7 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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