GREMLIN Database
ARAN - Probable arabinose-binding protein
UniProt: P94528 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 433 (397)
Sequences: 29970 (24026)
Seq/√Len: 1205.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
35_E66_K3.8251.00
418_T421_Q3.5771.00
114_A321_V3.4161.00
228_V420_K3.2761.00
158_D288_K3.2761.00
235_K239_N3.1411.00
37_T66_K2.9341.00
35_E64_K2.9291.00
157_M290_A2.9281.00
115_D140_K2.7671.00
232_Q236_D2.7571.00
177_H236_D2.6751.00
181_Q240_D2.5911.00
236_D240_D2.5341.00
50_V54_K2.4881.00
157_M161_K2.4801.00
172_T175_D2.4601.00
155_Y290_A2.4431.00
63_R323_L2.4241.00
55_E58_K2.3611.00
420_K424_D2.3581.00
57_N64_K2.2611.00
56_W326_E2.2431.00
225_D229_K2.2331.00
424_D428_G2.2201.00
76_Q79_D2.1981.00
136_S141_L2.1781.00
160_M267_S2.1711.00
326_E329_A2.1661.00
178_K182_K2.1441.00
223_N424_D2.0841.00
165_V179_A2.0711.00
51_E54_K2.0661.00
320_H323_L2.0651.00
117_T140_K2.0601.00
129_E133_T2.0521.00
37_T68_N2.0491.00
33_E64_K2.0441.00
378_S382_D2.0351.00
181_Q185_K2.0341.00
417_K425_R2.0211.00
55_E330_F1.9851.00
333_G337_G1.9701.00
39_W84_S1.9581.00
158_D162_K1.9581.00
252_H255_E1.9451.00
175_D178_K1.9061.00
232_Q419_P1.9021.00
229_K232_Q1.8911.00
126_K353_D1.8711.00
410_D417_K1.8551.00
54_K58_K1.8481.00
215_D219_K1.8331.00
133_T136_S1.8011.00
14_L17_L1.7921.00
113_L313_V1.7711.00
93_D320_H1.7631.00
119_L325_K1.7601.00
178_K181_Q1.7451.00
170_I175_D1.7391.00
322_E326_E1.7151.00
182_K186_V1.7061.00
55_E59_K1.7021.00
410_D416_Q1.6851.00
339_K343_S1.6831.00
401_D405_R1.6731.00
53_V57_N1.6721.00
232_Q420_K1.6621.00
55_E340_K1.6581.00
57_N61_P1.6571.00
34_T323_L1.6561.00
95_A315_P1.6521.00
174_D177_H1.6451.00
15_L18_V1.6391.00
421_Q425_R1.6331.00
53_V327_F1.6321.00
143_G311_A1.6251.00
73_P76_Q1.6231.00
54_K57_N1.6221.00
411_A422_A1.6101.00
228_V232_Q1.5931.00
228_V419_P1.5601.00
115_D118_P1.5511.00
135_Y311_A1.5431.00
177_H240_D1.5331.00
153_M292_R1.5281.00
425_R429_E1.5231.00
177_H181_Q1.5151.00
46_E50_V1.5141.00
155_Y292_R1.5121.00
171_K175_D1.5081.00
159_V266_A1.5021.00
157_M288_K1.4901.00
177_H237_M1.4831.00
51_E55_E1.4781.00
421_Q424_D1.4661.00
85_L91_V1.4531.00
260_M289_I1.4431.00
425_R428_G1.4381.00
424_D427_A1.4371.00
114_A316_K1.4281.00
235_K411_A1.4281.00
417_K422_A1.4211.00
402_L429_E1.4151.00
223_N427_A1.4141.00
183_V266_A1.4131.00
80_N84_S1.4111.00
181_Q242_T1.4101.00
259_F264_G1.4001.00
159_V183_V1.3991.00
174_D178_K1.3981.00
337_G340_K1.3801.00
340_K344_V1.3761.00
33_E62_D1.3751.00
34_T320_H1.3751.00
56_W63_R1.3721.00
56_W330_F1.3661.00
314_V328_L1.3661.00
226_T229_K1.3601.00
233_Y237_M1.3581.00
56_W327_F1.3311.00
40_T67_L1.3301.00
106_L142_Y1.3281.00
233_Y236_D1.3251.00
161_K167_P1.3101.00
191_M195_E1.3081.00
180_G267_S1.3001.00
318_S321_V1.2941.00
411_A419_P1.2781.00
163_A183_V1.2761.00
53_V67_L1.2681.00
382_D385_D1.2661.00
63_R326_E1.2601.00
236_D239_N1.2521.00
152_V291_I1.2481.00
406_S417_K1.2471.00
12_M16_T1.2321.00
167_P171_K1.2261.00
47_Q50_V1.2261.00
177_H233_Y1.2221.00
323_L326_E1.2201.00
153_M267_S1.2141.00
406_S425_R1.2101.00
135_Y141_L1.1941.00
184_R242_T1.1901.00
406_S410_D1.1861.00
165_V182_K1.1861.00
94_I328_L1.1781.00
318_S324_A1.1661.00
160_M165_V1.1661.00
123_D329_A1.1501.00
179_A182_K1.1471.00
330_F337_G1.1471.00
174_D298_K1.1471.00
109_S316_K1.1381.00
417_K421_Q1.1361.00
333_G336_E1.1321.00
327_F331_A1.1301.00
374_T378_S1.1281.00
161_K166_N1.1271.00
325_K329_A1.1241.00
118_P121_E1.1131.00
97_V313_V1.1131.00
156_N159_V1.1111.00
158_D287_G1.1091.00
106_L137_K1.1081.00
94_I324_A1.1021.00
258_G262_Q1.0901.00
192_G195_E1.0901.00
160_M179_A1.0841.00
93_D318_S1.0831.00
353_D356_S1.0821.00
36_L327_F1.0811.00
11_L14_L1.0791.00
47_Q51_E1.0761.00
56_W323_L1.0721.00
176_Y180_G1.0711.00
180_G242_T1.0681.00
11_L15_L1.0681.00
156_N287_G1.0651.00
327_F330_F1.0651.00
225_D228_V1.0611.00
11_L17_L1.0581.00
16_T19_I1.0571.00
7_C14_L1.0561.00
124_R132_L1.0561.00
410_D425_R1.0551.00
159_V162_K1.0541.00
229_K233_Y1.0481.00
159_V163_A1.0401.00
132_L136_S1.0391.00
81_L95_A1.0381.00
406_S426_A1.0361.00
316_K321_V1.0351.00
314_V325_K1.0341.00
255_E258_G1.0251.00
315_P318_S1.0231.00
235_K419_P1.0211.00
314_V324_A1.0191.00
15_L19_I1.0191.00
321_V325_K1.0121.00
176_Y267_S1.0071.00
34_T62_D1.0041.00
88_G317_Q1.0041.00
114_A318_S1.0031.00
187_T190_P1.0011.00
38_F312_T0.9931.00
405_R429_E0.9921.00
65_I327_F0.9901.00
228_V423_L0.9861.00
85_L112_P0.9861.00
334_S339_K0.9841.00
95_A313_V0.9811.00
206_I211_S0.9801.00
94_I327_F0.9791.00
358_K362_E0.9771.00
19_I22_C0.9771.00
259_F265_A0.9771.00
121_E124_R0.9771.00
10_V14_L0.9761.00
22_C25_E0.9751.00
402_L405_R0.9741.00
340_K343_S0.9701.00
182_K185_K0.9661.00
351_R354_V0.9651.00
232_Q235_K0.9641.00
57_N62_D0.9611.00
53_V65_I0.9551.00
209_Q229_K0.9541.00
163_A186_V0.9531.00
179_A267_S0.9491.00
18_V21_G0.9491.00
80_N83_I0.9481.00
126_K351_R0.9461.00
52_M55_E0.9461.00
165_V183_V0.9451.00
277_R280_D0.9441.00
231_L411_A0.9421.00
398_K401_D0.9381.00
406_S429_E0.9321.00
158_D161_K0.9301.00
336_E339_K0.9291.00
270_M274_Y0.9291.00
212_G215_D0.9281.00
379_V382_D0.9231.00
339_K354_V0.9221.00
51_E344_V0.9201.00
132_L141_L0.9191.00
14_L18_V0.9161.00
51_E340_K0.9151.00
405_R410_D0.9141.00
39_W70_V0.9101.00
336_E340_K0.9091.00
206_I227_N0.9071.00
78_H101_R0.9041.00
13_M16_T0.8981.00
22_C26_K0.8931.00
83_I87_A0.8881.00
129_E352_W0.8861.00
422_A426_A0.8861.00
55_E336_E0.8841.00
185_K188_G0.8761.00
220_L427_A0.8761.00
222_L227_N0.8751.00
154_F270_M0.8751.00
418_T422_A0.8721.00
8_F15_L0.8711.00
10_V17_L0.8651.00
413_K416_Q0.8621.00
143_G313_V0.8561.00
12_M18_V0.8541.00
39_W92_P0.8541.00
10_V16_T0.8531.00
95_A113_L0.8531.00
59_K336_E0.8501.00
38_F94_I0.8491.00
117_T121_E0.8491.00
7_C17_L0.8481.00
128_V352_W0.8461.00
36_L323_L0.8461.00
7_C10_V0.8451.00
59_K333_G0.8431.00
358_K361_K0.8381.00
375_G378_S0.8361.00
161_K288_K0.8341.00
402_L426_A0.8341.00
163_A167_P0.8311.00
177_H242_T0.8241.00
146_T312_T0.8231.00
384_K387_I0.8201.00
221_I224_N0.8191.00
160_M183_V0.8181.00
114_A315_P0.8181.00
129_E132_L0.8171.00
324_A328_L0.8171.00
12_M15_L0.8151.00
117_T141_L0.8141.00
10_V13_M0.8131.00
423_L427_A0.8121.00
163_A182_K0.8111.00
127_F332_K0.8061.00
113_L142_Y0.8061.00
55_E337_G0.8061.00
119_L322_E0.8051.00
106_L113_L0.8041.00
314_V318_S0.8001.00
231_L422_A0.8001.00
401_D404_N0.7961.00
339_K357_S0.7931.00
357_S360_L0.7921.00
84_S89_E0.7881.00
114_A118_P0.7871.00
155_Y167_P0.7861.00
36_L320_H0.7831.00
334_S337_G0.7821.00
171_K296_A0.7821.00
423_L426_A0.7811.00
91_V315_P0.7801.00
241_K245_P0.7791.00
322_E325_K0.7791.00
117_T136_S0.7741.00
231_L423_L0.7721.00
184_R192_G0.7711.00
237_M242_T0.7711.00
212_G216_K0.7691.00
244_I247_P0.7651.00
215_D221_I0.7631.00
34_T63_R0.7631.00
115_D142_Y0.7621.00
70_V80_N0.7601.00
11_L18_V0.7601.00
207_S388_N0.7561.00
402_L406_S0.7521.00
13_M17_L0.7521.00
62_D326_E0.7501.00
119_L123_D0.7501.00
180_G184_R0.7471.00
57_N65_I0.7471.00
48_F51_E0.7451.00
183_V188_G0.7421.00
114_A119_L0.7411.00
183_V187_T0.7381.00
118_P325_K0.7381.00
108_G112_P0.7381.00
166_N171_K0.7371.00
258_G261_N0.7371.00
167_P170_I0.7361.00
204_S207_S0.7361.00
59_K330_F0.7361.00
224_N227_N0.7361.00
52_M337_G0.7361.00
354_V357_S0.7351.00
7_C11_L0.7351.00
186_V190_P0.7321.00
156_N288_K0.7311.00
163_A266_A0.7311.00
400_S404_N0.7281.00
13_M18_V0.7271.00
114_A314_V0.7251.00
254_E257_Y0.7231.00
209_Q233_Y0.7231.00
177_H180_G0.7221.00
403_V426_A0.7171.00
202_F206_I0.7151.00
136_S139_G0.7151.00
130_A133_T0.7101.00
52_M330_F0.7091.00
152_V380_L0.7041.00
296_A299_E0.7021.00
165_V170_I0.7011.00
21_G24_A0.7011.00
411_A417_K0.6931.00
184_R241_K0.6921.00
7_C18_V0.6871.00
173_W233_Y0.6851.00
120_I141_L0.6851.00
39_W68_N0.6851.00
36_L324_A0.6851.00
381_L385_D0.6841.00
33_E61_P0.6801.00
254_E258_G0.6781.00
120_I123_D0.6771.00
276_G280_D0.6771.00
334_S353_D0.6761.00
94_I312_T0.6751.00
127_F132_L0.6721.00
184_R190_P0.6721.00
8_F12_M0.6721.00
105_F113_L0.6711.00
29_G32_G0.6701.00
104_N108_G0.6691.00
297_W300_G0.6691.00
179_A183_V0.6681.00
79_D83_I0.6681.00
359_E362_E0.6681.00
8_F11_L0.6661.00
275_M279_I0.6661.00
162_K188_G0.6651.00
57_N63_R0.6591.00
378_S381_L0.6591.00
261_N281_Y0.6561.00
189_K264_G0.6551.00
422_A425_R0.6531.00
329_A333_G0.6521.00
184_R187_T0.6521.00
395_D398_K0.6521.00
166_N179_A0.6521.00
20_A24_A0.6511.00
176_Y193_T0.6511.00
155_Y160_M0.6511.00
118_P140_K0.6491.00
9_L16_T0.6461.00
406_S422_A0.6461.00
85_L315_P0.6451.00
114_A325_K0.6451.00
43_G47_Q0.6451.00
244_I259_F0.6441.00
211_S227_N0.6431.00
224_N228_V0.6421.00
163_A179_A0.6401.00
405_R409_F0.6391.00
173_W177_H0.6381.00
256_Y268_V0.6371.00
181_Q184_R0.6361.00
234_L238_I0.6351.00
119_L122_K0.6351.00
191_M194_V0.6351.00
183_V267_S0.6321.00
352_W356_S0.6321.00
8_F18_V0.6311.00
124_R136_S0.6281.00
114_A317_Q0.6261.00
118_P122_K0.6251.00
102_F143_G0.6251.00
239_N242_T0.6241.00
321_V324_A0.6231.00
170_I179_A0.6231.00
409_F413_K0.6231.00
221_I427_A0.6221.00
8_F14_L0.6221.00
194_V265_A0.6211.00
123_D325_K0.6211.00
20_A23_S0.6201.00
235_K238_I0.6201.00
154_F291_I0.6191.00
379_V383_I0.6161.00
135_Y143_G0.6161.00
159_V188_G0.6151.00
9_L15_L0.6151.00
128_V355_W0.6141.00
396_F400_S0.6111.00
119_L321_V0.6111.00
77_M81_L0.6101.00
207_S212_G0.6091.00
9_L12_M0.6091.00
102_F106_L0.6081.00
6_V13_M0.6081.00
259_F262_Q0.6071.00
162_K186_V0.6071.00
59_K326_E0.6061.00
419_P423_L0.6051.00
420_K423_L0.6021.00
198_D201_T0.6021.00
103_S107_K0.6011.00
82_S104_N0.6001.00
56_W61_P0.6001.00
382_D386_E0.5981.00
52_M340_K0.5981.00
59_K62_D0.5971.00
125_D128_V0.5961.00
21_G25_E0.5961.00
68_N84_S0.5951.00
9_L13_M0.5951.00
52_M331_A0.5931.00
191_M245_P0.5931.00
38_F67_L0.5901.00
188_G191_M0.5901.00
78_H104_N0.5891.00
12_M17_L0.5881.00
229_K297_W0.5871.00
277_R281_Y0.5851.00
17_L20_A0.5851.00
375_G379_V0.5811.00
355_W358_K0.5791.00
226_T230_T0.5791.00
190_P264_G0.5781.00
68_N80_N0.5771.00
101_R104_N0.5751.00
37_T93_D0.5751.00
153_M269_L0.5741.00
31_S62_D0.5741.00
76_Q80_N0.5721.00
16_T20_A0.5721.00
91_V317_Q0.5701.00
224_N427_A0.5701.00
380_L384_K0.5701.00
56_W65_I0.5681.00
357_S361_K0.5681.00
296_A300_G0.5661.00
180_G237_M0.5661.00
156_N263_G0.5641.00
183_V186_V0.5641.00
149_G310_T0.5641.00
25_E28_S0.5631.00
189_K192_G0.5631.00
312_T328_L0.5621.00
32_G62_D0.5611.00
376_I379_V0.5611.00
235_K418_T0.5611.00
260_M287_G0.5611.00
251_H259_F0.5611.00
102_F113_L0.5581.00
97_V105_F0.5581.00
230_T234_L0.5571.00
209_Q230_T0.5571.00
128_V131_R0.5561.00
188_G192_G0.5541.00
186_V189_K0.5541.00
160_M167_P0.5531.00
279_I289_I0.5531.00
206_I230_T0.5491.00
132_L145_D0.5491.00
171_K176_Y0.5491.00
376_I380_L0.5481.00
116_L328_L0.5481.00
255_E259_F0.5481.00
34_T61_P0.5481.00
205_M230_T0.5481.00
215_D218_G0.5471.00
181_Q236_D0.5471.00
6_V17_L0.5461.00
18_V22_C0.5461.00
38_F53_V0.5451.00
203_L207_S0.5431.00
410_D422_A0.5411.00
227_N427_A0.5401.00
229_K298_K0.5391.00
37_T92_P0.5391.00
161_K164_G0.5381.00
117_T325_K0.5381.00
6_V9_L0.5381.00
334_S351_R0.5361.00
312_T331_A0.5361.00
79_D82_S0.5361.00
31_S34_T0.5351.00
84_S92_P0.5341.00
419_P422_A0.5331.00
385_D388_N0.5321.00
338_N350_L0.5311.00
33_E63_R0.5311.00
78_H105_F0.5291.00
325_K328_L0.5281.00
154_F275_M0.5271.00
171_K179_A0.5271.00
160_M266_A0.5251.00
163_A187_T0.5251.00
74_Y78_H0.5241.00
158_D263_G0.5241.00
256_Y265_A0.5231.00
36_L94_I0.5211.00
397_A401_D0.5201.00
106_L109_S0.5201.00
64_K67_L0.5191.00
170_I292_R0.5191.00
223_N420_K0.5191.00
154_F289_I0.5191.00
61_P323_L0.5191.00
17_L21_G0.5161.00
167_P179_A0.5141.00
174_D233_Y0.5141.00
112_P115_D0.5131.00
36_L93_D0.5131.00
37_T84_S0.5131.00
296_A303_R0.5121.00
274_Y278_F0.5121.00
144_L328_L0.5111.00
290_A293_P0.5111.00
167_P290_A0.5111.00
93_D319_K0.5111.00
36_L65_I0.5101.00
10_V15_L0.5091.00
410_D414_S0.5081.00
257_Y270_M0.5081.00
166_N170_I0.5081.00
387_I390_I0.5071.00
228_V424_D0.5071.00
49_Y52_M0.5071.00
237_M243_M0.5071.00
175_D179_A0.5061.00
124_R127_F0.5061.00
44_L47_Q0.5061.00
377_F381_L0.5031.00
216_K219_K0.5031.00
260_M268_V0.5021.00
406_S411_A0.5021.00
352_W355_W0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3uorA 1 0.8684 100 0.126 Contact Map
4r9fA 1 0.873 100 0.153 Contact Map
4r2fA 1 0.8637 100 0.154 Contact Map
4mfiA 1 0.8776 100 0.158 Contact Map
3vxbA 1 0.8637 100 0.19 Contact Map
4r6kA 1 0.8776 100 0.19 Contact Map
2z8fA 3 0.8891 100 0.212 Contact Map
4c1uA 1 0.8661 100 0.216 Contact Map
1eu8A 1 0.8845 100 0.221 Contact Map
4ovjA 1 0.8799 100 0.222 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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