G1PDH - BACSU - GREMLIN Contacts

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G1PDH - Glycerol-1-phosphate dehydrogenase [NAD(P)+]

UniProt:	P94527	Sequences: MNRIAADVQRAFENAGEKTLPIKVEEIVLGKQAADSLLDYVKRKNNQHIVLVCDANTHRIAGIDLENRLNQEGFQAECLIIPENEAGDVTADERSLIHVLIHTKQPTDVMIAVGSGTIHDIVRFAAFQRDLPFISYPTAPSVDGFTSAGAPIILYGTKTTIQTKAPSALFADLDLLKAAPQSMVAAGFGDMLGKITSLADWEISRHLAGEPYSPAGAKIVQEALAACIEHTEDIAMKTETGIRVLMESLLVSGLVMLALDHSRPASGGEHHISHWIEMELMEKKRPQILHGAKVGCAAVLLTDTYRKLAQDDGLNEFSPSRREAIQSAYQTLPRGEVLADWLRSAGGPAYFDEIGVGQDSVKNAFRHAHTLRDRCTGLRIINENKTLINHGLYE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	394 (324)
Sequences:	13560 (9708)
Seq/√Len:	539.3

ECOLI - ADH2 FUCO EUTG YQHD ADHE YBDH GLDA
BACSU - G1PDH GBSB YUGJ YUGK
HALSA - G1PDH Q9HNB5 Q9HHR2
SULSO - G1PDH Q97VW4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
230_H	233_D	3.273	1.00
101_I	104_K	3.020	1.00
357_G	360_S	2.889	1.00
63_I	67_N	2.828	1.00
110_M	122_V	2.756	1.00
225_A	344_S	2.749	1.00
31_K	174_D	2.717	1.00
48_H	75_Q	2.648	1.00
36_S	39_D	2.644	1.00
49_I	109_V	2.608	1.00
226_A	233_D	2.601	1.00
182_S	292_A	2.525	1.00
132_P	167_S	2.466	1.00
181_Q	185_A	2.410	1.00
223_A	244_V	2.402	1.00
303_D	339_A	2.396	1.00
99_V	125_A	2.392	1.00
208_A	313_G	2.350	1.00
32_Q	174_D	2.350	1.00
349_A	353_E	2.307	1.00
46_N	109_V	2.267	1.00
177_K	234_I	2.208	1.00
33_A	36_S	2.149	1.00
63_I	66_E	2.123	1.00
94_R	155_Y	2.098	1.00
56_N	60_I	2.070	1.00
112_A	122_V	2.054	1.00
35_D	64_D	2.049	1.00
66_E	70_N	2.046	1.00
340_D	344_S	2.035	1.00
350_Y	353_E	2.020	1.00
273_S	293_K	2.000	1.00
215_A	218_K	1.997	1.00
83_E	98_H	1.974	1.00
186_A	292_A	1.972	1.00
195_I	216_G	1.963	1.00
119_H	135_S	1.919	1.00
91_A	94_R	1.871	1.00
93_E	97_I	1.866	1.00
337_V	340_D	1.854	1.00
47_Q	108_D	1.830	1.00
88_D	95_S	1.829	1.00
54_D	57_T	1.802	1.00
52_V	122_V	1.795	1.00
103_T	131_L	1.795	1.00
38_L	68_R	1.789	1.00
226_A	230_H	1.767	1.00
191_M	220_V	1.680	1.00
95_S	98_H	1.668	1.00
49_I	111_I	1.644	1.00
40_Y	43_R	1.639	1.00
360_S	363_N	1.631	1.00
67_N	71_Q	1.619	1.00
326_Q	329_Y	1.611	1.00
225_A	229_E	1.597	1.00
210_E	313_G	1.597	1.00
92_D	95_S	1.592	1.00
192_L	217_A	1.569	1.00
233_D	237_K	1.512	1.00
55_A	82_P	1.503	1.00
223_A	226_A	1.496	1.00
214_P	320_S	1.496	1.00
58_H	62_G	1.491	1.00
306_R	311_D	1.480	1.00
174_D	177_K	1.473	1.00
134_I	168_A	1.470	1.00
98_H	101_I	1.448	1.00
171_A	246_M	1.448	1.00
66_E	78_C	1.442	1.00
318_S	334_R	1.441	1.00
315_N	319_P	1.422	1.00
58_H	82_P	1.414	1.00
26_E	40_Y	1.402	1.00
110_M	126_A	1.400	1.00
288_I	293_K	1.393	1.00
247_E	254_L	1.392	1.00
64_D	174_D	1.381	1.00
119_H	144_G	1.374	1.00
327_S	330_Q	1.364	1.00
268_G	298_A	1.360	1.00
55_A	59_R	1.351	1.00
180_P	183_M	1.350	1.00
37_L	65_L	1.343	1.00
30_G	36_S	1.343	1.00
96_L	121_I	1.343	1.00
31_K	177_K	1.340	1.00
40_Y	168_A	1.336	1.00
336_E	340_D	1.335	1.00
67_N	70_N	1.330	1.00
363_N	367_H	1.328	1.00
186_A	289_L	1.314	1.00
343_R	349_A	1.314	1.00
296_C	354_I	1.305	1.00
79_L	105_Q	1.299	1.00
34_A	64_D	1.292	1.00
88_D	92_D	1.289	1.00
55_A	83_E	1.280	1.00
188_F	224_L	1.279	1.00
65_L	113_V	1.277	1.00
79_L	102_H	1.275	1.00
102_H	105_Q	1.268	1.00
32_Q	35_D	1.263	1.00
112_A	133_F	1.261	1.00
214_P	218_K	1.252	1.00
90_T	152_I	1.248	1.00
48_H	105_Q	1.246	1.00
109_V	134_I	1.230	1.00
52_V	84_N	1.218	1.00
31_K	234_I	1.218	1.00
184_V	237_K	1.206	1.00
279_E	331_T	1.205	1.00
221_Q	321_R	1.201	1.00
233_D	236_M	1.200	1.00
272_I	297_A	1.198	1.00
52_V	125_A	1.194	1.00
99_V	103_T	1.183	1.00
176_L	246_M	1.183	1.00
363_N	366_R	1.173	1.00
303_D	332_L	1.171	1.00
50_V	99_V	1.163	1.00
98_H	102_H	1.162	1.00
149_G	162_Q	1.144	1.00
348_P	354_I	1.141	1.00
279_E	367_H	1.141	1.00
179_A	183_M	1.139	1.00
30_G	33_A	1.138	1.00
57_T	60_I	1.136	1.00
56_N	59_R	1.136	1.00
41_V	109_V	1.136	1.00
217_A	317_F	1.126	1.00
51_L	66_E	1.123	1.00
229_E	344_S	1.117	1.00
35_D	68_R	1.115	1.00
70_N	78_C	1.113	1.00
316_E	319_P	1.108	1.00
329_Y	333_P	1.107	1.00
50_V	79_L	1.106	1.00
58_H	80_I	1.103	1.00
176_L	237_K	1.103	1.00
316_E	320_S	1.102	1.00
362_K	366_R	1.101	1.00
34_A	175_L	1.101	1.00
303_D	306_R	1.100	1.00
48_H	108_D	1.097	1.00
28_V	40_Y	1.095	1.00
34_A	136_Y	1.092	1.00
288_I	296_C	1.090	1.00
188_F	245_L	1.087	1.00
36_S	40_Y	1.084	1.00
42_K	72_E	1.083	1.00
32_Q	172_D	1.080	1.00
96_L	152_I	1.076	1.00
97_I	101_I	1.074	1.00
62_G	66_E	1.074	1.00
201_W	205_R	1.071	1.00
189_G	342_L	1.065	1.00
361_V	364_A	1.061	1.00
229_E	233_D	1.061	1.00
104_K	108_D	1.054	1.00
33_A	170_F	1.052	1.00
31_K	243_R	1.035	1.00
302_T	338_L	1.034	1.00
200_D	230_H	1.034	1.00
64_D	68_R	1.031	1.00
365_F	368_A	1.030	1.00
54_D	83_E	1.028	1.00
79_L	107_T	1.026	1.00
94_R	98_H	1.022	1.00
361_V	365_F	1.019	1.00
197_S	314_L	1.018	1.00
181_Q	228_I	1.013	1.00
325_I	330_Q	1.008	1.00
319_P	330_Q	1.008	1.00
302_T	314_L	1.007	1.00
355_G	361_V	1.005	1.00
332_L	336_E	1.005	1.00
174_D	234_I	1.004	1.00
269_E	298_A	1.004	1.00
306_R	332_L	1.002	1.00
184_V	227_C	0.997	1.00
28_V	36_S	0.994	1.00
324_A	327_S	0.992	1.00
64_D	67_N	0.986	1.00
220_V	245_L	0.985	1.00
222_E	244_V	0.984	1.00
205_R	208_A	0.983	1.00
235_A	244_V	0.982	1.00
112_A	135_S	0.980	1.00
309_A	312_D	0.977	1.00
39_D	72_E	0.976	1.00
212_Y	215_A	0.973	1.00
189_G	347_G	0.971	1.00
51_L	62_G	0.970	1.00
28_V	168_A	0.966	1.00
198_L	255_V	0.965	1.00
140_P	184_V	0.956	1.00
27_I	250_L	0.956	1.00
62_G	78_C	0.951	1.00
49_I	74_F	0.951	1.00
279_E	363_N	0.951	1.00
228_I	345_A	0.947	1.00
226_A	229_E	0.943	1.00
70_N	75_Q	0.942	1.00
103_T	107_T	0.941	1.00
122_V	133_F	0.938	1.00
311_D	315_N	0.938	1.00
46_N	132_P	0.937	1.00
364_A	368_A	0.936	1.00
269_E	294_V	0.935	1.00
41_V	134_I	0.934	1.00
50_V	102_H	0.933	1.00
88_D	98_H	0.927	1.00
214_P	316_E	0.920	1.00
100_L	104_K	0.920	1.00
146_T	169_L	0.919	1.00
56_N	83_E	0.918	1.00
197_S	348_P	0.918	1.00
79_L	99_V	0.915	1.00
211_P	215_A	0.910	1.00
305_Y	348_P	0.906	1.00
50_V	107_T	0.901	1.00
48_H	106_P	0.900	1.00
119_H	137_P	0.897	1.00
68_R	71_Q	0.896	1.00
53_C	58_H	0.893	1.00
273_S	277_E	0.892	1.00
99_V	102_H	0.892	1.00
34_A	174_D	0.889	1.00
121_I	125_A	0.889	1.00
127_F	130_D	0.886	1.00
41_V	46_N	0.884	1.00
189_G	295_G	0.883	1.00
100_L	110_M	0.883	1.00
93_E	125_A	0.878	1.00
323_E	326_Q	0.873	1.00
107_T	339_A	0.870	1.00
220_V	223_A	0.869	1.00
40_Y	44_K	0.863	1.00
272_I	300_L	0.862	1.00
126_A	131_L	0.860	1.00
184_V	231_T	0.852	1.00
26_E	43_R	0.846	1.00
146_T	250_L	0.844	1.00
356_V	361_V	0.841	1.00
210_E	213_S	0.840	1.00
35_D	174_D	0.839	1.00
268_G	301_L	0.837	1.00
317_F	321_R	0.837	1.00
223_A	227_C	0.831	1.00
181_Q	229_E	0.828	1.00
296_C	299_V	0.827	1.00
215_A	219_I	0.826	1.00
39_D	43_R	0.825	1.00
333_P	336_E	0.823	1.00
270_H	290_H	0.818	1.00
50_V	104_K	0.818	1.00
38_L	42_K	0.817	1.00
193_G	298_A	0.817	1.00
61_A	113_V	0.815	1.00
204_S	208_A	0.813	1.00
341_W	345_A	0.813	1.00
312_D	327_S	0.808	1.00
96_L	125_A	0.806	1.00
218_K	222_E	0.804	1.00
312_D	316_E	0.803	1.00
70_N	73_G	0.801	1.00
112_A	119_H	0.801	1.00
160_T	163_T	0.801	1.00
355_G	360_S	0.798	1.00
273_S	294_V	0.797	1.00
54_D	60_I	0.797	1.00
185_A	228_I	0.796	1.00
339_A	343_R	0.795	1.00
81_I	118_I	0.792	1.00
39_D	42_K	0.792	1.00
236_M	243_R	0.790	1.00
34_A	172_D	0.788	1.00
126_A	133_F	0.788	1.00
37_L	136_Y	0.784	1.00
179_A	187_G	0.783	1.00
227_C	231_T	0.780	1.00
204_S	313_G	0.775	1.00
142_V	191_M	0.774	1.00
188_F	191_M	0.774	1.00
226_A	235_A	0.772	1.00
289_L	292_A	0.772	1.00
195_I	231_T	0.770	1.00
308_L	360_S	0.767	1.00
48_H	79_L	0.766	1.00
221_Q	225_A	0.763	1.00
358_Q	362_K	0.762	1.00
182_S	186_A	0.762	1.00
109_V	132_P	0.760	1.00
58_H	63_I	0.760	1.00
333_P	337_V	0.758	1.00
40_Y	170_F	0.757	1.00
198_L	210_E	0.756	1.00
312_D	315_N	0.754	1.00
135_S	166_P	0.754	1.00
53_C	118_I	0.753	1.00
315_N	330_Q	0.749	1.00
231_T	237_K	0.748	1.00
295_G	318_S	0.747	1.00
218_K	320_S	0.744	1.00
100_L	125_A	0.740	1.00
216_G	220_V	0.732	1.00
135_S	169_L	0.732	1.00
340_D	343_R	0.730	1.00
212_Y	251_V	0.730	1.00
358_Q	361_V	0.728	1.00
110_M	131_L	0.726	1.00
348_P	353_E	0.722	1.00
34_A	65_L	0.716	1.00
53_C	82_P	0.714	1.00
103_T	125_A	0.713	1.00
276_I	293_K	0.712	1.00
154_L	161_I	0.710	1.00
97_I	100_L	0.702	1.00
51_L	78_C	0.702	1.00
211_P	218_K	0.700	1.00
300_L	303_D	0.696	1.00
90_T	94_R	0.691	1.00
220_V	248_S	0.688	1.00
204_S	351_F	0.687	1.00
216_G	227_C	0.685	1.00
26_E	168_A	0.684	1.00
84_N	121_I	0.681	1.00
199_A	234_I	0.679	1.00
173_L	243_R	0.677	1.00
49_I	108_D	0.675	1.00
219_I	244_V	0.675	1.00
319_P	323_E	0.675	1.00
360_S	364_A	0.674	1.00
177_K	232_E	0.671	1.00
303_D	315_N	0.670	1.00
52_V	110_M	0.670	1.00
193_G	269_E	0.669	1.00
314_L	318_S	0.669	1.00
31_K	173_L	0.668	1.00
93_E	151_P	0.667	1.00
58_H	66_E	0.667	1.00
256_M	266_S	0.666	1.00
247_E	251_V	0.662	1.00
203_I	206_H	0.662	1.00
38_L	71_Q	0.662	1.00
50_V	103_T	0.661	1.00
90_T	287_Q	0.661	1.00
268_G	271_H	0.661	1.00
37_L	170_F	0.660	1.00
183_M	186_A	0.660	1.00
154_L	157_T	0.659	1.00
228_I	346_G	0.658	1.00
27_I	232_E	0.657	1.00
47_Q	75_Q	0.655	1.00
196_T	317_F	0.654	1.00
311_D	328_A	0.653	1.00
28_V	170_F	0.651	1.00
311_D	314_L	0.649	1.00
92_D	287_Q	0.649	1.00
199_A	316_E	0.649	1.00
222_E	226_A	0.646	1.00
221_Q	337_V	0.642	1.00
225_A	228_I	0.641	1.00
81_I	98_H	0.640	1.00
203_I	260_D	0.640	1.00
51_L	113_V	0.635	1.00
202_E	205_R	0.634	1.00
98_H	156_G	0.634	1.00
195_I	252_S	0.633	1.00
237_K	247_E	0.631	1.00
278_M	331_T	0.631	1.00
362_K	365_F	0.631	1.00
96_L	124_F	0.631	1.00
194_K	198_L	0.630	1.00
243_R	247_E	0.628	1.00
164_K	167_S	0.627	1.00
301_L	305_Y	0.626	1.00
176_L	184_V	0.626	1.00
223_A	236_M	0.623	1.00
325_I	329_Y	0.622	1.00
136_Y	170_F	0.620	1.00
42_K	47_Q	0.619	1.00
182_S	289_L	0.618	1.00
227_C	236_M	0.618	1.00
183_M	289_L	0.618	1.00
317_F	334_R	0.617	1.00
28_V	33_A	0.617	1.00
272_I	275_W	0.614	1.00
148_A	257_L	0.613	1.00
133_F	167_S	0.611	1.00
272_I	364_A	0.606	1.00
298_A	318_S	0.605	1.00
359_D	363_N	0.604	1.00
206_H	227_C	0.600	1.00
197_S	204_S	0.600	1.00
61_A	64_D	0.598	1.00
41_V	111_I	0.598	1.00
29_L	243_R	0.597	1.00
181_Q	219_I	0.595	1.00
38_L	41_V	0.593	1.00
64_D	175_L	0.591	1.00
324_A	329_Y	0.590	1.00
223_A	245_L	0.590	1.00
158_K	290_H	0.589	1.00
192_L	321_R	0.586	0.99
256_M	259_L	0.584	0.99
198_L	213_S	0.580	0.99
331_T	334_R	0.580	0.99
38_L	72_E	0.576	0.99
53_C	80_I	0.576	0.99
336_E	339_A	0.575	0.99
359_D	362_K	0.573	0.99
95_S	99_V	0.573	0.99
235_A	243_R	0.572	0.99
196_T	217_A	0.572	0.99
231_T	234_I	0.572	0.99
299_V	342_L	0.569	0.99
343_R	353_E	0.568	0.99
35_D	71_Q	0.568	0.99
111_I	134_I	0.566	0.99
267_G	305_Y	0.565	0.99
200_D	203_I	0.564	0.99
94_R	156_G	0.563	0.99
223_A	235_A	0.560	0.99
272_I	301_L	0.557	0.99
317_F	338_L	0.556	0.99
63_I	70_N	0.556	0.99
361_V	368_A	0.556	0.99
34_A	68_R	0.555	0.99
266_S	274_H	0.555	0.99
357_G	364_A	0.555	0.99
61_A	175_L	0.554	0.99
48_H	107_T	0.554	0.99
112_A	118_I	0.553	0.99
303_D	307_K	0.550	0.99
227_C	245_L	0.550	0.99
159_T	163_T	0.547	0.99
306_R	331_T	0.546	0.99
124_F	150_A	0.546	0.99
93_E	155_Y	0.546	0.99
275_W	367_H	0.546	0.99
157_T	160_T	0.546	0.99
226_A	236_M	0.546	0.99
158_K	162_Q	0.544	0.99
217_A	221_Q	0.543	0.99
141_S	176_L	0.543	0.99
222_E	225_A	0.541	0.99
79_L	96_L	0.539	0.99
140_P	246_M	0.536	0.99
195_I	213_S	0.536	0.99
41_V	74_F	0.535	0.99
276_I	288_I	0.531	0.99
52_V	99_V	0.530	0.99
59_R	63_I	0.530	0.99
88_D	287_Q	0.528	0.99
189_G	298_A	0.526	0.99
181_Q	184_V	0.524	0.99
288_I	292_A	0.521	0.99
65_L	68_R	0.521	0.99
165_A	249_L	0.520	0.99
30_G	173_L	0.519	0.99
90_T	93_E	0.518	0.99
192_L	196_T	0.517	0.99
69_L	74_F	0.516	0.99
134_I	170_F	0.516	0.99
57_T	61_A	0.513	0.99
35_D	67_N	0.512	0.99
102_H	107_T	0.509	0.99
212_Y	216_G	0.508	0.99
103_T	129_R	0.507	0.99
113_V	136_Y	0.507	0.99
46_N	49_I	0.506	0.99
216_G	252_S	0.506	0.99
352_D	358_Q	0.506	0.99
286_P	364_A	0.506	0.99
224_L	228_I	0.506	0.99
75_Q	79_L	0.506	0.99
213_S	321_R	0.505	0.98
276_I	351_F	0.505	0.98
318_S	322_R	0.505	0.98
192_L	317_F	0.504	0.98
137_P	171_A	0.504	0.98
334_R	338_L	0.503	0.98
57_T	62_G	0.502	0.98
94_R	97_I	0.501	0.98
201_W	351_F	0.500	0.98

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3bfjA	5	0.8985	100	0.249	Contact Map
3ox4A	2	0.8934	100	0.251	Contact Map
1vljA	2	0.9213	100	0.254	Contact Map
4fr2A	2	0.8959	100	0.262	Contact Map
1rrmA	2	0.8959	100	0.267	Contact Map
3zdrA	2	0.901	100	0.285	Contact Map
4qgsA	2	0.8756	100	0.288	Contact Map
1o2dA	1	0.8553	100	0.296	Contact Map
3iv7A	2	0.8604	100	0.299	Contact Map
3w5sA	2	0.8655	100	0.3	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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