GREMLIN Database
G1PDH - Glycerol-1-phosphate dehydrogenase [NAD(P)+]
UniProt: P94527 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (324)
Sequences: 13560 (9708)
Seq/√Len: 539.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
230_H233_D3.2731.00
101_I104_K3.0201.00
357_G360_S2.8891.00
63_I67_N2.8281.00
110_M122_V2.7561.00
225_A344_S2.7491.00
31_K174_D2.7171.00
48_H75_Q2.6481.00
36_S39_D2.6441.00
49_I109_V2.6081.00
226_A233_D2.6011.00
182_S292_A2.5251.00
132_P167_S2.4661.00
181_Q185_A2.4101.00
223_A244_V2.4021.00
303_D339_A2.3961.00
99_V125_A2.3921.00
208_A313_G2.3501.00
32_Q174_D2.3501.00
349_A353_E2.3071.00
46_N109_V2.2671.00
177_K234_I2.2081.00
33_A36_S2.1491.00
63_I66_E2.1231.00
94_R155_Y2.0981.00
56_N60_I2.0701.00
112_A122_V2.0541.00
35_D64_D2.0491.00
66_E70_N2.0461.00
340_D344_S2.0351.00
350_Y353_E2.0201.00
273_S293_K2.0001.00
215_A218_K1.9971.00
83_E98_H1.9741.00
186_A292_A1.9721.00
195_I216_G1.9631.00
119_H135_S1.9191.00
91_A94_R1.8711.00
93_E97_I1.8661.00
337_V340_D1.8541.00
47_Q108_D1.8301.00
88_D95_S1.8291.00
54_D57_T1.8021.00
52_V122_V1.7951.00
103_T131_L1.7951.00
38_L68_R1.7891.00
226_A230_H1.7671.00
191_M220_V1.6801.00
95_S98_H1.6681.00
49_I111_I1.6441.00
40_Y43_R1.6391.00
360_S363_N1.6311.00
67_N71_Q1.6191.00
326_Q329_Y1.6111.00
225_A229_E1.5971.00
210_E313_G1.5971.00
92_D95_S1.5921.00
192_L217_A1.5691.00
233_D237_K1.5121.00
55_A82_P1.5031.00
223_A226_A1.4961.00
214_P320_S1.4961.00
58_H62_G1.4911.00
306_R311_D1.4801.00
174_D177_K1.4731.00
134_I168_A1.4701.00
98_H101_I1.4481.00
171_A246_M1.4481.00
66_E78_C1.4421.00
318_S334_R1.4411.00
315_N319_P1.4221.00
58_H82_P1.4141.00
26_E40_Y1.4021.00
110_M126_A1.4001.00
288_I293_K1.3931.00
247_E254_L1.3921.00
64_D174_D1.3811.00
119_H144_G1.3741.00
327_S330_Q1.3641.00
268_G298_A1.3601.00
55_A59_R1.3511.00
180_P183_M1.3501.00
37_L65_L1.3431.00
30_G36_S1.3431.00
96_L121_I1.3431.00
31_K177_K1.3401.00
40_Y168_A1.3361.00
336_E340_D1.3351.00
67_N70_N1.3301.00
363_N367_H1.3281.00
186_A289_L1.3141.00
343_R349_A1.3141.00
296_C354_I1.3051.00
79_L105_Q1.2991.00
34_A64_D1.2921.00
88_D92_D1.2891.00
55_A83_E1.2801.00
188_F224_L1.2791.00
65_L113_V1.2771.00
79_L102_H1.2751.00
102_H105_Q1.2681.00
32_Q35_D1.2631.00
112_A133_F1.2611.00
214_P218_K1.2521.00
90_T152_I1.2481.00
48_H105_Q1.2461.00
109_V134_I1.2301.00
52_V84_N1.2181.00
31_K234_I1.2181.00
184_V237_K1.2061.00
279_E331_T1.2051.00
221_Q321_R1.2011.00
233_D236_M1.2001.00
272_I297_A1.1981.00
52_V125_A1.1941.00
99_V103_T1.1831.00
176_L246_M1.1831.00
363_N366_R1.1731.00
303_D332_L1.1711.00
50_V99_V1.1631.00
98_H102_H1.1621.00
149_G162_Q1.1441.00
348_P354_I1.1411.00
279_E367_H1.1411.00
179_A183_M1.1391.00
30_G33_A1.1381.00
57_T60_I1.1361.00
56_N59_R1.1361.00
41_V109_V1.1361.00
217_A317_F1.1261.00
51_L66_E1.1231.00
229_E344_S1.1171.00
35_D68_R1.1151.00
70_N78_C1.1131.00
316_E319_P1.1081.00
329_Y333_P1.1071.00
50_V79_L1.1061.00
58_H80_I1.1031.00
176_L237_K1.1031.00
316_E320_S1.1021.00
362_K366_R1.1011.00
34_A175_L1.1011.00
303_D306_R1.1001.00
48_H108_D1.0971.00
28_V40_Y1.0951.00
34_A136_Y1.0921.00
288_I296_C1.0901.00
188_F245_L1.0871.00
36_S40_Y1.0841.00
42_K72_E1.0831.00
32_Q172_D1.0801.00
96_L152_I1.0761.00
97_I101_I1.0741.00
62_G66_E1.0741.00
201_W205_R1.0711.00
189_G342_L1.0651.00
361_V364_A1.0611.00
229_E233_D1.0611.00
104_K108_D1.0541.00
33_A170_F1.0521.00
31_K243_R1.0351.00
302_T338_L1.0341.00
200_D230_H1.0341.00
64_D68_R1.0311.00
365_F368_A1.0301.00
54_D83_E1.0281.00
79_L107_T1.0261.00
94_R98_H1.0221.00
361_V365_F1.0191.00
197_S314_L1.0181.00
181_Q228_I1.0131.00
325_I330_Q1.0081.00
319_P330_Q1.0081.00
302_T314_L1.0071.00
355_G361_V1.0051.00
332_L336_E1.0051.00
174_D234_I1.0041.00
269_E298_A1.0041.00
306_R332_L1.0021.00
184_V227_C0.9971.00
28_V36_S0.9941.00
324_A327_S0.9921.00
64_D67_N0.9861.00
220_V245_L0.9851.00
222_E244_V0.9841.00
205_R208_A0.9831.00
235_A244_V0.9821.00
112_A135_S0.9801.00
309_A312_D0.9771.00
39_D72_E0.9761.00
212_Y215_A0.9731.00
189_G347_G0.9711.00
51_L62_G0.9701.00
28_V168_A0.9661.00
198_L255_V0.9651.00
140_P184_V0.9561.00
27_I250_L0.9561.00
62_G78_C0.9511.00
49_I74_F0.9511.00
279_E363_N0.9511.00
228_I345_A0.9471.00
226_A229_E0.9431.00
70_N75_Q0.9421.00
103_T107_T0.9411.00
122_V133_F0.9381.00
311_D315_N0.9381.00
46_N132_P0.9371.00
364_A368_A0.9361.00
269_E294_V0.9351.00
41_V134_I0.9341.00
50_V102_H0.9331.00
88_D98_H0.9271.00
214_P316_E0.9201.00
100_L104_K0.9201.00
146_T169_L0.9191.00
56_N83_E0.9181.00
197_S348_P0.9181.00
79_L99_V0.9151.00
211_P215_A0.9101.00
305_Y348_P0.9061.00
50_V107_T0.9011.00
48_H106_P0.9001.00
119_H137_P0.8971.00
68_R71_Q0.8961.00
53_C58_H0.8931.00
273_S277_E0.8921.00
99_V102_H0.8921.00
34_A174_D0.8891.00
121_I125_A0.8891.00
127_F130_D0.8861.00
41_V46_N0.8841.00
189_G295_G0.8831.00
100_L110_M0.8831.00
93_E125_A0.8781.00
323_E326_Q0.8731.00
107_T339_A0.8701.00
220_V223_A0.8691.00
40_Y44_K0.8631.00
272_I300_L0.8621.00
126_A131_L0.8601.00
184_V231_T0.8521.00
26_E43_R0.8461.00
146_T250_L0.8441.00
356_V361_V0.8411.00
210_E213_S0.8401.00
35_D174_D0.8391.00
268_G301_L0.8371.00
317_F321_R0.8371.00
223_A227_C0.8311.00
181_Q229_E0.8281.00
296_C299_V0.8271.00
215_A219_I0.8261.00
39_D43_R0.8251.00
333_P336_E0.8231.00
270_H290_H0.8181.00
50_V104_K0.8181.00
38_L42_K0.8171.00
193_G298_A0.8171.00
61_A113_V0.8151.00
204_S208_A0.8131.00
341_W345_A0.8131.00
312_D327_S0.8081.00
96_L125_A0.8061.00
218_K222_E0.8041.00
312_D316_E0.8031.00
70_N73_G0.8011.00
112_A119_H0.8011.00
160_T163_T0.8011.00
355_G360_S0.7981.00
273_S294_V0.7971.00
54_D60_I0.7971.00
185_A228_I0.7961.00
339_A343_R0.7951.00
81_I118_I0.7921.00
39_D42_K0.7921.00
236_M243_R0.7901.00
34_A172_D0.7881.00
126_A133_F0.7881.00
37_L136_Y0.7841.00
179_A187_G0.7831.00
227_C231_T0.7801.00
204_S313_G0.7751.00
142_V191_M0.7741.00
188_F191_M0.7741.00
226_A235_A0.7721.00
289_L292_A0.7721.00
195_I231_T0.7701.00
308_L360_S0.7671.00
48_H79_L0.7661.00
221_Q225_A0.7631.00
358_Q362_K0.7621.00
182_S186_A0.7621.00
109_V132_P0.7601.00
58_H63_I0.7601.00
333_P337_V0.7581.00
40_Y170_F0.7571.00
198_L210_E0.7561.00
312_D315_N0.7541.00
135_S166_P0.7541.00
53_C118_I0.7531.00
315_N330_Q0.7491.00
231_T237_K0.7481.00
295_G318_S0.7471.00
218_K320_S0.7441.00
100_L125_A0.7401.00
216_G220_V0.7321.00
135_S169_L0.7321.00
340_D343_R0.7301.00
212_Y251_V0.7301.00
358_Q361_V0.7281.00
110_M131_L0.7261.00
348_P353_E0.7221.00
34_A65_L0.7161.00
53_C82_P0.7141.00
103_T125_A0.7131.00
276_I293_K0.7121.00
154_L161_I0.7101.00
97_I100_L0.7021.00
51_L78_C0.7021.00
211_P218_K0.7001.00
300_L303_D0.6961.00
90_T94_R0.6911.00
220_V248_S0.6881.00
204_S351_F0.6871.00
216_G227_C0.6851.00
26_E168_A0.6841.00
84_N121_I0.6811.00
199_A234_I0.6791.00
173_L243_R0.6771.00
49_I108_D0.6751.00
219_I244_V0.6751.00
319_P323_E0.6751.00
360_S364_A0.6741.00
177_K232_E0.6711.00
303_D315_N0.6701.00
52_V110_M0.6701.00
193_G269_E0.6691.00
314_L318_S0.6691.00
31_K173_L0.6681.00
93_E151_P0.6671.00
58_H66_E0.6671.00
256_M266_S0.6661.00
247_E251_V0.6621.00
203_I206_H0.6621.00
38_L71_Q0.6621.00
50_V103_T0.6611.00
90_T287_Q0.6611.00
268_G271_H0.6611.00
37_L170_F0.6601.00
183_M186_A0.6601.00
154_L157_T0.6591.00
228_I346_G0.6581.00
27_I232_E0.6571.00
47_Q75_Q0.6551.00
196_T317_F0.6541.00
311_D328_A0.6531.00
28_V170_F0.6511.00
311_D314_L0.6491.00
92_D287_Q0.6491.00
199_A316_E0.6491.00
222_E226_A0.6461.00
221_Q337_V0.6421.00
225_A228_I0.6411.00
81_I98_H0.6401.00
203_I260_D0.6401.00
51_L113_V0.6351.00
202_E205_R0.6341.00
98_H156_G0.6341.00
195_I252_S0.6331.00
237_K247_E0.6311.00
278_M331_T0.6311.00
362_K365_F0.6311.00
96_L124_F0.6311.00
194_K198_L0.6301.00
243_R247_E0.6281.00
164_K167_S0.6271.00
301_L305_Y0.6261.00
176_L184_V0.6261.00
223_A236_M0.6231.00
325_I329_Y0.6221.00
136_Y170_F0.6201.00
42_K47_Q0.6191.00
182_S289_L0.6181.00
227_C236_M0.6181.00
183_M289_L0.6181.00
317_F334_R0.6171.00
28_V33_A0.6171.00
272_I275_W0.6141.00
148_A257_L0.6131.00
133_F167_S0.6111.00
272_I364_A0.6061.00
298_A318_S0.6051.00
359_D363_N0.6041.00
206_H227_C0.6001.00
197_S204_S0.6001.00
61_A64_D0.5981.00
41_V111_I0.5981.00
29_L243_R0.5971.00
181_Q219_I0.5951.00
38_L41_V0.5931.00
64_D175_L0.5911.00
324_A329_Y0.5901.00
223_A245_L0.5901.00
158_K290_H0.5891.00
192_L321_R0.5860.99
256_M259_L0.5840.99
198_L213_S0.5800.99
331_T334_R0.5800.99
38_L72_E0.5760.99
53_C80_I0.5760.99
336_E339_A0.5750.99
359_D362_K0.5730.99
95_S99_V0.5730.99
235_A243_R0.5720.99
196_T217_A0.5720.99
231_T234_I0.5720.99
299_V342_L0.5690.99
343_R353_E0.5680.99
35_D71_Q0.5680.99
111_I134_I0.5660.99
267_G305_Y0.5650.99
200_D203_I0.5640.99
94_R156_G0.5630.99
223_A235_A0.5600.99
272_I301_L0.5570.99
317_F338_L0.5560.99
63_I70_N0.5560.99
361_V368_A0.5560.99
34_A68_R0.5550.99
266_S274_H0.5550.99
357_G364_A0.5550.99
61_A175_L0.5540.99
48_H107_T0.5540.99
112_A118_I0.5530.99
303_D307_K0.5500.99
227_C245_L0.5500.99
159_T163_T0.5470.99
306_R331_T0.5460.99
124_F150_A0.5460.99
93_E155_Y0.5460.99
275_W367_H0.5460.99
157_T160_T0.5460.99
226_A236_M0.5460.99
158_K162_Q0.5440.99
217_A221_Q0.5430.99
141_S176_L0.5430.99
222_E225_A0.5410.99
79_L96_L0.5390.99
140_P246_M0.5360.99
195_I213_S0.5360.99
41_V74_F0.5350.99
276_I288_I0.5310.99
52_V99_V0.5300.99
59_R63_I0.5300.99
88_D287_Q0.5280.99
189_G298_A0.5260.99
181_Q184_V0.5240.99
288_I292_A0.5210.99
65_L68_R0.5210.99
165_A249_L0.5200.99
30_G173_L0.5190.99
90_T93_E0.5180.99
192_L196_T0.5170.99
69_L74_F0.5160.99
134_I170_F0.5160.99
57_T61_A0.5130.99
35_D67_N0.5120.99
102_H107_T0.5090.99
212_Y216_G0.5080.99
103_T129_R0.5070.99
113_V136_Y0.5070.99
46_N49_I0.5060.99
216_G252_S0.5060.99
352_D358_Q0.5060.99
286_P364_A0.5060.99
224_L228_I0.5060.99
75_Q79_L0.5060.99
213_S321_R0.5050.98
276_I351_F0.5050.98
318_S322_R0.5050.98
192_L317_F0.5040.98
137_P171_A0.5040.98
334_R338_L0.5030.98
57_T62_G0.5020.98
94_R97_I0.5010.98
201_W351_F0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bfjA 5 0.8985 100 0.249 Contact Map
3ox4A 2 0.8934 100 0.251 Contact Map
1vljA 2 0.9213 100 0.254 Contact Map
4fr2A 2 0.8959 100 0.262 Contact Map
1rrmA 2 0.8959 100 0.267 Contact Map
3zdrA 2 0.901 100 0.285 Contact Map
4qgsA 2 0.8756 100 0.288 Contact Map
1o2dA 1 0.8553 100 0.296 Contact Map
3iv7A 2 0.8604 100 0.299 Contact Map
3w5sA 2 0.8655 100 0.3 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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