GREMLIN Database
ARAL - Arabinose operon protein AraL
UniProt: P94526 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 272 (250)
Sequences: 4244 (2899)
Seq/√Len: 183.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
227_G234_S5.4231.00
14_A212_E5.1221.00
13_P233_K3.9571.00
42_R77_D3.3071.00
214_M235_A3.3061.00
225_A229_L2.9971.00
196_W200_E2.8741.00
155_A176_I2.8021.00
233_K253_D2.6331.00
180_E188_E2.3491.00
60_A75_V2.3381.00
97_K116_Q2.3271.00
15_G206_M2.2301.00
40_T44_M2.2011.00
258_S261_D2.0971.00
224_I234_S2.0241.00
40_T43_R1.9351.00
208_L213_C1.9181.00
180_E187_T1.8661.00
257_D261_D1.8651.00
238_L257_D1.8131.00
64_K68_G1.7791.00
160_R181_T1.7681.00
39_K43_R1.7671.00
203_C213_C1.7381.00
30_L35_R1.7221.00
27_G165_E1.6761.00
85_T128_V1.6651.00
100_V110_L1.6521.00
215_I232_M1.6291.00
177_G180_E1.6131.00
18_I216_I1.6121.00
60_A64_K1.6021.00
243_K246_E1.6011.00
49_V205_A1.5781.00
26_R29_E1.5731.00
136_T139_D1.5721.00
85_T154_I1.5571.00
238_L255_V1.5421.00
199_A226_M1.5401.00
31_I258_S1.5271.00
20_L50_F1.5271.00
132_H139_D1.5031.00
17_L51_L1.5001.00
177_G181_T1.4971.00
15_G208_L1.4881.00
228_K253_D1.4801.00
20_L25_F1.4501.00
24_V50_F1.4491.00
199_A215_I1.4441.00
97_K125_D1.4441.00
16_I214_M1.4391.00
96_S125_D1.4181.00
154_I191_V1.4171.00
35_R39_K1.4081.00
242_A246_E1.4001.00
235_A256_L1.3821.00
153_I188_E1.3761.00
92_H152_R1.3741.00
103_E133_E1.3731.00
36_E260_K1.3401.00
195_S229_L1.3311.00
39_K72_E1.3091.00
200_E210_A1.3051.00
86_A113_A1.3051.00
104_Q108_D1.2981.00
63_R75_V1.2971.00
59_R83_S1.2831.00
13_P214_M1.2601.00
164_N169_A1.2561.00
201_A204_T1.2541.00
61_M64_K1.2521.00
56_N131_L1.2461.00
147_A179_I1.2321.00
108_D111_R1.2301.00
63_R67_L1.2251.00
74_D77_D1.2231.00
238_L244_Q1.2211.00
162_F171_D1.2201.00
41_L46_K1.2201.00
225_A250_Y1.2051.00
59_R109_E1.2041.00
47_K77_D1.2011.00
93_Y126_W1.1971.00
64_K67_L1.1941.00
34_A71_I1.1921.00
145_Q148_A1.1861.00
145_Q166_D1.1811.00
24_V38_I1.1791.00
14_A46_K1.1781.00
140_L178_A1.1721.00
42_R48_I1.1721.00
238_L242_A1.1691.00
16_I46_K1.1661.00
60_A108_D1.1641.00
36_E39_K1.1601.00
58_S61_M1.1521.00
84_V198_M1.1491.00
82_S86_A1.1381.00
141_N145_Q1.1311.00
57_I65_K1.1291.00
63_R78_I1.1281.00
16_I41_L1.1281.00
18_I37_A1.1271.00
17_L202_A1.1141.00
209_S212_E1.1081.00
24_V71_I1.1041.00
129_I176_I1.1041.00
99_W146_A1.1001.00
87_A91_K1.0931.00
244_Q257_D1.0901.00
50_F73_T1.0861.00
33_G36_E1.0861.00
20_L23_T1.0811.00
256_L262_V1.0791.00
147_A183_A1.0781.00
236_L242_A1.0741.00
98_V115_V1.0711.00
126_W152_R1.0701.00
152_R189_L1.0691.00
219_S222_S1.0641.00
35_R71_I1.0561.00
15_G47_K1.0521.00
199_A232_M1.0511.00
18_I48_I1.0491.00
67_L75_V1.0281.00
90_K115_V1.0221.00
49_V206_M1.0160.99
110_L128_V1.0120.99
15_G213_C1.0120.99
202_A206_M1.0100.99
185_A188_E1.0060.99
55_G81_S0.9980.99
124_A146_A0.9940.99
30_L69_A0.9910.99
18_I259_I0.9880.99
52_S80_L0.9870.99
23_T131_L0.9850.99
160_R221_E0.9850.99
48_I77_D0.9840.99
158_K190_V0.9840.99
79_V201_A0.9810.99
233_K254_Y0.9760.99
219_S241_S0.9710.99
85_T191_V0.9700.99
62_C78_I0.9580.99
34_A259_I0.9570.99
189_L197_L0.9550.99
142_Q146_A0.9500.99
131_L135_L0.9500.99
101_L143_A0.9470.99
228_K234_S0.9470.99
140_L144_F0.9430.99
67_L72_E0.9410.99
107_V111_R0.9390.99
87_A201_A0.9350.99
176_I179_I0.9330.99
42_R72_E0.9320.99
236_L255_V0.9280.99
31_I34_A0.9220.99
88_F92_H0.9200.99
176_I190_V0.9150.99
141_N170_I0.9110.99
28_N65_K0.9090.99
28_N68_G0.9060.99
200_E204_T0.9050.99
176_I180_E0.9010.99
88_F191_V0.9000.99
67_L73_T0.8990.99
29_E165_E0.8980.99
91_K204_T0.8950.99
214_M233_K0.8950.99
51_L215_I0.8940.99
127_L143_A0.8930.99
129_I153_I0.8930.99
55_G130_S0.8900.99
24_V259_I0.8890.99
145_Q169_A0.8880.99
79_V202_A0.8860.99
51_L198_M0.8850.99
33_G260_K0.8820.99
143_A179_I0.8810.99
104_Q107_V0.8770.98
147_A150_G0.8760.98
85_T156_T0.8740.98
23_T199_A0.8680.98
49_V77_D0.8670.98
61_M108_D0.8650.98
79_V205_A0.8560.98
144_F182_S0.8560.98
140_L143_A0.8530.98
221_E241_S0.8460.98
62_C80_L0.8440.98
159_D222_S0.8410.98
25_F50_F0.8400.98
65_K69_A0.8380.98
25_F69_A0.8340.98
49_V79_V0.8250.98
172_V176_I0.8200.98
93_Y96_S0.8170.98
108_D112_L0.8170.98
88_F154_I0.8150.98
86_A90_K0.8150.98
224_I228_K0.8130.98
83_S109_E0.8120.98
86_A109_E0.8080.97
234_S253_D0.8030.97
82_S85_T0.8010.97
155_A172_V0.8000.97
141_N169_A0.7940.97
98_V128_V0.7940.97
107_V119_S0.7930.97
47_K206_M0.7910.97
38_I50_F0.7880.97
155_A190_V0.7870.97
33_G258_S0.7870.97
135_L140_L0.7850.97
99_W127_L0.7830.97
100_V107_V0.7820.97
208_L212_E0.7820.97
92_H189_L0.7740.97
203_C232_M0.7680.97
202_A226_M0.7650.96
203_C210_A0.7610.96
174_G181_T0.7600.96
97_K123_E0.7600.96
138_D142_Q0.7590.96
30_L71_I0.7580.96
105_G109_E0.7520.96
89_L128_V0.7520.96
147_A185_A0.7490.96
11_V44_M0.7490.96
247_Q250_Y0.7470.96
201_A205_A0.7470.96
61_M105_G0.7460.96
73_T77_D0.7410.96
129_I175_M0.7390.96
13_P253_D0.7390.96
144_F148_A0.7390.96
81_S156_T0.7310.95
147_A153_I0.7290.95
42_R74_D0.7280.95
20_L24_V0.7280.95
35_R70_G0.7270.95
81_S157_N0.7230.95
84_V201_A0.7200.95
99_W143_A0.7170.95
215_I226_M0.7170.95
228_K250_Y0.7130.95
89_L115_V0.7120.95
23_T226_M0.7090.95
26_R165_E0.7070.95
50_F71_I0.7060.94
109_E112_L0.7060.94
143_A147_A0.7040.94
32_E260_K0.6990.94
174_G178_A0.6980.94
18_I24_V0.6970.94
135_L139_D0.6950.94
90_K113_A0.6940.94
65_K68_G0.6940.94
160_R177_G0.6870.94
13_P16_I0.6830.93
13_P212_E0.6790.93
102_G106_L0.6780.93
131_L162_F0.6780.93
252_P255_V0.6780.93
95_F125_D0.6750.93
199_A230_Y0.6740.93
26_R31_I0.6660.93
37_A48_I0.6620.92
129_I155_A0.6600.92
30_L70_G0.6590.92
17_L198_M0.6580.92
99_W139_D0.6450.91
17_L213_C0.6420.91
161_S219_S0.6410.91
60_A112_L0.6390.91
141_N144_F0.6380.91
203_C230_Y0.6350.91
236_L239_T0.6350.91
52_S62_C0.6320.91
23_T132_H0.6290.90
95_F116_Q0.6270.90
146_A151_A0.6250.90
226_M230_Y0.6220.90
88_F189_L0.6210.90
210_A232_M0.6210.90
12_S233_K0.6190.90
28_N165_E0.6180.90
36_E40_T0.6160.89
220_I252_P0.6150.89
20_L66_L0.6100.89
135_L175_M0.6100.89
158_K195_S0.6090.89
199_A227_G0.6090.89
178_A181_T0.6070.89
214_M254_Y0.6070.89
199_A202_A0.6040.88
89_L110_L0.6040.88
144_F179_I0.6040.88
34_A258_S0.6020.88
215_I227_G0.6020.88
96_S115_V0.6000.88
87_A90_K0.6000.88
15_G49_V0.5990.88
25_F66_L0.5980.88
20_L62_C0.5980.88
23_T162_F0.5960.88
158_K176_I0.5950.88
174_G182_S0.5930.88
54_R62_C0.5870.87
135_L178_A0.5860.87
154_I189_L0.5860.87
11_V46_K0.5850.87
93_Y152_R0.5840.87
87_A113_A0.5830.87
237_V256_L0.5810.86
127_L130_S0.5810.86
19_D22_G0.5810.86
220_I224_I0.5800.86
147_A151_A0.5790.86
151_A185_A0.5790.86
157_N172_V0.5790.86
176_I188_E0.5770.86
118_A121_P0.5770.86
158_K180_E0.5770.86
220_I248_R0.5750.86
196_W230_Y0.5740.86
140_L179_I0.5720.86
87_A205_A0.5710.86
106_L110_L0.5700.85
34_A38_I0.5690.85
38_I42_R0.5680.85
132_H137_Y0.5670.85
57_I62_C0.5670.85
178_A182_S0.5650.85
42_R50_F0.5600.84
86_A110_L0.5590.84
86_A115_V0.5560.84
57_I61_M0.5550.84
132_H135_L0.5480.83
20_L222_S0.5480.83
13_P235_A0.5470.83
52_S126_W0.5460.83
98_V126_W0.5450.83
244_Q255_V0.5450.83
152_R185_A0.5440.83
26_R171_D0.5440.83
237_V240_G0.5430.83
161_S241_S0.5430.83
220_I228_K0.5390.82
82_S106_L0.5350.82
197_L200_E0.5290.81
84_V191_V0.5280.81
18_I38_I0.5270.81
170_I174_G0.5250.80
106_L156_T0.5210.80
17_L232_M0.5200.80
131_L175_M0.5190.80
103_E106_L0.5190.80
49_V202_A0.5170.79
97_K118_A0.5170.79
28_N69_A0.5170.79
159_D163_P0.5160.79
18_I41_L0.5150.79
118_A124_A0.5100.79
25_F65_K0.5070.78
171_D239_T0.5050.78
84_V87_A0.5050.78
37_A260_K0.5040.78
224_I253_D0.5030.78
89_L93_Y0.5020.77
169_A174_G0.5000.77
79_V84_V0.5000.77
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3kc2A 2 0.9338 100 0.377 Contact Map
2ho4A 1 0.9228 100 0.428 Contact Map
1zjjA 2 0.9338 100 0.471 Contact Map
2oycA 2 0.9743 100 0.494 Contact Map
4i9fA 2 0.9559 100 0.505 Contact Map
1vjrA 1 0.9485 100 0.517 Contact Map
3pdwA 1 0.9375 100 0.528 Contact Map
3eprA 3 0.9485 100 0.53 Contact Map
2hx1A 3 0.9632 100 0.535 Contact Map
2x4dA 2 0.9559 100 0.544 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0096 seconds.