ARAL - BACSU - GREMLIN Contacts

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ARAL - Arabinose operon protein AraL

UniProt:	P94526	Sequences: MRIMASHDTPVSPAGILIDLDGTVFRGNELIEGAREAIKTLRRMGKKIVFLSNRGNISRAMCRKKLLGAGIETDVNDIVLSSSVTAAFLKKHYRFSKVWVLGEQGLVDELRLAGVQNASEPKEADWLVISLHETLTYDDLNQAFQAAAGGARIIATNKDRSFPNEDGNAIDVAGMIGAIETSAQAKTELVVGKPSWLMAEAACTAMGLSAHECMIIGDSIESDIAMGKLYGMKSALVLTGSAKQGEQRLYTPDYVLDSIKDVTKLAEEGILI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	272 (250)
Sequences:	4244 (2899)
Seq/√Len:	183.4

ECOLI - NAGD
BACSU - ARAL YUTF
HALSA - Q9HRF8 Q9HR34
SULSO - Q97W80

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
227_G	234_S	5.423	1.00
14_A	212_E	5.122	1.00
13_P	233_K	3.957	1.00
42_R	77_D	3.307	1.00
214_M	235_A	3.306	1.00
225_A	229_L	2.997	1.00
196_W	200_E	2.874	1.00
155_A	176_I	2.802	1.00
233_K	253_D	2.633	1.00
180_E	188_E	2.349	1.00
60_A	75_V	2.338	1.00
97_K	116_Q	2.327	1.00
15_G	206_M	2.230	1.00
40_T	44_M	2.201	1.00
258_S	261_D	2.097	1.00
224_I	234_S	2.024	1.00
40_T	43_R	1.935	1.00
208_L	213_C	1.918	1.00
180_E	187_T	1.866	1.00
257_D	261_D	1.865	1.00
238_L	257_D	1.813	1.00
64_K	68_G	1.779	1.00
160_R	181_T	1.768	1.00
39_K	43_R	1.767	1.00
203_C	213_C	1.738	1.00
30_L	35_R	1.722	1.00
27_G	165_E	1.676	1.00
85_T	128_V	1.665	1.00
100_V	110_L	1.652	1.00
215_I	232_M	1.629	1.00
177_G	180_E	1.613	1.00
18_I	216_I	1.612	1.00
60_A	64_K	1.602	1.00
243_K	246_E	1.601	1.00
49_V	205_A	1.578	1.00
26_R	29_E	1.573	1.00
136_T	139_D	1.572	1.00
85_T	154_I	1.557	1.00
238_L	255_V	1.542	1.00
199_A	226_M	1.540	1.00
31_I	258_S	1.527	1.00
20_L	50_F	1.527	1.00
132_H	139_D	1.503	1.00
17_L	51_L	1.500	1.00
177_G	181_T	1.497	1.00
15_G	208_L	1.488	1.00
228_K	253_D	1.480	1.00
20_L	25_F	1.450	1.00
24_V	50_F	1.449	1.00
199_A	215_I	1.444	1.00
97_K	125_D	1.444	1.00
16_I	214_M	1.439	1.00
96_S	125_D	1.418	1.00
154_I	191_V	1.417	1.00
35_R	39_K	1.408	1.00
242_A	246_E	1.400	1.00
235_A	256_L	1.382	1.00
153_I	188_E	1.376	1.00
92_H	152_R	1.374	1.00
103_E	133_E	1.373	1.00
36_E	260_K	1.340	1.00
195_S	229_L	1.331	1.00
39_K	72_E	1.309	1.00
200_E	210_A	1.305	1.00
86_A	113_A	1.305	1.00
104_Q	108_D	1.298	1.00
63_R	75_V	1.297	1.00
59_R	83_S	1.283	1.00
13_P	214_M	1.260	1.00
164_N	169_A	1.256	1.00
201_A	204_T	1.254	1.00
61_M	64_K	1.252	1.00
56_N	131_L	1.246	1.00
147_A	179_I	1.232	1.00
108_D	111_R	1.230	1.00
63_R	67_L	1.225	1.00
74_D	77_D	1.223	1.00
238_L	244_Q	1.221	1.00
162_F	171_D	1.220	1.00
41_L	46_K	1.220	1.00
225_A	250_Y	1.205	1.00
59_R	109_E	1.204	1.00
47_K	77_D	1.201	1.00
93_Y	126_W	1.197	1.00
64_K	67_L	1.194	1.00
34_A	71_I	1.192	1.00
145_Q	148_A	1.186	1.00
145_Q	166_D	1.181	1.00
24_V	38_I	1.179	1.00
14_A	46_K	1.178	1.00
140_L	178_A	1.172	1.00
42_R	48_I	1.172	1.00
238_L	242_A	1.169	1.00
16_I	46_K	1.166	1.00
60_A	108_D	1.164	1.00
36_E	39_K	1.160	1.00
58_S	61_M	1.152	1.00
84_V	198_M	1.149	1.00
82_S	86_A	1.138	1.00
141_N	145_Q	1.131	1.00
57_I	65_K	1.129	1.00
63_R	78_I	1.128	1.00
16_I	41_L	1.128	1.00
18_I	37_A	1.127	1.00
17_L	202_A	1.114	1.00
209_S	212_E	1.108	1.00
24_V	71_I	1.104	1.00
129_I	176_I	1.104	1.00
99_W	146_A	1.100	1.00
87_A	91_K	1.093	1.00
244_Q	257_D	1.090	1.00
50_F	73_T	1.086	1.00
33_G	36_E	1.086	1.00
20_L	23_T	1.081	1.00
256_L	262_V	1.079	1.00
147_A	183_A	1.078	1.00
236_L	242_A	1.074	1.00
98_V	115_V	1.071	1.00
126_W	152_R	1.070	1.00
152_R	189_L	1.069	1.00
219_S	222_S	1.064	1.00
35_R	71_I	1.056	1.00
15_G	47_K	1.052	1.00
199_A	232_M	1.051	1.00
18_I	48_I	1.049	1.00
67_L	75_V	1.028	1.00
90_K	115_V	1.022	1.00
49_V	206_M	1.016	0.99
110_L	128_V	1.012	0.99
15_G	213_C	1.012	0.99
202_A	206_M	1.010	0.99
185_A	188_E	1.006	0.99
55_G	81_S	0.998	0.99
124_A	146_A	0.994	0.99
30_L	69_A	0.991	0.99
18_I	259_I	0.988	0.99
52_S	80_L	0.987	0.99
23_T	131_L	0.985	0.99
160_R	221_E	0.985	0.99
48_I	77_D	0.984	0.99
158_K	190_V	0.984	0.99
79_V	201_A	0.981	0.99
233_K	254_Y	0.976	0.99
219_S	241_S	0.971	0.99
85_T	191_V	0.970	0.99
62_C	78_I	0.958	0.99
34_A	259_I	0.957	0.99
189_L	197_L	0.955	0.99
142_Q	146_A	0.950	0.99
131_L	135_L	0.950	0.99
101_L	143_A	0.947	0.99
228_K	234_S	0.947	0.99
140_L	144_F	0.943	0.99
67_L	72_E	0.941	0.99
107_V	111_R	0.939	0.99
87_A	201_A	0.935	0.99
176_I	179_I	0.933	0.99
42_R	72_E	0.932	0.99
236_L	255_V	0.928	0.99
31_I	34_A	0.922	0.99
88_F	92_H	0.920	0.99
176_I	190_V	0.915	0.99
141_N	170_I	0.911	0.99
28_N	65_K	0.909	0.99
28_N	68_G	0.906	0.99
200_E	204_T	0.905	0.99
176_I	180_E	0.901	0.99
88_F	191_V	0.900	0.99
67_L	73_T	0.899	0.99
29_E	165_E	0.898	0.99
91_K	204_T	0.895	0.99
214_M	233_K	0.895	0.99
51_L	215_I	0.894	0.99
127_L	143_A	0.893	0.99
129_I	153_I	0.893	0.99
55_G	130_S	0.890	0.99
24_V	259_I	0.889	0.99
145_Q	169_A	0.888	0.99
79_V	202_A	0.886	0.99
51_L	198_M	0.885	0.99
33_G	260_K	0.882	0.99
143_A	179_I	0.881	0.99
104_Q	107_V	0.877	0.98
147_A	150_G	0.876	0.98
85_T	156_T	0.874	0.98
23_T	199_A	0.868	0.98
49_V	77_D	0.867	0.98
61_M	108_D	0.865	0.98
79_V	205_A	0.856	0.98
144_F	182_S	0.856	0.98
140_L	143_A	0.853	0.98
221_E	241_S	0.846	0.98
62_C	80_L	0.844	0.98
159_D	222_S	0.841	0.98
25_F	50_F	0.840	0.98
65_K	69_A	0.838	0.98
25_F	69_A	0.834	0.98
49_V	79_V	0.825	0.98
172_V	176_I	0.820	0.98
93_Y	96_S	0.817	0.98
108_D	112_L	0.817	0.98
88_F	154_I	0.815	0.98
86_A	90_K	0.815	0.98
224_I	228_K	0.813	0.98
83_S	109_E	0.812	0.98
86_A	109_E	0.808	0.97
234_S	253_D	0.803	0.97
82_S	85_T	0.801	0.97
155_A	172_V	0.800	0.97
141_N	169_A	0.794	0.97
98_V	128_V	0.794	0.97
107_V	119_S	0.793	0.97
47_K	206_M	0.791	0.97
38_I	50_F	0.788	0.97
155_A	190_V	0.787	0.97
33_G	258_S	0.787	0.97
135_L	140_L	0.785	0.97
99_W	127_L	0.783	0.97
100_V	107_V	0.782	0.97
208_L	212_E	0.782	0.97
92_H	189_L	0.774	0.97
203_C	232_M	0.768	0.97
202_A	226_M	0.765	0.96
203_C	210_A	0.761	0.96
174_G	181_T	0.760	0.96
97_K	123_E	0.760	0.96
138_D	142_Q	0.759	0.96
30_L	71_I	0.758	0.96
105_G	109_E	0.752	0.96
89_L	128_V	0.752	0.96
147_A	185_A	0.749	0.96
11_V	44_M	0.749	0.96
247_Q	250_Y	0.747	0.96
201_A	205_A	0.747	0.96
61_M	105_G	0.746	0.96
73_T	77_D	0.741	0.96
129_I	175_M	0.739	0.96
13_P	253_D	0.739	0.96
144_F	148_A	0.739	0.96
81_S	156_T	0.731	0.95
147_A	153_I	0.729	0.95
42_R	74_D	0.728	0.95
20_L	24_V	0.728	0.95
35_R	70_G	0.727	0.95
81_S	157_N	0.723	0.95
84_V	201_A	0.720	0.95
99_W	143_A	0.717	0.95
215_I	226_M	0.717	0.95
228_K	250_Y	0.713	0.95
89_L	115_V	0.712	0.95
23_T	226_M	0.709	0.95
26_R	165_E	0.707	0.95
50_F	71_I	0.706	0.94
109_E	112_L	0.706	0.94
143_A	147_A	0.704	0.94
32_E	260_K	0.699	0.94
174_G	178_A	0.698	0.94
18_I	24_V	0.697	0.94
135_L	139_D	0.695	0.94
90_K	113_A	0.694	0.94
65_K	68_G	0.694	0.94
160_R	177_G	0.687	0.94
13_P	16_I	0.683	0.93
13_P	212_E	0.679	0.93
102_G	106_L	0.678	0.93
131_L	162_F	0.678	0.93
252_P	255_V	0.678	0.93
95_F	125_D	0.675	0.93
199_A	230_Y	0.674	0.93
26_R	31_I	0.666	0.93
37_A	48_I	0.662	0.92
129_I	155_A	0.660	0.92
30_L	70_G	0.659	0.92
17_L	198_M	0.658	0.92
99_W	139_D	0.645	0.91
17_L	213_C	0.642	0.91
161_S	219_S	0.641	0.91
60_A	112_L	0.639	0.91
141_N	144_F	0.638	0.91
203_C	230_Y	0.635	0.91
236_L	239_T	0.635	0.91
52_S	62_C	0.632	0.91
23_T	132_H	0.629	0.90
95_F	116_Q	0.627	0.90
146_A	151_A	0.625	0.90
226_M	230_Y	0.622	0.90
88_F	189_L	0.621	0.90
210_A	232_M	0.621	0.90
12_S	233_K	0.619	0.90
28_N	165_E	0.618	0.90
36_E	40_T	0.616	0.89
220_I	252_P	0.615	0.89
20_L	66_L	0.610	0.89
135_L	175_M	0.610	0.89
158_K	195_S	0.609	0.89
199_A	227_G	0.609	0.89
178_A	181_T	0.607	0.89
214_M	254_Y	0.607	0.89
199_A	202_A	0.604	0.88
89_L	110_L	0.604	0.88
144_F	179_I	0.604	0.88
34_A	258_S	0.602	0.88
215_I	227_G	0.602	0.88
96_S	115_V	0.600	0.88
87_A	90_K	0.600	0.88
15_G	49_V	0.599	0.88
25_F	66_L	0.598	0.88
20_L	62_C	0.598	0.88
23_T	162_F	0.596	0.88
158_K	176_I	0.595	0.88
174_G	182_S	0.593	0.88
54_R	62_C	0.587	0.87
135_L	178_A	0.586	0.87
154_I	189_L	0.586	0.87
11_V	46_K	0.585	0.87
93_Y	152_R	0.584	0.87
87_A	113_A	0.583	0.87
237_V	256_L	0.581	0.86
127_L	130_S	0.581	0.86
19_D	22_G	0.581	0.86
220_I	224_I	0.580	0.86
147_A	151_A	0.579	0.86
151_A	185_A	0.579	0.86
157_N	172_V	0.579	0.86
176_I	188_E	0.577	0.86
118_A	121_P	0.577	0.86
158_K	180_E	0.577	0.86
220_I	248_R	0.575	0.86
196_W	230_Y	0.574	0.86
140_L	179_I	0.572	0.86
87_A	205_A	0.571	0.86
106_L	110_L	0.570	0.85
34_A	38_I	0.569	0.85
38_I	42_R	0.568	0.85
132_H	137_Y	0.567	0.85
57_I	62_C	0.567	0.85
178_A	182_S	0.565	0.85
42_R	50_F	0.560	0.84
86_A	110_L	0.559	0.84
86_A	115_V	0.556	0.84
57_I	61_M	0.555	0.84
132_H	135_L	0.548	0.83
20_L	222_S	0.548	0.83
13_P	235_A	0.547	0.83
52_S	126_W	0.546	0.83
98_V	126_W	0.545	0.83
244_Q	255_V	0.545	0.83
152_R	185_A	0.544	0.83
26_R	171_D	0.544	0.83
237_V	240_G	0.543	0.83
161_S	241_S	0.543	0.83
220_I	228_K	0.539	0.82
82_S	106_L	0.535	0.82
197_L	200_E	0.529	0.81
84_V	191_V	0.528	0.81
18_I	38_I	0.527	0.81
170_I	174_G	0.525	0.80
106_L	156_T	0.521	0.80
17_L	232_M	0.520	0.80
131_L	175_M	0.519	0.80
103_E	106_L	0.519	0.80
49_V	202_A	0.517	0.79
97_K	118_A	0.517	0.79
28_N	69_A	0.517	0.79
159_D	163_P	0.516	0.79
18_I	41_L	0.515	0.79
118_A	124_A	0.510	0.79
25_F	65_K	0.507	0.78
171_D	239_T	0.505	0.78
84_V	87_A	0.505	0.78
37_A	260_K	0.504	0.78
224_I	253_D	0.503	0.78
89_L	93_Y	0.502	0.77
169_A	174_G	0.500	0.77
79_V	84_V	0.500	0.77

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3kc2A	2	0.9338	100	0.377	Contact Map
2ho4A	1	0.9228	100	0.428	Contact Map
1zjjA	2	0.9338	100	0.471	Contact Map
2oycA	2	0.9743	100	0.494	Contact Map
4i9fA	2	0.9559	100	0.505	Contact Map
1vjrA	1	0.9485	100	0.517	Contact Map
3pdwA	1	0.9375	100	0.528	Contact Map
3eprA	3	0.9485	100	0.53	Contact Map
2hx1A	3	0.9632	100	0.535	Contact Map
2x4dA	2	0.9559	100	0.544	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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