GREMLIN Database
ARAD - L-ribulose-5-phosphate 4-epimerase
UniProt: P94525 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (199)
Sequences: 6320 (3867)
Seq/√Len: 274.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_N64_E4.7981.00
175_T179_N3.1891.00
99_W196_H3.1131.00
192_E196_H3.0671.00
38_R58_V2.8661.00
209_T213_E2.6631.00
5_L31_G2.6071.00
108_R198_I2.5881.00
40_V56_L2.5161.00
39_I80_V2.4541.00
8_E178_L2.4491.00
89_I173_W2.2001.00
81_Y146_K2.1471.00
38_R66_V2.0601.00
98_Q192_E2.0551.00
102_S196_H2.0411.00
99_W192_E2.0251.00
208_N211_L1.9781.00
10_L53_A1.9471.00
81_Y84_K1.9091.00
52_T55_D1.9061.00
99_W195_Y1.8861.00
7_K11_A1.8661.00
140_Y146_K1.8281.00
31_G177_A1.8261.00
162_G187_L1.8251.00
40_V58_V1.8111.00
93_V180_A1.7971.00
196_H199_M1.7061.00
15_K19_H1.6961.00
129_R166_N1.6941.00
90_G176_D1.6551.00
33_D40_V1.6551.00
91_G177_A1.6071.00
59_L76_T1.6051.00
176_D179_N1.5761.00
9_V29_V1.5551.00
62_D84_K1.5331.00
12_A181_I1.5301.00
109_D124_A1.5191.00
33_D36_K1.5121.00
107_G166_N1.4701.00
10_L14_L1.4561.00
174_G179_N1.4441.00
65_V68_G1.4361.00
19_H185_V1.4341.00
7_K53_A1.4331.00
85_A153_Q1.4321.00
9_V56_L1.4201.00
4_T8_E1.4131.00
126_P155_H1.3991.00
14_L18_E1.3911.00
95_T184_A1.3651.00
170_P187_L1.3601.00
111_P194_A1.3541.00
39_I61_L1.3411.00
135_E147_V1.3401.00
98_Q102_S1.3391.00
85_A149_A1.3371.00
31_G91_G1.3261.00
172_C184_A1.2891.00
81_Y85_A1.2851.00
86_F89_I1.2751.00
96_H168_H1.2451.00
10_L56_L1.2321.00
80_V84_K1.2311.00
110_I191_A1.2271.00
30_S92_I1.2221.00
211_L214_K1.2181.00
103_W198_I1.2141.00
123_S213_E1.2021.00
58_V67_E1.1841.00
15_K18_E1.1761.00
146_K150_E1.1611.00
30_S83_Y1.1571.00
98_Q189_T1.1481.00
161_P183_N1.1451.00
83_Y92_I1.1411.00
100_A170_P1.1311.00
129_R150_E1.1261.00
195_Y200_L1.1231.00
101_T104_A1.1211.00
16_L29_V1.1131.00
46_V55_D1.1091.00
198_I202_K1.1021.00
107_G205_T1.1021.00
12_A177_A1.1001.00
165_V171_F1.0901.00
147_V150_E1.0891.00
194_A198_I1.0821.00
17_Q49_S1.0801.00
32_I90_G1.0771.00
94_H168_H1.0721.00
33_D58_V1.0711.00
95_T170_P1.0701.00
16_L93_V1.0621.00
41_I73_S1.0371.00
99_W188_E1.0311.00
188_E192_E1.0281.00
106_S200_L1.0271.00
152_F173_W1.0261.00
148_I165_V1.0251.00
162_G172_C1.0161.00
113_L194_A1.0161.00
195_Y199_M1.0121.00
46_V70_L1.0091.00
13_N29_V1.0011.00
100_A187_L0.9911.00
86_F173_W0.9821.00
189_T192_E0.9651.00
39_I76_T0.9641.00
109_D127_C0.9621.00
97_S100_A0.9591.00
12_A29_V0.9561.00
33_D38_R0.9481.00
174_G183_N0.9451.00
55_D70_L0.9391.00
19_H181_I0.9331.00
43_P46_V0.9291.00
207_I211_L0.9241.00
5_L33_D0.9191.00
51_L55_D0.9101.00
107_G203_D0.9091.00
61_L84_K0.9061.00
8_E11_A0.9031.00
152_F163_V0.9021.00
128_T147_V0.8991.00
122_D209_T0.8971.00
210_V214_K0.8901.00
57_V71_K0.8881.00
39_I59_L0.8831.00
123_S209_T0.8811.00
8_E31_G0.8791.00
16_L181_I0.8761.00
82_L152_F0.8721.00
93_V184_A0.8711.00
213_E216_F0.8651.00
129_R147_V0.8651.00
60_N66_V0.8581.00
43_P56_L0.8471.00
10_L51_L0.8421.00
55_D69_S0.8411.00
210_V213_E0.8341.00
98_Q196_H0.8301.00
41_I75_D0.8290.99
102_S195_Y0.8270.99
110_I190_V0.8220.99
170_P184_A0.8190.99
81_Y149_A0.8130.99
110_I164_L0.8120.99
166_N205_T0.8080.99
82_L89_I0.8040.99
37_E61_L0.8040.99
126_P163_V0.8030.99
50_D178_L0.7990.99
4_T7_K0.7980.99
78_T171_F0.7950.99
150_E153_Q0.7930.99
6_K67_E0.7890.99
97_S184_A0.7870.99
32_I37_E0.7800.99
105_Q113_L0.7790.99
32_I61_L0.7770.99
179_N183_N0.7760.99
85_A150_E0.7710.99
11_A50_D0.7680.99
125_I187_L0.7630.99
15_K181_I0.7630.99
44_S71_K0.7600.99
206_P209_T0.7600.99
97_S188_E0.7590.99
128_T165_V0.7580.99
134_E138_H0.7550.99
13_N48_Y0.7520.99
35_E38_R0.7400.99
207_I212_H0.7380.99
187_L191_A0.7380.99
6_K40_V0.7370.99
78_T148_I0.7350.99
211_L215_H0.7290.99
42_K83_Y0.7280.99
106_S202_K0.7250.99
46_V51_L0.7200.99
76_T80_V0.7150.99
103_W194_A0.7150.99
30_S41_I0.7140.98
90_G175_T0.7130.98
22_V29_V0.7130.98
141_E147_V0.7120.98
82_L171_F0.7120.98
20_Q192_E0.7030.98
151_T163_V0.6970.98
172_C183_N0.6970.98
42_K51_L0.6960.98
205_T208_N0.6950.98
24_F182_H0.6890.98
135_E142_L0.6870.98
84_K149_A0.6830.98
108_R202_K0.6820.98
77_P140_Y0.6780.98
109_D155_H0.6780.98
128_T151_T0.6730.98
208_N214_K0.6700.98
209_T212_H0.6700.98
101_T193_M0.6680.98
25_T44_S0.6660.98
113_L198_I0.6640.98
27_G48_Y0.6640.98
58_V66_V0.6640.98
50_D55_D0.6630.98
47_E50_D0.6610.98
149_A152_F0.6600.97
5_L8_E0.6540.97
6_K58_V0.6520.97
139_D142_L0.6430.97
179_N182_H0.6420.97
109_D126_P0.6410.97
86_F152_F0.6330.97
16_L21_L0.6330.97
197_S203_D0.6300.97
124_A155_H0.6280.97
91_G180_A0.6280.97
111_P206_P0.6260.97
106_S195_Y0.6260.97
101_T169_G0.6250.97
167_N205_T0.6190.96
28_N75_D0.6190.96
23_T26_W0.6160.96
32_I39_I0.6150.96
23_T189_T0.6110.96
61_L80_V0.6090.96
125_I162_G0.5980.96
197_S201_N0.5960.95
103_W191_A0.5960.95
44_S73_S0.5960.95
104_A164_L0.5960.95
17_Q22_V0.5920.95
97_S170_P0.5920.95
161_P179_N0.5910.95
88_N175_T0.5910.95
116_T186_V0.5890.95
5_L40_V0.5860.95
28_N73_S0.5860.95
105_Q114_G0.5820.95
163_V171_F0.5820.95
8_E176_D0.5800.95
102_S193_M0.5780.95
120_Y183_N0.5770.95
129_R135_E0.5740.94
147_V151_T0.5710.94
9_V40_V0.5710.94
103_W108_R0.5700.94
100_A164_L0.5680.94
38_R61_L0.5670.94
134_E137_I0.5670.94
129_R205_T0.5660.94
6_K56_L0.5650.94
106_S197_S0.5640.94
99_W102_S0.5630.94
103_W195_Y0.5620.94
28_N42_K0.5570.94
120_Y186_V0.5560.93
141_E146_K0.5510.93
112_P117_H0.5500.93
77_P81_Y0.5500.93
164_L170_P0.5480.93
81_Y142_L0.5480.93
161_P175_T0.5460.93
124_A206_P0.5450.93
82_L92_I0.5440.93
100_A191_A0.5430.93
63_G80_V0.5430.93
60_N63_G0.5430.93
17_Q48_Y0.5420.93
59_L80_V0.5400.92
86_F161_P0.5390.92
17_Q23_T0.5390.92
9_V13_N0.5340.92
9_V31_G0.5330.92
77_P145_G0.5300.92
44_S74_S0.5280.92
151_T154_H0.5280.92
100_A184_A0.5260.91
26_W189_T0.5260.91
93_V172_C0.5240.91
140_Y145_G0.5230.91
15_K24_F0.5230.91
13_N42_K0.5220.91
114_G117_H0.5210.91
11_A14_L0.5200.91
82_L149_A0.5190.91
83_Y91_G0.5130.90
115_T118_A0.5130.90
29_V177_A0.5120.90
18_E49_S0.5110.90
127_C166_N0.5070.90
161_P173_W0.5040.90
19_H24_F0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4c24A 3 0.9039 100 0.143 Contact Map
1k0wA 3 0.9301 100 0.148 Contact Map
1e4cP 3 0.8908 100 0.169 Contact Map
3ocrA 4 0.9476 100 0.18 Contact Map
2opiA 3 0.8777 100 0.195 Contact Map
2z7bA 3 0.9476 100 0.203 Contact Map
4xxfA 3 0.9127 100 0.206 Contact Map
2v9lA 3 0.952 100 0.211 Contact Map
2fk5A 4 0.821 100 0.219 Contact Map
4m6rA 3 0.8865 100 0.225 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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