GREMLIN Database
ARAA - L-arabinose isomerase
UniProt: P94523 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 496 (451)
Sequences: 1687 (891)
Seq/√Len: 42.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_T298_K5.3771.00
216_V268_Q4.4571.00
230_A234_R3.9931.00
217_M284_M3.9451.00
226_D253_K3.8901.00
430_S433_T3.6591.00
32_K36_E3.6101.00
8_E46_K3.4861.00
407_N426_K3.3401.00
21_E25_E3.3351.00
161_Q457_Q3.2681.00
178_A271_Y3.1951.00
455_A471_L3.1041.00
28_D32_K3.0661.00
224_E264_A2.9801.00
36_E40_G2.9511.00
169_L465_A2.9081.00
154_E432_K2.8961.00
216_V264_A2.8751.00
230_A233_D2.8321.00
169_L173_R2.7931.00
229_Y253_K2.7681.00
390_A458_M2.6791.00
221_T224_E2.6631.00
403_L469_S2.6031.00
285_K373_E2.5581.00
407_N428_E2.5391.00
8_E69_S2.5181.00
220_I260_L2.5151.00
388_I458_M2.4671.00
226_D230_A2.4611.00
327_S355_V2.4211.00
144_K460_D2.4091.00
398_R468_E2.3301.00
29_Q33_S2.3131.00
169_L464_M2.3081.00
35_C39_S2.2581.00
289_G348_M2.2311.00
405_E455_A2.2271.00
175_I272_T2.2191.00
342_M426_K2.1891.00
313_L390_A2.1671.00
392_I401_L2.1430.99
317_M458_M2.1340.99
170_N174_H2.1340.99
405_E453_L2.1040.99
461_W465_A2.1040.99
180_F213_L2.0730.99
158_E436_E2.0450.99
228_L231_E2.0300.99
146_I159_M2.0240.99
177_V273_A1.9840.99
337_E340_N1.9720.99
262_L291_A1.9520.99
329_M351_V1.9430.99
39_S42_S1.9380.99
260_L264_A1.9370.99
314_V448_C1.9290.99
100_M159_M1.9080.99
431_L435_A1.9030.99
50_K65_E1.8940.99
176_K270_G1.8860.99
386_S407_N1.8630.98
178_A208_Y1.8570.98
222_D257_K1.8240.98
8_E48_T1.7930.98
33_S151_D1.7540.98
387_A408_G1.7530.98
238_I252_I1.7400.98
304_G348_M1.7230.97
175_I273_A1.7120.97
12_V53_V1.7040.97
197_A312_A1.6980.97
175_I316_M1.6950.97
289_G304_G1.6840.97
224_E227_T1.6670.97
61_E65_E1.6630.97
119_F123_N1.6550.97
178_A207_G1.6430.97
357_L410_E1.6310.96
222_D253_K1.6250.96
13_T31_A1.6180.96
391_S444_A1.6150.96
39_S46_K1.6100.96
259_E294_R1.5910.96
172_S316_M1.5800.96
206_D271_Y1.5700.96
276_T302_F1.5700.96
459_L471_L1.5630.95
101_H132_Y1.5570.95
383_I451_Y1.5530.95
108_R337_E1.5530.95
178_A265_F1.5430.95
231_E298_K1.5410.95
85_A132_Y1.5300.95
215_E219_R1.5260.95
8_E71_T1.4910.94
226_D229_Y1.4900.94
214_V284_M1.4840.94
223_D227_T1.4730.94
74_G166_A1.4600.93
37_G40_G1.4570.93
363_E379_V1.4470.93
229_Y233_D1.4440.93
216_V219_R1.4420.93
17_H54_T1.4400.93
342_M409_Q1.4380.93
54_T58_T1.4290.93
41_I156_K1.4230.93
237_V361_K1.4020.92
379_V422_R1.4000.92
254_E285_K1.3910.92
109_D337_E1.3860.92
317_M448_C1.3830.91
304_G328_F1.3760.91
321_A453_L1.3740.91
145_V440_L1.3640.91
29_Q32_K1.3570.91
172_S203_W1.3470.90
201_F399_F1.3330.90
44_R160_S1.3310.90
153_E157_K1.3270.90
455_A469_S1.3260.90
9_F45_Y1.3210.89
263_T267_E1.3180.89
382_G423_V1.3140.89
229_Y256_A1.3080.89
157_K161_Q1.3080.89
273_A448_C1.2990.89
158_E432_K1.2970.89
255_Q376_A1.2950.88
196_G200_Q1.2920.88
293_Q378_L1.2890.88
45_Y73_A1.2870.88
274_F302_F1.2820.88
386_S428_E1.2770.88
207_G277_S1.2690.87
264_A268_Q1.2690.87
237_V359_Q1.2650.87
250_A254_E1.2620.87
273_A311_A1.2540.87
231_E235_L1.2540.87
25_E28_D1.2510.87
255_Q290_L1.2490.87
340_N426_K1.2490.87
210_I280_V1.2450.86
358_D383_I1.2320.86
75_I99_L1.2260.86
327_S352_C1.2230.85
26_L122_S1.2170.85
440_L463_E1.2150.85
161_Q456_E1.2140.85
171_E174_H1.2100.85
89_I132_Y1.2040.84
136_N141_L1.2030.84
90_E198_H1.2000.84
103_H435_A1.1890.84
33_S36_E1.1850.83
386_S405_E1.1840.83
361_K364_V1.1830.83
318_K352_C1.1820.83
184_M350_E1.1810.83
459_L469_S1.1750.83
393_V444_A1.1710.83
223_D226_D1.1660.82
101_H133_G1.1590.82
232_Y256_A1.1510.82
72_C75_I1.1430.81
450_S454_T1.1360.81
60_R64_R1.1350.81
403_L459_L1.1320.81
462_A469_S1.1260.80
9_F163_M1.1240.80
12_V62_L1.1230.80
381_N414_D1.1150.80
313_L448_C1.1120.79
254_E258_I1.1050.79
30_H125_S1.1000.79
242_T252_I1.1000.79
12_V75_I1.0990.79
252_I364_V1.0820.77
217_M261_G1.0820.77
393_V402_V1.0790.77
227_T231_E1.0770.77
232_Y294_R1.0760.77
129_D145_V1.0750.77
453_L457_Q1.0700.77
198_H205_V1.0640.76
358_D381_N1.0620.76
62_L75_I1.0600.76
255_Q362_I1.0580.76
187_V278_F1.0570.76
221_T227_T1.0570.76
267_E300_Y1.0540.76
227_T230_A1.0520.75
401_L462_A1.0490.75
321_A454_T1.0460.75
201_F392_I1.0410.75
26_L29_Q1.0400.75
133_G439_I1.0390.75
252_I255_Q1.0390.75
77_T88_W1.0360.74
42_S234_R1.0280.74
305_E446_H1.0270.74
436_E440_L1.0230.73
171_E316_M1.0210.73
77_T132_Y1.0190.73
186_H279_E1.0170.73
173_R257_K1.0140.73
408_G423_V1.0130.73
320_M457_Q1.0080.72
233_D243_K1.0050.72
153_E156_K1.0050.72
405_E471_L1.0030.72
165_T457_Q1.0010.72
388_I452_E0.9930.71
405_E428_E0.9920.71
406_V447_T0.9890.71
208_Y212_D0.9880.71
35_C47_I0.9830.70
160_S164_D0.9810.70
219_R257_K0.9780.70
191_D194_K0.9750.70
258_I262_L0.9730.70
260_L390_A0.9710.69
199_I396_G0.9700.69
228_L260_L0.9650.69
357_L383_I0.9630.69
266_L274_F0.9570.68
109_D338_P0.9570.68
178_A269_G0.9570.68
421_A424_L0.9550.68
73_A170_N0.9540.68
157_K160_S0.9520.68
222_D226_D0.9500.68
7_Y170_N0.9500.68
171_E315_R0.9470.67
174_H270_G0.9420.67
171_E273_A0.9380.67
133_G145_V0.9350.66
60_R90_E0.9330.66
65_E70_E0.9300.66
37_G156_K0.9240.65
384_S410_E0.9160.65
24_L28_D0.9160.65
67_E96_Q0.9130.65
55_S58_T0.9120.64
9_F255_Q0.9070.64
276_T292_V0.9040.64
239_S243_K0.9030.64
337_E341_E0.9010.64
337_E397_G0.8960.63
389_Q447_T0.8960.63
27_V31_A0.8940.63
153_E222_D0.8920.63
220_I225_V0.8920.63
358_D410_E0.8900.63
171_E319_I0.8840.62
30_H76_I0.8830.62
423_V426_K0.8830.62
33_S106_Y0.8800.62
82_F189_V0.8770.61
310_T391_S0.8750.61
158_E456_E0.8750.61
127_H445_H0.8740.61
391_S401_L0.8730.61
266_L300_Y0.8730.61
137_S470_V0.8720.61
297_E354_T0.8700.61
268_Q386_S0.8690.61
320_M461_W0.8690.61
166_A464_M0.8680.61
332_Y438_W0.8680.61
383_I452_E0.8680.61
7_Y45_Y0.8670.61
352_C355_V0.8660.60
362_I376_A0.8600.60
229_Y238_I0.8590.60
174_H177_V0.8580.60
214_V285_K0.8540.59
454_T457_Q0.8510.59
210_I284_M0.8500.59
200_Q467_I0.8500.59
277_S444_A0.8490.59
36_E222_D0.8450.59
82_F187_V0.8450.59
98_P385_G0.8400.58
276_T290_L0.8350.58
53_V62_L0.8340.58
421_A427_P0.8310.57
203_W312_A0.8290.57
240_E243_K0.8280.57
29_Q268_Q0.8270.57
355_V383_I0.8250.57
321_A326_T0.8240.57
259_E263_T0.8210.56
290_L362_I0.8210.56
381_N422_R0.8160.56
142_S466_G0.8150.56
187_V346_S0.8120.55
82_F278_F0.8120.55
53_V58_T0.8110.55
93_S216_V0.8110.55
364_V369_I0.8100.55
56_P186_H0.8100.55
142_S436_E0.8100.55
327_S351_V0.8070.55
117_M121_N0.8050.55
364_V376_A0.8050.55
132_Y136_N0.8050.55
58_T61_E0.8040.55
455_A459_L0.8020.55
125_S292_V0.8020.55
363_E369_I0.8010.54
93_S199_I0.7990.54
25_E29_Q0.7980.54
216_V220_I0.7960.54
193_D196_G0.7950.54
366_S369_I0.7940.54
387_A449_L0.7940.54
392_I467_I0.7930.54
225_V257_K0.7890.53
356_A383_I0.7840.53
174_H272_T0.7840.53
225_V229_Y0.7830.53
164_D457_Q0.7780.52
416_P425_W0.7780.52
47_I76_I0.7780.52
205_V303_A0.7780.52
28_D31_A0.7760.52
161_Q165_T0.7750.52
301_G318_K0.7750.52
242_T376_A0.7730.52
303_A346_S0.7720.52
172_S312_A0.7720.52
102_L155_V0.7720.52
419_P423_V0.7700.52
16_Q19_Y0.7700.52
179_R308_W0.7690.51
401_L467_I0.7690.51
28_D51_P0.7640.51
350_E379_V0.7630.51
278_F420_V0.7630.51
11_F35_C0.7620.51
329_M345_G0.7610.51
33_S37_G0.7610.51
164_D175_I0.7600.51
89_I139_M0.7590.51
142_S173_R0.7570.50
390_A403_L0.7530.50
442_G445_H0.7530.50
154_E157_K0.7500.50
73_A167_A0.7500.50
9_F73_A0.7490.50
403_L455_A0.7490.50
335_H338_P0.7480.49
408_G449_L0.7480.49
384_S408_G0.7480.49
168_A461_W0.7470.49
418_L425_W0.7450.49
31_A35_C0.7440.49
47_I452_E0.7420.49
160_S223_D0.7410.49
110_I423_V0.7400.49
401_L458_M0.7400.49
218_D230_A0.7400.49
77_T99_L0.7390.49
32_K61_E0.7380.49
343_I427_P0.7370.48
228_L263_T0.7370.48
153_E234_R0.7370.48
341_E432_K0.7350.48
349_L421_A0.7340.48
152_D432_K0.7340.48
148_G155_V0.7330.48
262_L298_K0.7300.48
173_R428_E0.7300.48
408_G451_Y0.7290.48
362_I366_S0.7250.47
57_E61_E0.7200.47
250_A463_E0.7190.47
106_Y125_S0.7180.47
141_L161_Q0.7180.47
299_G347_H0.7180.47
347_H442_G0.7180.47
237_V358_D0.7160.46
168_A316_M0.7140.46
38_L42_S0.7120.46
197_A308_W0.7090.46
362_I365_H0.7090.46
27_V30_H0.7080.46
53_V75_I0.7050.45
278_F348_M0.7040.45
96_Q173_R0.7010.45
303_A311_A0.7000.45
317_M321_A0.6990.45
36_E267_E0.6980.45
85_A184_M0.6970.45
37_G42_S0.6970.45
237_V267_E0.6950.45
159_M231_E0.6950.45
64_R94_S0.6940.44
37_G151_D0.6940.44
422_R427_P0.6940.44
341_E430_S0.6930.44
222_D225_V0.6930.44
252_I376_A0.6920.44
17_H21_E0.6910.44
230_A358_D0.6890.44
62_L213_L0.6870.44
234_R459_L0.6870.44
223_D339_G0.6850.44
172_S177_V0.6810.43
32_K42_S0.6810.43
9_F76_I0.6810.43
127_H278_F0.6810.43
226_D234_R0.6800.43
278_F346_S0.6780.43
76_I100_M0.6770.43
346_S420_V0.6740.43
371_G375_P0.6740.43
278_F289_G0.6720.42
355_V387_A0.6720.42
317_M390_A0.6720.42
203_W255_Q0.6720.42
225_V253_K0.6690.42
219_R230_A0.6680.42
356_A380_F0.6680.42
32_K157_K0.6680.42
74_G162_W0.6680.42
186_H452_E0.6660.42
171_E175_I0.6650.42
172_S457_Q0.6640.42
213_L458_M0.6630.42
147_A436_E0.6610.41
422_R425_W0.6610.41
124_Q332_Y0.6600.41
368_S371_G0.6570.41
175_I448_C0.6570.41
267_E298_K0.6560.41
213_L262_L0.6550.41
419_P427_P0.6550.41
137_S167_A0.6540.41
46_K230_A0.6520.41
278_F445_H0.6520.41
179_R207_G0.6520.41
418_L421_A0.6510.40
64_R67_E0.6510.40
211_G282_H0.6500.40
157_K223_D0.6500.40
238_I243_K0.6490.40
7_Y167_A0.6480.40
208_Y213_L0.6460.40
403_L458_M0.6450.40
92_L97_K0.6440.40
64_R234_R0.6430.40
82_F445_H0.6420.40
7_Y73_A0.6420.40
386_S453_L0.6410.40
221_T230_A0.6390.39
40_G61_E0.6390.39
108_R335_H0.6380.39
367_L370_G0.6380.39
317_M325_R0.6380.39
415_M422_R0.6370.39
156_K160_S0.6370.39
34_I42_S0.6350.39
53_V234_R0.6340.39
388_I405_E0.6340.39
39_S47_I0.6320.39
186_H314_V0.6310.39
29_Q42_S0.6300.39
292_V302_F0.6290.39
238_I242_T0.6290.39
418_L427_P0.6290.39
35_C49_H0.6280.38
208_Y265_F0.6270.38
22_E26_L0.6270.38
19_Y27_V0.6250.38
295_L300_Y0.6250.38
25_E413_K0.6250.38
39_S224_E0.6240.38
81_T85_A0.6220.38
53_V59_I0.6200.38
74_G369_I0.6190.38
266_L302_F0.6190.38
17_H55_S0.6190.38
421_A425_W0.6170.37
64_R69_S0.6160.37
12_V263_T0.6140.37
313_L391_S0.6140.37
41_I160_S0.6130.37
274_F292_V0.6130.37
37_G222_D0.6120.37
42_S71_T0.6120.37
57_E176_K0.6110.37
100_M146_I0.6100.37
267_E270_G0.6090.37
51_P58_T0.6090.37
391_S447_T0.6070.37
225_V260_L0.6060.36
36_E230_A0.6060.36
389_Q404_N0.6060.36
448_C458_M0.6050.36
10_W66_A0.6050.36
173_R177_V0.6040.36
140_G164_D0.6040.36
152_D155_V0.6030.36
192_G308_W0.6020.36
424_L427_P0.6010.36
45_Y170_N0.6010.36
230_A270_G0.6000.36
395_I400_R0.5990.36
152_D338_P0.5980.36
70_E238_I0.5980.36
250_A253_K0.5970.36
422_R426_K0.5970.36
460_D463_E0.5940.35
93_S96_Q0.5920.35
336_F341_E0.5910.35
347_H445_H0.5910.35
166_A364_V0.5890.35
30_H42_S0.5880.35
12_V91_G0.5880.35
342_M424_L0.5870.35
366_S370_G0.5860.35
228_L259_E0.5860.35
418_L422_R0.5830.35
187_V420_V0.5830.35
46_K267_E0.5830.35
34_I76_I0.5810.34
82_F289_G0.5810.34
142_S463_E0.5800.34
316_M320_M0.5790.34
214_V218_D0.5780.34
465_A469_S0.5780.34
250_A285_K0.5780.34
128_G307_D0.5770.34
341_E426_K0.5770.34
36_E39_S0.5770.34
75_I301_G0.5760.34
125_S231_E0.5750.34
186_H277_S0.5750.34
434_A437_A0.5750.34
203_W273_A0.5740.34
239_S363_E0.5740.34
48_T51_P0.5740.34
173_R273_A0.5730.34
56_P230_A0.5730.34
107_N119_F0.5690.33
282_H372_K0.5690.33
73_A132_Y0.5680.33
60_R96_Q0.5680.33
124_Q278_F0.5680.33
61_E173_R0.5680.33
223_D414_D0.5660.33
38_L143_R0.5660.33
383_I471_L0.5650.33
278_F330_E0.5650.33
232_Y259_E0.5640.33
61_E222_D0.5640.33
146_I149_Y0.5640.33
235_L402_V0.5640.33
28_D48_T0.5610.33
229_Y252_I0.5610.33
168_A176_K0.5600.33
273_A316_M0.5600.33
351_V355_V0.5590.33
370_G422_R0.5580.32
187_V349_L0.5570.32
34_I407_N0.5570.32
30_H34_I0.5560.32
312_A315_R0.5560.32
168_A171_E0.5560.32
64_R96_Q0.5550.32
264_A267_E0.5550.32
157_K358_D0.5540.32
339_G436_E0.5540.32
294_R301_G0.5540.32
257_K432_K0.5530.32
451_Y469_S0.5510.32
152_D157_K0.5510.32
142_S151_D0.5490.32
356_A382_G0.5490.32
108_R151_D0.5480.32
80_H138_R0.5480.32
131_E330_E0.5480.32
339_G410_E0.5470.32
204_Q271_Y0.5470.32
69_S470_V0.5460.31
404_N434_A0.5460.31
215_E283_G0.5450.31
65_E69_S0.5440.31
75_I142_S0.5420.31
262_L302_F0.5420.31
119_F125_S0.5420.31
224_E260_L0.5410.31
427_P434_A0.5400.31
317_M450_S0.5400.31
184_M278_F0.5400.31
73_A168_A0.5400.31
167_A172_S0.5400.31
148_G202_G0.5380.31
35_C250_A0.5380.31
363_E366_S0.5380.31
388_I455_A0.5370.31
30_H40_G0.5370.31
223_D298_K0.5360.31
388_I450_S0.5360.31
40_G456_E0.5360.31
63_L92_L0.5360.31
85_A178_A0.5360.31
124_Q127_H0.5350.31
24_L27_V0.5350.31
33_S157_K0.5350.31
419_P425_W0.5350.31
172_S461_W0.5350.31
293_Q351_V0.5340.30
335_H342_M0.5340.30
169_L176_K0.5340.30
124_Q130_R0.5340.30
387_A406_V0.5330.30
32_K316_M0.5330.30
107_N123_N0.5290.30
297_E378_L0.5280.30
82_F127_H0.5270.30
348_M420_V0.5260.30
204_Q256_A0.5260.30
296_M350_E0.5260.30
94_S270_G0.5250.30
400_R441_A0.5250.30
467_I470_V0.5250.30
157_K218_D0.5250.30
142_S174_H0.5240.30
364_V367_L0.5220.30
63_L75_I0.5220.30
146_I461_W0.5210.29
61_E456_E0.5210.29
32_K58_T0.5210.29
365_H370_G0.5200.29
238_I362_I0.5200.29
176_K204_Q0.5200.29
108_R338_P0.5200.29
250_A407_N0.5190.29
329_M352_C0.5190.29
60_R94_S0.5190.29
193_D396_G0.5140.29
93_S139_M0.5140.29
57_E64_R0.5140.29
250_A410_E0.5130.29
169_L397_G0.5120.29
416_P419_P0.5120.29
47_I218_D0.5120.29
186_H349_L0.5120.29
430_S461_W0.5110.29
186_H206_D0.5100.29
64_R71_T0.5090.29
184_M187_V0.5090.29
131_E189_V0.5090.29
365_H369_I0.5080.28
82_F347_H0.5070.28
277_S391_S0.5060.28
125_S424_L0.5040.28
310_T313_L0.5040.28
56_P90_E0.5040.28
219_R225_V0.5030.28
22_E28_D0.5030.28
99_L141_L0.5030.28
191_D346_S0.5020.28
236_Y293_Q0.5010.28
25_E46_K0.5010.28
235_L410_E0.5010.28
124_Q184_M0.5000.28
252_I451_Y0.5000.28
52_V385_G0.5000.28
60_R151_D0.5000.28
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4f2dA 5 0.9899 100 0.25 Contact Map
4lqlA 5 0.9476 100 0.307 Contact Map
1fuiA 5 0.9597 100 0.376 Contact Map
3a9sA 5 0.9536 100 0.381 Contact Map
3rotA 2 0.5262 96.7 0.946 Contact Map
4rxmA 1 0.5625 96.6 0.946 Contact Map
3hs3A 2 0.506 96.2 0.948 Contact Map
4rk1A 4 0.5282 96.2 0.948 Contact Map
3l6uA 2 0.5282 95.9 0.95 Contact Map
4wt7A 1 0.5726 95.7 0.95 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0127 seconds.