GREMLIN Database
EABN1 - Extracellular endo-alpha-(1->5)-L-arabinanase 1
UniProt: P94522 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (265)
Sequences: 7367 (4707)
Seq/√Len: 289.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
173_N189_K6.3071.00
53_S71_K4.8331.00
74_D77_N4.8281.00
225_Y251_K4.8031.00
170_K221_Y4.3761.00
114_K137_T4.2911.00
53_S73_S3.9861.00
138_S141_S3.7661.00
114_K135_S3.6621.00
225_Y249_R3.3341.00
189_K198_T3.3051.00
57_L144_W3.1981.00
191_D196_K2.9491.00
292_N313_D2.7791.00
136_S143_G2.7331.00
168_F174_P2.6491.00
50_E115_Y2.5851.00
71_K81_Q2.5711.00
177_A187_L2.5451.00
187_L254_T2.4951.00
317_S320_W2.4241.00
50_E110_Y2.1461.00
57_L108_I2.1381.00
110_Y113_G2.1311.00
188_T197_P2.1101.00
253_I257_Y2.0191.00
191_D195_M1.9211.00
193_S196_K1.9051.00
49_K52_S1.8831.00
108_I117_L1.8751.00
202_Y254_T1.8141.00
191_D198_T1.7661.00
288_I314_L1.7651.00
135_S147_E1.7521.00
71_K79_T1.7131.00
186_K203_S1.6561.00
203_S206_A1.6411.00
178_F188_T1.6391.00
222_Q316_W1.6321.00
249_R320_W1.6301.00
84_I117_L1.6241.00
54_W72_S1.5331.00
177_A219_L1.5071.00
229_M247_Y1.5041.00
177_A253_I1.4951.00
296_R312_N1.4831.00
177_A257_Y1.4461.00
249_R258_L1.4411.00
295_V311_I1.4321.00
52_S73_S1.4081.00
250_S257_Y1.3941.00
68_R80_V1.3791.00
221_Y226_Y1.3731.00
220_T288_I1.3701.00
220_T316_W1.3661.00
220_T229_M1.3601.00
42_L70_L1.3571.00
249_R261_S1.3471.00
250_S256_P1.3451.00
167_T226_Y1.3451.00
116_W133_L1.3401.00
167_T219_L1.3401.00
67_L117_L1.3271.00
251_K258_L1.3231.00
224_G251_K1.3211.00
219_L257_Y1.3211.00
48_I115_Y1.2851.00
87_T90_S1.2831.00
133_L195_M1.2621.00
191_D194_T1.2591.00
223_N319_G1.2531.00
33_A36_G1.2511.00
164_P176_L1.2451.00
42_L58_G1.2421.00
72_S75_A1.2321.00
171_D221_Y1.2231.00
298_A310_L1.2061.00
135_S145_K1.1851.00
136_S142_G1.1841.00
136_S141_S1.1841.00
221_Y224_G1.1681.00
214_L230_V1.1621.00
286_Q294_L1.1581.00
57_L140_S1.1571.00
131_I176_L1.1501.00
68_R83_S1.1471.00
175_W254_T1.1351.00
119_Y146_D1.1261.00
205_A248_G1.1201.00
187_L253_I1.1201.00
47_M295_V1.1181.00
118_Y194_T1.1161.00
85_F134_A1.1151.00
118_Y176_L1.1061.00
72_S77_N1.1061.00
192_K196_K1.1041.00
107_D165_E1.0971.00
137_T145_K1.0861.00
56_A309_L1.0841.00
58_G70_L1.0811.00
187_L204_I1.0801.00
67_L103_Q1.0791.00
110_Y115_Y1.0771.00
187_L257_Y1.0681.00
245_I294_L1.0631.00
167_T253_I1.0501.00
89_L92_W1.0481.00
169_D221_Y1.0461.00
232_F246_A1.0421.00
72_S78_W1.0321.00
293_I313_D1.0201.00
75_A311_I1.0171.00
111_Y174_P1.0061.00
199_G202_Y1.0031.00
184_G203_S1.0031.00
218_T287_D0.9991.00
86_T89_L0.9931.00
176_L188_T0.9881.00
89_L146_D0.9741.00
201_L204_I0.9701.00
280_W310_L0.9671.00
189_K199_G0.9671.00
227_Y247_Y0.9631.00
117_L134_A0.9611.00
50_E53_S0.9571.00
69_V108_I0.9531.00
118_Y166_L0.9531.00
284_G288_I0.9521.00
132_G146_D0.9521.00
185_I230_V0.9511.00
180_S186_K0.9511.00
177_A228_L0.9511.00
70_L80_V0.9491.00
71_K141_S0.9481.00
178_F201_L0.9471.00
205_A259_D0.9461.00
81_Q141_S0.9411.00
109_Q168_F0.9411.00
166_L174_P0.9391.00
88_P91_W0.9381.00
185_I217_P0.9341.00
192_K195_M0.9291.00
229_M245_I0.9261.00
287_D295_V0.9251.00
213_A217_P0.9221.00
138_S142_G0.9161.00
219_L253_I0.9151.00
87_T93_S0.9131.00
80_V83_S0.9091.00
252_S256_P0.9071.00
282_G299_Y0.9061.00
138_S143_G0.9041.00
67_L119_Y0.9031.00
106_P117_L0.9011.00
229_M288_I0.9011.00
190_L195_M0.8901.00
222_Q225_Y0.8881.00
252_S257_Y0.8871.00
62_T66_G0.8861.00
175_W189_K0.8771.00
54_W289_V0.8741.00
264_S267_E0.8691.00
123_S126_S0.8661.00
89_L93_S0.8621.00
73_S79_T0.8611.00
293_I311_I0.8611.00
48_I108_I0.8551.00
118_Y133_L0.8541.00
284_G287_D0.8521.00
138_S144_W0.8511.00
166_L176_L0.8501.00
32_A35_W0.8501.00
109_Q166_L0.8471.00
188_T199_G0.8431.00
112_N174_P0.8401.00
222_Q319_G0.8381.00
131_I164_P0.8381.00
201_L205_A0.8341.00
57_L69_V0.8321.00
85_F88_P0.8321.00
35_W38_S0.8301.00
285_G288_I0.8281.00
185_I228_L0.8261.00
169_D172_G0.8241.00
177_A217_P0.8231.00
283_P298_A0.8201.00
285_G289_V0.8201.00
75_A78_W0.8181.00
103_Q119_Y0.8161.00
55_Y69_V0.8081.00
47_M287_D0.8000.99
187_L219_L0.7980.99
289_V295_V0.7980.99
188_T201_L0.7960.99
122_S129_S0.7960.99
258_L261_S0.7940.99
269_G278_D0.7880.99
169_D226_Y0.7860.99
280_W284_G0.7820.99
60_G68_R0.7820.99
300_D308_K0.7820.99
43_H307_P0.7700.99
53_S81_Q0.7690.99
57_L106_P0.7590.99
119_Y132_G0.7570.99
90_S93_S0.7560.99
87_T91_W0.7500.99
140_S143_G0.7490.99
229_M286_Q0.7490.99
190_L194_T0.7450.99
159_Y197_P0.7440.99
200_S203_S0.7430.99
233_D244_K0.7410.99
55_Y71_K0.7400.99
98_N101_Q0.7400.99
54_W75_A0.7360.99
88_P93_S0.7350.99
280_W298_A0.7330.99
296_R310_L0.7290.99
33_A76_K0.7250.99
119_Y134_A0.7250.99
42_L56_A0.7220.99
233_D242_T0.7210.99
186_K201_L0.7190.99
229_M314_L0.7190.99
250_S255_G0.7170.99
123_S130_A0.7150.99
167_T170_K0.7140.99
165_E177_A0.7120.99
82_K143_G0.7080.99
111_Y168_F0.7080.99
246_A259_D0.6980.99
120_S164_P0.6980.99
297_H300_D0.6980.99
250_S253_I0.6970.99
111_Y116_W0.6890.98
34_F37_A0.6880.98
230_V246_A0.6870.98
44_D105_A0.6870.98
227_Y249_R0.6850.98
185_I214_L0.6840.98
190_L193_S0.6820.98
176_L190_L0.6810.98
245_I286_Q0.6800.98
170_K224_G0.6800.98
229_M316_W0.6790.98
58_G216_A0.6770.98
59_T106_P0.6740.98
46_T218_T0.6740.98
69_V144_W0.6730.98
249_R316_W0.6730.98
32_A36_G0.6680.98
101_Q122_S0.6680.98
248_G257_Y0.6660.98
147_E195_M0.6650.98
111_Y166_L0.6650.98
181_F184_G0.6630.98
234_K239_V0.6620.98
165_E218_T0.6610.98
44_D59_T0.6610.98
85_F91_W0.6610.98
247_Y265_M0.6600.98
162_I217_P0.6580.98
258_L264_S0.6570.98
49_K289_V0.6540.98
173_N198_T0.6530.98
67_L106_P0.6530.98
232_F244_K0.6500.98
286_Q295_V0.6500.98
243_Y284_G0.6490.98
69_V84_I0.6490.98
105_A285_G0.6480.98
294_L314_L0.6420.97
46_T287_D0.6390.97
105_A163_D0.6370.97
295_V309_L0.6350.97
280_W283_P0.6340.97
200_S204_I0.6330.97
202_Y206_A0.6310.97
49_K54_W0.6310.97
118_Y190_L0.6300.97
46_T107_D0.6300.97
281_K284_G0.6280.97
116_W135_S0.6260.97
47_M54_W0.6250.97
199_G206_A0.6240.97
263_K267_E0.6240.97
225_Y250_S0.6230.97
44_D285_G0.6190.97
136_S144_W0.6180.97
131_I150_V0.6170.97
118_Y164_P0.6150.97
231_S286_Q0.6150.97
98_N123_S0.6130.97
74_D78_W0.6120.97
217_P228_L0.6090.97
218_T286_Q0.6090.97
244_K263_K0.6080.97
170_K226_Y0.6070.96
55_Y115_Y0.6070.96
47_M75_A0.6060.96
230_V248_G0.6060.96
101_Q123_S0.6040.96
67_L134_A0.6030.96
178_F186_K0.5990.96
187_L202_Y0.5980.96
243_Y282_G0.5970.96
248_G265_M0.5960.96
118_Y131_I0.5960.96
47_M289_V0.5940.96
112_N172_G0.5910.96
181_F213_A0.5880.96
199_G204_I0.5870.96
293_I298_A0.5860.96
228_L257_Y0.5840.96
253_I256_P0.5830.96
195_M198_T0.5790.95
104_W122_S0.5780.95
33_A293_I0.5770.95
121_V129_S0.5750.95
219_L226_Y0.5750.95
180_S184_G0.5730.95
303_D308_K0.5720.95
88_P92_W0.5710.95
57_L117_L0.5710.95
294_L312_N0.5690.95
109_Q174_P0.5680.95
129_S180_S0.5660.95
112_N116_W0.5650.95
111_Y194_T0.5640.95
241_S302_N0.5630.95
252_S255_G0.5610.95
295_V298_A0.5610.95
245_I296_R0.5570.94
219_L228_L0.5570.94
233_D246_A0.5550.94
294_L298_A0.5540.94
169_D253_I0.5540.94
198_T201_L0.5520.94
63_E66_G0.5510.94
37_A309_L0.5510.94
49_K53_S0.5490.94
57_L67_L0.5480.94
43_H61_L0.5470.94
201_L206_A0.5470.94
86_T90_S0.5470.94
31_E34_F0.5470.94
167_T171_D0.5450.94
118_Y195_M0.5440.94
90_S103_Q0.5430.94
72_S76_K0.5430.94
231_S243_Y0.5420.94
171_D175_W0.5410.93
137_T143_G0.5410.93
150_V176_L0.5400.93
208_P211_G0.5370.93
65_R306_I0.5350.93
200_S205_A0.5350.93
283_P286_Q0.5340.93
263_K266_L0.5340.93
192_K198_T0.5320.93
167_T173_N0.5300.93
141_S144_W0.5290.93
59_T243_Y0.5280.93
315_N318_S0.5280.93
99_Y119_Y0.5280.93
41_L306_I0.5260.93
86_T91_W0.5260.93
59_T104_W0.5250.92
83_S86_T0.5250.92
174_P190_L0.5240.92
205_A214_L0.5230.92
134_A144_W0.5220.92
163_D285_G0.5220.92
120_S162_I0.5220.92
44_D104_W0.5210.92
166_L190_L0.5190.92
134_A147_E0.5180.92
292_N315_N0.5180.92
268_G277_N0.5180.92
151_I196_K0.5180.92
230_V265_M0.5140.92
57_L84_I0.5140.92
40_E70_L0.5140.92
226_Y250_S0.5130.92
250_S258_L0.5110.91
67_L84_I0.5090.91
123_S128_T0.5090.91
45_P56_A0.5080.91
146_D149_L0.5080.91
216_A286_Q0.5070.91
160_N180_S0.5060.91
283_P297_H0.5060.91
85_F90_S0.5050.91
160_N184_G0.5050.91
293_I296_R0.5040.91
55_Y81_Q0.5010.91
305_G308_K0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uv4A 1 0.8978 100 0.271 Contact Map
2x8sA 1 0.8607 100 0.276 Contact Map
3c2uA 3 0.8514 100 0.298 Contact Map
1yifA 3 0.8483 100 0.299 Contact Map
3cu9A 2 0.9288 100 0.301 Contact Map
2exhA 3 0.8483 100 0.303 Contact Map
1gyhA 1 0.8762 100 0.306 Contact Map
4kcbA 1 0.8885 100 0.308 Contact Map
1yrzA 1 0.8483 100 0.308 Contact Map
4kc7A 1 0.8607 100 0.32 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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