GREMLIN Database
YSDC - Putative aminopeptidase YsdC
UniProt: P94521 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 361 (335)
Sequences: 2598 (1704)
Seq/√Len: 93.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
147_R151_L4.8771.00
17_A30_V3.4821.00
175_F332_H3.1801.00
87_F140_I2.8691.00
338_N341_K2.8401.00
20_I90_V2.7271.00
12_K16_D2.6771.00
15_T178_A2.6481.00
144_A150_A2.6181.00
255_K258_K2.6091.00
275_L315_L2.5941.00
192_D195_R2.5861.00
106_V162_V2.5441.00
80_T86_R2.5201.00
66_A211_T2.4741.00
286_A345_E2.4561.00
63_I347_I2.3791.00
85_I105_I2.2861.00
62_K207_Y2.2821.00
32_K36_E2.2791.00
289_P338_N2.2341.00
32_K44_T2.1881.00
114_G140_I2.1351.00
53_K205_I2.1281.00
281_A285_E2.0951.00
21_P90_V2.0751.00
196_N344_T2.0411.00
85_I161_I2.0381.00
345_E348_K2.0331.00
279_V315_L2.0241.00
337_E341_K2.0091.00
71_E179_K2.0041.00
200_T348_K1.9821.00
174_K334_D1.9611.00
148_E152_E1.9561.00
279_V346_V1.9511.00
13_D34_Y1.9351.00
23_N160_M1.9261.00
31_M187_C1.9231.00
194_L208_G1.9221.00
33_S36_E1.9171.00
260_P338_N1.9141.00
148_E151_L1.9111.00
81_D147_R1.9061.00
53_K207_Y1.8811.00
142_I155_V1.8771.00
229_Q309_A1.8701.00
13_D30_V1.8651.00
76_V161_I1.8521.00
55_T205_I1.7931.00
142_I150_A1.7651.00
62_K205_I1.7461.00
19_G27_V1.7421.00
226_H309_A1.7371.00
67_G190_A1.7221.00
331_L336_Y1.7111.00
103_V140_I1.7071.00
144_A153_W1.7031.00
185_I336_Y1.6891.00
105_I140_I1.6781.00
264_V292_F1.6751.00
13_D33_S1.6711.00
80_T84_F1.6521.00
41_E53_K1.6021.00
32_K50_L1.5971.00
119_K128_A1.5931.00
28_R69_L1.5861.00
176_L181_W1.5511.00
56_G205_I1.5321.00
107_T110_G1.5221.00
156_L159_D1.5111.00
64_M305_I1.4911.00
66_A301_D1.4871.00
19_G184_R1.4851.00
39_A52_A1.4701.00
282_T286_A1.4591.00
156_L284_E1.4501.00
49_S223_T1.4491.00
34_Y195_R1.4401.00
9_T12_K1.4340.99
222_K304_A1.4190.99
113_T168_T1.4120.99
34_Y37_P1.4100.99
87_F138_M1.4100.99
42_V50_L1.4070.99
93_W163_P1.4060.99
196_N341_K1.4030.99
262_I290_Y1.4020.99
35_I191_I1.3930.99
75_M88_Q1.3770.99
87_F161_I1.3700.99
187_C210_G1.3700.99
64_M224_A1.3650.99
65_I347_I1.3580.99
280_V290_Y1.3460.99
214_E325_H1.3330.99
12_K167_F1.3240.99
9_T13_D1.3240.99
8_L169_V1.3070.99
64_M209_V1.3070.99
64_M230_P1.3030.99
76_V85_I1.3010.99
174_K332_H1.3010.99
31_M191_I1.2990.99
321_T324_I1.2760.99
31_M210_G1.2740.99
10_M30_V1.2720.99
233_A305_I1.2720.99
79_I150_A1.2680.99
278_A346_V1.2680.99
189_I339_A1.2650.99
235_G302_S1.2640.99
234_F279_V1.2590.99
74_F98_M1.2550.99
20_I73_G1.2540.99
169_V333_R1.2500.99
103_V116_I1.2230.98
18_K104_T1.2220.98
195_R199_N1.2210.98
193_V344_T1.2200.98
146_S149_E1.2130.98
193_V343_I1.2100.98
340_V344_T1.2090.98
29_Q33_S1.2090.98
215_E325_H1.1980.98
21_P73_G1.1980.98
151_L156_L1.1960.98
185_I331_L1.1820.98
145_S149_E1.1740.98
43_T227_T1.1720.98
15_T167_F1.1560.98
102_R168_T1.1520.98
193_V340_V1.1510.98
78_Q86_R1.1480.97
28_R44_T1.1400.97
85_I142_I1.1350.97
302_S314_A1.1310.97
105_I161_I1.1310.97
256_M259_G1.1280.97
280_V292_F1.1170.97
18_K106_V1.1150.97
170_M177_L1.1140.97
239_G261_Q1.1100.97
278_A282_T1.1030.97
69_L187_C1.1020.97
238_V324_I1.0920.97
126_P129_R1.0880.97
90_V160_M1.0860.96
17_A26_E1.0850.96
102_R164_H1.0840.96
10_M34_Y1.0810.96
276_R280_V1.0720.96
209_V224_A1.0680.96
317_I339_A1.0680.96
35_I52_A1.0650.96
89_T95_A1.0600.96
64_M228_I1.0530.96
239_G293_D1.0500.96
10_M191_I1.0490.96
190_A236_V1.0480.96
108_K159_D1.0420.96
257_G332_H1.0420.96
108_K277_D1.0390.95
188_A336_Y1.0390.95
149_E152_E1.0370.95
130_K134_E1.0370.95
284_E290_Y1.0370.95
38_F195_R1.0360.95
192_D196_N1.0350.95
207_Y228_I1.0320.95
105_I159_D1.0260.95
29_Q32_K1.0250.95
35_I194_L1.0210.95
87_F116_I1.0180.95
59_N205_I1.0140.95
51_I209_V1.0100.95
41_E55_T1.0060.95
150_A155_V1.0060.95
225_A305_I1.0050.95
272_H313_P1.0030.95
235_G305_I0.9920.94
31_M69_L0.9910.94
262_I276_R0.9910.94
30_V34_Y0.9880.94
239_G318_T0.9860.94
188_A340_V0.9820.94
182_D325_H0.9800.94
260_P339_A0.9800.94
344_T348_K0.9790.94
334_D337_E0.9780.94
258_K289_P0.9650.93
104_T164_H0.9640.93
127_E130_K0.9620.93
197_L202_H0.9560.93
288_I342_L0.9500.93
263_I293_D0.9390.92
58_E61_P0.9380.92
269_M316_S0.9380.92
177_L330_M0.9380.92
127_E131_K0.9350.92
229_Q310_N0.9320.92
52_A210_G0.9280.92
103_V114_G0.9250.92
16_D167_F0.9230.92
26_E111_E0.9230.92
113_T164_H0.9200.92
274_G313_P0.9190.92
35_I210_G0.9190.92
8_L167_F0.9180.91
25_R274_G0.9140.91
189_I340_V0.9110.91
40_D52_A0.9100.91
277_D281_A0.9090.91
260_P317_I0.9080.91
190_A208_G0.9040.91
45_D49_S0.9020.91
28_R50_L0.9010.91
56_G60_G0.9000.91
238_V321_T0.8990.91
182_D214_E0.8940.90
98_M116_I0.8940.90
26_E106_V0.8940.90
236_V343_I0.8940.90
183_N186_G0.8940.90
23_N106_V0.8940.90
192_D336_Y0.8930.90
63_I204_N0.8910.90
60_G205_I0.8910.90
254_S261_Q0.8890.90
62_K231_D0.8860.90
48_G212_V0.8850.90
55_T59_N0.8790.90
61_P204_N0.8790.90
85_I150_A0.8680.89
20_I160_M0.8650.89
88_Q265_Y0.8640.89
234_F343_I0.8560.88
25_R29_Q0.8520.88
32_K42_V0.8510.88
63_I206_V0.8480.88
56_G202_H0.8470.88
303_G306_H0.8460.88
134_E137_D0.8430.88
268_S303_G0.8430.88
42_V52_A0.8360.87
218_L304_A0.8310.87
237_D293_D0.8270.87
240_I324_I0.8260.87
213_Q218_L0.8230.86
74_F161_I0.8220.86
102_R328_A0.8210.86
192_D340_V0.8200.86
69_L210_G0.8190.86
176_L333_R0.8150.86
112_I142_I0.8140.86
196_N340_V0.8110.85
95_A98_M0.8100.85
43_T53_K0.8060.85
235_G314_A0.8060.85
280_V284_E0.8030.85
92_G325_H0.8020.85
17_A27_V0.8020.85
8_L12_K0.8010.85
260_P342_L0.8000.85
99_L138_M0.7990.85
11_L188_A0.7970.84
298_G324_I0.7960.84
267_A299_G0.7910.84
183_N238_V0.7900.84
308_T312_V0.7900.84
125_S128_A0.7890.84
182_D215_E0.7870.84
105_I142_I0.7870.84
92_G214_E0.7870.84
341_K345_E0.7830.83
243_D322_R0.7820.83
67_G183_N0.7780.83
218_L303_G0.7760.83
305_I312_V0.7730.83
104_T111_E0.7710.82
53_K62_K0.7670.82
319_I339_A0.7640.82
181_W331_L0.7560.81
84_F245_P0.7540.81
221_A225_A0.7520.81
71_E180_A0.7510.81
259_G291_Q0.7510.81
54_K194_L0.7510.81
189_I193_V0.7480.81
189_I336_Y0.7450.80
170_M330_M0.7430.80
104_T113_T0.7380.80
77_T88_Q0.7380.80
85_I112_I0.7370.80
206_V347_I0.7350.79
27_V69_L0.7320.79
17_A34_Y0.7310.79
259_G335_D0.7300.79
279_V317_I0.7290.79
112_I155_V0.7270.79
271_S316_S0.7260.79
61_P231_D0.7230.78
94_W97_V0.7230.78
35_I39_A0.7210.78
233_A312_V0.7210.78
334_D338_N0.7210.78
188_A192_D0.7200.78
293_D318_T0.7180.78
68_H214_E0.7180.78
263_I295_I0.7180.78
167_F176_L0.7080.77
299_G303_G0.7080.77
39_A42_V0.7080.77
11_L181_W0.7040.76
114_G142_I0.7030.76
259_G262_I0.7020.76
31_M50_L0.7010.76
227_T310_N0.7000.76
167_F178_A0.6980.76
189_I236_V0.6920.75
202_H206_V0.6920.75
81_D127_E0.6910.75
336_Y340_V0.6910.75
234_F315_L0.6900.75
100_A327_H0.6880.75
321_T331_L0.6860.75
242_G253_Q0.6810.74
63_I232_I0.6780.74
193_V347_I0.6770.74
324_I329_A0.6770.74
44_T50_L0.6740.73
40_D54_K0.6710.73
271_S276_R0.6700.73
225_A308_T0.6690.73
107_T159_D0.6670.72
30_V33_S0.6660.72
156_L280_V0.6650.72
226_H310_N0.6610.72
283_A342_L0.6600.72
196_N200_T0.6560.71
217_G299_G0.6550.71
92_G299_G0.6550.71
232_I346_V0.6550.71
282_T345_E0.6540.71
262_I315_L0.6520.71
142_I153_W0.6480.70
35_I42_V0.6480.70
26_E33_S0.6440.70
197_L206_V0.6440.70
74_F87_F0.6430.70
51_I207_Y0.6420.70
92_G215_E0.6420.70
273_K313_P0.6400.69
235_G343_I0.6390.69
213_Q216_V0.6380.69
286_A341_K0.6370.69
281_A284_E0.6350.69
151_L284_E0.6330.69
178_A181_W0.6310.68
278_A281_A0.6290.68
49_S209_V0.6280.68
190_A193_V0.6280.68
107_T154_G0.6270.68
20_I162_V0.6270.68
25_R28_R0.6240.67
112_I144_A0.6240.67
107_T112_I0.6240.67
273_K277_D0.6210.67
11_L176_L0.6160.66
263_I316_S0.6150.66
282_T346_V0.6140.66
256_M320_A0.6130.66
38_F198_Q0.6130.66
84_F139_F0.6120.66
284_E287_G0.6110.66
117_G323_Y0.6110.66
58_E205_I0.6100.66
271_S298_G0.6090.66
226_H229_Q0.6070.65
183_N237_D0.6060.65
66_A235_G0.6000.64
80_T139_F0.5980.64
300_T325_H0.5980.64
149_E172_N0.5980.64
237_D300_T0.5960.64
105_I155_V0.5950.64
14_L27_V0.5940.64
270_V303_G0.5930.64
8_L178_A0.5930.64
78_Q81_D0.5920.63
23_N26_E0.5910.63
298_G316_S0.5910.63
266_D298_G0.5870.63
239_G254_S0.5870.63
145_S334_D0.5860.63
79_I280_V0.5840.62
238_V293_D0.5840.62
18_K26_E0.5830.62
213_Q219_R0.5830.62
185_I340_V0.5810.62
72_V329_A0.5780.62
46_R313_P0.5780.62
95_A133_V0.5750.61
178_A330_M0.5750.61
15_T179_K0.5740.61
316_S324_I0.5740.61
75_M90_V0.5720.61
65_I190_A0.5720.61
183_N214_E0.5710.61
125_S129_R0.5710.61
8_L333_R0.5700.60
66_A275_L0.5680.60
43_T207_Y0.5680.60
209_V233_A0.5680.60
230_P233_A0.5650.60
240_I293_D0.5640.60
51_I224_A0.5630.60
282_T288_I0.5620.59
222_K225_A0.5610.59
31_M52_A0.5610.59
108_K281_A0.5590.59
68_H215_E0.5590.59
65_I343_I0.5580.59
56_G59_N0.5560.59
106_V161_I0.5550.58
217_G266_D0.5540.58
11_L15_T0.5530.58
12_K169_V0.5530.58
181_W336_Y0.5520.58
39_A194_L0.5510.58
260_P341_K0.5510.58
332_H336_Y0.5470.57
126_P130_K0.5450.57
232_I275_L0.5430.57
197_L347_I0.5420.57
16_D166_E0.5410.57
298_G303_G0.5400.56
218_L299_G0.5400.56
40_D198_Q0.5400.56
40_D194_L0.5390.56
74_F93_W0.5380.56
322_R335_D0.5380.56
266_D303_G0.5380.56
169_V174_K0.5370.56
23_N90_V0.5370.56
50_L191_I0.5370.56
34_Y191_I0.5350.56
18_K162_V0.5340.56
117_G122_H0.5320.55
40_D53_K0.5320.55
40_D55_T0.5320.55
71_E117_G0.5310.55
74_F163_P0.5300.55
65_I193_V0.5290.55
28_R48_G0.5280.55
176_L331_L0.5280.55
63_I234_F0.5280.55
291_Q335_D0.5280.55
95_A135_I0.5270.55
264_V276_R0.5270.55
19_G179_K0.5260.54
261_Q318_T0.5260.54
89_T135_I0.5260.54
171_N174_K0.5250.54
89_T93_W0.5250.54
299_G325_H0.5250.54
214_E300_T0.5250.54
199_N287_G0.5250.54
35_I38_F0.5240.54
68_H325_H0.5230.54
185_I319_I0.5230.54
163_P327_H0.5220.54
254_S293_D0.5210.54
94_W128_A0.5210.54
219_R270_V0.5210.54
269_M324_I0.5190.53
243_D256_M0.5190.53
224_A305_I0.5180.53
277_D280_V0.5170.53
50_L75_M0.5170.53
305_I314_A0.5160.53
181_W185_I0.5140.53
73_G90_V0.5140.53
93_W124_L0.5130.53
60_G204_N0.5130.53
93_W121_P0.5120.53
36_E42_V0.5120.53
262_I280_V0.5100.52
10_M195_R0.5100.52
306_H314_A0.5100.52
47_L223_T0.5100.52
10_M192_D0.5070.52
13_D16_D0.5060.52
120_P240_I0.5060.52
77_T87_F0.5060.52
116_I138_M0.5060.52
22_G160_M0.5050.52
286_A338_N0.5050.52
266_D324_I0.5050.52
186_G291_Q0.5050.52
333_R337_E0.5020.51
78_Q157_P0.5000.51
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4wwvA 4 0.9751 100 0.393 Contact Map
1y0yA 5 0.9197 100 0.412 Contact Map
2wznA 4 0.9307 100 0.419 Contact Map
3wt4A 4 0.9363 100 0.426 Contact Map
2wyrA 4 0.903 100 0.427 Contact Map
3vatA 4 0.9889 100 0.429 Contact Map
2fvgA 1 0.8615 100 0.43 Contact Map
2gljA 6 0.9446 100 0.439 Contact Map
2glfA 4 0.9418 100 0.447 Contact Map
1y7eA 4 0.8476 100 0.458 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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