GREMLIN Database
LRGB - Antiholin-like protein LrgB
UniProt: P94516 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 231 (220)
Sequences: 1921 (1343)
Seq/√Len: 90.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
135_I215_G5.5601.00
136_A154_V4.9021.00
138_P141_K4.1631.00
140_S150_T3.6621.00
128_P140_S3.2311.00
177_P200_G3.1491.00
14_S58_Y3.0831.00
165_G184_L3.0571.00
184_L196_G3.0541.00
161_V188_G2.7521.00
17_A43_L2.6561.00
131_A139_L2.4891.00
193_V207_A2.4581.00
195_V198_E2.3171.00
170_K180_K2.2851.00
113_A118_L2.2461.00
165_G169_L2.1481.00
113_A123_M2.0501.00
17_A40_A2.0291.00
39_V43_L1.9581.00
23_F27_K1.9171.00
21_G39_V1.9041.00
200_G203_E1.8471.00
169_L184_L1.8421.00
180_K203_E1.8321.00
125_S145_G1.7711.00
124_K143_I1.7711.00
59_N66_K1.7381.00
21_G40_A1.7331.00
125_S146_I1.7241.00
102_S214_V1.7211.00
100_A104_C1.7051.00
46_A50_I1.6791.00
20_I24_L1.6661.00
85_D89_K1.6621.00
46_A49_K1.6611.00
90_Y93_Q1.6271.00
17_A44_G1.6241.00
113_A126_M1.5981.00
209_I215_G1.5971.00
10_G53_F1.5901.00
182_L186_T1.5871.00
130_A157_N1.5551.00
167_L171_V1.5421.00
17_A21_G1.5391.00
17_A47_F1.5221.00
99_I217_V1.5031.00
109_V157_N1.4961.00
120_S124_K1.4831.00
110_Y127_L1.4530.99
47_F51_G1.4040.99
111_L115_G1.4040.99
132_T135_I1.3970.99
91_W95_M1.3770.99
59_N62_G1.3720.99
182_L210_A1.3640.99
20_I43_L1.3540.99
102_S106_V1.3380.99
16_A20_I1.3260.99
23_F28_T1.3240.99
182_L206_M1.3230.99
60_N63_E1.3220.99
134_A138_P1.3080.99
42_V46_A1.3070.99
128_P150_T1.3060.99
84_R88_K1.3060.99
106_V222_I1.2570.98
20_I23_F1.2560.98
139_L218_T1.2540.98
59_N63_E1.2490.98
131_A135_I1.2420.98
188_G207_A1.2370.98
111_L114_K1.2310.98
73_T78_I1.2300.98
90_Y206_M1.2240.98
177_P203_E1.2220.98
147_S151_A1.2160.98
133_T155_I1.2070.98
107_T111_L1.2020.98
25_F34_F1.1940.98
129_Q157_N1.1860.98
70_E134_A1.1760.98
155_I159_V1.1730.98
13_V44_G1.1700.98
45_I49_K1.1660.98
149_I153_A1.1610.97
137_L151_A1.1500.97
119_D122_V1.1190.97
48_L55_Y1.1150.97
34_F39_V1.0640.96
169_L174_V1.0560.96
73_T157_N1.0510.95
79_P208_S1.0490.95
106_V127_L1.0480.95
220_L224_V1.0470.95
82_K201_E1.0450.95
196_G200_G1.0450.95
28_T34_F1.0430.95
23_F26_K1.0350.95
157_N188_G1.0240.95
81_Y84_R1.0200.95
137_L147_S1.0190.95
150_T154_V1.0060.94
196_G204_A1.0060.94
57_D62_G0.9930.94
10_G61_G0.9910.94
197_I205_A0.9870.94
122_V125_S0.9840.93
24_L39_V0.9760.93
69_L190_A0.9650.93
110_Y123_M0.9640.93
85_D88_K0.9610.93
7_P61_G0.9540.92
102_S218_T0.9520.92
137_L140_S0.9490.92
35_T39_V0.9440.92
208_S212_V0.9430.92
101_G186_T0.9400.92
106_V221_V0.9340.92
186_T214_V0.9340.92
55_Y74_I0.9190.91
162_Y191_L0.9170.91
193_V204_A0.9140.91
22_T26_K0.9130.91
92_W95_M0.9110.91
98_I214_V0.9090.90
159_V191_L0.9010.90
49_K52_G0.8930.90
109_V129_Q0.8890.89
189_H192_G0.8830.89
122_V146_I0.8820.89
161_V207_A0.8820.89
178_I206_M0.8790.89
157_N160_I0.8710.88
127_L226_V0.8710.88
114_K123_M0.8690.88
180_K199_M0.8690.88
37_L191_L0.8640.88
51_G54_S0.8630.88
26_K29_K0.8590.88
34_F165_G0.8570.88
69_L134_A0.8550.88
19_G23_F0.8540.88
190_A208_S0.8510.87
197_I204_A0.8480.87
96_A100_A0.8480.87
125_S150_T0.8470.87
164_L167_L0.8470.87
176_N179_S0.8360.86
10_G62_G0.8290.86
138_P142_G0.8280.86
158_A161_V0.8240.86
54_S57_D0.8220.85
40_A43_L0.8200.85
32_F35_T0.8150.85
143_I222_I0.8080.84
91_W155_I0.8080.84
35_T38_F0.8000.84
140_S145_G0.7990.84
151_A154_V0.7980.84
57_D60_N0.7950.83
207_A210_A0.7900.83
161_V189_H0.7870.83
94_I182_L0.7790.82
202_V216_V0.7770.82
120_S228_L0.7770.82
76_F129_Q0.7740.82
90_Y178_I0.7740.82
98_I186_T0.7720.82
124_K226_V0.7710.82
18_F22_T0.7680.81
183_A187_S0.7650.81
43_L46_A0.7620.81
139_L222_I0.7610.81
206_M211_V0.7590.81
75_A151_A0.7560.80
116_I216_V0.7520.80
160_I164_L0.7480.80
86_K178_I0.7440.79
28_T32_F0.7410.79
52_G170_K0.7400.79
61_G128_P0.7350.78
25_F134_A0.7350.78
200_G206_M0.7310.78
125_S140_S0.7290.78
114_K228_L0.7280.78
109_V112_L0.7250.77
74_I149_I0.7250.77
126_M153_A0.7240.77
25_F28_T0.7230.77
85_D100_A0.7230.77
224_V227_Q0.7210.77
127_L222_I0.7190.77
97_S206_M0.7190.77
129_Q219_V0.7170.77
13_V47_F0.7170.77
105_S108_I0.7160.77
87_L205_A0.7140.76
131_A218_T0.7120.76
224_V228_L0.7090.76
80_L223_P0.7090.76
134_A147_S0.7090.76
133_T154_V0.7080.76
83_Q202_V0.7040.75
78_I105_S0.7020.75
38_F163_A0.6950.74
16_A52_G0.6940.74
112_L116_I0.6930.74
186_T208_S0.6800.73
97_S105_S0.6800.73
189_H193_V0.6780.73
49_K121_A0.6770.73
124_K145_G0.6760.72
102_S217_V0.6750.72
132_T215_G0.6720.72
86_K202_V0.6700.72
59_N64_I0.6680.72
35_T206_M0.6650.71
164_L168_F0.6570.70
106_V211_V0.6550.70
142_G212_V0.6540.70
166_A170_K0.6490.69
219_V222_I0.6470.69
166_A195_V0.6470.69
73_T218_T0.6440.69
28_T191_L0.6430.69
86_K206_M0.6420.68
40_A44_G0.6400.68
64_I103_I0.6390.68
99_I213_V0.6360.68
74_I79_P0.6350.68
100_A111_L0.6350.68
41_M133_T0.6310.67
77_A131_A0.6280.67
108_I112_L0.6270.67
169_L173_K0.6250.66
157_N189_H0.6230.66
197_I208_S0.6210.66
158_A189_H0.6210.66
76_F197_I0.6190.66
169_L183_A0.6190.66
65_I68_F0.6160.65
23_F164_L0.6150.65
215_G219_V0.6130.65
161_V193_V0.6120.65
97_S144_G0.6120.65
190_A193_V0.6110.65
35_T41_M0.6080.64
98_I210_A0.6070.64
133_T137_L0.6060.64
103_I107_T0.6050.64
22_T129_Q0.6050.64
207_A214_V0.6020.64
23_F29_K0.5990.63
103_I112_L0.5960.63
14_S190_A0.5950.63
7_P10_G0.5950.63
20_I47_F0.5940.63
188_G192_G0.5940.63
195_V207_A0.5930.62
10_G97_S0.5900.62
195_V199_M0.5900.62
24_L99_I0.5890.62
139_L219_V0.5850.61
105_S183_A0.5840.61
188_G221_V0.5840.61
98_I125_S0.5830.61
104_C108_I0.5800.61
107_T110_Y0.5760.60
42_V85_D0.5760.60
43_L144_G0.5730.60
85_D175_K0.5730.60
8_Y19_G0.5720.60
132_T166_A0.5720.60
70_E129_Q0.5670.59
195_V201_E0.5660.59
102_S187_S0.5660.59
78_I209_I0.5650.59
191_L194_A0.5650.59
133_T212_V0.5640.59
190_A198_E0.5640.59
111_L121_A0.5590.58
87_L96_A0.5590.58
211_V215_G0.5590.58
55_Y152_F0.5590.58
131_A154_V0.5570.58
87_L206_M0.5560.57
61_G207_A0.5540.57
7_P67_F0.5540.57
178_I210_A0.5520.57
52_G56_A0.5520.57
83_Q137_L0.5520.57
18_F176_N0.5510.57
35_T188_G0.5510.57
111_L228_L0.5500.57
103_I171_V0.5480.56
13_V43_L0.5450.56
114_K120_S0.5450.56
99_I221_V0.5440.56
139_L226_V0.5440.56
133_T150_T0.5430.56
57_D171_V0.5370.55
110_Y226_V0.5330.54
184_L207_A0.5310.54
52_G156_F0.5310.54
180_K213_V0.5310.54
25_F38_F0.5300.54
122_V223_P0.5300.54
135_I139_L0.5280.54
166_A215_G0.5280.54
76_F193_V0.5270.54
24_L34_F0.5250.53
109_V208_S0.5200.53
190_A211_V0.5200.53
96_A226_V0.5180.52
9_F51_G0.5180.52
85_D111_L0.5160.52
15_L19_G0.5150.52
162_Y194_A0.5140.52
34_F94_I0.5130.52
162_Y208_S0.5110.51
8_Y61_G0.5100.51
210_A219_V0.5060.51
155_I191_L0.5050.51
199_M203_E0.5050.51
80_L113_A0.5040.50
157_N214_V0.5040.50
13_V16_A0.5020.50
29_K95_M0.5010.50
136_A151_A0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3zuxA 1 0.7359 94.6 0.916 Contact Map
4n7wA 2 0.71 91.5 0.925 Contact Map
4czbA 2 0.9654 63.9 0.944 Contact Map
4bwzA 2 0.9264 38.5 0.952 Contact Map
4cz8A 2 0.9134 38 0.952 Contact Map
2a65A 2 0.3896 37.7 0.952 Contact Map
2zy9A 2 0.7922 31.2 0.954 Contact Map
3qe7A 2 0.9091 15.3 0.96 Contact Map
4r0cA 3 0.7532 8.4 0.965 Contact Map
4u9nA 2 0.7013 7.6 0.965 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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