GREMLIN Database
LRGA - Antiholin-like protein LrgA
UniProt: P94515 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 146 (116)
Sequences: 1784 (1351)
Seq/√Len: 125.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
19_I47_L4.5921.00
46_L50_L3.1071.00
108_A112_F2.7781.00
111_L114_Q2.7751.00
107_G111_L2.5411.00
110_G114_Q2.3161.00
27_A39_V2.2961.00
42_V46_L2.2661.00
81_M84_L1.9921.00
22_V47_L1.9111.00
19_I43_L1.8431.00
18_V22_V1.8251.00
93_Q97_V1.8241.00
12_Q61_L1.8071.00
54_K57_Q1.7961.00
20_M24_N1.7751.00
39_V43_L1.7531.00
100_L104_I1.7421.00
112_F115_L1.7251.00
23_S36_A1.7181.00
37_S72_L1.7111.00
87_M94_I1.6901.00
24_N28_A1.6671.00
90_Y93_Q1.6591.00
41_L77_G1.5871.00
20_M37_S1.5771.00
55_L58_V1.4641.00
43_L47_L1.4531.00
35_P76_S1.4511.00
115_L119_L1.4501.00
80_V83_S1.4491.00
26_I29_I1.4451.00
111_L115_L1.4331.00
51_K54_K1.4061.00
11_T57_Q1.3901.00
25_M29_I1.3621.00
41_L113_S1.2771.00
85_G88_Q1.2731.00
96_L100_L1.2571.00
83_S86_V1.2541.00
55_L59_E1.2491.00
19_I23_S1.2481.00
42_V64_S1.1620.99
47_L52_V1.1340.99
27_A30_V1.1110.99
116_I119_L1.1100.99
84_L88_Q1.1100.99
115_L118_S1.1010.99
16_F61_L1.0960.99
11_T14_F1.0960.99
105_L109_T1.0790.99
113_S117_L1.0740.99
119_L122_K1.0700.99
67_S76_S1.0680.99
85_G89_Q1.0640.98
47_L53_I1.0430.98
26_I43_L1.0320.98
59_E63_T1.0170.98
119_L123_R1.0070.98
23_S39_V1.0030.98
33_P38_V0.9930.98
13_A61_L0.9850.97
109_T113_S0.9730.97
27_A36_A0.9620.97
12_Q19_I0.9550.97
24_N36_A0.9520.97
22_V121_G0.9460.97
41_L58_V0.9450.97
26_I39_V0.9400.97
27_A31_P0.9280.96
17_A79_S0.9220.96
86_V90_Y0.9070.96
26_I30_V0.8870.95
44_L53_I0.8820.95
23_S79_S0.8790.95
90_Y94_I0.8680.95
38_V70_G0.8410.94
26_I31_P0.8360.94
15_I18_V0.8300.93
25_M28_A0.8300.93
26_I59_E0.8280.93
120_S123_R0.8140.93
58_V66_T0.8110.93
13_A23_S0.8030.92
13_A101_A0.8010.92
66_T69_I0.7970.92
82_N85_G0.7950.92
49_C52_V0.7830.91
47_L50_L0.7760.91
98_I105_L0.7740.91
37_S45_F0.7670.90
38_V83_S0.7650.90
42_V45_F0.7640.90
78_I81_M0.7630.90
81_M99_L0.7620.90
103_I107_G0.7480.89
70_G74_V0.7400.89
8_G60_T0.7380.89
17_A109_T0.7350.88
11_T15_I0.7330.88
102_T105_L0.7250.88
18_V115_L0.7220.88
20_M35_P0.7180.87
46_L112_F0.7140.87
45_F49_C0.7060.86
73_F76_S0.7050.86
23_S41_L0.7010.86
53_I57_Q0.6990.86
68_L71_F0.6940.85
37_S106_L0.6920.85
51_K55_L0.6910.85
12_Q64_S0.6830.85
109_T117_L0.6800.84
55_L90_Y0.6790.84
17_A23_S0.6740.84
52_V55_L0.6720.84
34_I79_S0.6690.83
58_V62_G0.6660.83
76_S87_M0.6650.83
86_V94_I0.6640.83
92_L99_L0.6580.82
38_V66_T0.6550.82
96_L122_K0.6540.82
77_G84_L0.6530.82
102_T106_L0.6530.82
65_L70_G0.6520.82
70_G77_G0.6500.81
37_S98_I0.6290.79
70_G101_A0.6270.79
114_Q119_L0.6260.79
11_T56_E0.6220.79
36_A39_V0.6220.79
98_I102_T0.6210.78
113_S116_I0.6210.78
40_G58_V0.6120.77
22_V43_L0.6100.77
97_V106_L0.6060.77
37_S66_T0.6050.77
88_Q122_K0.6010.76
70_G105_L0.5990.76
38_V69_I0.5940.75
78_I85_G0.5900.75
9_F80_V0.5830.74
27_A32_I0.5750.73
9_F60_T0.5670.72
19_I44_L0.5660.72
31_P42_V0.5660.72
112_F116_I0.5640.72
71_F86_V0.5610.71
59_E79_S0.5580.71
12_Q60_T0.5560.71
64_S69_I0.5500.70
53_I69_I0.5480.69
71_F74_V0.5380.68
77_G83_S0.5370.68
12_Q48_L0.5360.68
50_L55_L0.5350.68
19_I22_V0.5340.67
80_V84_L0.5330.67
47_L51_K0.5330.67
41_L103_I0.5330.67
77_G80_V0.5320.67
20_M110_G0.5250.66
16_F23_S0.5220.66
15_I19_I0.5220.66
19_I87_M0.5170.65
30_V39_V0.5160.65
38_V78_I0.5140.65
57_Q61_L0.5080.64
70_G93_Q0.5070.63
89_Q100_L0.5030.63
69_I74_V0.5030.63
12_Q20_M0.5010.63
54_K100_L0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2kluA 1 0.411 61.7 0.91 Contact Map
3w9iA 3 0.8356 61.7 0.91 Contact Map
4mt1A 3 0.8082 59.9 0.911 Contact Map
4dx5A 3 0.8904 53.5 0.915 Contact Map
4cz8A 2 0.9521 46.8 0.918 Contact Map
4k0jA 3 0.7877 33.4 0.925 Contact Map
3aqpA 1 0.7877 29.7 0.927 Contact Map
2kncA 1 0.363 26.9 0.928 Contact Map
2m20A 2 0.3425 20.6 0.932 Contact Map
4czbA 2 0.9521 19.6 0.933 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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