GREMLIN Database
LYTT - Sensory transduction protein LytT
UniProt: P94514 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 241 (203)
Sequences: 61631 (46610)
Seq/√Len: 3271.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
14_R32_E4.0441.00
14_R34_E3.6651.00
18_A32_E3.4181.00
7_V39_A2.7651.00
40_F68_R2.7621.00
36_I60_E2.6221.00
31_N48_P2.5971.00
60_E68_R2.4661.00
37_E59_G2.4481.00
33_A42_Q2.3421.00
35_N59_G2.2681.00
3_R31_N2.2531.00
20_L106_E2.2301.00
31_N42_Q2.1981.00
88_A108_R2.1441.00
80_F96_A2.1081.00
18_A22_K2.0611.00
3_R29_E2.0531.00
44_M72_M2.0391.00
56_D84_Y2.0241.00
66_A78_I1.9821.00
24_T110_Q1.9461.00
31_N46_Q1.9441.00
98_D112_T1.8631.00
53_L65_I1.8111.00
5_L33_A1.7991.00
136_K149_D1.7911.00
34_E38_S1.7511.00
51_L76_P1.6931.00
35_N38_S1.6921.00
36_I65_I1.6911.00
61_N64_D1.6871.00
42_Q46_Q1.6321.00
97_L119_V1.6171.00
80_F91_A1.5921.00
66_A80_F1.5731.00
40_F65_I1.5511.00
60_E64_D1.5301.00
164_N168_F1.5061.00
195_R198_V1.5051.00
37_E60_E1.4771.00
55_V80_F1.4651.00
43_M69_L1.4581.00
8_D14_R1.4441.00
200_N203_Y1.4381.00
68_R71_K1.4371.00
64_D67_K1.4341.00
176_D198_V1.4091.00
84_Y87_Y1.4061.00
68_R72_M1.4031.00
53_L66_A1.3931.00
180_V184_K1.3911.00
145_I152_D1.3751.00
55_V63_F1.3671.00
70_K97_L1.3591.00
138_A147_I1.3401.00
42_Q45_D1.3401.00
7_V57_L1.3391.00
42_Q48_P1.3351.00
21_L113_L1.3161.00
40_F60_E1.3121.00
9_D54_D1.3021.00
11_M34_E1.2921.00
3_R46_Q1.2811.00
50_L113_L1.2741.00
67_K94_V1.2671.00
33_A39_A1.2581.00
5_L39_A1.2451.00
133_G138_A1.2381.00
63_F90_K1.2381.00
41_D45_D1.2371.00
93_E114_K1.2321.00
110_Q114_K1.2291.00
79_V116_Y1.2211.00
147_I152_D1.1911.00
39_A65_I1.1781.00
141_V164_N1.1631.00
5_L48_P1.1541.00
38_S41_D1.1541.00
40_F44_M1.1441.00
67_K90_K1.1421.00
6_I17_L1.1261.00
37_E41_D1.1241.00
165_V184_K1.1231.00
24_T114_K1.1111.00
88_A101_T1.1091.00
169_D172_Y1.1071.00
63_F91_A1.0951.00
140_S143_E1.0891.00
97_L116_Y1.0691.00
38_S42_Q1.0651.00
77_A119_V1.0561.00
73_K76_P1.0481.00
51_L78_I1.0321.00
7_V51_L1.0231.00
11_M15_D1.0181.00
170_H174_V1.0181.00
131_H138_A1.0171.00
52_F109_I1.0161.00
90_K94_V1.0161.00
51_L69_L1.0131.00
199_V202_E1.0131.00
12_L16_E1.0131.00
39_A43_M1.0081.00
158_T161_G0.9951.00
44_M73_K0.9941.00
17_L81_A0.9891.00
43_M73_K0.9831.00
66_A94_V0.9821.00
3_R28_M0.9791.00
55_V61_N0.9701.00
93_E111_Q0.9681.00
90_K93_E0.9681.00
17_L109_I0.9601.00
57_L65_I0.9501.00
15_D32_E0.9491.00
79_V112_T0.9481.00
98_D115_K0.9481.00
10_E13_A0.9481.00
108_R112_T0.9431.00
33_A38_S0.9371.00
77_A123_I0.9291.00
89_L93_E0.9281.00
81_A104_F0.9091.00
161_G164_N0.9081.00
5_L42_Q0.9061.00
175_S180_V0.9051.00
15_D18_A0.9051.00
165_V174_V0.8931.00
64_D68_R0.8911.00
85_D101_T0.8891.00
139_L160_D0.8881.00
89_L107_E0.8851.00
63_F94_V0.8841.00
53_L78_I0.8841.00
165_V169_D0.8841.00
56_D83_A0.8831.00
52_F81_A0.8771.00
106_E110_Q0.8751.00
50_L117_K0.8721.00
18_A30_I0.8711.00
55_V84_Y0.8661.00
139_L167_T0.8661.00
7_V33_A0.8631.00
19_Y23_R0.8591.00
16_E20_L0.8591.00
28_M114_K0.8551.00
3_R48_P0.8521.00
116_Y119_V0.8461.00
65_I69_L0.8421.00
87_Y90_K0.8341.00
41_D44_M0.8301.00
5_L31_N0.8201.00
144_S161_G0.8201.00
111_Q115_K0.8161.00
202_E206_E0.8111.00
11_M14_R0.8091.00
36_I40_F0.8061.00
77_A120_N0.7971.00
66_A96_A0.7941.00
69_L78_I0.7931.00
53_L80_F0.7921.00
196_S200_N0.7881.00
8_D57_L0.7861.00
6_I14_R0.7851.00
92_F112_T0.7841.00
115_K118_K0.7841.00
7_V65_I0.7771.00
75_P123_I0.7771.00
82_T88_A0.7741.00
104_F109_I0.7701.00
4_V28_M0.7691.00
5_L43_M0.7691.00
130_S142_G0.7651.00
147_I150_T0.7631.00
43_M76_P0.7631.00
15_D19_Y0.7621.00
91_A96_A0.7531.00
107_E111_Q0.7531.00
179_V183_K0.7461.00
157_G161_G0.7411.00
108_R111_Q0.7341.00
14_R18_A0.7341.00
4_V50_L0.7311.00
180_V183_K0.7281.00
13_A104_F0.7221.00
77_A97_L0.7221.00
69_L74_H0.7171.00
60_E65_I0.7171.00
159_E207_I0.7161.00
158_T186_P0.7131.00
43_M48_P0.7131.00
88_A105_D0.7131.00
148_V209_P0.7111.00
52_F113_L0.7101.00
136_K148_V0.7081.00
36_I59_G0.7061.00
112_T116_Y0.7051.00
67_K71_K0.7031.00
83_A103_P0.6981.00
43_M51_L0.6931.00
142_G172_Y0.6921.00
120_N124_V0.6911.00
55_V87_Y0.6901.00
6_I18_A0.6881.00
144_S160_D0.6841.00
22_K25_N0.6821.00
28_M110_Q0.6801.00
93_E108_R0.6791.00
105_D108_R0.6781.00
6_I30_I0.6771.00
3_R49_D0.6711.00
6_I32_E0.6701.00
52_F79_V0.6671.00
148_V151_K0.6641.00
140_S145_I0.6621.00
77_A116_Y0.6621.00
131_H140_S0.6611.00
161_G165_V0.6611.00
165_V168_F0.6591.00
141_V168_F0.6561.00
149_D152_D0.6531.00
55_V91_A0.6521.00
33_A36_I0.6491.00
165_V181_I0.6471.00
40_F43_M0.6461.00
93_E98_D0.6461.00
7_V53_L0.6461.00
44_M68_R0.6391.00
184_K187_D0.6351.00
25_N28_M0.6321.00
114_K118_K0.6321.00
162_H166_K0.6311.00
43_M65_I0.6291.00
188_S191_I0.6271.00
162_H165_V0.6251.00
4_V21_L0.6241.00
199_V203_Y0.6231.00
13_A16_E0.6211.00
117_K120_N0.6181.00
20_L110_Q0.6181.00
139_L146_V0.6091.00
79_V98_D0.6081.00
69_L76_P0.5971.00
7_V36_I0.5971.00
182_E186_P0.5961.00
20_L24_T0.5881.00
137_L148_V0.5861.00
29_E46_Q0.5851.00
75_P122_D0.5831.00
70_K76_P0.5791.00
193_V196_S0.5791.00
172_Y175_S0.5781.00
133_G136_K0.5781.00
160_D164_N0.5761.00
89_L92_F0.5761.00
43_M74_H0.5741.00
194_H197_F0.5691.00
114_K117_K0.5691.00
53_L57_L0.5671.00
182_E187_D0.5651.00
55_V94_V0.5631.00
117_K121_R0.5611.00
66_A70_K0.5611.00
111_Q114_K0.5581.00
204_I208_Q0.5571.00
113_L116_Y0.5531.00
80_F94_V0.5521.00
176_D180_V0.5521.00
139_L164_N0.5511.00
115_K119_V0.5481.00
195_R199_V0.5451.00
167_T170_H0.5451.00
113_L117_K0.5441.00
203_Y206_E0.5441.00
182_E192_R0.5411.00
50_L77_A0.5401.00
50_L116_Y0.5401.00
16_E19_Y0.5381.00
120_N123_I0.5371.00
164_N167_T0.5361.00
92_F96_A0.5361.00
159_E162_H0.5321.00
107_E110_Q0.5321.00
47_K74_H0.5291.00
56_D86_Q0.5281.00
4_V52_F0.5281.00
47_K73_K0.5261.00
169_D174_V0.5261.00
17_L104_F0.5251.00
88_A92_F0.5251.00
156_A207_I0.5241.00
163_V166_K0.5231.00
145_I148_V0.5201.00
134_Q167_T0.5181.00
179_V194_H0.5161.00
12_L15_D0.5151.00
63_F87_Y0.5121.00
172_Y180_V0.5101.00
28_M117_K0.5081.00
5_L51_L0.5071.00
146_V153_I0.5061.00
119_V123_I0.5031.00
188_S192_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4cbvA 2 0.971 100 0.269 Contact Map
3r0jA 2 0.9046 100 0.365 Contact Map
1kgsA 1 0.9004 100 0.373 Contact Map
1ys7A 2 0.9295 100 0.376 Contact Map
4g97A 1 0.5311 100 0.379 Contact Map
3n0rA 1 0.4979 100 0.382 Contact Map
2oqrA 2 0.9253 100 0.383 Contact Map
3breA 4 0.971 100 0.393 Contact Map
4kfcA 2 0.9087 100 0.395 Contact Map
3q9sA 1 0.8631 99.9 0.398 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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