LYTS - BACSU - GREMLIN Contacts

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LYTS - Sensor protein LytS

UniProt:	P94513	Sequences: MIHLMIMMLERVGIIVILGFILAHTKLFRQALQNQDGYKGKAILISIFSLFSIISNYTGIEIQRNMIVNNDWVFTIDPSGSIANTRILGVEIGGLLGGPFVGAGIGILAGLHRFSLGGSTALSCAVSSILAGVLAGLIGRYFTKRYRMPTPRIAALVGIGMESLQMIIILLMAKPFSDAWELVSMIGIPMILINGTGSFIFLSIIQAIIRKEEQARALETHRVLTIADQTLPFFRQGLNENSCKSVAAIIHKLTGTDAVSLTDKEKILAHVGAGMDHHIPSKSLITGLSKKVIKTGHIMKAISQEEIECTHAECPLHAAIVLPLTSNGNTIGTLKMYFKSPAGLSQVEEELAEGLAMLFSTQLELGEAELQSKLLKDAEIKALQAQVNPHFLFNAINTISALCRTDVEKTRKLLLQLSVYFRSNLQGARQLLIPLSKELNHLNAYLSLEQARFPGKYKIELNIDSRLEQIEIPPFVLQVLVENALRHAFPKKQDICKVTVCVLSDDASVYMKVADNGRGIPPDVLPELGKKPFPSKEGTGTALYNLNQRLIGLFGQQAALHISSEVHKGTEVSFQVPMQQMKEGEEHAQGVNS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	593 (504)
Sequences:	4439 (4037)
Seq/√Len:	179.8

ECOLI - YPDA YEHU KDPD BARA RCSD RCSC TORS
BACSU - LYTS COMP
HALSA - Q9HQG5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
514_A	571_E	4.640	1.00
565_E	568_K	4.410	1.00
546_L	560_L	4.083	1.00
511_M	574_F	4.000	1.00
476_V	550_L	3.763	1.00
561_H	573_S	3.667	1.00
547_N	551_I	3.658	1.00
525_L	562_I	3.610	1.00
510_Y	575_Q	3.512	1.00
521_P	524_V	3.497	1.00
550_L	574_F	3.458	1.00
562_I	572_V	3.426	1.00
501_C	512_K	3.390	1.00
496_C	516_N	3.308	1.00
362_Q	365_L	3.306	1.00
476_V	549_R	3.160	1.00
512_K	573_S	3.131	1.00
433_I	468_E	3.056	1.00
515_D	519_G	3.020	1.00
549_R	553_L	2.976	1.00
468_E	553_L	2.855	1.00
434_P	437_K	2.829	1.00
373_K	377_D	2.828	1.00
564_S	567_H	2.724	1.00
366_G	369_E	2.684	1.00
508_S	575_Q	2.625	1.00
512_K	571_E	2.600	1.00
359_F	362_Q	2.574	1.00
501_C	514_A	2.497	1.00
476_V	546_L	2.480	1.00
377_D	381_K	2.454	1.00
564_S	570_T	2.427	1.00
376_K	380_I	2.391	1.00
497_K	516_N	2.354	1.00
477_L	511_M	2.292	1.00
556_Q	561_H	2.277	1.00
550_L	555_G	2.261	1.00
510_Y	573_S	2.239	1.00
503_L	512_K	2.237	1.00
499_T	514_A	2.224	1.00
373_K	376_K	2.221	1.00
564_S	568_K	2.206	1.00
460_E	499_T	2.202	1.00
520_I	524_V	2.198	1.00
525_L	564_S	2.177	1.00
520_I	528_L	2.146	1.00
345_S	348_E	2.133	1.00
362_Q	366_G	2.131	1.00
359_F	363_L	2.105	1.00
241_N	247_A	2.081	1.00
524_V	527_E	2.046	1.00
458_K	497_K	2.037	1.00
505_D	510_Y	1.999	1.00
377_D	380_I	1.994	1.00
248_A	252_K	1.975	1.00
373_K	380_I	1.961	1.00
344_L	348_E	1.930	1.00
221_H	225_T	1.909	1.00
372_S	375_L	1.902	1.00
563_S	573_S	1.886	1.00
521_P	566_V	1.872	1.00
562_I	570_T	1.861	1.00
374_L	377_D	1.849	1.00
462_N	501_C	1.847	1.00
476_V	574_F	1.847	1.00
355_L	359_F	1.841	1.00
431_L	470_I	1.814	1.00
563_S	571_E	1.811	1.00
389_P	394_N	1.802	1.00
468_E	473_P	1.788	1.00
481_V	500_V	1.769	1.00
375_L	379_E	1.761	1.00
242_S	247_A	1.747	1.00
243_C	247_A	1.740	1.00
529_G	560_L	1.735	1.00
323_P	326_S	1.724	1.00
319_A	323_P	1.720	1.00
368_A	371_Q	1.720	1.00
332_G	336_M	1.718	1.00
391_F	475_F	1.716	1.00
392_L	410_T	1.714	1.00
217_A	220_T	1.707	1.00
509_V	578_M	1.690	1.00
352_A	362_Q	1.686	1.00
365_L	369_E	1.672	1.00
223_V	227_A	1.660	1.00
380_I	384_Q	1.653	1.00
551_I	556_Q	1.646	1.00
220_T	224_L	1.640	1.00
482_E	486_R	1.613	1.00
355_L	358_L	1.610	1.00
391_F	395_A	1.591	1.00
503_L	510_Y	1.590	1.00
522_P	525_L	1.589	1.00
450_Q	453_F	1.552	1.00
472_I	475_F	1.546	1.00
533_F	536_K	1.544	1.00
449_E	452_R	1.542	1.00
392_L	413_L	1.541	1.00
556_Q	575_Q	1.535	1.00
504_S	578_M	1.533	1.00
376_K	381_K	1.521	1.00
363_L	366_G	1.513	1.00
360_S	363_L	1.489	1.00
352_A	355_L	1.488	1.00
365_L	368_A	1.482	1.00
348_E	351_L	1.477	1.00
220_T	223_V	1.477	1.00
49_S	52_S	1.474	1.00
393_F	418_S	1.463	1.00
244_K	247_A	1.463	1.00
354_G	359_F	1.449	1.00
361_T	365_L	1.448	1.00
361_T	364_E	1.438	1.00
502_V	511_M	1.432	1.00
354_G	362_Q	1.430	1.00
534_P	537_E	1.427	1.00
378_A	381_K	1.427	1.00
460_E	497_K	1.418	1.00
332_G	337_Y	1.417	1.00
520_I	525_L	1.415	1.00
348_E	352_A	1.407	1.00
394_N	410_T	1.405	1.00
354_G	358_L	1.403	1.00
541_T	545_N	1.391	1.00
463_I	467_L	1.389	1.00
256_T	260_S	1.387	1.00
529_G	572_V	1.383	1.00
416_Q	472_I	1.380	1.00
441_H	474_P	1.378	1.00
332_G	339_K	1.367	1.00
411_R	415_L	1.365	1.00
387_V	417_L	1.361	1.00
401_A	405_T	1.354	1.00
487_H	536_K	1.342	1.00
480_L	572_V	1.340	1.00
346_Q	349_E	1.339	1.00
357_M	361_T	1.335	1.00
435_L	511_M	1.334	1.00
393_F	401_A	1.331	1.00
358_L	362_Q	1.329	1.00
442_L	481_V	1.326	1.00
493_Q	516_N	1.311	1.00
323_P	332_G	1.311	1.00
332_G	335_K	1.310	1.00
356_A	362_Q	1.304	1.00
373_K	381_K	1.303	1.00
436_S	440_N	1.293	1.00
510_Y	561_H	1.288	1.00
250_I	254_T	1.287	1.00
83_A	87_I	1.277	1.00
375_L	378_A	1.273	1.00
472_I	549_R	1.270	1.00
86_R	89_G	1.267	1.00
323_P	336_M	1.266	1.00
410_T	413_L	1.260	1.00
328_G	331_I	1.257	1.00
352_A	356_A	1.252	1.00
247_A	250_I	1.247	1.00
246_V	250_I	1.246	1.00
290_K	294_K	1.239	1.00
358_L	361_T	1.232	1.00
348_E	355_L	1.230	1.00
247_A	251_H	1.221	1.00
515_D	569_G	1.214	1.00
398_T	402_L	1.213	1.00
561_H	574_F	1.212	1.00
477_L	481_V	1.212	1.00
389_P	395_A	1.202	1.00
42_A	45_I	1.198	1.00
353_E	357_M	1.197	1.00
400_S	411_R	1.197	1.00
372_S	376_K	1.190	1.00
272_G	275_M	1.189	1.00
374_L	380_I	1.188	1.00
373_K	379_E	1.188	1.00
433_I	473_P	1.184	1.00
345_S	349_E	1.184	1.00
139_G	142_F	1.173	1.00
493_Q	496_C	1.172	1.00
165_Q	169_I	1.171	1.00
391_F	413_L	1.169	1.00
362_Q	368_A	1.165	1.00
366_G	370_L	1.164	1.00
224_L	228_D	1.161	1.00
317_H	323_P	1.161	1.00
455_G	459_I	1.160	1.00
336_M	339_K	1.155	1.00
393_F	411_R	1.149	1.00
550_L	576_V	1.146	1.00
137_L	140_R	1.145	1.00
396_I	414_L	1.144	1.00
544_Y	548_Q	1.140	1.00
367_E	371_Q	1.130	1.00
327_N	331_I	1.130	1.00
436_S	502_V	1.121	1.00
225_T	229_Q	1.120	1.00
533_F	537_E	1.116	1.00
520_I	564_S	1.116	1.00
384_Q	389_P	1.115	1.00
360_S	364_E	1.115	1.00
532_P	536_K	1.113	1.00
133_V	139_G	1.110	1.00
480_L	574_F	1.108	1.00
532_P	535_S	1.108	1.00
469_Q	472_I	1.103	1.00
518_R	536_K	1.100	1.00
350_E	354_G	1.100	1.00
351_L	356_A	1.098	1.00
381_K	384_Q	1.096	1.00
257_D	260_S	1.095	1.00
528_L	562_I	1.094	1.00
333_T	337_Y	1.094	1.00
332_G	340_S	1.092	1.00
359_F	365_L	1.090	1.00
462_N	499_T	1.087	1.00
249_I	253_L	1.084	1.00
389_P	393_F	1.078	1.00
354_G	357_M	1.070	1.00
464_D	467_L	1.070	1.00
445_Y	449_E	1.067	1.00
393_F	410_T	1.064	1.00
221_H	224_L	1.059	1.00
241_N	244_K	1.058	1.00
487_H	534_P	1.058	1.00
378_A	382_A	1.056	1.00
255_G	260_S	1.055	1.00
341_P	345_S	1.055	1.00
358_L	365_L	1.053	1.00
401_A	475_F	1.053	1.00
344_L	352_A	1.051	1.00
386_Q	389_P	1.051	1.00
271_V	274_G	1.048	1.00
80_G	87_I	1.041	1.00
223_V	226_I	1.027	0.99
356_A	359_F	1.027	0.99
318_A	323_P	1.022	0.99
519_G	569_G	1.020	0.99
323_P	331_I	1.019	0.99
327_N	330_T	1.016	0.99
135_A	141_Y	1.016	0.99
123_S	131_A	1.013	0.99
381_K	386_Q	1.011	0.99
132_G	137_L	1.009	0.99
520_I	570_T	1.008	0.99
395_A	545_N	1.007	0.99
532_P	537_E	1.006	0.99
348_E	356_A	1.006	0.99
213_E	216_R	1.005	0.99
447_S	451_A	1.002	0.99
438_E	473_P	1.001	0.99
77_D	80_G	0.999	0.99
54_I	58_T	0.998	0.99
463_I	502_V	0.996	0.99
247_A	259_V	0.988	0.99
499_T	516_N	0.980	0.99
422_R	539_T	0.979	0.99
354_G	365_L	0.977	0.99
555_G	577_P	0.972	0.99
502_V	509_V	0.967	0.99
162_E	169_I	0.965	0.99
359_F	366_G	0.964	0.99
244_K	248_A	0.962	0.99
529_G	562_I	0.955	0.99
328_G	333_T	0.955	0.99
409_K	474_P	0.955	0.99
435_L	509_V	0.954	0.99
400_S	408_E	0.951	0.99
352_A	359_F	0.950	0.99
392_L	396_I	0.950	0.99
59_G	63_Q	0.947	0.99
394_N	411_R	0.946	0.99
106_G	110_G	0.946	0.99
394_N	401_A	0.939	0.99
380_I	383_L	0.931	0.99
485_L	498_V	0.931	0.99
162_E	165_Q	0.930	0.99
555_G	576_V	0.929	0.99
394_N	487_H	0.929	0.99
396_I	418_S	0.927	0.99
475_F	545_N	0.924	0.99
376_K	379_E	0.923	0.99
333_T	340_S	0.916	0.99
348_E	354_G	0.916	0.99
386_Q	487_H	0.913	0.99
223_V	228_D	0.912	0.99
181_E	185_M	0.912	0.99
247_A	260_S	0.912	0.99
164_L	168_I	0.902	0.99
394_N	534_P	0.901	0.99
493_Q	553_L	0.899	0.99
341_P	344_L	0.897	0.99
230_T	233_F	0.897	0.99
349_E	353_E	0.897	0.99
379_E	531_K	0.894	0.99
329_N	332_G	0.893	0.99
392_L	414_L	0.892	0.99
352_A	358_L	0.890	0.99
291_K	295_T	0.888	0.99
247_A	253_L	0.887	0.99
58_T	61_E	0.887	0.99
137_L	141_Y	0.887	0.99
288_L	292_V	0.886	0.98
57_Y	61_E	0.884	0.98
378_A	391_F	0.880	0.98
45_I	52_S	0.878	0.98
383_L	386_Q	0.877	0.98
258_A	262_T	0.876	0.98
382_A	386_Q	0.874	0.98
419_V	423_S	0.870	0.98
45_I	49_S	0.869	0.98
325_T	331_I	0.867	0.98
356_A	361_T	0.866	0.98
166_M	169_I	0.866	0.98
343_G	349_E	0.866	0.98
480_L	546_L	0.865	0.98
271_V	277_H	0.862	0.98
163_S	167_I	0.861	0.98
247_A	255_G	0.860	0.98
386_Q	394_N	0.860	0.98
438_E	442_L	0.859	0.98
57_Y	60_I	0.857	0.98
474_P	478_Q	0.855	0.98
347_V	352_A	0.854	0.98
213_E	217_A	0.852	0.98
334_L	337_Y	0.849	0.98
385_A	395_A	0.846	0.98
123_S	126_V	0.845	0.98
127_S	131_A	0.842	0.98
527_E	530_K	0.841	0.98
154_A	158_G	0.835	0.98
237_G	247_A	0.834	0.98
241_N	245_S	0.831	0.98
123_S	127_S	0.831	0.98
162_E	166_M	0.831	0.98
84_N	87_I	0.829	0.98
137_L	142_F	0.828	0.98
195_G	203_S	0.825	0.98
284_L	289_S	0.825	0.98
391_F	478_Q	0.824	0.98
505_D	575_Q	0.819	0.97
321_V	333_T	0.817	0.97
376_K	486_R	0.816	0.97
135_A	139_G	0.815	0.97
153_I	157_V	0.809	0.97
80_G	83_A	0.807	0.97
79_S	83_A	0.807	0.97
230_T	235_R	0.805	0.97
202_L	206_Q	0.804	0.97
400_S	403_C	0.803	0.97
391_F	394_N	0.803	0.97
391_F	545_N	0.802	0.97
321_V	335_K	0.799	0.97
274_G	278_H	0.794	0.97
482_E	487_H	0.793	0.97
442_L	445_Y	0.791	0.97
364_E	368_A	0.789	0.97
550_L	553_L	0.788	0.97
349_E	352_A	0.788	0.97
83_A	91_E	0.787	0.97
518_R	564_S	0.787	0.97
83_A	86_R	0.785	0.97
132_G	136_G	0.785	0.97
528_L	572_V	0.785	0.97
379_E	382_A	0.783	0.97
518_R	570_T	0.782	0.97
418_S	422_R	0.780	0.97
203_S	206_Q	0.779	0.97
363_L	369_E	0.779	0.97
74_F	77_D	0.779	0.97
391_F	472_I	0.777	0.97
438_E	474_P	0.776	0.97
525_L	529_G	0.775	0.97
263_D	266_K	0.770	0.96
273_A	276_D	0.770	0.96
487_H	516_N	0.765	0.96
376_K	384_Q	0.765	0.96
250_I	253_L	0.764	0.96
289_S	293_I	0.762	0.96
102_G	113_R	0.762	0.96
351_L	355_L	0.762	0.96
511_M	576_V	0.761	0.96
389_P	486_R	0.761	0.96
334_L	339_K	0.760	0.96
317_H	320_I	0.759	0.96
328_G	340_S	0.759	0.96
91_E	95_L	0.759	0.96
445_Y	448_L	0.758	0.96
337_Y	340_S	0.755	0.96
550_L	560_L	0.755	0.96
161_M	165_Q	0.754	0.96
384_Q	486_R	0.749	0.96
121_A	124_C	0.748	0.96
323_P	327_N	0.747	0.96
486_R	534_P	0.746	0.96
195_G	202_L	0.746	0.96
79_S	82_I	0.745	0.96
205_I	208_I	0.745	0.96
381_K	531_K	0.745	0.96
522_P	565_E	0.744	0.96
353_E	358_L	0.744	0.96
381_K	389_P	0.742	0.96
148_M	151_P	0.742	0.96
457_Y	461_L	0.742	0.96
391_F	531_K	0.740	0.95
243_C	246_V	0.740	0.95
422_R	425_L	0.738	0.95
139_G	143_T	0.736	0.95
219_E	222_R	0.736	0.95
271_V	278_H	0.735	0.95
242_S	250_I	0.734	0.95
383_L	389_P	0.733	0.95
353_E	356_A	0.732	0.95
215_A	218_L	0.727	0.95
86_R	92_I	0.727	0.95
44_L	47_I	0.725	0.95
440_N	444_A	0.724	0.95
102_G	110_G	0.723	0.95
110_G	114_F	0.723	0.95
245_S	254_T	0.721	0.95
126_V	133_V	0.719	0.95
211_K	214_Q	0.719	0.95
134_L	138_I	0.717	0.95
386_Q	410_T	0.716	0.95
561_H	575_Q	0.715	0.95
398_T	403_C	0.715	0.95
475_F	478_Q	0.714	0.94
479_V	538_G	0.713	0.94
358_L	363_L	0.713	0.94
420_Y	548_Q	0.709	0.94
241_N	255_G	0.708	0.94
196_T	199_F	0.708	0.94
348_E	362_Q	0.707	0.94
473_P	477_L	0.707	0.94
129_I	133_V	0.706	0.94
241_N	249_I	0.704	0.94
356_A	360_S	0.704	0.94
229_Q	232_P	0.702	0.94
367_E	370_L	0.701	0.94
121_A	132_G	0.701	0.94
285_I	288_L	0.700	0.94
124_C	127_S	0.700	0.94
318_A	325_T	0.699	0.94
229_Q	233_F	0.699	0.94
333_T	336_M	0.699	0.94
232_P	235_R	0.697	0.94
398_T	401_A	0.696	0.94
295_T	299_M	0.696	0.94
378_A	385_A	0.696	0.94
445_Y	478_Q	0.696	0.94
257_D	262_T	0.695	0.94
197_G	202_L	0.691	0.93
178_D	185_M	0.689	0.93
271_V	276_D	0.688	0.93
357_M	362_Q	0.687	0.93
574_F	577_P	0.687	0.93
372_S	377_D	0.686	0.93
520_I	562_I	0.686	0.93
355_L	362_Q	0.686	0.93
87_I	90_V	0.684	0.93
416_Q	545_N	0.684	0.93
534_P	539_T	0.684	0.93
165_Q	168_I	0.684	0.93
77_D	89_G	0.682	0.93
422_R	535_S	0.681	0.93
467_L	502_V	0.680	0.93
200_I	203_S	0.680	0.93
231_L	234_F	0.679	0.93
254_T	260_S	0.678	0.93
323_P	335_K	0.678	0.93
288_L	293_I	0.678	0.93
55_S	59_G	0.677	0.93
226_I	230_T	0.675	0.93
127_S	132_G	0.674	0.93
548_Q	551_I	0.674	0.93
270_H	274_G	0.673	0.93
393_F	486_R	0.672	0.93
136_G	140_R	0.672	0.93
508_S	556_Q	0.672	0.93
392_L	532_P	0.671	0.92
391_F	397_N	0.670	0.92
203_S	207_A	0.670	0.92
256_T	259_V	0.669	0.92
155_A	162_E	0.668	0.92
348_E	358_L	0.668	0.92
408_E	412_K	0.668	0.92
481_V	498_V	0.666	0.92
322_L	332_G	0.666	0.92
282_K	285_I	0.665	0.92
56_N	59_G	0.665	0.92
287_G	296_G	0.665	0.92
486_R	533_F	0.664	0.92
420_Y	544_Y	0.664	0.92
386_Q	391_F	0.663	0.92
399_I	403_C	0.662	0.92
243_C	249_I	0.660	0.92
328_G	332_G	0.659	0.92
216_R	219_E	0.659	0.92
48_F	55_S	0.658	0.92
160_G	166_M	0.657	0.92
228_D	235_R	0.657	0.92
473_P	553_L	0.656	0.92
389_P	487_H	0.655	0.92
397_N	402_L	0.655	0.92
121_A	125_A	0.654	0.92
128_S	131_A	0.654	0.92
356_A	365_L	0.654	0.92
546_L	574_F	0.653	0.91
393_F	416_Q	0.652	0.91
396_I	405_T	0.652	0.91
334_L	340_S	0.652	0.91
322_L	336_M	0.651	0.91
274_G	277_H	0.650	0.91
350_E	353_E	0.650	0.91
231_L	236_Q	0.649	0.91
475_F	549_R	0.647	0.91
166_M	170_L	0.644	0.91
291_K	294_K	0.644	0.91
247_A	254_T	0.643	0.91
79_S	86_R	0.643	0.91
344_L	354_G	0.643	0.91
417_L	421_F	0.642	0.91
106_G	113_R	0.641	0.91
54_I	57_Y	0.641	0.91
53_I	56_N	0.641	0.91
395_A	416_Q	0.640	0.91
54_I	63_Q	0.640	0.91
399_I	550_L	0.639	0.91
220_T	227_A	0.637	0.90
377_D	397_N	0.636	0.90
317_H	321_V	0.636	0.90
385_A	391_F	0.635	0.90
335_K	338_F	0.635	0.90
357_M	360_S	0.635	0.90
49_S	58_T	0.632	0.90
102_G	106_G	0.632	0.90
487_H	533_F	0.631	0.90
223_V	233_F	0.631	0.90
126_V	131_A	0.630	0.90
380_I	389_P	0.630	0.90
288_L	298_I	0.630	0.90
53_I	57_Y	0.629	0.90
386_Q	486_R	0.628	0.90
484_A	498_V	0.627	0.90
472_I	553_L	0.626	0.90
399_I	555_G	0.626	0.90
228_D	234_F	0.626	0.90
379_E	386_Q	0.625	0.90
341_P	348_E	0.623	0.89
229_Q	235_R	0.623	0.89
384_Q	394_N	0.622	0.89
335_K	339_K	0.621	0.89
394_N	398_T	0.621	0.89
531_K	548_Q	0.620	0.89
287_G	291_K	0.620	0.89
286_T	292_V	0.619	0.89
55_S	60_I	0.619	0.89
323_P	328_G	0.619	0.89
212_E	216_R	0.616	0.89
191_I	194_N	0.616	0.89
439_L	511_M	0.612	0.89
195_G	198_S	0.612	0.89
376_K	383_L	0.612	0.89
374_L	378_A	0.611	0.89
411_R	424_N	0.610	0.88
422_R	482_E	0.610	0.88
120_T	123_S	0.610	0.88
374_L	381_K	0.610	0.88
223_V	231_L	0.608	0.88
202_L	207_A	0.608	0.88
385_A	421_F	0.607	0.88
179_A	182_L	0.606	0.88
323_P	333_T	0.604	0.88
224_L	230_T	0.603	0.88
370_L	373_K	0.602	0.88
546_L	549_R	0.602	0.88
330_T	337_Y	0.601	0.88
89_G	93_G	0.601	0.88
211_K	215_A	0.599	0.88
191_I	195_G	0.599	0.88
55_S	58_T	0.598	0.87
227_A	230_T	0.597	0.87
480_L	550_L	0.597	0.87
532_P	539_T	0.597	0.87
320_I	323_P	0.596	0.87
394_N	539_T	0.595	0.87
120_T	125_A	0.594	0.87
220_T	225_T	0.592	0.87
394_N	486_R	0.591	0.87
180_W	183_V	0.591	0.87
140_R	144_K	0.591	0.87
198_S	201_F	0.590	0.87
545_N	549_R	0.590	0.87
125_A	132_G	0.590	0.87
361_T	366_G	0.589	0.87
49_S	54_I	0.589	0.87
361_T	369_E	0.589	0.87
384_Q	549_R	0.588	0.87
325_T	328_G	0.588	0.87
292_V	295_T	0.587	0.86
186_I	189_P	0.587	0.86
386_Q	393_F	0.587	0.86
230_T	236_Q	0.587	0.86
49_S	59_G	0.585	0.86
77_D	84_N	0.584	0.86
243_C	250_I	0.584	0.86
194_N	202_L	0.582	0.86
242_S	246_V	0.581	0.86
47_I	54_I	0.581	0.86
382_A	385_A	0.581	0.86
122_L	127_S	0.579	0.86
219_E	223_V	0.578	0.86
389_P	392_L	0.577	0.86
231_L	235_R	0.576	0.85
389_P	401_A	0.576	0.85
399_I	475_F	0.575	0.85
321_V	325_T	0.575	0.85
89_G	94_G	0.574	0.85
224_L	227_A	0.574	0.85
45_I	63_Q	0.574	0.85
549_R	552_G	0.573	0.85
217_A	221_H	0.573	0.85
49_S	61_E	0.573	0.85
413_L	421_F	0.572	0.85
223_V	230_T	0.569	0.85
54_I	61_E	0.569	0.85
392_L	417_L	0.568	0.85
127_S	130_L	0.567	0.85
446_L	478_Q	0.567	0.85
99_P	102_G	0.567	0.85
410_T	414_L	0.566	0.84
380_I	487_H	0.566	0.84
394_N	418_S	0.566	0.84
282_K	286_T	0.565	0.84
49_S	63_Q	0.565	0.84
317_H	325_T	0.565	0.84
44_L	48_F	0.563	0.84
403_C	406_D	0.563	0.84
436_S	463_I	0.562	0.84
251_H	255_G	0.561	0.84
462_N	503_L	0.561	0.84
478_Q	481_V	0.561	0.84
414_L	553_L	0.560	0.84
43_I	47_I	0.560	0.84
384_Q	397_N	0.559	0.84
383_L	552_G	0.559	0.84
393_F	478_Q	0.557	0.84
248_A	251_H	0.557	0.84
385_A	496_C	0.557	0.84
521_P	528_L	0.557	0.84
157_V	161_M	0.555	0.83
233_F	236_Q	0.555	0.83
450_Q	485_L	0.555	0.83
48_F	62_I	0.555	0.83
449_E	453_F	0.554	0.83
249_I	255_G	0.554	0.83
42_A	46_S	0.553	0.83
187_G	191_I	0.553	0.83
82_I	86_R	0.551	0.83
322_L	325_T	0.551	0.83
402_L	412_K	0.550	0.83
295_T	298_I	0.550	0.83
54_I	59_G	0.549	0.83
405_T	418_S	0.548	0.83
450_Q	455_G	0.548	0.83
393_F	402_L	0.547	0.82
194_N	197_G	0.546	0.82
77_D	86_R	0.546	0.82
283_S	286_T	0.546	0.82
229_Q	236_Q	0.546	0.82
392_L	395_A	0.546	0.82
394_N	405_T	0.545	0.82
468_E	555_G	0.544	0.82
124_C	132_G	0.544	0.82
79_S	87_I	0.543	0.82
472_I	545_N	0.543	0.82
332_G	338_F	0.542	0.82
395_A	487_H	0.542	0.82
342_A	345_S	0.542	0.82
395_A	479_V	0.541	0.82
327_N	333_T	0.539	0.81
393_F	415_L	0.539	0.81
234_F	240_E	0.539	0.81
221_H	228_D	0.538	0.81
352_A	363_L	0.537	0.81
321_V	329_N	0.537	0.81
417_L	424_N	0.537	0.81
410_T	417_L	0.536	0.81
387_V	392_L	0.535	0.81
246_V	254_T	0.535	0.81
349_E	354_G	0.534	0.81
397_N	400_S	0.534	0.81
120_T	124_C	0.533	0.81
194_N	198_S	0.531	0.81
363_L	367_E	0.531	0.81
397_N	552_G	0.529	0.80
106_G	111_L	0.529	0.80
212_E	215_A	0.529	0.80
475_F	546_L	0.529	0.80
472_I	476_V	0.527	0.80
182_L	186_I	0.527	0.80
333_T	338_F	0.526	0.80
439_L	502_V	0.526	0.80
423_S	426_Q	0.526	0.80
487_H	545_N	0.523	0.80
480_L	543_L	0.523	0.80
246_V	256_T	0.522	0.79
275_M	279_I	0.521	0.79
381_K	385_A	0.520	0.79
126_V	137_L	0.520	0.79
48_F	58_T	0.520	0.79
293_I	296_G	0.520	0.79
450_Q	498_V	0.519	0.79
228_D	231_L	0.519	0.79
291_K	296_G	0.518	0.79
246_V	249_I	0.517	0.79
106_G	112_H	0.516	0.79
45_I	56_N	0.516	0.79
420_Y	532_P	0.516	0.79
247_A	262_T	0.515	0.79
258_A	261_L	0.515	0.79
135_A	140_R	0.515	0.79
293_I	298_I	0.514	0.78
437_K	441_H	0.514	0.78
194_N	199_F	0.514	0.78
349_E	356_A	0.514	0.78
214_Q	218_L	0.511	0.78
49_S	105_I	0.511	0.78
397_N	401_A	0.511	0.78
226_I	233_F	0.511	0.78
160_G	164_L	0.511	0.78
347_V	351_L	0.510	0.78
342_A	348_E	0.509	0.78
394_N	397_N	0.508	0.78
386_Q	547_N	0.507	0.77
384_Q	423_S	0.505	0.77
198_S	205_I	0.505	0.77
318_A	322_L	0.505	0.77
157_V	162_E	0.504	0.77
351_L	358_L	0.504	0.77
80_G	95_L	0.504	0.77
380_I	386_Q	0.504	0.77
476_V	553_L	0.504	0.77
319_A	322_L	0.504	0.77
214_Q	217_A	0.504	0.77
84_N	90_V	0.503	0.77
321_V	326_S	0.503	0.77
132_G	135_A	0.503	0.77
80_G	84_N	0.502	0.77
364_E	367_E	0.502	0.77
325_T	330_T	0.502	0.77
451_A	454_P	0.501	0.77
391_F	479_V	0.501	0.77
47_I	58_T	0.501	0.77
245_S	249_I	0.500	0.76
401_A	418_S	0.500	0.76

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.5767	100	0.584	Contact Map
4gczA	2	0.575	100	0.59	Contact Map
3a0rA	2	0.5228	100	0.599	Contact Map
4bixA	2	0.3541	100	0.614	Contact Map
4ctiA	2	0.3558	100	0.617	Contact Map
3d36A	2	0.3356	100	0.617	Contact Map
4q20A	2	0.3508	100	0.619	Contact Map
4mpcA	2	0.4958	100	0.625	Contact Map
2c2aA	2	0.3558	100	0.628	Contact Map
3jz3A	2	0.2395	100	0.629	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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