GREMLIN Database
UPPP - Undecaprenyl-diphosphatase
UniProt: P94507 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 276 (257)
Sequences: 4127 (2695)
Seq/√Len: 168.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_R197_D3.5571.00
100_G198_F3.3761.00
166_F184_G3.0041.00
5_E8_V2.8321.00
15_V33_V2.8241.00
105_A209_G2.6951.00
72_I204_M2.6701.00
10_A236_C2.5471.00
141_W258_V2.5181.00
130_I268_G2.4061.00
101_L206_I2.3551.00
191_N194_A2.3401.00
16_E60_S2.3081.00
133_A265_I2.2781.00
134_I138_F2.2721.00
250_R254_K2.2531.00
116_D214_S2.2401.00
185_G190_L2.2331.00
212_F216_V2.1811.00
104_A206_I2.1041.00
14_I240_V2.0341.00
112_E214_S1.9891.00
161_I165_L1.9751.00
213_L217_K1.9681.00
69_K73_L1.8761.00
126_A268_G1.8481.00
99_V157_Y1.8401.00
13_G236_C1.7981.00
64_V245_V1.7871.00
104_A168_C1.7851.00
127_I131_A1.7671.00
250_R253_N1.7531.00
62_L238_F1.7441.00
268_G272_L1.7401.00
30_M53_K1.7371.00
6_L232_V1.7281.00
107_L168_C1.7251.00
9_A13_G1.7131.00
60_S241_A1.6811.00
28_G125_V1.6751.00
193_R253_N1.6691.00
100_G202_M1.6471.00
209_G213_L1.6371.00
158_K162_A1.6321.00
262_I266_I1.6191.00
121_S124_T1.6171.00
74_N90_H1.6081.00
32_I271_L1.6031.00
126_A271_L1.6001.00
114_Y118_Y1.5951.00
156_S159_Q1.5821.00
67_V246_R1.5641.00
128_G172_W1.5421.00
12_L33_V1.5351.00
58_L211_S1.5301.00
236_C240_V1.5231.00
138_F142_V1.5221.00
126_A272_L1.5181.00
12_L30_M1.4891.00
75_L94_I1.4881.00
92_L96_Q1.4491.00
269_V273_L1.4371.00
208_M212_F1.4351.00
112_E116_D1.4331.00
258_V262_I1.4271.00
111_F114_Y1.4241.00
137_L258_V1.4231.00
270_I274_I1.4131.00
4_W8_V1.4031.00
111_F115_I1.3861.00
105_A109_F1.3501.00
123_K127_I1.3181.00
213_L216_V1.3161.00
135_L183_S1.3101.00
9_A52_F1.3081.00
159_Q188_L1.3081.00
19_T24_V1.3071.00
98_A102_V1.3021.00
130_I272_L1.2931.00
96_Q157_Y1.2891.00
137_L261_A1.2871.00
128_G131_A1.2861.00
66_I238_F1.2831.00
239_V243_F1.2791.00
214_S217_K1.2721.00
240_V244_V1.2701.00
251_L255_I1.2681.00
151_T154_R1.2481.00
123_K272_L1.2471.00
147_T159_Q1.2411.00
51_S218_H1.2341.00
46_E50_N1.2211.00
107_L111_F1.2181.00
112_E217_K1.2171.00
51_S55_V1.2031.00
49_A53_K1.2011.00
68_F249_L1.2011.00
124_T128_G1.1931.00
9_A232_V1.1861.00
9_A229_F1.1771.00
44_M49_A1.1731.00
231_I235_I1.1711.00
181_T199_T1.1711.00
238_F242_L1.1681.00
11_I15_V1.1661.00
105_A108_G1.1641.00
91_K95_A1.1601.00
101_L105_A1.1561.00
175_F180_S1.1561.00
57_Q207_M1.1521.00
10_A14_I1.1471.00
162_A184_G1.1441.00
246_R250_R1.1421.00
140_D192_H1.1401.00
159_Q190_L1.1341.00
6_L228_P1.1321.00
251_L259_P1.1261.00
70_D73_L1.1211.00
157_Y161_I1.1151.00
162_A188_L1.1041.00
32_I122_V1.0971.00
227_M231_I1.0971.00
106_V110_L1.0941.00
127_I272_L1.0891.00
96_Q160_A1.0881.00
29_H263_Y1.0881.00
6_L10_A1.0821.00
209_G212_F1.0751.00
137_L141_W1.0731.00
58_L207_M1.0701.00
163_V190_L1.0630.99
155_I190_L1.0630.99
196_A252_I1.0580.99
70_D74_N1.0570.99
66_I69_K1.0560.99
6_L229_F1.0270.99
8_V37_W1.0270.99
99_V161_I1.0210.99
54_V214_S1.0150.99
196_A249_L1.0050.99
216_V220_D1.0050.99
21_Y241_A1.0010.99
248_F255_I0.9950.99
67_V249_L0.9950.99
259_P262_I0.9920.99
185_G195_A0.9920.99
14_I18_L0.9900.99
33_V37_W0.9880.99
226_L229_F0.9860.99
93_S201_I0.9850.99
65_A72_I0.9840.99
114_Y117_E0.9730.99
56_I233_G0.9630.99
109_F209_G0.9620.99
24_V248_F0.9600.99
165_L169_L0.9570.99
31_I125_V0.9390.99
168_C171_L0.9330.99
223_S226_L0.9300.99
32_I129_L0.9290.99
159_Q185_G0.9240.99
54_V210_A0.9230.99
244_V247_F0.9210.99
232_V236_C0.9140.98
59_G234_F0.9120.98
132_G169_L0.9110.98
249_L252_I0.9100.98
104_A171_L0.9010.98
159_Q162_A0.9000.98
265_I269_V0.8970.98
107_L171_L0.8970.98
68_F197_D0.8960.98
88_Q91_K0.8950.98
163_V202_M0.8890.98
132_G264_R0.8840.98
224_S228_P0.8840.98
115_I171_L0.8740.98
67_V242_L0.8720.98
228_P231_I0.8700.98
139_A187_I0.8630.98
122_V271_L0.8620.98
242_L246_R0.8620.98
266_I270_I0.8610.98
135_L139_A0.8550.98
124_T172_W0.8530.98
78_L95_A0.8530.98
137_L265_I0.8530.98
104_A108_G0.8510.98
9_A236_C0.8510.98
45_S49_A0.8470.97
196_A248_F0.8410.97
32_I267_L0.8380.97
88_Q92_L0.8340.97
10_A232_V0.8320.97
35_D122_V0.8260.97
228_P232_V0.8220.97
165_L168_C0.8210.97
152_L194_A0.8210.97
163_V185_G0.8200.97
214_S218_H0.8170.97
94_I98_A0.8100.97
18_L24_V0.8070.97
151_T194_A0.8050.97
243_F246_R0.8040.97
97_I201_I0.8040.97
183_S261_A0.8030.97
226_L230_F0.7940.96
139_A183_S0.7920.96
65_A208_M0.7920.96
125_V128_G0.7910.96
76_L79_K0.7870.96
120_F172_W0.7860.96
30_M237_A0.7860.96
124_T127_I0.7790.96
19_T29_H0.7660.95
107_L110_L0.7650.95
142_V146_K0.7650.95
130_I265_I0.7650.95
48_A226_L0.7640.95
141_W144_K0.7630.95
55_V211_S0.7610.95
107_L165_L0.7590.95
267_L270_I0.7490.95
202_M206_I0.7490.95
50_N57_Q0.7450.95
136_M179_G0.7440.95
264_R271_L0.7440.95
162_A165_L0.7350.94
136_M140_D0.7350.94
155_I194_A0.7350.94
50_N116_D0.7340.94
55_V234_F0.7270.94
142_V145_R0.7250.94
140_D257_L0.7250.94
95_A98_A0.7250.94
61_I204_M0.7240.94
27_T57_Q0.7200.94
132_G175_F0.7200.94
215_L219_W0.7190.94
106_V109_F0.7150.93
34_D49_A0.7140.93
216_V219_W0.7130.93
27_T61_I0.7110.93
179_G186_V0.7110.93
7_F11_I0.7080.93
89_G92_L0.7070.93
50_N53_K0.7040.93
9_A233_G0.7030.93
72_I76_L0.7020.93
136_M183_S0.6990.93
51_S54_V0.6960.93
86_Q91_K0.6900.92
93_S152_L0.6900.92
27_T30_M0.6890.92
96_Q100_G0.6850.92
130_I134_I0.6840.92
197_D201_I0.6830.92
231_I234_F0.6820.92
11_I33_V0.6790.92
129_L264_R0.6740.91
56_I237_A0.6740.91
256_K259_P0.6640.91
36_I274_I0.6630.91
51_S214_S0.6620.91
203_A207_M0.6590.90
198_F202_M0.6580.90
140_D258_V0.6520.90
105_A213_L0.6500.90
162_A166_F0.6480.90
133_A137_L0.6470.90
16_E27_T0.6410.89
14_I236_C0.6400.89
105_A110_L0.6390.89
119_L124_T0.6390.89
256_K264_R0.6380.89
89_G153_D0.6370.89
140_D245_V0.6360.89
183_S186_V0.6360.89
113_D117_E0.6360.89
92_L95_A0.6340.89
141_W145_R0.6320.88
12_L37_W0.6320.88
131_A175_F0.6310.88
134_I265_I0.6300.88
75_L97_I0.6290.88
61_I64_V0.6290.88
267_L271_L0.6280.88
225_D228_P0.6260.88
169_L180_S0.6260.88
224_S227_M0.6250.88
87_E90_H0.6250.88
49_A120_F0.6230.88
185_G188_L0.6220.88
66_I242_L0.6200.88
134_I137_L0.6180.87
155_I159_Q0.6170.87
11_I37_W0.6170.87
57_Q60_S0.6130.87
17_G240_V0.6130.87
61_I203_A0.6120.87
255_I259_P0.6100.87
251_L256_K0.6090.87
35_D274_I0.6080.86
31_I122_V0.6040.86
52_F233_G0.6020.86
179_G183_S0.6010.86
239_V242_L0.5990.86
193_R197_D0.5970.85
34_D37_W0.5950.85
171_L206_I0.5950.85
18_L248_F0.5930.85
237_A240_V0.5900.85
94_I97_I0.5880.85
95_A99_V0.5880.85
57_Q61_I0.5860.84
151_T191_N0.5850.84
86_Q89_G0.5830.84
166_F169_L0.5810.84
178_S200_F0.5780.84
16_E56_I0.5780.84
73_L76_L0.5770.84
73_L77_G0.5750.83
234_F237_A0.5750.83
155_I160_A0.5740.83
247_F250_R0.5710.83
211_S215_L0.5660.82
77_G85_D0.5630.82
163_V198_F0.5630.82
175_F264_R0.5580.81
118_Y124_T0.5580.81
264_R267_L0.5570.81
62_L234_F0.5570.81
172_W175_F0.5540.81
70_D77_G0.5540.81
131_A135_L0.5540.81
16_E61_I0.5510.81
77_G88_Q0.5510.81
114_Y119_L0.5490.80
21_Y30_M0.5480.80
130_I269_V0.5460.80
12_L49_A0.5460.80
261_A265_I0.5450.80
68_F71_R0.5450.80
101_L209_G0.5450.80
16_E57_Q0.5440.80
100_G155_I0.5420.80
132_G172_W0.5400.79
125_V129_L0.5400.79
258_V261_A0.5390.79
91_K94_I0.5380.79
24_V129_L0.5380.79
261_A264_R0.5360.79
136_M257_L0.5350.79
137_L262_I0.5340.79
110_L114_Y0.5300.78
180_S184_G0.5300.78
55_V230_F0.5250.77
45_S48_A0.5250.77
92_L157_Y0.5240.77
183_S202_M0.5240.77
192_H256_K0.5230.77
215_L218_H0.5220.77
64_V204_M0.5220.77
104_A115_I0.5210.77
103_P108_G0.5200.77
136_M256_K0.5200.77
152_L203_A0.5190.77
170_S234_F0.5190.77
34_D53_K0.5190.77
115_I172_W0.5170.76
137_L140_D0.5160.76
182_I257_L0.5160.76
192_H252_I0.5150.76
110_L113_D0.5150.76
56_I207_M0.5130.76
140_D186_V0.5090.75
28_G32_I0.5060.75
152_L155_I0.5050.75
95_A157_Y0.5040.75
133_A261_A0.5040.75
31_I35_D0.5020.74
16_E132_G0.5020.74
86_Q147_T0.5000.74
168_C172_W0.5000.74
109_F213_L0.5000.74
65_A204_M0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4w252 1 0.2246 23.6 0.963 Contact Map
3mp7B 1 0.1957 16.7 0.965 Contact Map
2ww9B 1 0.2174 9.1 0.969 Contact Map
3ux4A 3 0.3768 6.9 0.971 Contact Map
3ne5A 3 0.808 5.7 0.972 Contact Map
3w9iA 3 0.7862 3.9 0.974 Contact Map
1jb0M 1 0.1123 3.9 0.974 Contact Map
4mt1A 3 0.8043 3.8 0.974 Contact Map
1rh5B 1 0.2029 3.7 0.974 Contact Map
1iflA 10 0.192 3.2 0.975 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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