GREMLIN Database
YRDN - Probable tautomerase YrdN
UniProt: P94502 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 129 (123)
Sequences: 819 (599)
Seq/√Len: 54.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_E47_P4.7691.00
45_E50_H3.4481.00
63_T102_D3.0531.00
32_F73_S2.6191.00
25_H29_V2.6091.00
89_A103_L2.2581.00
84_F88_L2.1671.00
5_R70_S2.1601.00
88_L105_V2.0601.00
4_L24_A1.9551.00
6_F24_A1.9071.00
73_S107_I1.8910.99
11_G45_E1.8430.99
26_N91_R1.8220.99
7_D46_H1.8210.99
78_E113_A1.7670.99
22_D39_R1.7580.99
20_L67_V1.7560.99
3_L42_I1.7370.99
98_I103_L1.7040.99
12_R16_S1.6940.99
77_P80_K1.6730.99
30_E87_L1.6560.99
17_L50_H1.5910.98
21_L43_V1.5730.98
16_S65_N1.5600.98
14_Q49_N1.5570.98
60_F119_L1.5320.98
87_L91_R1.4830.97
86_R90_E1.4590.97
21_L41_Q1.4480.97
75_S109_E1.4340.96
8_L17_L1.4170.96
21_L39_R1.3610.95
7_D44_H1.3390.95
23_V96_C1.3310.95
26_N30_E1.3290.95
23_V27_V1.3260.94
110_N114_D1.3140.94
88_L103_L1.2840.93
31_A87_L1.2640.93
78_E82_Q1.2560.93
30_E91_R1.2350.92
101_T119_L1.2230.92
68_V104_I1.2230.92
12_R65_N1.2000.91
19_K23_V1.1940.91
74_K112_N1.1470.89
83_K86_R1.1440.89
70_S108_V1.1180.88
90_E94_S1.0980.87
18_K52_I1.0930.86
87_L90_E1.0830.86
26_N94_S1.0670.85
74_K121_E1.0540.84
81_K114_D1.0490.84
26_N36_Q1.0220.82
63_T101_T1.0130.82
56_T61_N1.0050.81
6_F43_V0.9990.81
109_E114_D0.9870.80
5_R44_H0.9830.80
6_F21_L0.9730.79
27_V88_L0.9700.79
7_D42_I0.9630.78
54_E57_G0.9400.77
90_E100_S0.9330.76
37_Q54_E0.9270.76
116_S120_G0.9190.75
93_E100_S0.9150.75
17_L45_E0.9150.75
66_L104_I0.9140.75
11_G16_S0.9060.74
20_L92_L0.9020.74
53_I66_L0.8900.73
93_E99_A0.8890.73
24_A69_L0.8840.72
24_A43_V0.8820.72
23_V91_R0.8780.72
23_V95_E0.8710.71
92_L96_C0.8700.71
8_L43_V0.8490.69
69_L92_L0.8480.69
48_E64_K0.8440.69
72_T85_Y0.8430.69
33_D80_K0.8380.68
13_D16_S0.8330.68
32_F80_K0.8320.68
111_D114_D0.8220.67
99_A102_D0.8210.67
7_D106_S0.8160.66
83_K87_L0.8130.66
25_H34_V0.8070.65
25_H41_Q0.8030.65
85_Y115_W0.7940.64
2_P38_D0.7920.64
14_Q47_P0.7920.64
34_V84_F0.7910.64
51_M66_L0.7850.63
20_L98_I0.7830.63
27_V91_R0.7820.63
57_G73_S0.7750.62
54_E62_R0.7680.61
91_R94_S0.7590.60
27_V84_F0.7580.60
89_A105_V0.7580.60
13_D17_L0.7560.60
6_F69_L0.7460.59
4_L69_L0.7300.57
19_K95_E0.7300.57
38_D117_F0.7290.57
29_V37_Q0.7290.57
27_V34_V0.7290.57
28_V40_Y0.7280.57
70_S106_S0.7230.57
71_V84_F0.7230.57
60_F101_T0.7210.57
69_L75_S0.7210.57
8_L67_V0.7050.55
37_Q52_I0.7050.55
85_Y120_G0.7010.54
72_T108_V0.6930.54
46_H50_H0.6910.53
117_F123_Q0.6830.53
28_V34_V0.6760.52
10_E45_E0.6750.52
48_E95_E0.6720.51
40_Y104_I0.6600.50
95_E100_S0.6560.50
39_R55_D0.6510.49
85_Y107_I0.6480.49
106_S114_D0.6480.49
19_K96_C0.6460.49
74_K111_D0.6420.48
72_T100_S0.6400.48
21_L25_H0.6400.48
88_L91_R0.6390.48
17_L20_L0.6370.48
16_S96_C0.6330.47
32_F57_G0.6240.46
39_R52_I0.6210.46
21_L40_Y0.6210.46
97_G103_L0.6060.44
39_R62_R0.6000.44
26_N95_E0.5960.43
25_H84_F0.5950.43
46_H70_S0.5920.43
106_S110_N0.5900.43
105_V109_E0.5880.42
18_K86_R0.5860.42
2_P120_G0.5850.42
4_L75_S0.5830.42
21_L52_I0.5800.42
41_Q110_N0.5650.40
61_N99_A0.5620.40
47_P50_H0.5620.40
45_E70_S0.5560.39
18_K22_D0.5560.39
15_S26_N0.5540.39
79_E90_E0.5540.39
72_T106_S0.5520.39
42_I46_H0.5500.39
71_V76_R0.5490.38
14_Q83_K0.5460.38
24_A75_S0.5440.38
93_E96_C0.5420.38
49_N53_I0.5370.37
23_V69_L0.5360.37
64_K94_S0.5320.37
91_R95_E0.5310.37
69_L103_L0.5310.37
42_I51_M0.5310.37
29_V41_Q0.5290.36
23_V71_V0.5270.36
11_G17_L0.5270.36
82_Q114_D0.5200.36
19_K97_G0.5180.35
31_A83_K0.5120.35
58_L118_G0.5120.35
42_I56_T0.5090.35
117_F120_G0.5090.35
63_T99_A0.5080.34
16_S45_E0.5030.34
83_K94_S0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2aalA 3 0.9922 100 0.401 Contact Map
4lhpA 3 0.9845 100 0.441 Contact Map
3c6vA 3 0.938 99.9 0.478 Contact Map
4jcuA 3 0.938 99.9 0.498 Contact Map
1mwwA 3 0.9225 99.9 0.509 Contact Map
1u9dA 3 0.8295 99.9 0.52 Contact Map
3e6qA 4 0.8837 99.9 0.52 Contact Map
4lkbF 4 0.9225 99.9 0.531 Contact Map
3fwtA 3 0.8682 99.9 0.545 Contact Map
3fwuA 3 0.8605 99.9 0.547 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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