GREMLIN Database
GLTR - HTH-type transcriptional regulator GltR
UniProt: P94501 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 296 (281)
Sequences: 79335 (57269)
Seq/√Len: 3416.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
70_K74_T3.6521.00
15_E24_T3.3921.00
157_E285_R2.6671.00
95_G140_L2.5251.00
67_Y81_A2.4871.00
11_T24_T2.4191.00
161_D262_S2.2391.00
158_K262_S2.2381.00
91_P122_N2.2351.00
226_V233_S2.2271.00
158_K161_D2.2211.00
172_H184_Q2.2181.00
45_T60_P2.1491.00
91_P120_D2.1001.00
163_E237_R2.0971.00
8_V35_K2.0911.00
111_H283_H2.0541.00
10_L69_E2.0521.00
177_S180_D2.0471.00
20_K23_L2.0231.00
67_Y74_T2.0201.00
161_D260_F2.0191.00
10_L14_R2.0031.00
227_S248_R1.9901.00
165_V237_R1.9851.00
93_R122_N1.9631.00
11_T15_E1.9541.00
10_L65_V1.9211.00
11_T14_R1.9211.00
14_R69_E1.9151.00
223_I243_H1.9041.00
168_T252_H1.8681.00
13_A57_L1.8651.00
227_S243_H1.8641.00
8_V32_V1.8571.00
71_I75_I1.8531.00
187_L231_G1.8511.00
65_V69_E1.8291.00
165_V251_S1.7791.00
185_T213_L1.7531.00
49_Y56_T1.7131.00
156_Q264_M1.7001.00
63_I81_A1.7001.00
13_A65_V1.6681.00
134_A139_E1.6661.00
64_L78_A1.6601.00
18_I36_I1.6391.00
15_E20_K1.6251.00
155_V269_K1.5891.00
10_L68_S1.5641.00
14_R24_T1.5341.00
67_Y70_K1.5341.00
157_E267_R1.5161.00
17_S20_K1.5091.00
133_Q137_H1.5081.00
5_L35_K1.4981.00
112_Y280_F1.4961.00
5_L42_D1.4931.00
9_F65_V1.4721.00
8_V27_Y1.4701.00
5_L38_Q1.4601.00
46_K49_Y1.4421.00
87_A118_N1.4391.00
11_T25_L1.4391.00
28_A31_N1.4361.00
281_L285_R1.4341.00
155_V267_R1.4241.00
67_Y77_E1.4181.00
112_Y119_V1.4171.00
102_A220_E1.4171.00
145_I266_I1.4151.00
19_S29_Q1.4141.00
267_R281_L1.4071.00
147_G264_M1.3851.00
51_H56_T1.3841.00
273_I277_L1.3801.00
59_P62_Q1.3791.00
196_R200_N1.3721.00
93_R124_V1.3631.00
71_I78_A1.3571.00
115_L283_H1.3571.00
134_A140_L1.3531.00
279_A282_T1.3531.00
74_T77_E1.3501.00
10_L72_L1.3481.00
135_V143_A1.3461.00
89_S118_N1.3371.00
170_A248_R1.3301.00
136_L153_D1.3161.00
64_L79_R1.3161.00
162_E238_S1.3081.00
265_F281_L1.3021.00
111_H115_L1.2891.00
66_S70_K1.2841.00
222_I233_S1.2791.00
170_A250_R1.2631.00
142_G265_F1.2621.00
224_G227_S1.2571.00
113_N213_L1.2541.00
3_I75_I1.2521.00
67_Y78_A1.2511.00
243_H248_R1.2491.00
184_Q232_I1.2461.00
42_D79_R1.2401.00
168_T232_I1.2391.00
142_G277_L1.2351.00
158_K264_M1.2271.00
63_I66_S1.2201.00
237_R251_S1.2201.00
27_Y31_N1.2161.00
110_A114_N1.1971.00
113_N185_T1.1961.00
241_A245_K1.1831.00
237_R241_A1.1781.00
9_F48_F1.1761.00
110_A228_A1.1751.00
34_N38_Q1.1721.00
156_Q266_I1.1621.00
9_F13_A1.1521.00
173_P184_Q1.1421.00
126_G134_A1.1391.00
62_Q66_S1.1351.00
63_I67_Y1.1321.00
122_N215_E1.1211.00
172_H175_I1.1191.00
37_Q41_N1.1131.00
107_Q228_A1.1101.00
116_Y279_A1.1061.00
34_N37_Q1.1041.00
6_L68_S1.0971.00
70_K77_E1.0931.00
185_T211_I1.0891.00
251_S254_I1.0881.00
157_E281_L1.0801.00
282_T285_R1.0791.00
223_I227_S1.0711.00
11_T21_A1.0701.00
167_V251_S1.0671.00
101_A125_T1.0651.00
18_I55_I1.0651.00
111_H114_N1.0601.00
224_G228_A1.0541.00
9_F47_L1.0541.00
71_I74_T1.0461.00
33_T37_Q1.0441.00
278_S282_T1.0391.00
112_Y283_H1.0351.00
203_L208_L1.0311.00
136_L151_H1.0311.00
108_L284_M1.0301.00
216_F222_I1.0291.00
242_S246_E1.0251.00
12_T21_A1.0191.00
79_R83_G1.0191.00
187_L222_I1.0161.00
35_K38_Q1.0161.00
92_L280_F1.0161.00
163_E260_F1.0161.00
169_S229_G1.0081.00
168_T172_H1.0051.00
197_A200_N0.9991.00
73_H77_E0.9981.00
283_H286_D0.9931.00
4_Q7_Q0.9921.00
124_V134_A0.9921.00
188_V212_K0.9801.00
64_L68_S0.9761.00
7_Q76_E0.9711.00
12_T18_I0.9661.00
57_L61_G0.9631.00
178_I256_D0.9631.00
38_Q41_N0.9611.00
27_Y32_V0.9601.00
112_Y116_Y0.9591.00
167_V240_I0.9571.00
76_E79_R0.9521.00
8_V25_L0.9471.00
76_E80_A0.9441.00
13_A48_F0.9431.00
166_L232_I0.9431.00
172_H176_S0.9421.00
21_A32_V0.9351.00
216_F225_C0.9231.00
134_A137_H0.9211.00
9_F57_L0.9181.00
20_K24_T0.9171.00
9_F39_L0.9141.00
70_K73_H0.9071.00
274_T277_L0.9061.00
108_L283_H0.9031.00
115_L286_D0.8971.00
45_T82_M0.8901.00
147_G262_S0.8821.00
16_G56_T0.8801.00
98_E218_I0.8801.00
95_G143_A0.8801.00
95_G145_I0.8731.00
48_F55_I0.8661.00
66_S69_E0.8611.00
75_I79_R0.8581.00
199_L203_L0.8571.00
202_I206_E0.8561.00
174_V184_Q0.8541.00
140_L143_A0.8531.00
120_D211_I0.8501.00
185_T212_K0.8481.00
19_S23_L0.8451.00
132_I136_L0.8441.00
110_A230_L0.8351.00
155_V158_K0.8341.00
25_L32_V0.8321.00
168_T173_P0.8301.00
197_A201_H0.8301.00
268_R271_T0.8271.00
60_P82_M0.8261.00
124_V140_L0.8241.00
119_V276_A0.8221.00
94_I142_G0.8211.00
51_H54_G0.8211.00
154_L266_I0.8181.00
77_E81_A0.8161.00
13_A61_G0.8151.00
243_H246_E0.8141.00
60_P63_I0.8121.00
177_S255_S0.8111.00
90_G276_A0.8091.00
29_Q33_T0.8091.00
273_I278_S0.8091.00
13_A16_G0.8071.00
167_V233_S0.8041.00
75_I78_A0.8011.00
113_N230_L0.8001.00
16_G62_Q0.7981.00
14_R65_V0.7941.00
240_I243_H0.7911.00
9_F64_L0.7911.00
176_S185_T0.7901.00
282_T286_D0.7861.00
179_Q182_Q0.7811.00
74_T78_A0.7811.00
15_E21_A0.7781.00
275_P279_A0.7771.00
16_G54_G0.7761.00
4_Q35_K0.7761.00
3_I72_L0.7741.00
37_Q46_K0.7731.00
7_Q11_T0.7721.00
168_T174_V0.7701.00
186_M210_P0.7681.00
169_S230_L0.7661.00
163_E253_T0.7611.00
153_D269_K0.7571.00
172_H185_T0.7571.00
90_G119_V0.7561.00
12_T48_F0.7561.00
69_E73_H0.7561.00
78_A82_M0.7541.00
5_L8_V0.7521.00
198_K202_I0.7521.00
175_I250_R0.7481.00
202_I205_E0.7391.00
240_I244_E0.7391.00
96_S101_A0.7391.00
199_L202_I0.7381.00
225_C230_L0.7371.00
49_Y58_T0.7361.00
62_Q65_V0.7361.00
68_S71_I0.7331.00
180_D183_T0.7321.00
142_G280_F0.7301.00
167_V235_L0.7291.00
115_L279_A0.7291.00
218_I221_A0.7281.00
171_S175_I0.7271.00
112_Y279_A0.7261.00
18_I32_V0.7241.00
182_Q208_L0.7231.00
167_V244_E0.7231.00
12_T36_I0.7171.00
138_Y268_R0.7171.00
279_A283_H0.7141.00
173_P176_S0.7131.00
88_P116_Y0.7131.00
12_T32_V0.7111.00
236_P239_I0.7071.00
169_S172_H0.7071.00
244_E247_G0.7061.00
168_T250_R0.7051.00
136_L154_L0.7041.00
200_N204_Q0.7011.00
177_S256_D0.7001.00
60_P64_L0.6931.00
201_H205_E0.6901.00
59_P63_I0.6881.00
93_R140_L0.6861.00
7_Q10_L0.6861.00
190_R215_E0.6851.00
31_N35_K0.6851.00
171_S229_G0.6841.00
141_N277_L0.6831.00
244_E251_S0.6801.00
57_L62_Q0.6761.00
93_R141_N0.6711.00
56_T62_Q0.6701.00
102_A224_G0.6611.00
64_L82_M0.6611.00
198_K201_H0.6521.00
171_S174_V0.6511.00
197_A202_I0.6491.00
67_Y71_I0.6491.00
49_Y54_G0.6491.00
242_S245_K0.6451.00
73_H76_E0.6441.00
23_L26_N0.6431.00
189_F222_I0.6421.00
111_H286_D0.6411.00
77_E80_A0.6401.00
40_E45_T0.6391.00
163_E257_K0.6391.00
183_T211_I0.6371.00
214_M225_C0.6321.00
271_T274_T0.6311.00
186_M232_I0.6311.00
40_E50_R0.6301.00
125_T217_G0.6301.00
201_H204_Q0.6281.00
166_L234_L0.6251.00
120_D215_E0.6231.00
107_Q110_A0.6211.00
36_I40_E0.6181.00
105_L108_L0.6181.00
196_R215_E0.6171.00
171_S250_R0.6171.00
7_Q72_L0.6151.00
96_S105_L0.6151.00
275_P278_S0.6151.00
166_L181_V0.6091.00
146_S261_V0.6071.00
179_Q206_E0.6061.00
80_A84_E0.6051.00
98_E127_P0.6051.00
68_S72_L0.6021.00
190_R217_G0.5971.00
4_Q38_Q0.5971.00
92_L276_A0.5961.00
142_G281_L0.5961.00
9_F61_G0.5941.00
170_A247_G0.5891.00
12_T17_S0.5871.00
43_L64_L0.5871.00
200_N203_L0.5861.00
92_L142_G0.5851.00
21_A25_L0.5841.00
72_L76_E0.5821.00
45_T49_Y0.5761.00
107_Q111_H0.5761.00
89_S120_D0.5711.00
4_Q8_V0.5701.00
43_L82_M0.5701.00
63_I82_M0.5651.00
45_T85_S0.5641.00
116_Y119_V0.5641.00
31_N34_N0.5641.00
227_S246_E0.5641.00
48_F57_L0.5621.00
267_R278_S0.5621.00
216_F221_A0.5611.00
162_E261_V0.5601.00
125_T218_I0.5591.00
135_V266_I0.5581.00
195_Y199_L0.5571.00
135_V154_L0.5571.00
95_G126_G0.5551.00
160_L263_T0.5541.00
166_L186_M0.5531.00
95_G124_V0.5521.00
280_F284_M0.5521.00
203_L210_P0.5511.00
222_I226_V0.5501.00
172_H232_I0.5491.00
13_A62_Q0.5481.00
235_L240_I0.5481.00
159_V265_F0.5471.00
144_F284_M0.5451.00
57_L65_V0.5431.00
182_Q209_L0.5421.00
30_S34_N0.5421.00
168_T175_I0.5421.00
164_M234_L0.5411.00
28_A34_N0.5401.00
100_T104_W0.5371.00
155_V270_D0.5351.00
18_I29_Q0.5331.00
107_Q224_G0.5311.00
225_C231_G0.5311.00
191_K215_E0.5311.00
90_G118_N0.5301.00
195_Y198_K0.5301.00
80_A83_G0.5301.00
254_I257_K0.5291.00
18_I54_G0.5261.00
147_G156_Q0.5261.00
104_W108_L0.5241.00
43_L46_K0.5241.00
84_E88_P0.5221.00
8_V36_I0.5211.00
27_Y35_K0.5211.00
46_K60_P0.5201.00
106_P110_A0.5171.00
102_A218_I0.5171.00
66_S81_A0.5171.00
16_G55_I0.5121.00
81_A84_E0.5121.00
67_Y82_M0.5111.00
219_L236_P0.5101.00
109_L121_L0.5091.00
78_A81_A0.5091.00
136_L139_E0.5031.00
96_S123_L0.5031.00
8_V21_A0.5001.00
110_A113_N0.5001.00
277_L281_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1uthA 2 0.7534 100 0.088 Contact Map
2esnA 3 0.9764 100 0.09 Contact Map
3fxqA 3 0.9764 100 0.091 Contact Map
1al3A 1 0.7095 100 0.103 Contact Map
1ixcA 4 0.9696 100 0.104 Contact Map
3fzvA 4 0.9527 100 0.105 Contact Map
2h9bA 2 0.6926 100 0.105 Contact Map
2h98A 2 0.6926 100 0.106 Contact Map
4x6gA 4 1 100 0.107 Contact Map
3szpA 3 0.9628 100 0.119 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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