GREMLIN Database
BRNQ - Branched-chain amino acid transport system carrier protein BrnQ
UniProt: P94499 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 440 (426)
Sequences: 1598 (1189)
Seq/√Len: 57.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_A302_I5.3041.00
381_F425_G4.8601.00
382_A422_A4.3661.00
137_C323_V4.1361.00
130_I330_T4.0671.00
191_K195_E3.8941.00
378_S426_G3.8771.00
229_V233_K3.8551.00
136_A298_S3.7281.00
425_G429_G3.6551.00
328_F332_V3.6171.00
39_K180_P3.3631.00
204_V208_F3.1761.00
59_A205_A2.9661.00
57_L239_A2.8511.00
168_V172_R2.8481.00
9_Y219_Q2.6801.00
265_N338_T2.5971.00
236_A240_V2.5091.00
306_S321_I2.4841.00
41_V250_S2.4531.00
19_A150_V2.4231.00
82_F379_L2.4181.00
104_G129_T2.4051.00
14_G237_I2.4041.00
302_I322_A2.3701.00
157_I292_V2.3521.00
357_S382_A2.3441.00
59_A359_I2.3051.00
99_A203_L2.2761.00
86_F355_A2.2641.00
377_G381_F2.2101.00
129_T334_N2.2061.00
357_S422_A2.1541.00
126_I130_I2.1461.00
137_C141_L2.1411.00
317_S320_K2.1321.00
167_A171_I2.1221.00
139_L299_V2.0921.00
108_F124_S2.0301.00
52_G56_P1.9721.00
135_L295_L1.9541.00
139_L147_I1.9531.00
89_I351_M1.9521.00
302_I326_S1.9461.00
223_T226_Q1.9301.00
316_I320_K1.9161.00
216_L227_L1.9101.00
22_F27_L1.9041.00
78_V82_F1.8831.00
15_L155_T1.8821.00
136_A326_S1.8671.00
137_C322_A1.8040.99
420_I424_A1.7840.99
103_S298_S1.7780.99
37_A44_A1.7640.99
335_I339_Q1.7610.99
45_N250_S1.7350.99
264_E268_E1.7180.99
225_K229_V1.7160.99
339_Q342_K1.7110.99
131_L135_L1.7040.99
163_G167_A1.6930.99
104_G133_F1.6880.99
139_L295_L1.6880.99
104_G134_A1.6850.99
61_T232_A1.6640.99
372_T376_Q1.6450.99
166_V248_A1.6280.99
159_L245_M1.6240.99
422_A425_G1.6190.99
202_A359_I1.6120.99
98_F347_V1.5990.99
84_I88_T1.5930.99
390_G394_A1.5860.98
377_G429_G1.5840.98
251_Y255_S1.5630.98
158_K289_M1.5600.98
6_S9_Y1.5530.98
173_P255_S1.5530.98
295_L299_V1.5510.98
140_S303_T1.5450.98
161_F289_M1.5410.98
31_P249_L1.5350.98
138_L149_I1.5270.98
381_F429_G1.5100.98
13_I216_L1.5070.98
59_A202_A1.5050.98
354_I383_F1.5030.98
137_C326_S1.4990.98
381_F384_I1.4850.98
43_V46_A1.4820.98
316_I321_I1.4780.98
206_F355_A1.4720.98
177_I254_A1.4710.98
305_C325_L1.4650.97
350_T387_L1.4640.97
310_H317_S1.4570.97
105_N125_L1.4430.97
368_F374_V1.4310.97
104_G136_A1.4270.97
31_P269_V1.4230.97
241_L245_M1.4230.97
17_L60_I1.4180.97
183_G191_K1.4140.97
45_N247_T1.4120.97
345_M349_L1.4120.97
267_A337_L1.4100.97
354_I379_L1.4040.97
331_L335_I1.3880.96
389_D417_G1.3880.96
158_K296_T1.3860.96
285_L289_M1.3860.96
380_L383_F1.3840.96
114_P117_S1.3800.96
123_V127_I1.3710.96
169_A252_M1.3560.96
98_F341_I1.3530.96
306_S322_A1.3530.96
94_I99_A1.3420.96
128_F291_T1.3300.95
46_A189_F1.3190.95
77_R365_H1.3170.95
92_L97_F1.3150.95
382_A386_S1.3080.95
83_G165_L1.3060.95
93_A98_F1.3050.95
361_L374_V1.2990.95
189_F193_F1.2940.95
74_L362_T1.2870.95
430_Y434_I1.2690.94
125_L129_T1.2560.94
20_L99_A1.2540.94
377_G425_G1.2490.94
263_L269_V1.2480.94
377_G432_L1.2460.94
160_T164_L1.2460.94
99_A309_F1.2430.94
20_L150_V1.2370.93
168_V278_F1.2370.93
20_L340_L1.2310.93
127_I131_L1.2250.93
82_F354_I1.2190.93
198_L340_L1.2190.93
173_P256_S1.2140.93
365_H375_Y1.2040.92
49_L53_V1.2010.92
134_A138_L1.2010.92
376_Q380_L1.1990.92
302_I325_L1.1960.92
49_L243_A1.1900.92
100_I329_S1.1850.92
411_M414_I1.1850.92
269_V273_V1.1840.92
321_I325_L1.1830.92
373_E377_G1.1810.92
365_H370_G1.1810.92
19_A296_T1.1790.92
129_T333_A1.1750.91
350_T390_G1.1700.91
54_G96_P1.1500.91
313_F321_I1.1470.90
81_V85_V1.1430.90
377_G428_C1.1380.90
357_S379_L1.1280.90
76_S83_G1.1270.90
420_I427_I1.1210.89
15_L19_A1.1200.89
32_M36_L1.1170.89
330_T333_A1.1070.89
47_G189_F1.1020.89
126_I330_T1.1010.89
125_L334_N1.1000.88
71_L87_T1.0960.88
238_A242_L1.0760.87
63_F209_G1.0730.87
403_R407_Q1.0720.87
292_V296_T1.0680.87
92_L309_F1.0530.86
110_I209_G1.0500.86
155_T158_K1.0460.86
386_S390_G1.0370.85
97_F343_V1.0370.85
41_V254_A1.0320.85
49_L162_I1.0320.85
40_N43_V1.0320.85
190_F416_L1.0290.85
51_T56_P1.0280.85
107_S291_T1.0260.85
371_K433_S1.0260.85
350_T354_I1.0250.85
63_F213_V1.0240.85
58_L360_F1.0240.85
53_V243_A1.0220.84
381_F385_I1.0140.84
16_M20_L1.0100.84
55_L356_I1.0060.84
165_L289_M1.0010.83
323_V327_V0.9990.83
99_A208_F0.9940.83
31_P270_L0.9930.83
227_L231_C0.9910.83
20_L208_F0.9860.82
142_N149_I0.9850.82
357_S378_S0.9760.82
20_L106_V0.9750.82
389_D392_K0.9740.82
377_G426_G0.9710.81
306_S343_V0.9710.81
10_I233_K0.9640.81
392_K402_N0.9640.81
19_A158_K0.9630.81
203_L351_M0.9580.80
121_S124_S0.9570.80
93_A351_M0.9550.80
12_I19_A0.9520.80
214_N217_K0.9510.80
126_I334_N0.9470.80
17_L22_F0.9460.80
86_F90_L0.9410.79
27_L289_M0.9390.79
310_H316_I0.9370.79
20_L341_I0.9360.79
80_P193_F0.9320.79
10_I241_L0.9320.79
22_F159_L0.9320.79
385_I409_L0.9320.79
172_R277_Y0.9320.79
208_F212_I0.9310.78
62_A66_S0.9290.78
432_L435_F0.9290.78
8_S12_I0.9280.78
108_F128_F0.9220.78
301_L344_S0.9190.78
107_S128_F0.9190.78
78_V379_L0.9180.77
242_L296_T0.9170.77
21_F60_I0.9160.77
240_V401_V0.9130.77
42_W46_A0.9110.77
384_I428_C0.9080.77
158_K293_A0.9070.77
381_F422_A0.9070.77
170_L251_Y0.9050.76
87_T308_F0.9030.76
103_S107_S0.9020.76
275_S283_S0.9010.76
77_R362_T0.9000.76
112_V115_F0.9000.76
94_I204_V0.8980.76
147_I215_A0.8970.76
90_L203_L0.8960.76
108_F121_S0.8930.76
389_D393_A0.8920.75
390_G393_A0.8910.75
90_L351_M0.8900.75
161_F288_L0.8870.75
177_I255_S0.8860.75
158_K242_L0.8860.75
58_L363_F0.8820.75
225_K424_A0.8820.75
44_A195_E0.8700.74
12_I16_M0.8680.73
16_M266_G0.8670.73
116_L124_S0.8660.73
96_P348_L0.8630.73
100_I298_S0.8610.73
142_N319_K0.8610.73
55_L111_G0.8610.73
266_G337_L0.8590.73
110_I290_I0.8590.73
373_E432_L0.8590.73
50_V189_F0.8580.73
82_F86_F0.8580.73
198_L386_S0.8570.72
170_L248_A0.8570.72
327_V331_L0.8560.72
235_A269_V0.8550.72
81_V299_V0.8540.72
148_D219_Q0.8540.72
238_A292_V0.8500.72
154_L297_T0.8480.72
237_I356_I0.8480.72
146_I245_M0.8470.72
98_F344_S0.8460.71
171_I174_I0.8420.71
62_A362_T0.8370.71
155_T296_T0.8360.71
57_L267_A0.8360.71
178_Q257_V0.8350.71
160_T427_I0.8340.70
221_A226_Q0.8340.70
264_E338_T0.8330.70
331_L399_E0.8310.70
227_L234_A0.8290.70
135_L291_T0.8250.70
61_T228_I0.8230.69
407_Q423_I0.8190.69
180_P184_Y0.8190.69
165_L274_S0.8160.69
63_F74_L0.8130.68
103_S329_S0.8110.68
76_S80_P0.8100.68
274_S278_F0.8080.68
145_K148_D0.8040.68
72_Q311_E0.8040.68
96_P301_L0.8000.67
122_P126_I0.8000.67
147_I158_K0.7960.67
103_S325_L0.7950.67
128_F290_I0.7940.67
67_G74_L0.7910.66
18_F22_F0.7910.66
431_I435_F0.7910.66
10_I237_I0.7890.66
158_K308_F0.7890.66
147_I296_T0.7880.66
70_N209_G0.7870.66
52_G206_F0.7870.66
417_G427_I0.7840.66
91_Y207_V0.7820.65
97_F332_V0.7820.65
145_K149_I0.7800.65
344_S350_T0.7800.65
290_I344_S0.7790.65
20_L60_I0.7790.65
408_I424_A0.7770.65
22_F241_L0.7730.65
117_S354_I0.7710.64
186_S190_F0.7710.64
95_G99_A0.7710.64
373_E376_Q0.7690.64
9_Y14_G0.7660.64
158_K292_V0.7660.64
207_V242_L0.7650.64
110_I271_A0.7640.64
182_K186_S0.7630.64
21_F205_A0.7620.63
124_S127_I0.7580.63
94_I306_S0.7580.63
277_Y375_Y0.7530.62
20_L98_F0.7510.62
399_E402_N0.7510.62
349_L393_A0.7510.62
225_K384_I0.7510.62
75_A358_L0.7490.62
88_T309_F0.7440.62
105_N248_A0.7440.62
19_A242_L0.7420.61
132_F289_M0.7420.61
35_Q256_S0.7410.61
96_P100_I0.7400.61
265_N268_E0.7380.61
127_I360_F0.7360.61
207_V304_A0.7340.61
378_S429_G0.7330.60
305_C309_F0.7320.60
70_N73_S0.7310.60
88_T312_L0.7300.60
316_I324_V0.7290.60
19_A239_A0.7290.60
96_P344_S0.7290.60
147_I150_V0.7290.60
71_L90_L0.7280.60
256_S273_V0.7280.60
31_P211_I0.7270.60
177_I251_Y0.7250.60
251_Y254_A0.7230.59
335_I340_L0.7220.59
389_D412_Y0.7210.59
108_F159_L0.7180.59
135_L138_L0.7180.59
384_I397_K0.7170.59
296_T308_F0.7170.59
128_F166_V0.7160.59
150_V351_M0.7160.59
189_F195_E0.7160.59
289_M340_L0.7160.59
19_A198_L0.7150.58
91_Y188_A0.7140.58
287_G314_P0.7140.58
324_V387_L0.7090.58
185_T188_A0.7080.58
317_S324_V0.7050.57
70_N311_E0.7020.57
264_E299_V0.7020.57
140_S204_V0.6990.57
112_V245_M0.6970.57
103_S248_A0.6960.56
290_I311_E0.6950.56
106_V332_V0.6940.56
240_V243_A0.6940.56
263_L268_E0.6940.56
242_L308_F0.6930.56
143_P307_S0.6920.56
16_M19_A0.6910.56
71_L207_V0.6890.56
41_V45_N0.6870.55
412_Y417_G0.6860.55
6_S46_A0.6860.55
123_V167_A0.6840.55
399_E403_R0.6840.55
127_I424_A0.6840.55
411_M416_L0.6830.55
14_G241_L0.6820.55
98_F340_L0.6820.55
99_A301_L0.6800.55
174_I255_S0.6790.55
26_N29_F0.6780.54
308_F312_L0.6780.54
107_S283_S0.6770.54
327_V330_T0.6750.54
59_A241_L0.6750.54
208_F301_L0.6710.54
64_V235_A0.6700.54
97_F347_V0.6690.54
109_E113_K0.6680.53
225_K288_L0.6670.53
58_L359_I0.6650.53
25_G29_F0.6650.53
202_A349_L0.6650.53
90_L239_A0.6630.53
65_F211_I0.6600.53
366_S369_K0.6590.52
210_I305_C0.6590.52
134_A137_C0.6590.52
230_V340_L0.6590.52
64_V200_L0.6580.52
184_Y337_L0.6570.52
401_V430_Y0.6570.52
361_L375_Y0.6560.52
231_C237_I0.6560.52
49_L55_L0.6520.52
109_E265_N0.6500.51
52_G209_G0.6490.51
91_Y300_G0.6490.51
373_E423_I0.6470.51
184_Y266_G0.6460.51
342_K398_I0.6460.51
78_V273_V0.6450.51
28_I267_A0.6450.51
136_A295_L0.6450.51
166_V217_K0.6430.51
259_E289_M0.6410.50
267_A412_Y0.6410.50
134_A275_S0.6410.50
81_V84_I0.6410.50
21_F234_A0.6410.50
61_T235_A0.6400.50
115_F146_I0.6340.50
33_L105_N0.6330.50
52_G274_S0.6330.50
132_F375_Y0.6300.49
404_I423_I0.6300.49
324_V377_G0.6300.49
383_F387_L0.6300.49
19_A286_L0.6280.49
103_S133_F0.6280.49
33_L250_S0.6270.49
10_I230_V0.6260.49
127_I427_I0.6240.49
423_I426_G0.6230.48
109_E212_I0.6230.48
174_I276_Y0.6230.48
100_I104_G0.6230.48
361_L378_S0.6190.48
327_V427_I0.6170.48
21_F26_N0.6160.48
140_S322_A0.6160.48
427_I431_I0.6150.48
349_L390_G0.6140.47
259_E276_Y0.6140.47
12_I146_I0.6130.47
108_F126_I0.6130.47
155_T159_L0.6120.47
69_Q73_S0.6120.47
221_A230_V0.6120.47
357_S360_F0.6120.47
284_I386_S0.6110.47
184_Y188_A0.6090.47
89_I347_V0.6080.47
400_V423_I0.6050.46
313_F350_T0.6040.46
91_Y266_G0.6030.46
73_S76_S0.6030.46
22_F273_V0.6010.46
178_Q327_V0.6010.46
27_L328_F0.5980.46
176_T424_A0.5970.46
246_Y294_C0.5970.46
8_S76_S0.5970.46
409_L417_G0.5950.45
85_V327_V0.5950.45
53_V193_F0.5950.45
52_G239_A0.5940.45
272_K275_S0.5940.45
110_I250_S0.5940.45
46_A50_V0.5930.45
364_L367_V0.5930.45
388_F405_F0.5920.45
104_G241_L0.5920.45
221_A248_A0.5890.45
95_G301_L0.5860.44
257_V260_L0.5850.44
91_Y304_A0.5830.44
368_F426_G0.5820.44
8_S144_S0.5820.44
178_Q186_S0.5820.44
195_E266_G0.5790.44
398_I403_R0.5780.44
95_G208_F0.5780.44
283_S287_G0.5780.44
67_G72_Q0.5780.44
263_L273_V0.5770.43
310_H321_I0.5760.43
195_E198_L0.5760.43
198_L416_L0.5750.43
132_F136_A0.5750.43
48_F64_V0.5750.43
23_G26_N0.5740.43
210_I337_L0.5720.43
33_L195_E0.5720.43
373_E391_L0.5720.43
127_I134_A0.5720.43
63_F70_N0.5720.43
128_F394_A0.5710.43
380_L384_I0.5700.43
37_A288_L0.5700.43
106_V125_L0.5700.43
373_E424_A0.5690.43
144_S235_A0.5690.43
377_G380_L0.5670.42
99_A103_S0.5670.42
22_F166_V0.5670.42
268_E272_K0.5670.42
157_I160_T0.5660.42
238_A412_Y0.5660.42
175_G237_I0.5660.42
141_L323_V0.5650.42
19_A51_T0.5640.42
86_F207_V0.5640.42
52_G65_F0.5640.42
90_L322_A0.5640.42
73_S350_T0.5630.42
15_L162_I0.5630.42
92_L328_F0.5630.42
61_T64_V0.5630.42
99_A204_V0.5620.42
289_M292_V0.5590.41
16_M91_Y0.5580.41
111_G114_P0.5580.41
275_S280_S0.5570.41
240_V244_V0.5570.41
20_L204_V0.5560.41
112_V299_V0.5560.41
121_S234_A0.5550.41
207_V355_A0.5540.41
292_V419_L0.5520.41
53_V242_L0.5520.41
293_A299_V0.5510.41
182_K420_I0.5500.41
94_I111_G0.5500.41
190_F194_Q0.5500.41
397_K400_V0.5490.40
63_F67_G0.5480.40
131_L384_I0.5480.40
252_M263_L0.5480.40
133_F238_A0.5480.40
213_V235_A0.5480.40
419_L423_I0.5460.40
22_F33_L0.5460.40
328_F331_L0.5460.40
66_S154_L0.5460.40
231_C235_A0.5450.40
320_K384_I0.5440.40
104_G298_S0.5440.40
215_A310_H0.5430.40
424_A428_C0.5430.40
323_V432_L0.5430.40
143_P303_T0.5430.40
385_I405_F0.5430.40
64_V213_V0.5410.40
171_I403_R0.5410.40
149_I153_F0.5400.39
52_G93_A0.5390.39
365_H371_K0.5390.39
15_L198_L0.5380.39
306_S423_I0.5340.39
22_F340_L0.5320.39
103_S344_S0.5320.39
173_P220_G0.5320.39
97_F328_F0.5320.39
141_L319_K0.5300.38
47_G56_P0.5290.38
52_G290_I0.5280.38
134_A364_L0.5280.38
271_A283_S0.5280.38
422_A429_G0.5270.38
362_T421_P0.5270.38
337_L341_I0.5250.38
91_Y210_I0.5230.38
409_L422_A0.5230.38
135_L400_V0.5230.38
411_M420_I0.5220.38
104_G107_S0.5220.38
407_Q432_L0.5220.38
54_G351_M0.5210.37
89_I146_I0.5200.37
222_S431_I0.5200.37
165_L341_I0.5190.37
59_A204_V0.5180.37
134_A328_F0.5180.37
187_Q330_T0.5180.37
52_G97_F0.5170.37
216_L290_I0.5170.37
77_R375_Y0.5160.37
80_P85_V0.5160.37
35_Q262_I0.5150.37
67_G255_S0.5140.37
357_S412_Y0.5120.37
134_A403_R0.5100.36
132_F298_S0.5100.36
13_I17_L0.5100.36
403_R434_I0.5090.36
326_S338_T0.5090.36
36_L104_G0.5090.36
86_F206_F0.5080.36
23_G30_P0.5070.36
367_V427_I0.5060.36
252_M285_L0.5040.36
50_V85_V0.5030.36
324_V360_F0.5030.36
128_F134_A0.5020.36
86_F91_Y0.5010.35
428_C432_L0.5010.35
19_A304_A0.5010.35
386_S398_I0.5010.35
204_V245_M0.5010.35
10_I189_F0.5000.35
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3giaA 1 0.9273 100 0.801 Contact Map
3l1lA 2 0.8773 99.3 0.905 Contact Map
3dh4A 3 0.8886 98.7 0.926 Contact Map
2xq2A 2 0.8932 98.5 0.928 Contact Map
4djkA 2 0.8818 98.4 0.932 Contact Map
2a65A 2 0.9432 97.7 0.943 Contact Map
2jlnA 1 0.8841 97.3 0.947 Contact Map
4us3A 1 0.9 97.3 0.947 Contact Map
4xp4A 1 0.9409 97.1 0.949 Contact Map
4wgvA 2 0.8091 96.4 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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