GREMLIN Database
CYSH1 - Phosphoadenosine phosphosulfate reductase
UniProt: P94498 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 233 (203)
Sequences: 4633 (2765)
Seq/√Len: 194.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
190_Y195_D4.1481.00
37_Q137_P4.1081.00
53_D57_K3.4211.00
74_K78_E2.8351.00
27_L140_L2.6831.00
111_K114_E2.5001.00
34_Y138_A2.4371.00
120_C206_C2.4281.00
122_Y127_V2.3811.00
53_D182_Y2.3791.00
63_E93_I2.3571.00
82_R86_R2.2961.00
78_E82_R2.2121.00
146_D176_W2.0121.00
52_I64_I1.9931.00
120_C203_C1.8931.00
119_Q122_Y1.8841.00
57_K186_N1.8741.00
57_K182_Y1.8631.00
39_V136_H1.8591.00
68_D94_L1.8361.00
178_D181_R1.7901.00
26_V156_F1.7691.00
214_E218_S1.7501.00
203_C206_C1.7291.00
175_T178_D1.7101.00
46_I183_T1.7041.00
66_F72_H1.6911.00
181_R185_R1.6731.00
127_V131_E1.6731.00
68_D77_Y1.6701.00
121_C206_C1.6451.00
174_W182_Y1.6131.00
95_K132_A1.5941.00
23_A54_L1.5821.00
53_D56_Y1.5651.00
53_D186_N1.5631.00
74_K204_A1.5481.00
82_R189_D1.5451.00
138_A168_V1.5151.00
25_S28_K1.5121.00
29_W33_H1.5031.00
121_C203_C1.4941.00
51_L140_L1.4651.00
102_E106_E1.4591.00
190_Y194_H1.4541.00
76_T191_N1.4521.00
141_S169_C1.4311.00
75_E196_Q1.4271.00
177_K181_R1.4241.00
30_A168_V1.4241.00
155_N158_N1.4011.00
30_A38_L1.3951.00
52_I83_V1.3941.00
199_P210_A1.3741.00
154_T172_I1.3531.00
215_D218_S1.3531.00
28_K58_V1.3481.00
194_H199_P1.3351.00
46_I201_I1.3241.00
81_E85_E1.3181.00
180_W190_Y1.3151.00
40_Y55_I1.3131.00
86_R187_E1.3081.00
34_Y166_V1.2781.00
87_Y90_L1.2711.00
211_F214_E1.2611.00
24_L54_L1.2561.00
28_K32_G1.2401.00
24_L57_K1.2371.00
145_R172_I1.2281.00
26_V173_H1.2251.00
40_Y51_L1.2191.00
146_D175_T1.2141.00
159_K166_V1.2101.00
27_L55_I1.2101.00
54_L58_V1.2051.00
208_S222_N1.1991.00
39_V65_V1.1931.00
143_L154_T1.1801.00
44_F80_I1.1761.00
54_L182_Y1.1641.00
51_L171_L1.1611.00
103_E107_E1.1571.00
196_Q209_P1.1501.00
22_G25_S1.1421.00
98_D102_E1.1401.00
182_Y186_N1.1261.00
24_L28_K1.1261.00
143_L172_I1.1241.00
176_W180_W1.1181.00
145_R173_H1.1091.00
27_L54_L1.0921.00
65_V132_A1.0901.00
50_V179_I1.0861.00
45_G48_G1.0801.00
24_L58_V1.0711.00
119_Q123_L1.0691.00
180_W184_S1.0631.00
217_R220_R1.0611.00
143_L169_C1.0571.00
193_L201_I1.0491.00
46_I194_H1.0421.00
104_Q108_H1.0391.00
61_D91_N1.0341.00
180_W194_H1.0201.00
53_D87_Y1.0141.00
71_L205_P1.0141.00
38_L140_L1.0131.00
69_T125_K1.0091.00
49_I83_V1.0081.00
63_E91_N1.0071.00
56_Y87_Y0.9961.00
84_K92_I0.9951.00
81_E84_K0.9870.99
50_V183_T0.9840.99
38_L138_A0.9810.99
130_R163_F0.9810.99
50_V53_D0.9650.99
193_L197_G0.9600.99
50_V182_Y0.9520.99
80_I84_K0.9500.99
157_L168_V0.9480.99
31_Y34_Y0.9380.99
99_L103_E0.9370.99
83_V87_Y0.9330.99
77_Y80_I0.9310.99
46_I180_W0.9300.99
154_T158_N0.9270.99
192_P196_Q0.9140.99
41_A65_V0.9130.99
55_I62_A0.9120.99
84_K91_N0.9110.99
183_T190_Y0.9110.99
43_S48_G0.9090.99
95_K131_E0.9050.99
25_S29_W0.8970.99
176_W216_L0.8890.99
26_V168_V0.8870.99
82_R85_E0.8850.99
20_Y24_L0.8750.99
214_E217_R0.8750.99
194_H197_G0.8740.99
18_D21_K0.8690.99
121_C125_K0.8660.99
161_E164_K0.8620.99
60_K90_L0.8580.99
133_L139_W0.8490.98
183_T188_L0.8480.98
155_N172_I0.8450.98
100_T127_V0.8400.98
75_E78_E0.8360.98
19_P22_G0.8340.98
149_P152_A0.8310.98
156_F173_H0.8300.98
108_H119_Q0.8240.98
212_T215_D0.8210.98
53_D188_L0.8200.98
130_R134_S0.8190.98
200_S207_T0.8190.98
86_R189_D0.8180.98
42_C83_V0.8040.98
42_C49_I0.8020.98
181_R184_S0.8010.98
127_V130_R0.7990.98
73_F193_L0.7960.98
104_Q112_L0.7950.98
78_E81_E0.7920.98
104_Q109_G0.7880.97
208_S214_E0.7850.97
63_E136_H0.7810.97
216_L220_R0.7790.97
217_R221_W0.7740.97
47_E147_Q0.7730.97
78_E192_P0.7710.97
39_V139_W0.7690.97
200_S219_G0.7660.97
73_F198_Y0.7530.97
64_I90_L0.7520.97
120_C124_R0.7520.97
49_I79_T0.7420.96
176_W199_P0.7400.96
23_A174_W0.7340.96
129_L133_L0.7270.96
84_K90_L0.7250.96
158_N169_C0.7250.96
56_Y90_L0.7190.96
66_F80_I0.7110.95
159_K164_K0.7100.95
81_E94_L0.7040.95
148_G151_R0.7040.95
156_F172_I0.7020.95
98_D127_V0.7000.95
23_A30_A0.7000.95
21_K25_S0.6990.95
55_I60_K0.6940.95
120_C128_P0.6910.95
50_V174_W0.6900.95
56_Y60_K0.6900.95
208_S218_S0.6900.95
106_E109_G0.6880.95
70_G96_K0.6850.94
191_N197_G0.6850.94
102_E105_A0.6820.94
125_K203_C0.6820.94
79_T190_Y0.6800.94
120_C123_L0.6800.94
37_Q135_G0.6700.94
120_C125_K0.6700.94
23_A26_V0.6690.94
101_L105_A0.6690.94
214_E222_N0.6620.93
80_I94_L0.6610.93
47_E194_H0.6600.93
43_S142_G0.6530.93
72_H125_K0.6500.93
22_G173_H0.6470.93
139_W167_K0.6420.92
46_I147_Q0.6400.92
113_W117_P0.6350.92
93_I136_H0.6270.91
67_L95_K0.6190.91
84_K94_L0.6170.91
50_V171_L0.6170.91
132_A135_G0.6140.91
82_R192_P0.6120.90
217_R222_N0.6120.90
212_T216_L0.6120.90
93_I132_A0.6110.90
89_G97_P0.6080.90
184_S195_D0.6080.90
75_E192_P0.6070.90
40_Y49_I0.6040.90
71_L101_L0.6010.90
52_I87_Y0.6000.90
100_T103_E0.6000.90
18_D22_G0.5990.89
43_S203_C0.5980.89
112_L119_Q0.5970.89
211_F216_L0.5970.89
111_K115_R0.5950.89
198_Y209_P0.5940.89
113_W126_V0.5940.89
32_G35_G0.5930.89
68_D96_K0.5920.89
89_G93_I0.5880.89
87_Y189_D0.5870.88
72_H200_S0.5860.88
112_L116_E0.5860.88
206_C222_N0.5850.88
79_T192_P0.5850.88
144_R180_W0.5840.88
76_T201_I0.5810.88
26_V30_A0.5780.88
213_A216_L0.5750.87
174_W178_D0.5730.87
112_L115_R0.5720.87
47_E180_W0.5710.87
113_W119_Q0.5710.87
158_N165_S0.5700.87
67_L141_S0.5680.87
52_I90_L0.5670.87
71_L203_C0.5670.87
71_L204_A0.5670.87
100_T104_Q0.5670.87
66_F77_Y0.5650.87
43_S148_G0.5600.86
67_L129_L0.5590.86
159_K163_F0.5590.86
44_F147_Q0.5560.86
67_L200_S0.5510.85
87_Y188_L0.5490.85
73_F207_T0.5480.85
191_N194_H0.5480.85
57_K177_K0.5430.84
152_A172_I0.5370.84
44_F49_I0.5360.84
71_L113_W0.5360.84
91_N95_K0.5330.83
184_S190_Y0.5300.83
19_P178_D0.5280.83
31_Y62_A0.5270.83
174_W179_I0.5250.82
29_W157_L0.5240.82
41_A199_P0.5220.82
190_Y197_G0.5210.82
24_L27_L0.5190.82
113_W118_N0.5190.82
22_G156_F0.5170.81
112_L123_L0.5170.81
49_I183_T0.5160.81
108_H112_L0.5150.81
123_L127_V0.5140.81
159_K165_S0.5100.80
91_N94_L0.5080.80
59_K62_A0.5060.80
177_K184_S0.5050.80
214_E219_G0.5050.80
71_L105_A0.5030.80
70_G128_P0.5030.80
52_I56_Y0.5020.79
75_E193_L0.5020.79
193_L198_Y0.5000.79
69_T202_G0.5000.79
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bwvA 2 0.9185 100 0.251 Contact Map
2oq2A 2 0.9957 100 0.255 Contact Map
2goyA 3 0.9142 100 0.31 Contact Map
2o8vA 2 0.9185 100 0.322 Contact Map
1zunA 1 0.7468 100 0.372 Contact Map
3fwkA 1 0.8884 100 0.433 Contact Map
2wsiA 1 0.8755 100 0.449 Contact Map
1surA 2 0.867 100 0.504 Contact Map
2ywbA 4 0.9399 99.8 0.687 Contact Map
2dplA 2 0.824 99.8 0.689 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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