ALR2 - BACSU - GREMLIN Contacts

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ALR2 - Alanine racemase 2

UniProt:	P94494	Sequences: MIKLCREVWIEVNLDAVKKNLRAIRRHIPHKSKIMAVVKANGYGHGSIEVARHALEHGASELAVASVEEGIVLRKAGITAPILVLGFTSLSCVKKSAAWNITLSAFQVDWMKEANEILEKEASANRLAIHINVDTGMGRLGVRTKEELLEVVKALKASKFLRWTGIFTHFSTADEPDTTLTKLQHEKFISFLSFLKKQGIELPTVHMCNTAAAIAFPEFSADMIRLGIGLYGLYPSAYIKQLNLVKLEPALSLKARIAYVKTMRTEPRTVSYGATYIAEPNEVIATLPIGYADGYSRALSNRGFVLHRGKRVPVAGRVTMDMIMVSLGENGEGKQGDEVVIYGKQKGAEISVDEVAEMLNTINYEVVSTLSRRIPRFYIRDGEIFKVSTPVLYV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	394 (357)
Sequences:	5057 (3759)
Seq/√Len:	198.9

ECOLI - ALR1 ALR2
BACSU - ALR2 ALR1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
17_V	250_A	3.687	1.00
168_T	207_M	3.413	1.00
304_F	311_R	3.100	1.00
285_A	327_L	2.866	1.00
262_T	283_V	2.860	1.00
257_I	285_A	2.823	1.00
71_I	99_W	2.802	1.00
19_K	248_E	2.769	1.00
269_T	274_A	2.766	1.00
210_T	229_G	2.707	1.00
189_I	221_A	2.698	1.00
264_R	281_N	2.642	1.00
269_T	277_I	2.637	1.00
311_R	354_E	2.609	1.00
254_K	338_E	2.593	1.00
284_I	315_A	2.486	1.00
70_G	101_I	2.470	1.00
55_L	80_A	2.410	1.00
262_T	281_N	2.382	1.00
11_E	254_K	2.371	1.00
24_I	229_G	2.340	1.00
13_N	16_A	2.288	1.00
96_S	103_L	2.230	1.00
33_K	60_S	2.220	1.00
275_T	317_R	2.196	1.00
138_G	268_R	2.184	1.00
253_L	289_I	2.140	1.00
276_Y	282_E	2.133	1.00
37_V	63_A	2.111	1.00
263_M	278_A	2.089	1.00
344_K	349_E	2.086	1.00
128_A	162_R	2.084	1.00
255_A	287_L	2.082	1.00
35_M	223_M	2.074	1.00
134_D	138_G	2.068	1.00
312_V	330_N	2.062	1.00
271_S	319_T	2.060	1.00
305_V	325_V	2.053	1.00
257_I	333_G	2.024	1.00
185_H	219_F	2.019	1.00
233_L	363_N	1.942	1.00
280_P	329_E	1.939	1.00
183_L	187_K	1.937	1.00
265_T	281_N	1.935	1.00
233_L	367_V	1.924	1.00
370_L	374_I	1.923	1.00
23_A	26_R	1.887	1.00
19_K	23_A	1.867	1.00
192_L	205_V	1.864	1.00
352_V	367_V	1.851	1.00
180_L	274_A	1.850	1.00
295_Y	341_I	1.846	1.00
308_R	337_D	1.820	1.00
48_I	76_A	1.816	1.00
334_K	337_D	1.794	1.00
41_N	372_R	1.790	1.00
142_V	151_V	1.777	1.00
104_S	167_F	1.755	1.00
9_W	254_K	1.753	1.00
112_K	154_A	1.739	1.00
18_K	53_H	1.734	1.00
36_A	230_L	1.715	1.00
172_T	274_A	1.705	1.00
340_V	349_E	1.681	1.00
186_E	190_S	1.649	1.00
260_V	327_L	1.632	1.00
185_H	221_A	1.601	1.00
307_H	325_V	1.571	1.00
264_R	268_R	1.562	1.00
264_R	278_A	1.555	1.00
102_T	164_T	1.548	1.00
296_S	369_T	1.538	1.00
55_L	62_L	1.534	1.00
133_V	191_F	1.523	1.00
21_L	230_L	1.517	1.00
306_L	350_I	1.515	1.00
18_K	57_H	1.506	1.00
353_D	363_N	1.504	1.00
35_M	63_A	1.484	1.00
172_T	181_T	1.476	1.00
286_T	324_M	1.474	1.00
130_H	206_H	1.473	1.00
47_S	72_V	1.470	1.00
38_V	51_A	1.468	1.00
213_A	226_L	1.465	1.00
205_V	222_D	1.460	1.00
307_H	312_V	1.449	1.00
17_V	50_V	1.436	1.00
282_E	326_S	1.394	1.00
51_A	73_L	1.378	1.00
321_D	373_R	1.376	1.00
172_T	175_E	1.375	1.00
10_I	374_I	1.369	1.00
16_A	248_E	1.367	1.00
48_I	72_V	1.364	1.00
306_L	340_V	1.362	1.00
28_I	32_S	1.356	1.00
287_L	323_I	1.355	1.00
49_E	378_Y	1.352	1.00
251_L	342_Y	1.351	1.00
208_C	219_F	1.349	1.00
100_N	125_N	1.346	1.00
35_M	61_E	1.343	1.00
282_E	328_G	1.339	1.00
126_R	162_R	1.322	1.00
128_A	164_T	1.315	1.00
115_N	158_S	1.308	1.00
303_G	314_V	1.308	1.00
33_K	61_E	1.305	1.00
319_T	324_M	1.302	1.00
28_I	224_I	1.299	1.00
185_H	189_I	1.292	1.00
287_L	339_V	1.275	1.00
36_A	59_A	1.274	1.00
117_I	123_S	1.273	1.00
108_V	112_K	1.271	1.00
208_C	220_S	1.263	1.00
182_K	186_E	1.251	1.00
115_N	160_F	1.243	1.00
8_V	289_I	1.240	1.00
260_V	335_Q	1.240	1.00
257_I	260_V	1.235	1.00
53_H	57_H	1.235	1.00
173_A	211_A	1.231	1.00
14_L	378_Y	1.229	1.00
149_L	194_F	1.228	1.00
278_A	282_E	1.218	1.00
268_R	278_A	1.210	1.00
108_V	154_A	1.207	1.00
21_L	59_A	1.199	1.00
49_E	52_R	1.193	1.00
45_H	251_L	1.186	1.00
62_L	80_A	1.186	1.00
19_K	246_K	1.185	1.00
275_T	301_N	1.185	1.00
24_I	226_L	1.180	1.00
115_N	154_A	1.178	1.00
182_K	218_E	1.170	1.00
10_I	253_L	1.169	1.00
144_T	190_S	1.162	1.00
180_L	269_T	1.158	1.00
175_E	178_T	1.140	1.00
8_V	255_A	1.133	1.00
284_I	324_M	1.130	1.00
263_M	270_V	1.121	1.00
185_H	207_M	1.120	1.00
187_K	190_S	1.110	1.00
95_K	99_W	1.103	1.00
279_E	282_E	1.096	1.00
9_W	377_F	1.095	1.00
71_I	75_K	1.095	1.00
253_L	374_I	1.095	1.00
275_T	300_S	1.093	1.00
21_L	34_I	1.090	1.00
75_K	99_W	1.089	1.00
342_Y	352_V	1.084	1.00
208_C	212_A	1.082	1.00
327_L	333_G	1.080	1.00
295_Y	355_V	1.080	1.00
73_L	78_I	1.080	1.00
112_K	116_E	1.077	1.00
289_I	341_I	1.069	1.00
29_P	32_S	1.067	1.00
287_L	325_V	1.064	1.00
256_R	338_E	1.061	1.00
109_D	335_Q	1.060	1.00
189_I	193_S	1.055	1.00
183_L	186_E	1.052	1.00
23_A	27_H	1.049	1.00
257_I	327_L	1.048	1.00
84_V	101_I	1.047	1.00
40_A	292_A	1.047	1.00
134_D	261_K	1.045	1.00
17_V	54_A	1.043	1.00
94_K	98_A	1.042	1.00
306_L	311_R	1.041	1.00
359_L	366_V	1.039	1.00
306_L	349_E	1.038	1.00
111_M	155_L	1.033	1.00
25_R	60_S	1.019	1.00
102_T	128_A	1.014	1.00
280_P	328_G	1.013	1.00
34_I	226_L	1.013	1.00
318_V	323_I	1.012	1.00
14_L	53_H	1.007	1.00
55_L	79_T	1.003	1.00
54_A	230_L	0.998	1.00
304_F	313_P	0.993	1.00
95_K	98_A	0.990	1.00
295_Y	314_V	0.990	1.00
229_G	247_L	0.989	1.00
132_N	140_L	0.989	1.00
351_S	354_E	0.981	1.00
143_R	268_R	0.975	0.99
305_V	323_I	0.974	0.99
61_E	102_T	0.972	0.99
304_F	358_M	0.971	0.99
21_L	54_A	0.970	0.99
28_I	34_I	0.967	0.99
81_P	102_T	0.967	0.99
189_I	218_E	0.966	0.99
162_R	203_P	0.966	0.99
343_G	350_I	0.959	0.99
10_I	251_L	0.958	0.99
74_R	82_I	0.957	0.99
356_A	361_T	0.952	0.99
148_L	191_F	0.949	0.99
196_K	205_V	0.947	0.99
217_P	220_S	0.943	0.99
48_I	52_R	0.940	0.99
259_Y	335_Q	0.932	0.99
105_A	111_M	0.931	0.99
29_P	220_S	0.930	0.99
181_T	216_F	0.922	0.99
105_A	129_I	0.915	0.99
254_K	340_V	0.912	0.99
327_L	330_N	0.910	0.99
282_E	315_A	0.909	0.99
267_P	278_A	0.895	0.99
140_L	286_T	0.891	0.99
213_A	224_I	0.891	0.99
89_S	92_C	0.889	0.99
13_N	379_I	0.886	0.99
257_I	307_H	0.886	0.99
312_V	325_V	0.885	0.99
22_R	57_H	0.884	0.99
94_K	122_A	0.879	0.99
312_V	328_G	0.878	0.99
172_T	180_L	0.876	0.99
18_K	22_R	0.876	0.99
228_I	364_Y	0.872	0.99
204_T	222_D	0.871	0.99
226_L	229_G	0.871	0.99
296_S	359_L	0.869	0.99
196_K	201_E	0.867	0.99
310_K	331_G	0.866	0.99
350_I	354_E	0.866	0.99
205_V	221_A	0.859	0.99
111_M	158_S	0.859	0.99
61_E	81_P	0.859	0.99
140_L	322_M	0.856	0.99
117_I	122_A	0.856	0.99
178_T	215_A	0.856	0.99
255_A	288_P	0.853	0.99
251_L	370_L	0.850	0.99
11_E	377_F	0.849	0.99
298_A	360_N	0.849	0.99
287_L	305_V	0.846	0.99
24_I	34_I	0.843	0.99
36_A	54_A	0.842	0.99
9_W	256_R	0.841	0.98
307_H	339_V	0.838	0.98
283_V	332_E	0.834	0.98
263_M	268_R	0.833	0.98
18_K	56_E	0.833	0.98
133_V	148_L	0.831	0.98
144_T	187_K	0.831	0.98
52_R	76_A	0.829	0.98
97_A	127_L	0.826	0.98
170_F	212_A	0.824	0.98
46_G	378_Y	0.819	0.98
8_V	374_I	0.819	0.98
33_K	204_T	0.816	0.98
74_R	100_N	0.814	0.98
188_F	205_V	0.814	0.98
298_A	359_L	0.811	0.98
325_V	339_V	0.810	0.98
170_F	207_M	0.806	0.98
109_D	112_K	0.803	0.98
61_E	223_M	0.802	0.98
22_R	58_G	0.801	0.98
21_L	57_H	0.797	0.98
228_I	233_L	0.794	0.98
58_G	80_A	0.792	0.98
168_T	221_A	0.792	0.98
100_N	128_A	0.792	0.98
299_L	358_M	0.790	0.98
295_Y	303_G	0.787	0.98
166_I	192_L	0.787	0.98
233_L	352_V	0.782	0.98
270_V	282_E	0.775	0.97
271_S	324_M	0.773	0.97
73_L	82_I	0.773	0.97
308_R	334_K	0.772	0.97
172_T	273_G	0.770	0.97
308_R	333_G	0.768	0.97
37_V	85_L	0.767	0.97
269_T	278_A	0.767	0.97
213_A	220_S	0.766	0.97
138_G	143_R	0.766	0.97
14_L	49_E	0.764	0.97
90_L	113_E	0.760	0.97
270_V	284_I	0.758	0.97
14_L	50_V	0.758	0.97
10_I	45_H	0.757	0.97
258_A	288_P	0.757	0.97
164_T	203_P	0.756	0.97
270_V	324_M	0.755	0.97
153_K	157_A	0.754	0.97
204_T	223_M	0.753	0.97
129_I	161_L	0.753	0.97
12_V	378_Y	0.748	0.97
84_V	96_S	0.745	0.97
130_H	165_G	0.744	0.97
148_L	152_V	0.744	0.97
172_T	178_T	0.742	0.97
280_P	326_S	0.742	0.97
10_I	370_L	0.740	0.97
211_A	235_P	0.739	0.97
13_N	252_S	0.739	0.97
111_M	151_V	0.737	0.97
174_D	273_G	0.737	0.97
182_K	216_F	0.737	0.97
185_H	208_C	0.736	0.97
305_V	341_I	0.735	0.96
83_L	130_H	0.735	0.96
300_S	303_G	0.733	0.96
50_V	250_A	0.733	0.96
165_G	206_H	0.732	0.96
12_V	250_A	0.728	0.96
71_I	95_K	0.727	0.96
51_A	78_I	0.727	0.96
108_V	147_E	0.726	0.96
296_S	366_V	0.725	0.96
13_N	344_K	0.723	0.96
352_V	363_N	0.722	0.96
310_K	329_E	0.721	0.96
133_V	166_I	0.719	0.96
297_R	365_E	0.717	0.96
228_I	363_N	0.715	0.96
38_V	62_L	0.714	0.96
105_A	114_A	0.712	0.96
138_G	263_M	0.711	0.96
307_H	333_G	0.710	0.96
15_D	18_K	0.709	0.96
151_V	155_L	0.703	0.95
97_A	117_I	0.702	0.95
295_Y	323_I	0.701	0.95
330_N	333_G	0.699	0.95
171_S	180_L	0.698	0.95
23_A	246_K	0.698	0.95
278_A	281_N	0.698	0.95
150_E	153_K	0.697	0.95
92_C	95_K	0.697	0.95
53_H	56_E	0.696	0.95
312_V	329_E	0.694	0.95
267_P	281_N	0.694	0.95
83_L	102_T	0.692	0.95
63_A	223_M	0.691	0.95
143_R	146_E	0.690	0.95
147_E	150_E	0.688	0.95
188_F	207_M	0.687	0.95
149_L	153_K	0.687	0.95
50_V	54_A	0.684	0.95
354_E	357_E	0.684	0.95
255_A	323_I	0.684	0.95
263_M	284_I	0.682	0.95
252_S	340_V	0.682	0.95
299_L	359_L	0.679	0.95
323_I	341_I	0.678	0.95
333_G	337_D	0.678	0.95
135_T	184_Q	0.675	0.94
297_R	362_I	0.674	0.94
11_E	252_S	0.673	0.94
265_T	279_E	0.671	0.94
279_E	313_P	0.671	0.94
7_E	256_R	0.670	0.94
289_I	323_I	0.669	0.94
41_N	47_S	0.668	0.94
65_A	321_D	0.668	0.94
155_L	163_W	0.667	0.94
11_E	379_I	0.666	0.94
193_S	197_K	0.664	0.94
234_Y	245_V	0.660	0.94
282_E	329_E	0.660	0.94
118_L	127_L	0.660	0.94
248_E	344_K	0.658	0.94
165_G	204_T	0.658	0.94
211_A	228_I	0.656	0.93
214_I	245_V	0.656	0.93
237_A	357_E	0.655	0.93
67_V	96_S	0.655	0.93
308_R	332_E	0.654	0.93
70_G	99_W	0.651	0.93
190_S	193_S	0.650	0.93
253_L	370_L	0.648	0.93
16_A	19_K	0.647	0.93
16_A	247_L	0.645	0.93
106_F	259_Y	0.644	0.93
33_K	223_M	0.643	0.93
207_M	221_A	0.642	0.93
48_I	78_I	0.642	0.93
253_L	342_Y	0.642	0.93
312_V	327_L	0.640	0.93
88_T	103_L	0.639	0.93
25_R	34_I	0.639	0.93
152_V	195_L	0.635	0.92
19_K	22_R	0.633	0.92
47_S	292_A	0.632	0.92
303_G	355_V	0.632	0.92
310_K	330_N	0.631	0.92
342_Y	366_V	0.630	0.92
108_V	150_E	0.629	0.92
283_V	329_E	0.627	0.92
259_Y	286_T	0.627	0.92
50_V	57_H	0.623	0.92
109_D	113_E	0.621	0.92
22_R	25_R	0.621	0.92
363_N	367_V	0.620	0.91
87_F	106_F	0.619	0.91
22_R	26_R	0.616	0.91
150_E	154_A	0.616	0.91
302_R	358_M	0.614	0.91
270_V	315_A	0.613	0.91
143_R	261_K	0.612	0.91
310_K	332_E	0.611	0.91
260_V	283_V	0.609	0.91
63_A	85_L	0.609	0.91
215_A	236_S	0.609	0.91
303_G	358_M	0.609	0.91
361_T	366_V	0.609	0.91
304_F	354_E	0.607	0.91
72_V	372_R	0.602	0.90
79_T	100_N	0.601	0.90
212_A	216_F	0.600	0.90
258_A	322_M	0.599	0.90
299_L	303_G	0.599	0.90
194_F	197_K	0.599	0.90
54_A	62_L	0.598	0.90
94_K	117_I	0.597	0.90
312_V	333_G	0.589	0.89
340_V	350_I	0.587	0.89
154_A	157_A	0.586	0.89
193_S	196_K	0.585	0.89
40_A	373_R	0.584	0.89
353_D	357_E	0.582	0.89
82_I	101_I	0.582	0.89
355_V	366_V	0.581	0.89
166_I	203_P	0.581	0.89
260_V	285_A	0.580	0.89
67_V	70_G	0.576	0.88
42_G	47_S	0.575	0.88
314_V	323_I	0.575	0.88
305_V	339_V	0.575	0.88
36_A	62_L	0.574	0.88
174_D	317_R	0.574	0.88
293_D	373_R	0.574	0.88
293_D	321_D	0.573	0.88
61_E	83_L	0.571	0.88
148_L	151_V	0.571	0.88
60_S	81_P	0.570	0.88
283_V	327_L	0.569	0.88
143_R	147_E	0.568	0.87
13_N	248_E	0.565	0.87
34_I	224_I	0.563	0.87
240_K	245_V	0.562	0.87
118_L	161_L	0.561	0.87
314_V	325_V	0.561	0.87
306_L	309_G	0.560	0.87
296_S	299_L	0.560	0.87
32_S	224_I	0.558	0.87
51_A	62_L	0.557	0.86
111_M	115_N	0.556	0.86
35_M	83_L	0.555	0.86
270_V	278_A	0.555	0.86
72_V	76_A	0.554	0.86
178_T	216_F	0.553	0.86
262_T	282_E	0.553	0.86
312_V	331_G	0.552	0.86
329_E	333_G	0.550	0.86
190_S	194_F	0.549	0.86
23_A	245_V	0.549	0.86
78_I	81_P	0.548	0.86
16_A	250_A	0.547	0.85
178_T	181_T	0.545	0.85
188_F	192_L	0.544	0.85
314_V	318_V	0.542	0.85
228_I	367_V	0.540	0.85
234_Y	239_I	0.540	0.85
311_R	350_I	0.539	0.85
240_K	244_L	0.538	0.85
354_E	358_M	0.536	0.84
144_T	191_F	0.536	0.84
300_S	360_N	0.535	0.84
118_L	123_S	0.534	0.84
71_I	101_I	0.533	0.84
97_A	118_L	0.533	0.84
15_D	19_K	0.530	0.84
97_A	123_S	0.529	0.84
135_T	171_S	0.529	0.84
276_Y	315_A	0.528	0.83
255_A	339_V	0.527	0.83
131_I	152_V	0.527	0.83
342_Y	355_V	0.526	0.83
61_E	204_T	0.526	0.83
113_E	116_E	0.526	0.83
342_Y	370_L	0.524	0.83
180_L	183_L	0.523	0.83
308_R	330_N	0.523	0.83
341_I	355_V	0.523	0.83
185_H	216_F	0.522	0.83
155_L	161_L	0.522	0.83
110_W	114_A	0.521	0.83
216_F	219_F	0.520	0.83
54_A	59_A	0.519	0.82
131_I	163_W	0.519	0.82
265_T	278_A	0.518	0.82
149_L	152_V	0.518	0.82
328_G	331_G	0.518	0.82
234_Y	246_K	0.518	0.82
48_I	51_A	0.517	0.82
21_L	62_L	0.517	0.82
55_L	58_G	0.515	0.82
191_F	194_F	0.515	0.82
42_G	52_R	0.515	0.82
40_A	321_D	0.515	0.82
83_L	104_S	0.514	0.82
89_S	256_R	0.514	0.82
131_I	142_V	0.514	0.82
364_Y	368_S	0.513	0.82
285_A	333_G	0.512	0.82
103_L	127_L	0.511	0.81
87_F	103_L	0.510	0.81
24_I	213_A	0.509	0.81
340_V	343_G	0.506	0.81
189_I	192_L	0.506	0.81
54_A	57_H	0.506	0.81
9_W	338_E	0.505	0.81
189_I	205_V	0.505	0.81
292_A	373_R	0.504	0.81
174_D	297_R	0.502	0.80
234_Y	353_D	0.501	0.80
84_V	88_T	0.501	0.80
299_L	355_V	0.501	0.80
98_A	125_N	0.500	0.80
14_L	18_K	0.500	0.80

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1bd0A	2	0.967	100	0.222	Contact Map
2vd8A	2	0.9315	100	0.239	Contact Map
3e5pA	2	0.9365	100	0.249	Contact Map
3hurA	4	0.9492	100	0.251	Contact Map
4a3qA	2	0.9036	100	0.252	Contact Map
3co8A	2	0.9264	100	0.27	Contact Map
4lusA	2	0.967	100	0.273	Contact Map
3s46A	2	0.9289	100	0.273	Contact Map
1vfsA	2	0.9645	100	0.275	Contact Map
4dzaA	2	0.9315	100	0.284	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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