GREMLIN Database
ALR2 - Alanine racemase 2
UniProt: P94494 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 394 (357)
Sequences: 5057 (3759)
Seq/√Len: 198.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_V250_A3.6871.00
168_T207_M3.4131.00
304_F311_R3.1001.00
285_A327_L2.8661.00
262_T283_V2.8601.00
257_I285_A2.8231.00
71_I99_W2.8021.00
19_K248_E2.7691.00
269_T274_A2.7661.00
210_T229_G2.7071.00
189_I221_A2.6981.00
264_R281_N2.6421.00
269_T277_I2.6371.00
311_R354_E2.6091.00
254_K338_E2.5931.00
284_I315_A2.4861.00
70_G101_I2.4701.00
55_L80_A2.4101.00
262_T281_N2.3821.00
11_E254_K2.3711.00
24_I229_G2.3401.00
13_N16_A2.2881.00
96_S103_L2.2301.00
33_K60_S2.2201.00
275_T317_R2.1961.00
138_G268_R2.1841.00
253_L289_I2.1401.00
276_Y282_E2.1331.00
37_V63_A2.1111.00
263_M278_A2.0891.00
344_K349_E2.0861.00
128_A162_R2.0841.00
255_A287_L2.0821.00
35_M223_M2.0741.00
134_D138_G2.0681.00
312_V330_N2.0621.00
271_S319_T2.0601.00
305_V325_V2.0531.00
257_I333_G2.0241.00
185_H219_F2.0191.00
233_L363_N1.9421.00
280_P329_E1.9391.00
183_L187_K1.9371.00
265_T281_N1.9351.00
233_L367_V1.9241.00
370_L374_I1.9231.00
23_A26_R1.8871.00
19_K23_A1.8671.00
192_L205_V1.8641.00
352_V367_V1.8511.00
180_L274_A1.8501.00
295_Y341_I1.8461.00
308_R337_D1.8201.00
48_I76_A1.8161.00
334_K337_D1.7941.00
41_N372_R1.7901.00
142_V151_V1.7771.00
104_S167_F1.7551.00
9_W254_K1.7531.00
112_K154_A1.7391.00
18_K53_H1.7341.00
36_A230_L1.7151.00
172_T274_A1.7051.00
340_V349_E1.6811.00
186_E190_S1.6491.00
260_V327_L1.6321.00
185_H221_A1.6011.00
307_H325_V1.5711.00
264_R268_R1.5621.00
264_R278_A1.5551.00
102_T164_T1.5481.00
296_S369_T1.5381.00
55_L62_L1.5341.00
133_V191_F1.5231.00
21_L230_L1.5171.00
306_L350_I1.5151.00
18_K57_H1.5061.00
353_D363_N1.5041.00
35_M63_A1.4841.00
172_T181_T1.4761.00
286_T324_M1.4741.00
130_H206_H1.4731.00
47_S72_V1.4701.00
38_V51_A1.4681.00
213_A226_L1.4651.00
205_V222_D1.4601.00
307_H312_V1.4491.00
17_V50_V1.4361.00
282_E326_S1.3941.00
51_A73_L1.3781.00
321_D373_R1.3761.00
172_T175_E1.3751.00
10_I374_I1.3691.00
16_A248_E1.3671.00
48_I72_V1.3641.00
306_L340_V1.3621.00
28_I32_S1.3561.00
287_L323_I1.3551.00
49_E378_Y1.3521.00
251_L342_Y1.3511.00
208_C219_F1.3491.00
100_N125_N1.3461.00
35_M61_E1.3431.00
282_E328_G1.3391.00
126_R162_R1.3221.00
128_A164_T1.3151.00
115_N158_S1.3081.00
303_G314_V1.3081.00
33_K61_E1.3051.00
319_T324_M1.3021.00
28_I224_I1.2991.00
185_H189_I1.2921.00
287_L339_V1.2751.00
36_A59_A1.2741.00
117_I123_S1.2731.00
108_V112_K1.2711.00
208_C220_S1.2631.00
182_K186_E1.2511.00
115_N160_F1.2431.00
8_V289_I1.2401.00
260_V335_Q1.2401.00
257_I260_V1.2351.00
53_H57_H1.2351.00
173_A211_A1.2311.00
14_L378_Y1.2291.00
149_L194_F1.2281.00
278_A282_E1.2181.00
268_R278_A1.2101.00
108_V154_A1.2071.00
21_L59_A1.1991.00
49_E52_R1.1931.00
45_H251_L1.1861.00
62_L80_A1.1861.00
19_K246_K1.1851.00
275_T301_N1.1851.00
24_I226_L1.1801.00
115_N154_A1.1781.00
182_K218_E1.1701.00
10_I253_L1.1691.00
144_T190_S1.1621.00
180_L269_T1.1581.00
175_E178_T1.1401.00
8_V255_A1.1331.00
284_I324_M1.1301.00
263_M270_V1.1211.00
185_H207_M1.1201.00
187_K190_S1.1101.00
95_K99_W1.1031.00
279_E282_E1.0961.00
9_W377_F1.0951.00
71_I75_K1.0951.00
253_L374_I1.0951.00
275_T300_S1.0931.00
21_L34_I1.0901.00
75_K99_W1.0891.00
342_Y352_V1.0841.00
208_C212_A1.0821.00
327_L333_G1.0801.00
295_Y355_V1.0801.00
73_L78_I1.0801.00
112_K116_E1.0771.00
289_I341_I1.0691.00
29_P32_S1.0671.00
287_L325_V1.0641.00
256_R338_E1.0611.00
109_D335_Q1.0601.00
189_I193_S1.0551.00
183_L186_E1.0521.00
23_A27_H1.0491.00
257_I327_L1.0481.00
84_V101_I1.0471.00
40_A292_A1.0471.00
134_D261_K1.0451.00
17_V54_A1.0431.00
94_K98_A1.0421.00
306_L311_R1.0411.00
359_L366_V1.0391.00
306_L349_E1.0381.00
111_M155_L1.0331.00
25_R60_S1.0191.00
102_T128_A1.0141.00
280_P328_G1.0131.00
34_I226_L1.0131.00
318_V323_I1.0121.00
14_L53_H1.0071.00
55_L79_T1.0031.00
54_A230_L0.9981.00
304_F313_P0.9931.00
95_K98_A0.9901.00
295_Y314_V0.9901.00
229_G247_L0.9891.00
132_N140_L0.9891.00
351_S354_E0.9811.00
143_R268_R0.9750.99
305_V323_I0.9740.99
61_E102_T0.9720.99
304_F358_M0.9710.99
21_L54_A0.9700.99
28_I34_I0.9670.99
81_P102_T0.9670.99
189_I218_E0.9660.99
162_R203_P0.9660.99
343_G350_I0.9590.99
10_I251_L0.9580.99
74_R82_I0.9570.99
356_A361_T0.9520.99
148_L191_F0.9490.99
196_K205_V0.9470.99
217_P220_S0.9430.99
48_I52_R0.9400.99
259_Y335_Q0.9320.99
105_A111_M0.9310.99
29_P220_S0.9300.99
181_T216_F0.9220.99
105_A129_I0.9150.99
254_K340_V0.9120.99
327_L330_N0.9100.99
282_E315_A0.9090.99
267_P278_A0.8950.99
140_L286_T0.8910.99
213_A224_I0.8910.99
89_S92_C0.8890.99
13_N379_I0.8860.99
257_I307_H0.8860.99
312_V325_V0.8850.99
22_R57_H0.8840.99
94_K122_A0.8790.99
312_V328_G0.8780.99
172_T180_L0.8760.99
18_K22_R0.8760.99
228_I364_Y0.8720.99
204_T222_D0.8710.99
226_L229_G0.8710.99
296_S359_L0.8690.99
196_K201_E0.8670.99
310_K331_G0.8660.99
350_I354_E0.8660.99
205_V221_A0.8590.99
111_M158_S0.8590.99
61_E81_P0.8590.99
140_L322_M0.8560.99
117_I122_A0.8560.99
178_T215_A0.8560.99
255_A288_P0.8530.99
251_L370_L0.8500.99
11_E377_F0.8490.99
298_A360_N0.8490.99
287_L305_V0.8460.99
24_I34_I0.8430.99
36_A54_A0.8420.99
9_W256_R0.8410.98
307_H339_V0.8380.98
283_V332_E0.8340.98
263_M268_R0.8330.98
18_K56_E0.8330.98
133_V148_L0.8310.98
144_T187_K0.8310.98
52_R76_A0.8290.98
97_A127_L0.8260.98
170_F212_A0.8240.98
46_G378_Y0.8190.98
8_V374_I0.8190.98
33_K204_T0.8160.98
74_R100_N0.8140.98
188_F205_V0.8140.98
298_A359_L0.8110.98
325_V339_V0.8100.98
170_F207_M0.8060.98
109_D112_K0.8030.98
61_E223_M0.8020.98
22_R58_G0.8010.98
21_L57_H0.7970.98
228_I233_L0.7940.98
58_G80_A0.7920.98
168_T221_A0.7920.98
100_N128_A0.7920.98
299_L358_M0.7900.98
295_Y303_G0.7870.98
166_I192_L0.7870.98
233_L352_V0.7820.98
270_V282_E0.7750.97
271_S324_M0.7730.97
73_L82_I0.7730.97
308_R334_K0.7720.97
172_T273_G0.7700.97
308_R333_G0.7680.97
37_V85_L0.7670.97
269_T278_A0.7670.97
213_A220_S0.7660.97
138_G143_R0.7660.97
14_L49_E0.7640.97
90_L113_E0.7600.97
270_V284_I0.7580.97
14_L50_V0.7580.97
10_I45_H0.7570.97
258_A288_P0.7570.97
164_T203_P0.7560.97
270_V324_M0.7550.97
153_K157_A0.7540.97
204_T223_M0.7530.97
129_I161_L0.7530.97
12_V378_Y0.7480.97
84_V96_S0.7450.97
130_H165_G0.7440.97
148_L152_V0.7440.97
172_T178_T0.7420.97
280_P326_S0.7420.97
10_I370_L0.7400.97
211_A235_P0.7390.97
13_N252_S0.7390.97
111_M151_V0.7370.97
174_D273_G0.7370.97
182_K216_F0.7370.97
185_H208_C0.7360.97
305_V341_I0.7350.96
83_L130_H0.7350.96
300_S303_G0.7330.96
50_V250_A0.7330.96
165_G206_H0.7320.96
12_V250_A0.7280.96
71_I95_K0.7270.96
51_A78_I0.7270.96
108_V147_E0.7260.96
296_S366_V0.7250.96
13_N344_K0.7230.96
352_V363_N0.7220.96
310_K329_E0.7210.96
133_V166_I0.7190.96
297_R365_E0.7170.96
228_I363_N0.7150.96
38_V62_L0.7140.96
105_A114_A0.7120.96
138_G263_M0.7110.96
307_H333_G0.7100.96
15_D18_K0.7090.96
151_V155_L0.7030.95
97_A117_I0.7020.95
295_Y323_I0.7010.95
330_N333_G0.6990.95
171_S180_L0.6980.95
23_A246_K0.6980.95
278_A281_N0.6980.95
150_E153_K0.6970.95
92_C95_K0.6970.95
53_H56_E0.6960.95
312_V329_E0.6940.95
267_P281_N0.6940.95
83_L102_T0.6920.95
63_A223_M0.6910.95
143_R146_E0.6900.95
147_E150_E0.6880.95
188_F207_M0.6870.95
149_L153_K0.6870.95
50_V54_A0.6840.95
354_E357_E0.6840.95
255_A323_I0.6840.95
263_M284_I0.6820.95
252_S340_V0.6820.95
299_L359_L0.6790.95
323_I341_I0.6780.95
333_G337_D0.6780.95
135_T184_Q0.6750.94
297_R362_I0.6740.94
11_E252_S0.6730.94
265_T279_E0.6710.94
279_E313_P0.6710.94
7_E256_R0.6700.94
289_I323_I0.6690.94
41_N47_S0.6680.94
65_A321_D0.6680.94
155_L163_W0.6670.94
11_E379_I0.6660.94
193_S197_K0.6640.94
234_Y245_V0.6600.94
282_E329_E0.6600.94
118_L127_L0.6600.94
248_E344_K0.6580.94
165_G204_T0.6580.94
211_A228_I0.6560.93
214_I245_V0.6560.93
237_A357_E0.6550.93
67_V96_S0.6550.93
308_R332_E0.6540.93
70_G99_W0.6510.93
190_S193_S0.6500.93
253_L370_L0.6480.93
16_A19_K0.6470.93
16_A247_L0.6450.93
106_F259_Y0.6440.93
33_K223_M0.6430.93
207_M221_A0.6420.93
48_I78_I0.6420.93
253_L342_Y0.6420.93
312_V327_L0.6400.93
88_T103_L0.6390.93
25_R34_I0.6390.93
152_V195_L0.6350.92
19_K22_R0.6330.92
47_S292_A0.6320.92
303_G355_V0.6320.92
310_K330_N0.6310.92
342_Y366_V0.6300.92
108_V150_E0.6290.92
283_V329_E0.6270.92
259_Y286_T0.6270.92
50_V57_H0.6230.92
109_D113_E0.6210.92
22_R25_R0.6210.92
363_N367_V0.6200.91
87_F106_F0.6190.91
22_R26_R0.6160.91
150_E154_A0.6160.91
302_R358_M0.6140.91
270_V315_A0.6130.91
143_R261_K0.6120.91
310_K332_E0.6110.91
260_V283_V0.6090.91
63_A85_L0.6090.91
215_A236_S0.6090.91
303_G358_M0.6090.91
361_T366_V0.6090.91
304_F354_E0.6070.91
72_V372_R0.6020.90
79_T100_N0.6010.90
212_A216_F0.6000.90
258_A322_M0.5990.90
299_L303_G0.5990.90
194_F197_K0.5990.90
54_A62_L0.5980.90
94_K117_I0.5970.90
312_V333_G0.5890.89
340_V350_I0.5870.89
154_A157_A0.5860.89
193_S196_K0.5850.89
40_A373_R0.5840.89
353_D357_E0.5820.89
82_I101_I0.5820.89
355_V366_V0.5810.89
166_I203_P0.5810.89
260_V285_A0.5800.89
67_V70_G0.5760.88
42_G47_S0.5750.88
314_V323_I0.5750.88
305_V339_V0.5750.88
36_A62_L0.5740.88
174_D317_R0.5740.88
293_D373_R0.5740.88
293_D321_D0.5730.88
61_E83_L0.5710.88
148_L151_V0.5710.88
60_S81_P0.5700.88
283_V327_L0.5690.88
143_R147_E0.5680.87
13_N248_E0.5650.87
34_I224_I0.5630.87
240_K245_V0.5620.87
118_L161_L0.5610.87
314_V325_V0.5610.87
306_L309_G0.5600.87
296_S299_L0.5600.87
32_S224_I0.5580.87
51_A62_L0.5570.86
111_M115_N0.5560.86
35_M83_L0.5550.86
270_V278_A0.5550.86
72_V76_A0.5540.86
178_T216_F0.5530.86
262_T282_E0.5530.86
312_V331_G0.5520.86
329_E333_G0.5500.86
190_S194_F0.5490.86
23_A245_V0.5490.86
78_I81_P0.5480.86
16_A250_A0.5470.85
178_T181_T0.5450.85
188_F192_L0.5440.85
314_V318_V0.5420.85
228_I367_V0.5400.85
234_Y239_I0.5400.85
311_R350_I0.5390.85
240_K244_L0.5380.85
354_E358_M0.5360.84
144_T191_F0.5360.84
300_S360_N0.5350.84
118_L123_S0.5340.84
71_I101_I0.5330.84
97_A118_L0.5330.84
15_D19_K0.5300.84
97_A123_S0.5290.84
135_T171_S0.5290.84
276_Y315_A0.5280.83
255_A339_V0.5270.83
131_I152_V0.5270.83
342_Y355_V0.5260.83
61_E204_T0.5260.83
113_E116_E0.5260.83
342_Y370_L0.5240.83
180_L183_L0.5230.83
308_R330_N0.5230.83
341_I355_V0.5230.83
185_H216_F0.5220.83
155_L161_L0.5220.83
110_W114_A0.5210.83
216_F219_F0.5200.83
54_A59_A0.5190.82
131_I163_W0.5190.82
265_T278_A0.5180.82
149_L152_V0.5180.82
328_G331_G0.5180.82
234_Y246_K0.5180.82
48_I51_A0.5170.82
21_L62_L0.5170.82
55_L58_G0.5150.82
191_F194_F0.5150.82
42_G52_R0.5150.82
40_A321_D0.5150.82
83_L104_S0.5140.82
89_S256_R0.5140.82
131_I142_V0.5140.82
364_Y368_S0.5130.82
285_A333_G0.5120.82
103_L127_L0.5110.81
87_F103_L0.5100.81
24_I213_A0.5090.81
340_V343_G0.5060.81
189_I192_L0.5060.81
54_A57_H0.5060.81
9_W338_E0.5050.81
189_I205_V0.5050.81
292_A373_R0.5040.81
174_D297_R0.5020.80
234_Y353_D0.5010.80
84_V88_T0.5010.80
299_L355_V0.5010.80
98_A125_N0.5000.80
14_L18_K0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1bd0A 2 0.967 100 0.222 Contact Map
2vd8A 2 0.9315 100 0.239 Contact Map
3e5pA 2 0.9365 100 0.249 Contact Map
3hurA 4 0.9492 100 0.251 Contact Map
4a3qA 2 0.9036 100 0.252 Contact Map
3co8A 2 0.9264 100 0.27 Contact Map
4lusA 2 0.967 100 0.273 Contact Map
3s46A 2 0.9289 100 0.273 Contact Map
1vfsA 2 0.9645 100 0.275 Contact Map
4dzaA 2 0.9315 100 0.284 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0115 seconds.