GREMLIN Database
XYLR - Xylose repressor
UniProt: P94490 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 384 (299)
Sequences: 9535 (7372)
Seq/√Len: 426.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
98_D102_T3.2561.00
170_D173_S3.2231.00
186_E229_R3.1811.00
106_D364_N3.1181.00
210_Y324_R2.6831.00
252_C257_C2.5431.00
97_T371_S2.4941.00
258_W308_G2.4791.00
232_S317_N2.4651.00
143_G374_V2.4591.00
250_C257_C2.4581.00
124_I178_K2.4521.00
95_I367_A2.4171.00
172_K176_Q2.3751.00
320_A357_L2.3321.00
209_I312_I2.3151.00
205_H320_A2.2821.00
270_S300_N2.2761.00
303_F341_E2.2371.00
94_G126_M2.2191.00
83_V127_I2.2181.00
202_A208_I2.1471.00
107_Q129_H2.1341.00
153_D156_Q2.1281.00
193_A220_G2.1071.00
144_I179_Y2.1061.00
241_M311_N2.0901.00
121_D178_K2.0871.00
192_G210_Y2.0151.00
94_G130_F1.9581.00
223_I228_Y1.9501.00
107_Q133_Q1.9431.00
299_Q337_S1.9021.00
302_G306_G1.8981.00
173_S177_E1.8961.00
306_G341_E1.8631.00
193_A222_I1.8571.00
207_N319_Q1.8451.00
231_V319_Q1.8421.00
174_S177_E1.8221.00
186_E190_N1.8191.00
128_H178_K1.8131.00
105_L133_Q1.7961.00
332_P336_N1.7851.00
309_L321_V1.7831.00
339_R343_S1.7451.00
240_H252_C1.7281.00
249_K255_R1.6801.00
199_F372_S1.6761.00
342_V356_L1.6731.00
186_E191_A1.6621.00
84_G367_A1.6611.00
302_G338_M1.6321.00
279_S282_D1.6211.00
285_N289_L1.6141.00
240_H250_C1.6061.00
307_I311_N1.6031.00
242_T311_N1.5601.00
169_I174_S1.5541.00
206_D224_N1.5481.00
286_L291_D1.5281.00
206_D319_Q1.5171.00
335_L339_R1.5091.00
146_I175_I1.5061.00
147_C191_A1.5021.00
288_H333_M1.4651.00
240_H257_C1.4531.00
250_C253_G1.4381.00
281_Q285_N1.4381.00
144_I181_V1.4281.00
205_H319_Q1.4101.00
267_L301_F1.4011.00
320_A355_E1.3961.00
82_S375_I1.3951.00
198_V376_D1.3871.00
195_G361_L1.3771.00
211_V309_L1.3751.00
340_S344_S1.3731.00
128_H179_Y1.3731.00
270_S273_T1.3601.00
197_K208_I1.3581.00
187_N237_E1.3461.00
83_V141_L1.3451.00
208_I222_I1.3431.00
248_P269_K1.3431.00
302_G337_S1.3411.00
91_Y108_Y1.3391.00
341_E344_S1.3381.00
124_I179_Y1.3321.00
331_H335_L1.3301.00
81_Y104_V1.3301.00
85_I123_L1.3301.00
341_E345_R1.3261.00
85_I94_G1.3231.00
312_I315_T1.3121.00
313_L342_V1.2831.00
335_L358_P1.2731.00
105_L130_F1.2591.00
141_L181_V1.2531.00
107_Q126_M1.2461.00
147_C366_P1.2451.00
80_G142_I1.2371.00
95_I103_I1.2361.00
121_D125_D1.2261.00
282_D285_N1.2211.00
337_S340_S1.2111.00
274_K296_N1.2041.00
191_A370_M1.2001.00
271_L297_A1.1801.00
287_A298_L1.1771.00
137_S140_G1.1761.00
186_E373_I1.1751.00
313_L321_V1.1661.00
208_I322_I1.1651.00
85_I127_I1.1561.00
115_S118_I1.1541.00
170_D174_S1.1541.00
196_E200_G1.1531.00
271_L294_T1.1491.00
217_I262_A1.1481.00
109_R126_M1.1461.00
117_E174_S1.1451.00
248_P260_L1.1441.00
120_K174_S1.1401.00
129_H133_Q1.1361.00
97_T103_I1.1301.00
84_G370_M1.1261.00
248_P261_Y1.1261.00
245_F307_I1.1251.00
205_H208_I1.1211.00
112_E122_I1.1151.00
109_R125_D1.1151.00
213_I305_L1.1131.00
193_A208_I1.1031.00
93_N108_Y1.1021.00
109_R129_H1.1011.00
209_I219_I1.0971.00
128_H138_P1.0831.00
174_S178_K1.0821.00
270_S297_A1.0751.00
337_S341_E1.0671.00
96_L130_F1.0631.00
176_Q183_V1.0521.00
96_L134_M1.0441.00
299_Q341_E1.0381.00
184_F374_V1.0341.00
270_S274_K1.0191.00
295_L299_Q1.0191.00
198_V372_S1.0181.00
216_G237_E1.0151.00
190_N227_L1.0131.00
175_I183_V1.0131.00
332_P358_P1.0111.00
253_G257_C1.0041.00
207_N223_I1.0031.00
299_Q340_S0.9941.00
151_L161_T0.9931.00
248_P270_S0.9921.00
248_P273_T0.9851.00
282_D286_L0.9801.00
128_H132_T0.9741.00
287_A295_L0.9721.00
91_Y264_E0.9711.00
161_T164_S0.9611.00
109_R122_I0.9581.00
244_D261_Y0.9541.00
285_N288_H0.9521.00
189_A212_S0.9451.00
126_M129_H0.9431.00
193_A210_Y0.9411.00
105_L134_M0.9401.00
78_K98_D0.9321.00
197_K222_I0.9321.00
124_I128_H0.9311.00
158_I168_D0.9311.00
84_G145_G0.9311.00
230_G235_S0.9301.00
336_N339_R0.9301.00
284_I298_L0.9301.00
82_S374_V0.9291.00
119_T166_W0.9211.00
92_I111_L0.9191.00
224_N228_Y0.9191.00
221_V228_Y0.9181.00
207_N231_V0.9121.00
307_I345_R0.9121.00
158_I170_D0.9101.00
203_K360_S0.9101.00
125_D129_H0.9071.00
302_G341_E0.9061.00
244_D247_G0.8971.00
89_V215_T0.8961.00
83_V131_I0.8951.00
244_D248_P0.8951.00
192_G366_P0.8931.00
230_G317_N0.8881.00
254_N345_R0.8871.00
287_A333_M0.8831.00
336_N340_S0.8821.00
331_H336_N0.8801.00
187_N216_G0.8791.00
209_I321_V0.8761.00
221_V316_F0.8601.00
209_I221_V0.8601.00
306_G342_V0.8591.00
272_Q276_K0.8591.00
230_G236_G0.8591.00
207_N228_Y0.8561.00
270_S301_F0.8551.00
207_N224_N0.8531.00
172_K185_I0.8501.00
271_L283_I0.8471.00
197_K225_N0.8451.00
274_K297_A0.8411.00
314_N347_Y0.8411.00
98_D104_V0.8361.00
122_I125_D0.8321.00
191_A373_I0.8291.00
288_H332_P0.8271.00
228_Y316_F0.8271.00
206_D225_N0.8231.00
103_I106_D0.8221.00
291_D294_T0.8201.00
278_L282_D0.8191.00
284_I288_H0.8151.00
313_L354_Y0.8121.00
116_P169_I0.8101.00
189_A220_G0.8081.00
267_L283_I0.8051.00
176_Q180_N0.8051.00
190_N237_E0.8041.00
322_I357_L0.8031.00
81_Y140_G0.7991.00
362_G365_A0.7981.00
329_E358_P0.7981.00
199_F368_L0.7961.00
250_C256_G0.7951.00
257_C260_L0.7951.00
258_W301_F0.7931.00
145_G374_V0.7891.00
303_F307_I0.7891.00
93_N106_D0.7881.00
331_H358_P0.7881.00
323_L328_I0.7861.00
176_Q182_P0.7851.00
97_T101_G0.7841.00
145_G191_A0.7801.00
200_G204_N0.7781.00
116_P174_S0.7761.00
286_L294_T0.7751.00
117_E121_D0.7751.00
184_F377_H0.7741.00
107_Q130_F0.7721.00
242_T245_F0.7721.00
85_I144_I0.7721.00
322_I359_S0.7701.00
87_V123_L0.7681.00
240_H253_G0.7641.00
180_N183_V0.7631.00
335_L338_M0.7611.00
118_I121_D0.7601.00
205_H355_E0.7581.00
188_E218_G0.7581.00
293_G296_N0.7521.00
274_K293_G0.7451.00
221_V236_G0.7451.00
287_A294_T0.7421.00
242_T254_N0.7391.00
88_G215_T0.7371.00
200_G203_K0.7351.00
83_V96_L0.7351.00
116_P166_W0.7351.00
343_S353_S0.7341.00
196_E361_L0.7301.00
303_F337_S0.7281.00
214_S326_S0.7261.00
268_L272_Q0.7191.00
157_K170_D0.7191.00
128_H131_I0.7181.00
267_L327_I0.7181.00
261_Y304_Y0.7171.00
241_M308_G0.7171.00
208_I320_A0.7161.00
130_F134_M0.7141.00
135_P138_P0.7121.00
309_L323_L0.7111.00
131_I141_L0.7081.00
292_I296_N0.7071.00
254_N257_C0.7061.00
303_F344_S0.7041.00
95_I106_D0.7041.00
331_H337_S0.7021.00
300_N304_Y0.7021.00
157_K172_K0.6971.00
148_V152_I0.6961.00
81_Y96_L0.6941.00
216_G259_E0.6931.00
296_N300_N0.6931.00
209_I318_P0.6901.00
357_L360_S0.6901.00
329_E363_Q0.6881.00
287_A290_N0.6861.00
242_T307_I0.6861.00
213_I327_I0.6861.00
309_L342_V0.6831.00
211_V238_M0.6821.00
243_I304_Y0.6791.00
306_G345_R0.6791.00
219_I238_M0.6791.00
334_V337_S0.6781.00
361_L365_A0.6771.00
94_G109_R0.6771.00
93_N367_A0.6761.00
306_G310_T0.6761.00
275_E278_L0.6761.00
97_T368_L0.6741.00
268_L283_I0.6721.00
250_C260_L0.6711.00
305_L338_M0.6701.00
235_S317_N0.6691.00
125_D128_H0.6691.00
286_L289_L0.6681.00
194_Y197_K0.6671.00
192_G324_R0.6661.00
173_S176_Q0.6661.00
269_K273_T0.6641.00
120_K169_I0.6641.00
310_T345_R0.6590.99
86_D366_P0.6570.99
259_E263_S0.6550.99
122_I126_M0.6540.99
297_A301_F0.6520.99
340_S343_S0.6520.99
247_G261_Y0.6500.99
361_L368_L0.6470.99
124_I175_I0.6470.99
187_N190_N0.6470.99
267_L297_A0.6470.99
163_N251_S0.6450.99
284_I330_S0.6420.99
131_I138_P0.6390.99
196_E359_S0.6350.99
271_L286_L0.6340.99
218_G237_E0.6340.99
82_S142_I0.6310.99
88_G326_S0.6280.99
84_G371_S0.6270.99
82_S97_T0.6260.99
231_V317_N0.6260.99
245_F303_F0.6260.99
148_V159_V0.6200.99
177_E180_N0.6190.99
92_I109_R0.6190.99
354_Y358_P0.6170.99
190_N220_G0.6170.99
103_I368_L0.6160.99
87_V148_V0.6140.99
151_L234_F0.6140.99
94_G107_Q0.6140.99
90_D215_T0.6130.99
84_G147_C0.6120.99
323_L356_L0.6120.99
244_D307_I0.6120.99
292_I295_L0.6120.99
87_V92_I0.6110.99
83_V144_I0.6090.99
129_H132_T0.6020.99
86_D326_S0.6020.99
332_P339_R0.5990.99
120_K171_L0.5980.99
175_I179_Y0.5960.99
201_A357_L0.5950.99
188_E212_S0.5940.99
143_G182_P0.5930.99
124_I174_S0.5920.99
310_T314_N0.5910.99
187_N218_G0.5910.99
274_K300_N0.5880.99
198_V375_I0.5860.99
243_I261_Y0.5830.99
266_A269_K0.5810.99
216_G239_G0.5790.99
162_P251_S0.5780.99
250_C254_N0.5780.99
96_L141_L0.5780.99
192_G212_S0.5770.99
254_N260_L0.5750.99
276_K282_D0.5740.99
302_G334_V0.5720.99
202_A322_I0.5660.98
231_V318_P0.5640.98
211_V219_I0.5610.98
309_L338_M0.5610.98
126_M130_F0.5590.98
243_I308_G0.5570.98
264_E268_L0.5570.98
127_I179_Y0.5550.98
157_K176_Q0.5510.98
127_I144_I0.5500.98
283_I287_A0.5500.98
295_L333_M0.5480.98
278_L283_I0.5460.98
154_K229_R0.5450.98
296_N299_Q0.5440.98
89_V188_E0.5430.98
196_E360_S0.5430.98
339_R355_E0.5420.98
212_S366_P0.5410.98
87_V119_T0.5400.98
287_A302_G0.5390.98
324_R359_S0.5390.98
238_M258_W0.5380.98
264_E327_I0.5380.98
244_D304_Y0.5380.98
268_L280_Y0.5340.98
284_I287_A0.5330.98
317_N354_Y0.5320.98
201_A360_S0.5320.98
262_A301_F0.5310.98
111_L119_T0.5300.98
280_Y283_I0.5290.98
262_A305_L0.5280.98
160_F167_R0.5280.98
118_I122_I0.5240.97
138_P181_V0.5240.97
153_D157_K0.5230.97
112_E118_I0.5230.97
123_L175_I0.5210.97
332_P335_L0.5210.97
265_K269_K0.5210.97
166_W169_I0.5190.97
252_C256_G0.5180.97
223_I318_P0.5170.97
244_D255_R0.5140.97
82_S143_G0.5140.97
253_G256_G0.5140.97
298_L302_G0.5120.97
146_I171_L0.5100.97
252_C260_L0.5080.97
343_S351_G0.5080.97
264_E326_S0.5070.97
331_H334_V0.5060.97
86_D187_N0.5040.97
280_Y284_I0.5040.97
210_Y322_I0.5040.97
187_N212_S0.5010.97
246_N303_F0.5010.97
333_M336_N0.5000.97
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1z05A 2 0.9818 100 0.148 Contact Map
1z6rA 3 0.9479 100 0.156 Contact Map
2hoeA 2 0.9141 100 0.209 Contact Map
4ijaA 2 0.9453 100 0.238 Contact Map
3o8mA 1 0.9245 100 0.355 Contact Map
2ap1A 2 0.763 100 0.37 Contact Map
1bdgA 1 0.888 100 0.371 Contact Map
4db3A 2 0.7786 100 0.374 Contact Map
2yhwA 2 0.763 100 0.378 Contact Map
3f9mA 1 0.8932 100 0.383 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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