GREMLIN Database
YEAD - Uncharacterized protein YeaD
UniProt: P94475 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 398 (353)
Sequences: 2796 (2280)
Seq/√Len: 121.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
65_R99_D5.3771.00
74_A261_S5.1011.00
221_D234_K4.3261.00
65_R131_Y4.2211.00
99_D131_Y4.0481.00
79_G130_S3.9761.00
140_E168_T3.9041.00
81_T128_T3.7751.00
62_Q85_R3.6461.00
267_L301_M3.6241.00
210_N230_Q3.6111.00
77_R132_E3.5001.00
85_R126_S3.1931.00
77_R134_A3.1151.00
140_E307_I3.0971.00
278_G291_I3.0131.00
225_S231_L2.9981.00
83_T128_T2.9141.00
72_L78_L2.9121.00
209_R215_D2.9001.00
64_S83_T2.8601.00
246_L267_L2.8501.00
71_Q303_R2.8091.00
80_V131_Y2.7681.00
81_T130_S2.6171.00
79_G132_E2.5251.00
244_L270_V2.4981.00
217_F220_L2.3561.00
248_M259_V2.2861.00
91_P120_F2.2091.00
149_R160_T2.1991.00
149_R158_E2.1901.00
246_L337_V2.1791.00
266_I337_V2.0361.00
21_T40_F2.0071.00
294_G297_H1.9891.00
245_F278_G1.9591.00
86_R121_P1.9331.00
83_T126_S1.9291.00
66_Q81_T1.9251.00
37_W40_F1.9161.00
138_R257_E1.9041.00
210_N232_M1.8941.00
221_D224_T1.8611.00
264_A302_L1.8581.00
86_R123_F1.8301.00
208_V232_M1.8281.00
249_D254_D1.8241.00
245_F332_A1.7681.00
64_S85_R1.7561.00
338_T360_L1.7451.00
122_W125_R1.7151.00
28_A40_F1.7091.00
142_H168_T1.7071.00
145_S162_F1.6741.00
246_L263_T1.6361.00
66_Q83_T1.6221.00
121_P125_R1.6121.00
175_Y265_S1.5951.00
260_V305_L1.5951.00
151_G158_E1.5751.00
62_Q87_K1.5421.00
245_F280_A1.5411.00
28_A37_W1.5331.00
256_F260_V1.5301.00
73_H76_D1.4941.00
262_V337_V1.4841.00
98_E147_R1.4811.00
268_H298_F1.4711.00
16_I20_L1.4591.00
33_G36_S1.4251.00
246_L277_A1.4251.00
271_L277_A1.4251.00
278_G297_H1.4241.00
316_I321_R1.4231.00
205_A208_V1.4151.00
219_A236_F1.4061.00
247_L280_A1.3991.00
178_F265_S1.3931.00
255_A339_G1.3841.00
121_P127_M1.3751.00
176_Q261_S1.3731.00
364_K368_L1.3711.00
352_G355_R1.3671.00
279_L305_L1.3551.00
48_L51_G1.3541.00
225_S228_R1.3491.00
175_Y268_H1.3411.00
205_A236_F1.3281.00
243_N278_G1.3271.00
65_R80_V1.3131.00
174_F261_S1.3021.00
14_L17_L1.2891.00
32_G40_F1.2861.00
25_F28_A1.2761.00
292_Q297_H1.2741.00
267_L277_A1.2731.00
72_L135_R1.2681.00
27_Y36_S1.2550.99
345_M349_A1.2510.99
345_M348_L1.2500.99
226_A263_T1.2440.99
271_L298_F1.2340.99
269_S273_N1.2330.99
335_V359_I1.2310.99
21_T44_L1.2190.99
80_V99_D1.2160.99
220_L231_L1.2110.99
19_L325_G1.2000.99
84_L324_L1.2000.99
343_E348_L1.1980.99
316_I319_Y1.1980.99
147_R160_T1.1940.99
78_L169_L1.1870.99
215_D233_T1.1850.99
250_R256_F1.1770.99
367_E371_A1.1760.99
34_F38_F1.1740.99
31_Q34_F1.1630.99
365_D368_L1.1610.99
361_A364_K1.1540.99
228_R232_M1.1490.99
138_R226_A1.1490.99
342_T346_L1.1430.99
192_S200_H1.1300.99
61_F86_R1.1290.99
204_V239_S1.1280.99
364_K369_S1.1240.99
305_L308_A1.1210.99
352_G365_D1.1160.99
145_S165_L1.1150.99
138_R306_A1.1060.99
245_F291_I1.1010.99
145_S164_E1.1010.99
176_Q265_S1.1000.99
249_D282_I1.0940.99
82_V129_M1.0890.99
97_I129_M1.0870.99
95_M118_L1.0830.98
76_D174_F1.0800.98
260_V308_A1.0770.98
248_M260_V1.0730.98
29_M34_F1.0720.98
170_F306_A1.0670.98
218_A233_T1.0650.98
76_D349_A1.0650.98
29_M37_W1.0640.98
140_E170_F1.0640.98
204_V237_E1.0510.98
40_F47_V1.0460.98
73_H175_Y1.0440.98
200_H275_A1.0340.98
50_A156_L1.0340.98
333_D359_I1.0340.98
80_V133_L1.0320.98
205_A234_K1.0290.98
97_I119_V1.0260.98
151_G155_G1.0260.98
101_L133_L1.0240.98
172_Y303_R1.0240.98
271_L297_H1.0230.98
63_A84_L1.0220.98
15_I24_V1.0210.98
177_R188_E1.0170.98
73_H172_Y1.0150.98
38_F41_Y1.0130.98
348_L352_G1.0110.98
192_S205_A1.0070.98
208_V234_K1.0070.98
336_V358_V1.0060.98
257_E264_A1.0040.98
202_S239_S1.0000.97
138_R154_L1.0000.97
27_Y31_Q0.9970.97
270_V275_A0.9940.97
99_D143_F0.9860.97
13_K21_T0.9810.97
13_K155_G0.9810.97
248_M256_F0.9750.97
224_T227_R0.9720.97
138_R260_V0.9710.97
102_P105_I0.9680.97
343_E347_H0.9610.97
263_T279_L0.9590.97
250_R281_S0.9580.97
349_A358_V0.9570.97
67_M169_L0.9540.97
267_L271_L0.9510.97
145_S229_S0.9500.97
23_A27_Y0.9470.96
225_S232_M0.9450.96
17_L227_R0.9450.96
170_F307_I0.9440.96
33_G38_F0.9380.96
205_A240_R0.9250.96
344_D347_H0.9210.96
17_L21_T0.9200.96
147_R162_F0.9090.96
200_H239_S0.9090.96
342_T345_M0.9050.95
105_I133_L0.8980.95
221_D227_R0.8890.95
24_V40_F0.8860.95
346_L349_A0.8860.95
142_H166_D0.8840.95
24_V27_Y0.8830.95
94_Y151_G0.8830.95
279_L304_H0.8810.95
208_V228_R0.8760.95
207_S235_E0.8750.95
281_S308_A0.8710.94
17_L24_V0.8710.94
258_E261_S0.8680.94
116_K119_V0.8620.94
21_T24_V0.8620.94
263_T337_V0.8600.94
257_E262_V0.8560.94
243_N276_G0.8550.94
144_H165_L0.8530.94
25_F29_M0.8510.94
53_L57_P0.8510.94
192_S202_S0.8500.94
224_T232_M0.8480.94
270_V277_A0.8460.93
369_S372_E0.8450.93
32_G35_V0.8450.93
115_A121_P0.8430.93
351_I355_R0.8400.93
61_F148_V0.8400.93
97_I148_V0.8370.93
323_E326_K0.8340.93
197_I278_G0.8330.93
333_D337_V0.8310.93
28_A32_G0.8310.93
13_K17_L0.8280.93
355_R358_V0.8270.93
144_H164_E0.8270.93
15_I19_L0.8260.93
28_A36_S0.8230.93
32_G37_W0.8210.92
356_V364_K0.8140.92
121_P124_K0.8110.92
60_S88_L0.8100.92
349_A353_G0.8090.92
32_G36_S0.8050.92
226_A257_E0.8040.92
359_I368_L0.8040.92
153_V220_L0.8020.92
245_F288_I0.7990.91
209_R235_E0.7940.91
282_I319_Y0.7920.91
30_F37_W0.7900.91
251_F315_P0.7900.91
334_Q358_V0.7880.91
222_W231_L0.7860.91
266_I270_V0.7840.91
76_D267_L0.7770.90
277_A301_M0.7760.90
34_F40_F0.7750.90
52_L84_L0.7740.90
281_S305_L0.7740.90
24_V28_A0.7690.90
342_T347_H0.7690.90
122_W127_M0.7660.90
33_G39_L0.7650.90
139_G305_L0.7600.89
220_L223_K0.7570.89
207_S223_K0.7570.89
99_D102_P0.7530.89
336_V345_M0.7510.89
68_D231_L0.7510.89
152_D157_I0.7500.89
178_F268_H0.7480.88
27_Y33_G0.7470.88
298_F305_L0.7460.88
187_Q220_L0.7450.88
224_T234_K0.7440.88
29_M36_S0.7430.88
36_S41_Y0.7430.88
280_A288_I0.7420.88
52_L56_Y0.7410.88
238_P242_K0.7400.88
297_H300_H0.7400.88
262_V266_I0.7390.88
47_V51_G0.7360.88
30_F42_A0.7340.88
34_F42_A0.7290.87
142_H320_A0.7240.87
146_V217_F0.7220.87
172_Y239_S0.7210.87
43_F69_K0.7170.86
41_Y225_S0.7140.86
25_F41_Y0.7140.86
38_F43_F0.7140.86
44_L48_L0.7130.86
184_E188_E0.7100.86
102_P141_H0.7080.86
244_L249_D0.7080.86
145_S355_R0.7060.85
192_S240_R0.7040.85
68_D79_G0.7020.85
103_E137_P0.7020.85
264_A305_L0.7010.85
211_Y215_D0.6980.85
208_V221_D0.6980.85
78_L143_F0.6950.85
259_V337_V0.6950.85
58_L62_Q0.6920.84
347_H351_I0.6920.84
40_F44_L0.6880.84
51_G55_L0.6830.84
355_R365_D0.6810.83
249_D338_T0.6800.83
284_K311_D0.6770.83
36_S40_F0.6760.83
71_Q170_F0.6730.83
48_L130_S0.6730.83
181_Q188_E0.6730.83
325_G355_R0.6700.82
223_K345_M0.6700.82
282_I317_S0.6700.82
24_V39_L0.6660.82
200_H249_D0.6640.82
159_K248_M0.6630.82
202_S240_R0.6620.82
292_Q300_H0.6610.81
366_A371_A0.6580.81
257_E261_S0.6570.81
19_L41_Y0.6560.81
362_K365_D0.6550.81
289_F294_G0.6550.81
27_Y41_Y0.6550.81
224_T264_A0.6550.81
39_L42_A0.6540.81
363_E366_A0.6530.81
16_I21_T0.6530.81
154_L270_V0.6500.80
248_M263_T0.6500.80
116_K121_P0.6490.80
95_M150_T0.6490.80
278_G290_P0.6480.80
122_W156_L0.6450.80
257_E260_V0.6440.80
367_E370_Q0.6440.80
86_R90_F0.6430.80
276_G293_E0.6420.80
58_L150_T0.6400.79
324_L327_P0.6400.79
268_H301_M0.6400.79
225_S289_F0.6400.79
29_M32_G0.6390.79
33_G40_F0.6380.79
329_V332_A0.6360.79
38_F51_G0.6350.79
239_S275_A0.6330.79
366_A370_Q0.6320.79
251_F254_D0.6320.79
63_A163_F0.6310.78
28_A33_G0.6280.78
28_A34_F0.6270.78
29_M35_V0.6270.78
92_L95_M0.6260.78
332_A339_G0.6250.78
96_V158_E0.6220.77
364_K367_E0.6220.77
202_S275_A0.6220.77
246_L359_I0.6200.77
31_Q35_V0.6140.77
177_R265_S0.6130.76
145_S152_D0.6120.76
63_A146_V0.6110.76
16_I22_A0.6100.76
208_V241_S0.6090.76
107_S114_A0.6090.76
12_W16_I0.6060.76
22_A77_R0.6060.76
153_V306_A0.6060.76
235_E262_V0.6050.75
68_D77_R0.6040.75
198_H227_R0.6040.75
18_T91_P0.6030.75
168_T307_I0.6030.75
359_I362_K0.6020.75
141_H208_V0.6020.75
58_L289_F0.6010.75
183_N247_L0.6010.75
331_Q356_V0.6000.75
358_V362_K0.6000.75
266_I335_V0.5980.75
41_Y45_P0.5970.74
71_Q172_Y0.5960.74
143_F236_F0.5960.74
312_A315_P0.5960.74
336_V349_A0.5950.74
216_R333_D0.5950.74
341_L365_D0.5940.74
138_R173_P0.5940.74
208_V244_L0.5930.74
37_W45_P0.5930.74
173_P257_E0.5930.74
117_R129_M0.5920.74
138_R224_T0.5880.73
41_Y49_Y0.5880.73
175_Y264_A0.5880.73
40_F43_F0.5870.73
149_R152_D0.5860.73
291_I294_G0.5850.73
12_W17_L0.5830.73
343_E350_E0.5820.73
100_C147_R0.5810.73
278_G288_I0.5800.72
338_T345_M0.5790.72
154_L309_H0.5780.72
85_R142_H0.5770.72
72_L143_F0.5760.72
86_R122_W0.5760.72
361_A365_D0.5760.72
300_H303_R0.5760.72
74_A174_F0.5750.72
208_V259_V0.5750.72
78_L147_R0.5750.72
68_D169_L0.5740.72
38_F68_D0.5740.72
237_E261_S0.5720.71
153_V156_L0.5720.71
322_E326_K0.5720.71
46_F49_Y0.5710.71
365_D369_S0.5680.71
62_Q157_I0.5680.71
339_G362_K0.5650.70
21_T25_F0.5650.70
30_F319_Y0.5650.70
38_F42_A0.5650.70
178_F217_F0.5650.70
176_Q258_E0.5620.70
194_S197_I0.5600.70
44_L87_K0.5590.70
271_L301_M0.5590.70
200_H204_V0.5560.69
119_V122_W0.5560.69
342_T351_I0.5560.69
39_L91_P0.5550.69
154_L265_S0.5530.69
289_F297_H0.5530.69
12_W126_S0.5520.69
172_Y306_A0.5520.69
245_F320_A0.5510.69
14_L18_T0.5510.69
358_V370_Q0.5510.69
210_N223_K0.5510.69
220_L279_L0.5500.68
86_R92_L0.5490.68
83_T86_R0.5480.68
60_S69_K0.5480.68
340_Q356_V0.5470.68
162_F360_L0.5460.68
60_S64_S0.5460.68
55_L60_S0.5450.68
164_E285_E0.5450.68
24_V30_F0.5450.68
172_Y219_A0.5430.67
233_T298_F0.5430.67
152_D265_S0.5430.67
250_R308_A0.5420.67
64_S166_D0.5420.67
263_T305_L0.5410.67
20_L36_S0.5400.67
60_S63_A0.5370.67
73_H78_L0.5370.67
232_M260_V0.5360.66
259_V339_G0.5360.66
260_V302_L0.5350.66
17_L32_G0.5350.66
68_D78_L0.5350.66
153_V270_V0.5340.66
98_E324_L0.5340.66
221_D232_M0.5330.66
92_L153_V0.5330.66
208_V214_G0.5310.66
288_I323_E0.5310.66
72_L171_V0.5300.66
27_Y40_F0.5290.65
346_L356_V0.5280.65
347_H350_E0.5280.65
202_S249_D0.5270.65
143_F146_V0.5260.65
32_G45_P0.5260.65
192_S332_A0.5260.65
195_S198_H0.5260.65
61_F65_R0.5260.65
122_W126_S0.5260.65
119_V129_M0.5250.65
176_Q250_R0.5240.65
15_I20_L0.5230.65
340_Q345_M0.5220.64
210_N228_R0.5220.64
65_R167_D0.5210.64
28_A169_L0.5200.64
192_S275_A0.5200.64
271_L293_E0.5200.64
26_S52_L0.5190.64
55_L157_I0.5190.64
102_P237_E0.5180.64
80_V132_E0.5180.64
221_D236_F0.5160.64
115_A118_L0.5160.64
38_F117_R0.5150.63
47_V50_A0.5150.63
31_Q123_F0.5150.63
39_L166_D0.5140.63
227_R270_V0.5120.63
121_P338_T0.5100.63
48_L52_L0.5090.62
54_A286_K0.5090.62
334_Q338_T0.5090.62
39_L125_R0.5080.62
358_V361_A0.5070.62
327_P359_I0.5070.62
289_F301_M0.5060.62
338_T344_D0.5060.62
69_K79_G0.5060.62
152_D156_L0.5050.62
99_D138_R0.5050.62
233_T236_F0.5040.62
188_E241_S0.5030.62
65_R138_R0.5020.61
297_H301_M0.5020.61
75_G210_N0.5020.61
86_R98_E0.5020.61
256_F310_C0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nvoA 2 0.794 99.2 0.827 Contact Map
1yvrA 1 0.9296 99.1 0.839 Contact Map
4bj3A 1 0.397 97.3 0.9 Contact Map
2x31A 2 0.3894 96.5 0.91 Contact Map
1mf7A 1 0.407 96.2 0.913 Contact Map
1mjnA 1 0.3945 96.2 0.913 Contact Map
2odpA 1 0.4095 95.5 0.917 Contact Map
4igiA 1 0.3844 95.5 0.917 Contact Map
4wfqA 1 0.392 95.4 0.918 Contact Map
2xggA 2 0.3191 95.4 0.918 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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