YEAD - BACSU - GREMLIN Contacts

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YEAD - Uncharacterized protein YeaD

UniProt:	P94475	Sequences: MNKKWQWLVYGWKLIILTLLTAAVFSYAMFQGGFVSWFLFYAFLPFVLYAGLLALYPLRSFQASRQMDKTQLHAGDRLGVTVTLRRKLPFPLMYMVIEDCLPEGIESLNRDGAAAKRLVFPWFKRSMTMSYELARVPRGEHHFHSVRVRTGDVLGLIEKTAFFELDDTLFVYPFYQRFSYQVNERHQEDGVSGSSPIHQHHSSVAASVRNYQPGDRFAALDWKTSARRSQLMTKEFEPSRSKNLFLLMDRFSSDAFEEVVSVTASILHSVLKNGAGAGLASIGKEKNIFPIQEGDQHFKHMLRHLAIAHCDAADPISRYAREELGKPSVRQADQVVVTGQLTEDMLHLAEIGGGRVTVILAKEKDAELSQAENVMIERMMKRQIRVRIMRGGRVSRVV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	398 (353)
Sequences:	2796 (2280)
Seq/√Len:	121.3

BACSU - YEAD
HALSA - Q9HSH8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
65_R	99_D	5.377	1.00
74_A	261_S	5.101	1.00
221_D	234_K	4.326	1.00
65_R	131_Y	4.221	1.00
99_D	131_Y	4.048	1.00
79_G	130_S	3.976	1.00
140_E	168_T	3.904	1.00
81_T	128_T	3.775	1.00
62_Q	85_R	3.646	1.00
267_L	301_M	3.624	1.00
210_N	230_Q	3.611	1.00
77_R	132_E	3.500	1.00
85_R	126_S	3.193	1.00
77_R	134_A	3.115	1.00
140_E	307_I	3.097	1.00
278_G	291_I	3.013	1.00
225_S	231_L	2.998	1.00
83_T	128_T	2.914	1.00
72_L	78_L	2.912	1.00
209_R	215_D	2.900	1.00
64_S	83_T	2.860	1.00
246_L	267_L	2.850	1.00
71_Q	303_R	2.809	1.00
80_V	131_Y	2.768	1.00
81_T	130_S	2.617	1.00
79_G	132_E	2.525	1.00
244_L	270_V	2.498	1.00
217_F	220_L	2.356	1.00
248_M	259_V	2.286	1.00
91_P	120_F	2.209	1.00
149_R	160_T	2.199	1.00
149_R	158_E	2.190	1.00
246_L	337_V	2.179	1.00
266_I	337_V	2.036	1.00
21_T	40_F	2.007	1.00
294_G	297_H	1.989	1.00
245_F	278_G	1.959	1.00
86_R	121_P	1.933	1.00
83_T	126_S	1.929	1.00
66_Q	81_T	1.925	1.00
37_W	40_F	1.916	1.00
138_R	257_E	1.904	1.00
210_N	232_M	1.894	1.00
221_D	224_T	1.861	1.00
264_A	302_L	1.858	1.00
86_R	123_F	1.830	1.00
208_V	232_M	1.828	1.00
249_D	254_D	1.824	1.00
245_F	332_A	1.768	1.00
64_S	85_R	1.756	1.00
338_T	360_L	1.745	1.00
122_W	125_R	1.715	1.00
28_A	40_F	1.709	1.00
142_H	168_T	1.707	1.00
145_S	162_F	1.674	1.00
246_L	263_T	1.636	1.00
66_Q	83_T	1.622	1.00
121_P	125_R	1.612	1.00
175_Y	265_S	1.595	1.00
260_V	305_L	1.595	1.00
151_G	158_E	1.575	1.00
62_Q	87_K	1.542	1.00
245_F	280_A	1.541	1.00
28_A	37_W	1.533	1.00
256_F	260_V	1.530	1.00
73_H	76_D	1.494	1.00
262_V	337_V	1.484	1.00
98_E	147_R	1.481	1.00
268_H	298_F	1.471	1.00
16_I	20_L	1.459	1.00
33_G	36_S	1.425	1.00
246_L	277_A	1.425	1.00
271_L	277_A	1.425	1.00
278_G	297_H	1.424	1.00
316_I	321_R	1.423	1.00
205_A	208_V	1.415	1.00
219_A	236_F	1.406	1.00
247_L	280_A	1.399	1.00
178_F	265_S	1.393	1.00
255_A	339_G	1.384	1.00
121_P	127_M	1.375	1.00
176_Q	261_S	1.373	1.00
364_K	368_L	1.371	1.00
352_G	355_R	1.367	1.00
279_L	305_L	1.355	1.00
48_L	51_G	1.354	1.00
225_S	228_R	1.349	1.00
175_Y	268_H	1.341	1.00
205_A	236_F	1.328	1.00
243_N	278_G	1.327	1.00
65_R	80_V	1.313	1.00
174_F	261_S	1.302	1.00
14_L	17_L	1.289	1.00
32_G	40_F	1.286	1.00
25_F	28_A	1.276	1.00
292_Q	297_H	1.274	1.00
267_L	277_A	1.273	1.00
72_L	135_R	1.268	1.00
27_Y	36_S	1.255	0.99
345_M	349_A	1.251	0.99
345_M	348_L	1.250	0.99
226_A	263_T	1.244	0.99
271_L	298_F	1.234	0.99
269_S	273_N	1.233	0.99
335_V	359_I	1.231	0.99
21_T	44_L	1.219	0.99
80_V	99_D	1.216	0.99
220_L	231_L	1.211	0.99
19_L	325_G	1.200	0.99
84_L	324_L	1.200	0.99
343_E	348_L	1.198	0.99
316_I	319_Y	1.198	0.99
147_R	160_T	1.194	0.99
78_L	169_L	1.187	0.99
215_D	233_T	1.185	0.99
250_R	256_F	1.177	0.99
367_E	371_A	1.176	0.99
34_F	38_F	1.174	0.99
31_Q	34_F	1.163	0.99
365_D	368_L	1.161	0.99
361_A	364_K	1.154	0.99
228_R	232_M	1.149	0.99
138_R	226_A	1.149	0.99
342_T	346_L	1.143	0.99
192_S	200_H	1.130	0.99
61_F	86_R	1.129	0.99
204_V	239_S	1.128	0.99
364_K	369_S	1.124	0.99
305_L	308_A	1.121	0.99
352_G	365_D	1.116	0.99
145_S	165_L	1.115	0.99
138_R	306_A	1.106	0.99
245_F	291_I	1.101	0.99
145_S	164_E	1.101	0.99
176_Q	265_S	1.100	0.99
249_D	282_I	1.094	0.99
82_V	129_M	1.089	0.99
97_I	129_M	1.087	0.99
95_M	118_L	1.083	0.98
76_D	174_F	1.080	0.98
260_V	308_A	1.077	0.98
248_M	260_V	1.073	0.98
29_M	34_F	1.072	0.98
170_F	306_A	1.067	0.98
218_A	233_T	1.065	0.98
76_D	349_A	1.065	0.98
29_M	37_W	1.064	0.98
140_E	170_F	1.064	0.98
204_V	237_E	1.051	0.98
40_F	47_V	1.046	0.98
73_H	175_Y	1.044	0.98
200_H	275_A	1.034	0.98
50_A	156_L	1.034	0.98
333_D	359_I	1.034	0.98
80_V	133_L	1.032	0.98
205_A	234_K	1.029	0.98
97_I	119_V	1.026	0.98
151_G	155_G	1.026	0.98
101_L	133_L	1.024	0.98
172_Y	303_R	1.024	0.98
271_L	297_H	1.023	0.98
63_A	84_L	1.022	0.98
15_I	24_V	1.021	0.98
177_R	188_E	1.017	0.98
73_H	172_Y	1.015	0.98
38_F	41_Y	1.013	0.98
348_L	352_G	1.011	0.98
192_S	205_A	1.007	0.98
208_V	234_K	1.007	0.98
336_V	358_V	1.006	0.98
257_E	264_A	1.004	0.98
202_S	239_S	1.000	0.97
138_R	154_L	1.000	0.97
27_Y	31_Q	0.997	0.97
270_V	275_A	0.994	0.97
99_D	143_F	0.986	0.97
13_K	21_T	0.981	0.97
13_K	155_G	0.981	0.97
248_M	256_F	0.975	0.97
224_T	227_R	0.972	0.97
138_R	260_V	0.971	0.97
102_P	105_I	0.968	0.97
343_E	347_H	0.961	0.97
263_T	279_L	0.959	0.97
250_R	281_S	0.958	0.97
349_A	358_V	0.957	0.97
67_M	169_L	0.954	0.97
267_L	271_L	0.951	0.97
145_S	229_S	0.950	0.97
23_A	27_Y	0.947	0.96
225_S	232_M	0.945	0.96
17_L	227_R	0.945	0.96
170_F	307_I	0.944	0.96
33_G	38_F	0.938	0.96
205_A	240_R	0.925	0.96
344_D	347_H	0.921	0.96
17_L	21_T	0.920	0.96
147_R	162_F	0.909	0.96
200_H	239_S	0.909	0.96
342_T	345_M	0.905	0.95
105_I	133_L	0.898	0.95
221_D	227_R	0.889	0.95
24_V	40_F	0.886	0.95
346_L	349_A	0.886	0.95
142_H	166_D	0.884	0.95
24_V	27_Y	0.883	0.95
94_Y	151_G	0.883	0.95
279_L	304_H	0.881	0.95
208_V	228_R	0.876	0.95
207_S	235_E	0.875	0.95
281_S	308_A	0.871	0.94
17_L	24_V	0.871	0.94
258_E	261_S	0.868	0.94
116_K	119_V	0.862	0.94
21_T	24_V	0.862	0.94
263_T	337_V	0.860	0.94
257_E	262_V	0.856	0.94
243_N	276_G	0.855	0.94
144_H	165_L	0.853	0.94
25_F	29_M	0.851	0.94
53_L	57_P	0.851	0.94
192_S	202_S	0.850	0.94
224_T	232_M	0.848	0.94
270_V	277_A	0.846	0.93
369_S	372_E	0.845	0.93
32_G	35_V	0.845	0.93
115_A	121_P	0.843	0.93
351_I	355_R	0.840	0.93
61_F	148_V	0.840	0.93
97_I	148_V	0.837	0.93
323_E	326_K	0.834	0.93
197_I	278_G	0.833	0.93
333_D	337_V	0.831	0.93
28_A	32_G	0.831	0.93
13_K	17_L	0.828	0.93
355_R	358_V	0.827	0.93
144_H	164_E	0.827	0.93
15_I	19_L	0.826	0.93
28_A	36_S	0.823	0.93
32_G	37_W	0.821	0.92
356_V	364_K	0.814	0.92
121_P	124_K	0.811	0.92
60_S	88_L	0.810	0.92
349_A	353_G	0.809	0.92
32_G	36_S	0.805	0.92
226_A	257_E	0.804	0.92
359_I	368_L	0.804	0.92
153_V	220_L	0.802	0.92
245_F	288_I	0.799	0.91
209_R	235_E	0.794	0.91
282_I	319_Y	0.792	0.91
30_F	37_W	0.790	0.91
251_F	315_P	0.790	0.91
334_Q	358_V	0.788	0.91
222_W	231_L	0.786	0.91
266_I	270_V	0.784	0.91
76_D	267_L	0.777	0.90
277_A	301_M	0.776	0.90
34_F	40_F	0.775	0.90
52_L	84_L	0.774	0.90
281_S	305_L	0.774	0.90
24_V	28_A	0.769	0.90
342_T	347_H	0.769	0.90
122_W	127_M	0.766	0.90
33_G	39_L	0.765	0.90
139_G	305_L	0.760	0.89
220_L	223_K	0.757	0.89
207_S	223_K	0.757	0.89
99_D	102_P	0.753	0.89
336_V	345_M	0.751	0.89
68_D	231_L	0.751	0.89
152_D	157_I	0.750	0.89
178_F	268_H	0.748	0.88
27_Y	33_G	0.747	0.88
298_F	305_L	0.746	0.88
187_Q	220_L	0.745	0.88
224_T	234_K	0.744	0.88
29_M	36_S	0.743	0.88
36_S	41_Y	0.743	0.88
280_A	288_I	0.742	0.88
52_L	56_Y	0.741	0.88
238_P	242_K	0.740	0.88
297_H	300_H	0.740	0.88
262_V	266_I	0.739	0.88
47_V	51_G	0.736	0.88
30_F	42_A	0.734	0.88
34_F	42_A	0.729	0.87
142_H	320_A	0.724	0.87
146_V	217_F	0.722	0.87
172_Y	239_S	0.721	0.87
43_F	69_K	0.717	0.86
41_Y	225_S	0.714	0.86
25_F	41_Y	0.714	0.86
38_F	43_F	0.714	0.86
44_L	48_L	0.713	0.86
184_E	188_E	0.710	0.86
102_P	141_H	0.708	0.86
244_L	249_D	0.708	0.86
145_S	355_R	0.706	0.85
192_S	240_R	0.704	0.85
68_D	79_G	0.702	0.85
103_E	137_P	0.702	0.85
264_A	305_L	0.701	0.85
211_Y	215_D	0.698	0.85
208_V	221_D	0.698	0.85
78_L	143_F	0.695	0.85
259_V	337_V	0.695	0.85
58_L	62_Q	0.692	0.84
347_H	351_I	0.692	0.84
40_F	44_L	0.688	0.84
51_G	55_L	0.683	0.84
355_R	365_D	0.681	0.83
249_D	338_T	0.680	0.83
284_K	311_D	0.677	0.83
36_S	40_F	0.676	0.83
71_Q	170_F	0.673	0.83
48_L	130_S	0.673	0.83
181_Q	188_E	0.673	0.83
325_G	355_R	0.670	0.82
223_K	345_M	0.670	0.82
282_I	317_S	0.670	0.82
24_V	39_L	0.666	0.82
200_H	249_D	0.664	0.82
159_K	248_M	0.663	0.82
202_S	240_R	0.662	0.82
292_Q	300_H	0.661	0.81
366_A	371_A	0.658	0.81
257_E	261_S	0.657	0.81
19_L	41_Y	0.656	0.81
362_K	365_D	0.655	0.81
289_F	294_G	0.655	0.81
27_Y	41_Y	0.655	0.81
224_T	264_A	0.655	0.81
39_L	42_A	0.654	0.81
363_E	366_A	0.653	0.81
16_I	21_T	0.653	0.81
154_L	270_V	0.650	0.80
248_M	263_T	0.650	0.80
116_K	121_P	0.649	0.80
95_M	150_T	0.649	0.80
278_G	290_P	0.648	0.80
122_W	156_L	0.645	0.80
257_E	260_V	0.644	0.80
367_E	370_Q	0.644	0.80
86_R	90_F	0.643	0.80
276_G	293_E	0.642	0.80
58_L	150_T	0.640	0.79
324_L	327_P	0.640	0.79
268_H	301_M	0.640	0.79
225_S	289_F	0.640	0.79
29_M	32_G	0.639	0.79
33_G	40_F	0.638	0.79
329_V	332_A	0.636	0.79
38_F	51_G	0.635	0.79
239_S	275_A	0.633	0.79
366_A	370_Q	0.632	0.79
251_F	254_D	0.632	0.79
63_A	163_F	0.631	0.78
28_A	33_G	0.628	0.78
28_A	34_F	0.627	0.78
29_M	35_V	0.627	0.78
92_L	95_M	0.626	0.78
332_A	339_G	0.625	0.78
96_V	158_E	0.622	0.77
364_K	367_E	0.622	0.77
202_S	275_A	0.622	0.77
246_L	359_I	0.620	0.77
31_Q	35_V	0.614	0.77
177_R	265_S	0.613	0.76
145_S	152_D	0.612	0.76
63_A	146_V	0.611	0.76
16_I	22_A	0.610	0.76
208_V	241_S	0.609	0.76
107_S	114_A	0.609	0.76
12_W	16_I	0.606	0.76
22_A	77_R	0.606	0.76
153_V	306_A	0.606	0.76
235_E	262_V	0.605	0.75
68_D	77_R	0.604	0.75
198_H	227_R	0.604	0.75
18_T	91_P	0.603	0.75
168_T	307_I	0.603	0.75
359_I	362_K	0.602	0.75
141_H	208_V	0.602	0.75
58_L	289_F	0.601	0.75
183_N	247_L	0.601	0.75
331_Q	356_V	0.600	0.75
358_V	362_K	0.600	0.75
266_I	335_V	0.598	0.75
41_Y	45_P	0.597	0.74
71_Q	172_Y	0.596	0.74
143_F	236_F	0.596	0.74
312_A	315_P	0.596	0.74
336_V	349_A	0.595	0.74
216_R	333_D	0.595	0.74
341_L	365_D	0.594	0.74
138_R	173_P	0.594	0.74
208_V	244_L	0.593	0.74
37_W	45_P	0.593	0.74
173_P	257_E	0.593	0.74
117_R	129_M	0.592	0.74
138_R	224_T	0.588	0.73
41_Y	49_Y	0.588	0.73
175_Y	264_A	0.588	0.73
40_F	43_F	0.587	0.73
149_R	152_D	0.586	0.73
291_I	294_G	0.585	0.73
12_W	17_L	0.583	0.73
343_E	350_E	0.582	0.73
100_C	147_R	0.581	0.73
278_G	288_I	0.580	0.72
338_T	345_M	0.579	0.72
154_L	309_H	0.578	0.72
85_R	142_H	0.577	0.72
72_L	143_F	0.576	0.72
86_R	122_W	0.576	0.72
361_A	365_D	0.576	0.72
300_H	303_R	0.576	0.72
74_A	174_F	0.575	0.72
208_V	259_V	0.575	0.72
78_L	147_R	0.575	0.72
68_D	169_L	0.574	0.72
38_F	68_D	0.574	0.72
237_E	261_S	0.572	0.71
153_V	156_L	0.572	0.71
322_E	326_K	0.572	0.71
46_F	49_Y	0.571	0.71
365_D	369_S	0.568	0.71
62_Q	157_I	0.568	0.71
339_G	362_K	0.565	0.70
21_T	25_F	0.565	0.70
30_F	319_Y	0.565	0.70
38_F	42_A	0.565	0.70
178_F	217_F	0.565	0.70
176_Q	258_E	0.562	0.70
194_S	197_I	0.560	0.70
44_L	87_K	0.559	0.70
271_L	301_M	0.559	0.70
200_H	204_V	0.556	0.69
119_V	122_W	0.556	0.69
342_T	351_I	0.556	0.69
39_L	91_P	0.555	0.69
154_L	265_S	0.553	0.69
289_F	297_H	0.553	0.69
12_W	126_S	0.552	0.69
172_Y	306_A	0.552	0.69
245_F	320_A	0.551	0.69
14_L	18_T	0.551	0.69
358_V	370_Q	0.551	0.69
210_N	223_K	0.551	0.69
220_L	279_L	0.550	0.68
86_R	92_L	0.549	0.68
83_T	86_R	0.548	0.68
60_S	69_K	0.548	0.68
340_Q	356_V	0.547	0.68
162_F	360_L	0.546	0.68
60_S	64_S	0.546	0.68
55_L	60_S	0.545	0.68
164_E	285_E	0.545	0.68
24_V	30_F	0.545	0.68
172_Y	219_A	0.543	0.67
233_T	298_F	0.543	0.67
152_D	265_S	0.543	0.67
250_R	308_A	0.542	0.67
64_S	166_D	0.542	0.67
263_T	305_L	0.541	0.67
20_L	36_S	0.540	0.67
60_S	63_A	0.537	0.67
73_H	78_L	0.537	0.67
232_M	260_V	0.536	0.66
259_V	339_G	0.536	0.66
260_V	302_L	0.535	0.66
17_L	32_G	0.535	0.66
68_D	78_L	0.535	0.66
153_V	270_V	0.534	0.66
98_E	324_L	0.534	0.66
221_D	232_M	0.533	0.66
92_L	153_V	0.533	0.66
208_V	214_G	0.531	0.66
288_I	323_E	0.531	0.66
72_L	171_V	0.530	0.66
27_Y	40_F	0.529	0.65
346_L	356_V	0.528	0.65
347_H	350_E	0.528	0.65
202_S	249_D	0.527	0.65
143_F	146_V	0.526	0.65
32_G	45_P	0.526	0.65
192_S	332_A	0.526	0.65
195_S	198_H	0.526	0.65
61_F	65_R	0.526	0.65
122_W	126_S	0.526	0.65
119_V	129_M	0.525	0.65
176_Q	250_R	0.524	0.65
15_I	20_L	0.523	0.65
340_Q	345_M	0.522	0.64
210_N	228_R	0.522	0.64
65_R	167_D	0.521	0.64
28_A	169_L	0.520	0.64
192_S	275_A	0.520	0.64
271_L	293_E	0.520	0.64
26_S	52_L	0.519	0.64
55_L	157_I	0.519	0.64
102_P	237_E	0.518	0.64
80_V	132_E	0.518	0.64
221_D	236_F	0.516	0.64
115_A	118_L	0.516	0.64
38_F	117_R	0.515	0.63
47_V	50_A	0.515	0.63
31_Q	123_F	0.515	0.63
39_L	166_D	0.514	0.63
227_R	270_V	0.512	0.63
121_P	338_T	0.510	0.63
48_L	52_L	0.509	0.62
54_A	286_K	0.509	0.62
334_Q	338_T	0.509	0.62
39_L	125_R	0.508	0.62
358_V	361_A	0.507	0.62
327_P	359_I	0.507	0.62
289_F	301_M	0.506	0.62
338_T	344_D	0.506	0.62
69_K	79_G	0.506	0.62
152_D	156_L	0.505	0.62
99_D	138_R	0.505	0.62
233_T	236_F	0.504	0.62
188_E	241_S	0.503	0.62
65_R	138_R	0.502	0.61
297_H	301_M	0.502	0.61
75_G	210_N	0.502	0.61
86_R	98_E	0.502	0.61
256_F	310_C	0.500	0.61

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2nvoA	2	0.794	99.2	0.827	Contact Map
1yvrA	1	0.9296	99.1	0.839	Contact Map
4bj3A	1	0.397	97.3	0.9	Contact Map
2x31A	2	0.3894	96.5	0.91	Contact Map
1mf7A	1	0.407	96.2	0.913	Contact Map
1mjnA	1	0.3945	96.2	0.913	Contact Map
2odpA	1	0.4095	95.5	0.917	Contact Map
4igiA	1	0.3844	95.5	0.917	Contact Map
4wfqA	1	0.392	95.4	0.918	Contact Map
2xggA	2	0.3191	95.4	0.918	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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