GREMLIN Database
YEAC - Uncharacterized protein YeaC
UniProt: P94474 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 320 (276)
Sequences: 21733 (12322)
Seq/√Len: 741.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
266_R273_D3.9051.00
204_A207_D3.6941.00
179_S182_E3.6531.00
103_G106_V2.9731.00
266_R270_I2.7491.00
19_N26_R2.6851.00
111_I148_A2.4981.00
188_S225_K2.4021.00
130_S139_Q2.3631.00
245_V249_G2.3411.00
28_I55_M2.3211.00
17_H20_R2.2851.00
88_N95_E2.2821.00
185_D189_L2.1561.00
185_D188_S2.1201.00
32_S59_L2.0761.00
107_L149_T2.0081.00
15_V30_I2.0051.00
224_I228_I1.9961.00
210_F213_R1.9881.00
56_V147_M1.9551.00
77_L80_D1.9531.00
218_V221_D1.9231.00
34_A260_Y1.8991.00
209_I213_R1.8981.00
207_D210_F1.8611.00
235_T238_H1.8541.00
278_A282_L1.8441.00
210_F214_E1.8421.00
260_Y264_H1.8411.00
229_V232_V1.8061.00
31_L280_F1.8061.00
88_N91_T1.8051.00
129_G143_P1.7761.00
54_M58_A1.7291.00
209_I212_Q1.7261.00
205_K209_I1.7241.00
228_I232_V1.7091.00
184_L188_S1.6801.00
232_V235_T1.6681.00
218_V222_D1.6231.00
260_Y276_Y1.6221.00
219_R222_D1.6201.00
233_Q237_Q1.6171.00
180_F184_L1.6101.00
125_A140_L1.6011.00
206_E210_F1.5971.00
184_L226_E1.5901.00
180_F230_E1.5631.00
225_K229_V1.5481.00
35_A42_V1.5451.00
231_I234_K1.5411.00
67_F71_Q1.5411.00
96_Y133_V1.5391.00
229_V233_Q1.5201.00
226_E230_E1.5161.00
231_I235_T1.5101.00
68_K71_Q1.4921.00
254_M258_Q1.4731.00
26_R182_E1.4651.00
148_A169_F1.4601.00
281_T288_L1.4461.00
188_S222_D1.4431.00
236_R239_P1.4291.00
270_I273_D1.4281.00
241_V247_P1.4131.00
30_I276_Y1.4121.00
21_V58_A1.4071.00
57_R128_E1.4011.00
190_Q194_H1.3921.00
214_E217_N1.3881.00
220_A223_S1.3871.00
284_H288_L1.3851.00
235_T239_P1.3771.00
32_S42_V1.3731.00
220_A254_M1.3701.00
207_D211_L1.3511.00
213_R216_Q1.3461.00
90_K93_E1.3451.00
287_M291_E1.3451.00
271_P275_Q1.3291.00
269_V273_D1.3011.00
28_I175_M1.2991.00
222_D225_K1.2951.00
289_H292_A1.2831.00
112_N150_Q1.2831.00
251_I255_K1.2821.00
276_Y279_P1.2801.00
264_H273_D1.2801.00
232_V236_R1.2781.00
30_I260_Y1.2721.00
255_K259_A1.2701.00
190_Q195_P1.2691.00
212_Q215_V1.2681.00
276_Y280_F1.2641.00
124_E128_E1.2631.00
203_I207_D1.2541.00
25_K28_I1.2501.00
257_A269_V1.2421.00
183_E212_Q1.2381.00
208_F212_Q1.2311.00
45_E172_K1.2291.00
193_S196_I1.2051.00
254_M257_A1.2031.00
69_R72_F1.1831.00
279_P283_P1.1741.00
31_L173_L1.1741.00
232_V250_S1.1661.00
69_R100_P1.1661.00
101_I131_V1.1571.00
273_D276_Y1.1531.00
213_R217_N1.1521.00
214_E262_L1.1501.00
202_V206_E1.1351.00
202_V205_K1.1311.00
72_F108_A1.1301.00
220_A224_I1.1271.00
17_H62_S1.1241.00
43_L111_I1.1221.00
274_I277_L1.1191.00
203_I236_R1.1191.00
234_K237_Q1.1021.00
206_E209_I1.1001.00
82_T121_A1.0981.00
32_S55_M1.0931.00
115_S118_T1.0881.00
208_F211_L1.0821.00
170_L252_A1.0801.00
226_E229_V1.0771.00
225_K228_I1.0731.00
89_A93_E1.0711.00
286_M289_H1.0711.00
22_M58_A1.0601.00
222_D226_E1.0571.00
212_Q216_Q1.0551.00
211_L214_E1.0531.00
200_E207_D1.0511.00
281_T284_H1.0471.00
288_L292_A1.0451.00
132_T139_Q1.0431.00
282_L286_M1.0391.00
88_N92_M1.0381.00
277_L280_F1.0341.00
108_A146_V1.0291.00
207_D213_R1.0271.00
277_L285_R1.0251.00
13_K18_I1.0241.00
233_Q236_R1.0211.00
71_Q74_P1.0201.00
278_A281_T1.0181.00
14_A62_S1.0131.00
274_I281_T1.0131.00
267_D271_P1.0111.00
31_L34_A1.0081.00
252_A256_A1.0061.00
285_R292_A0.9991.00
269_V274_I0.9991.00
257_A261_A0.9991.00
224_I227_Y0.9961.00
219_R223_S0.9931.00
98_P101_I0.9891.00
225_K232_V0.9881.00
67_F107_L0.9831.00
278_A284_H0.9831.00
36_L63_I0.9741.00
170_L256_A0.9721.00
228_I231_I0.9721.00
14_A33_L0.9711.00
184_L229_V0.9661.00
230_E233_Q0.9651.00
13_K16_E0.9641.00
201_P204_A0.9641.00
211_L215_V0.9631.00
192_K195_P0.9591.00
277_L281_T0.9581.00
98_P102_M0.9561.00
245_V282_L0.9541.00
221_D225_K0.9451.00
75_D80_D0.9421.00
244_G247_P0.9361.00
286_M290_P0.9351.00
37_L263_L0.9301.00
187_L190_Q0.9211.00
85_S134_D0.9151.00
200_E204_A0.9151.00
178_P182_E0.9131.00
34_A256_A0.9121.00
104_N143_P0.9111.00
99_G103_G0.9111.00
190_Q193_S0.9101.00
64_G67_F0.9091.00
211_L216_Q0.9081.00
259_A263_L0.9041.00
221_D224_I0.8961.00
230_E234_K0.8951.00
199_L202_V0.8941.00
285_R289_H0.8941.00
258_Q262_L0.8931.00
247_P250_S0.8931.00
30_I264_H0.8911.00
255_K258_Q0.8811.00
96_Y99_G0.8761.00
249_G256_A0.8751.00
98_P138_M0.8701.00
180_F233_Q0.8691.00
277_L284_H0.8681.00
89_A92_M0.8631.00
228_I235_T0.8581.00
204_A208_F0.8561.00
76_L80_D0.8541.00
129_G142_D0.8521.00
226_E232_V0.8521.00
224_I232_V0.8521.00
27_D31_L0.8461.00
274_I278_A0.8441.00
285_R291_E0.8361.00
281_T285_R0.8331.00
15_V19_N0.8321.00
272_D275_Q0.8271.00
182_E185_D0.8261.00
227_Y231_I0.8211.00
273_D277_L0.8181.00
219_R224_I0.8161.00
246_S249_G0.8151.00
96_Y100_P0.8131.00
77_L82_T0.8111.00
218_V223_S0.8101.00
285_R288_L0.8041.00
206_E215_V0.8031.00
42_V147_M0.8001.00
257_A263_L0.7881.00
228_I254_M0.7831.00
283_P287_M0.7801.00
156_E159_Y0.7781.00
223_S226_E0.7771.00
36_L59_L0.7741.00
120_S123_L0.7741.00
65_A72_F0.7731.00
202_V209_I0.7721.00
66_D103_G0.7671.00
231_I236_R0.7671.00
139_Q142_D0.7671.00
200_E203_I0.7601.00
201_P205_K0.7591.00
207_D214_E0.7581.00
229_V236_R0.7551.00
75_D79_S0.7551.00
267_D270_I0.7541.00
204_A211_L0.7511.00
204_A210_F0.7501.00
195_P198_T0.7491.00
227_Y232_V0.7481.00
283_P286_M0.7481.00
202_V207_D0.7431.00
93_E97_R0.7431.00
111_I165_Q0.7341.00
227_Y230_E0.7321.00
218_V225_K0.7261.00
183_E187_L0.7191.00
210_F217_N0.7181.00
76_L82_T0.7181.00
218_V224_I0.7161.00
274_I288_L0.7121.00
208_F215_V0.7101.00
211_L262_L0.7051.00
257_A274_I0.7031.00
280_F283_P0.7021.00
245_V248_R0.7001.00
28_I44_L0.6981.00
181_N185_D0.6981.00
189_L195_P0.6951.00
221_D229_V0.6921.00
74_P121_A0.6871.00
59_L147_M0.6871.00
93_E99_G0.6861.00
261_A265_H0.6841.00
259_A262_L0.6821.00
207_D212_Q0.6811.00
28_I173_L0.6811.00
272_D276_Y0.6801.00
22_M55_M0.6801.00
94_F99_G0.6791.00
36_L39_K0.6751.00
256_A259_A0.6751.00
232_V239_P0.6711.00
101_I125_A0.6701.00
260_Y277_L0.6691.00
46_D176_G0.6691.00
274_I292_A0.6641.00
110_E151_N0.6631.00
23_V189_L0.6591.00
44_L175_M0.6561.00
91_T95_E0.6551.00
200_E210_F0.6541.00
166_L172_K0.6511.00
205_K212_Q0.6501.00
232_V238_H0.6481.00
96_Y138_M0.6461.00
58_A62_S0.6421.00
234_K238_H0.6391.00
198_T201_P0.6361.00
15_V26_R0.6351.00
244_G248_R0.6351.00
204_A212_Q0.6341.00
180_F216_Q0.6331.00
180_F212_Q0.6301.00
45_E174_R0.6301.00
66_D71_Q0.6291.00
19_N61_K0.6291.00
225_K236_R0.6251.00
47_V50_V0.6241.00
221_D232_V0.6241.00
284_H292_A0.6231.00
14_A203_I0.6221.00
43_L150_Q0.6211.00
31_L38_A0.6211.00
258_Q261_A0.6191.00
194_H199_L0.6181.00
260_Y263_L0.6181.00
282_L285_R0.6171.00
288_L291_E0.6161.00
279_P282_L0.6141.00
264_H272_D0.6141.00
229_V234_K0.6141.00
191_E195_P0.6131.00
100_P103_G0.6131.00
178_P183_E0.6121.00
224_I235_T0.6121.00
243_L246_S0.6111.00
92_M99_G0.6111.00
249_G252_A0.6101.00
228_I233_Q0.6091.00
97_R101_I0.6071.00
274_I284_H0.6071.00
31_L39_K0.6061.00
200_E208_F0.6051.00
206_E213_R0.6051.00
277_L282_L0.6041.00
28_I31_L0.6031.00
280_F291_E0.6001.00
203_I206_E0.6001.00
99_G102_M0.5991.00
37_L215_V0.5971.00
116_P119_Q0.5961.00
206_E212_Q0.5931.00
26_R29_A0.5921.00
192_K196_I0.5911.00
208_F214_E0.5901.00
23_V185_D0.5891.00
29_A33_L0.5861.00
251_I254_M0.5861.00
220_A228_I0.5801.00
43_L148_A0.5801.00
189_L192_K0.5791.00
105_I145_F0.5781.00
270_I277_L0.5781.00
261_A264_H0.5761.00
221_D226_E0.5731.00
33_L37_L0.5731.00
269_V272_D0.5721.00
46_D51_G0.5711.00
26_R30_I0.5711.00
15_V18_I0.5691.00
268_Y272_D0.5671.00
284_H291_E0.5661.00
50_V175_M0.5591.00
227_Y234_K0.5591.00
261_A273_D0.5571.00
277_L291_E0.5561.00
184_L225_K0.5541.00
57_R61_K0.5541.00
67_F70_I0.5511.00
13_K17_H0.5501.00
34_A277_L0.5491.00
46_D174_R0.5471.00
199_L203_I0.5471.00
229_V239_P0.5451.00
220_A229_V0.5441.00
96_Y140_L0.5441.00
123_L126_M0.5431.00
31_L36_L0.5421.00
218_V229_V0.5401.00
201_P208_F0.5381.00
34_A38_A0.5351.00
228_I234_K0.5351.00
287_M290_P0.5341.00
121_A124_E0.5331.00
134_D138_M0.5331.00
220_A225_K0.5321.00
203_I211_L0.5301.00
183_E186_V0.5301.00
226_E235_T0.5281.00
31_L37_L0.5261.00
119_Q165_Q0.5251.00
280_F284_H0.5251.00
255_K262_L0.5221.00
120_S162_P0.5211.00
27_D176_G0.5181.00
275_Q279_P0.5171.00
101_I106_V0.5161.00
196_I199_L0.5151.00
191_E196_I0.5151.00
226_E236_R0.5131.00
39_K142_D0.5131.00
60_A105_I0.5091.00
248_R251_I0.5091.00
169_F172_K0.5071.00
257_A260_Y0.5061.00
262_L265_H0.5041.00
118_T121_A0.5031.00
236_R240_S0.5021.00
274_I282_L0.5001.00
116_P120_S0.5001.00
200_E216_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3vkgA 2 0.9781 100 0.367 Contact Map
4rh7A 1 0.9531 100 0.371 Contact Map
2r44A 1 0.9812 100 0.447 Contact Map
3ja83 1 0.8656 100 0.472 Contact Map
4akgA 2 0.8438 100 0.48 Contact Map
4r7yA 3 0.8844 100 0.484 Contact Map
3ja82 1 0.9344 100 0.5 Contact Map
3ja87 1 0.8938 100 0.51 Contact Map
3ja86 1 0.9 100 0.515 Contact Map
3ja84 1 0.8781 100 0.519 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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