GREMLIN Database
RSMB - Ribosomal RNA small subunit methyltransferase B
UniProt: P94464 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 447 (424)
Sequences: 3975 (2933)
Seq/√Len: 142.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
326_I371_V4.0361.00
365_R399_E4.0161.00
150_H174_H3.7771.00
393_I443_M3.6811.00
361_L395_A3.3321.00
312_R362_S3.2521.00
108_K116_A3.1771.00
60_D82_R3.0851.00
256_L323_F2.8931.00
425_R439_F2.8301.00
80_L107_A2.7891.00
84_S103_A2.7621.00
296_A304_I2.7471.00
278_S305_H2.7441.00
195_L215_V2.7161.00
157_E387_T2.7161.00
361_L392_V2.6681.00
161_A386_R2.6471.00
324_D372_K2.6291.00
253_E325_R2.5131.00
190_D193_E2.5121.00
376_T444_R2.5031.00
125_S129_E2.5031.00
328_V363_I2.4881.00
44_L94_I2.4881.00
163_G167_A2.4621.00
404_E444_R2.4091.00
208_G214_A2.4051.00
376_T442_S2.3561.00
194_L233_V2.3401.00
125_S128_R2.3321.00
195_L205_V2.2411.00
371_V377_L2.2271.00
258_A367_I2.2261.00
280_T323_F2.2131.00
368_A403_F2.1621.00
365_R400_H2.1511.00
368_A396_F2.1501.00
254_T278_S2.1041.00
150_H171_C2.0611.00
85_L126_I2.0581.00
357_A392_V1.9861.00
208_G238_E1.9651.00
395_A399_E1.9601.00
188_K300_G1.9451.00
51_G86_Y1.9371.00
396_F403_F1.9061.00
197_Q232_E1.9011.00
283_D289_V1.8881.00
121_G125_S1.8701.00
289_V308_T1.8501.00
152_E156_K1.8421.00
266_S281_S1.8391.00
206_E218_L1.8331.00
407_L444_R1.8251.00
273_M277_G1.8181.00
155_V171_C1.8111.00
260_A292_I1.7691.00
378_V442_S1.7521.00
189_A194_L1.7461.00
249_P253_E1.7331.00
184_V194_L1.7221.00
107_A119_V1.7181.00
142_R152_E1.7091.00
67_I118_F1.7071.00
405_P441_C1.7031.00
157_E385_D1.7011.00
289_V306_A1.6941.00
267_A299_L1.6931.00
405_P425_R1.6911.00
266_S279_V1.6631.00
390_D427_Q1.6481.00
396_F400_H1.6441.00
166_A431_H1.6431.00
244_A268_H1.6401.00
58_A90_Y1.6261.00
290_K293_K1.6131.00
371_V445_K1.5891.00
250_K253_E1.5841.00
186_Q213_D1.5731.00
226_H230_N1.5681.00
55_N58_A1.5541.00
101_H105_E1.5541.00
11_L83_L1.5411.00
158_W385_D1.5411.00
181_T216_K1.5341.00
166_A432_Y1.5231.00
335_F383_T1.5041.00
182_L233_V1.4881.00
381_T389_N1.4831.00
394_H398_Q1.4661.00
162_Y429_L1.4561.00
247_L269_I1.4551.00
48_L83_L1.4461.00
60_D78_I1.4381.00
191_R207_K1.4341.00
335_F385_D1.4321.00
159_A167_A1.4281.00
205_V215_V1.4261.00
89_E126_I1.4261.00
158_W171_C1.4141.00
13_A45_L1.4071.00
407_L442_S1.4051.00
73_V118_F1.4021.00
84_S99_A1.4021.00
393_I397_I1.3981.00
10_A48_L1.3881.00
428_I435_T1.3871.00
266_S304_I1.3811.00
13_A31_V1.3691.00
391_E394_H1.3681.00
121_G128_R1.3681.00
167_A171_C1.3671.00
66_F126_I1.3641.00
211_A238_E1.3451.00
204_E218_L1.3411.00
280_T307_E1.3391.00
13_A27_L1.3301.00
47_E86_Y1.3251.00
191_R215_V1.3161.00
234_S267_A1.3071.00
239_S435_T1.3041.00
80_L103_A1.3021.00
57_I346_Y1.2951.00
361_L399_E1.2841.00
254_T323_F1.2841.00
189_A232_E1.2741.00
245_R272_L1.2691.00
289_V292_I1.2591.00
12_E110_R1.2571.00
246_A440_I1.2561.00
88_M127_Q1.2471.00
213_D245_R1.2431.00
249_P255_V1.2431.00
227_F233_V1.2371.00
260_A266_S1.2311.00
286_K308_T1.2281.00
247_L325_R1.2211.00
254_T280_T1.2181.00
358_E362_S1.2141.00
18_E79_Q1.2131.00
243_V440_I1.2111.00
364_L396_F1.2091.00
248_D325_R1.2021.00
130_G133_S1.2011.00
188_K232_E1.1781.00
273_M276_K1.1751.00
269_I327_L1.1731.00
157_E350_P1.1721.00
386_R391_E1.1661.00
59_L85_L1.1661.00
254_T322_Q1.1641.00
214_A241_M1.1631.00
361_L365_R1.1591.00
201_E227_F1.1560.99
247_L378_V1.1510.99
17_L53_L1.1500.99
369_P400_H1.1470.99
59_L86_Y1.1440.99
366_E369_P1.1390.99
9_I31_V1.1350.99
249_P273_M1.1330.99
330_A363_I1.1280.99
45_L49_V1.1280.99
211_A214_A1.1270.99
196_D199_A1.1220.99
397_I443_M1.1210.99
181_T238_E1.1210.99
237_D339_R1.1180.99
255_V277_G1.1160.99
234_S271_E1.1150.99
141_V159_A1.1130.99
87_Q103_A1.1130.99
168_E172_R1.1120.99
368_A377_L1.1120.99
18_E56_K1.1070.99
311_A363_I1.1070.99
348_K352_D1.1040.99
15_I79_Q1.1020.99
333_S356_L1.1010.99
239_S428_I1.0940.99
269_I325_R1.0920.99
17_L49_V1.0920.99
143_R147_E1.0900.99
314_A370_L1.0890.99
309_M314_A1.0850.99
144_L168_E1.0780.99
312_R363_I1.0600.99
258_A282_L1.0530.99
251_S274_K1.0530.99
191_R195_L1.0530.99
44_L91_L1.0500.99
387_T391_E1.0480.99
248_D376_T1.0460.99
182_L217_L1.0440.99
349_K352_D1.0420.99
293_K306_A1.0420.99
195_L207_K1.0390.99
170_I384_M1.0320.99
359_I362_S1.0310.99
88_M96_D1.0270.99
172_R176_I1.0250.99
104_V120_N1.0250.99
23_Y26_L1.0240.99
243_V378_V1.0210.99
120_N124_R1.0170.99
333_S353_S1.0120.99
15_I19_Q1.0110.99
102_E105_E1.0060.99
175_L345_K1.0050.99
88_M99_A1.0010.99
100_I127_Q0.9880.98
144_L155_V0.9830.98
186_Q271_E0.9810.98
156_K160_D0.9800.98
181_T208_G0.9790.98
352_D355_R0.9780.98
353_S357_A0.9760.98
377_L396_F0.9750.98
206_E216_K0.9740.98
196_D200_A0.9730.98
253_E376_T0.9710.98
193_E197_Q0.9710.98
148_T171_C0.9710.98
80_L106_I0.9700.98
325_R376_T0.9690.98
338_I345_K0.9680.98
386_R390_D0.9680.98
147_E168_E0.9660.98
421_V424_G0.9630.98
194_L227_F0.9600.98
312_R359_I0.9590.98
94_I99_A0.9550.98
163_G166_A0.9520.98
74_K115_I0.9490.98
260_A281_S0.9470.98
44_L48_L0.9440.98
166_A169_K0.9410.98
201_E226_H0.9400.98
192_A196_D0.9390.98
178_P340_R0.9390.98
57_I146_T0.9370.98
64_K78_I0.9350.98
237_D340_R0.9330.98
255_V273_M0.9270.98
95_P98_A0.9260.98
404_E407_L0.9230.97
337_V341_K0.9230.97
227_F232_E0.9200.97
11_L15_I0.9180.97
8_D110_R0.9180.97
203_I225_T0.9170.97
9_I37_L0.9170.97
66_F129_E0.9150.97
174_H384_M0.9110.97
144_L171_C0.9110.97
67_I73_V0.9080.97
251_S276_K0.9060.97
145_A152_E0.9050.97
159_A164_F0.9040.97
150_H175_L0.9030.97
293_K297_D0.9010.97
400_H403_F0.8980.97
97_R101_H0.8970.97
150_H155_V0.8960.97
366_E370_L0.8950.97
429_L432_Y0.8920.97
145_A155_V0.8910.97
397_I405_P0.8850.97
155_V167_A0.8790.97
208_G211_A0.8780.97
47_E54_Q0.8770.97
47_E177_P0.8770.97
338_I344_M0.8750.97
77_V107_A0.8740.97
210_L238_E0.8730.96
371_V403_F0.8720.96
46_T50_Y0.8700.96
282_L309_M0.8700.96
184_V191_R0.8670.96
249_P272_L0.8650.96
104_V116_A0.8650.96
59_L90_Y0.8640.96
11_L79_Q0.8640.96
187_M301_L0.8630.96
182_L215_V0.8620.96
269_I277_G0.8610.96
287_H290_K0.8580.96
212_E245_R0.8560.96
16_K27_L0.8550.96
271_E301_L0.8510.96
267_A295_A0.8470.96
57_I152_E0.8460.96
328_V367_I0.8460.96
127_Q130_G0.8420.96
258_A311_A0.8420.96
294_E297_D0.8390.96
57_I149_S0.8390.96
274_K277_G0.8380.96
243_V268_H0.8360.96
189_A197_Q0.8360.96
112_H115_I0.8350.95
80_L84_S0.8340.95
249_P269_I0.8330.95
357_A361_L0.8330.95
44_L87_Q0.8310.95
355_R358_E0.8300.95
269_I279_V0.8280.95
248_D272_L0.8250.95
256_L282_L0.8240.95
91_L94_I0.8230.95
282_L307_E0.8210.95
87_Q99_A0.8180.95
191_R214_A0.8160.95
80_L119_V0.8130.95
200_A215_V0.8130.95
424_G439_F0.8110.95
270_A301_L0.8080.95
62_M126_I0.8080.95
79_Q82_R0.8070.95
154_L385_D0.8040.94
39_D43_G0.8040.94
357_A385_D0.8000.94
11_L106_I0.7990.94
199_A205_V0.7970.94
94_I98_A0.7970.94
113_K117_S0.7950.94
105_E108_K0.7930.94
314_A366_E0.7930.94
365_R395_A0.7890.94
425_R441_C0.7870.94
430_P437_G0.7870.94
326_I377_L0.7860.94
156_K350_P0.7820.94
396_F402_D0.7810.94
354_A387_T0.7810.94
189_A193_E0.7800.94
57_I145_A0.7790.93
226_H229_Q0.7780.93
327_L380_S0.7770.93
87_Q94_I0.7770.93
104_V124_R0.7750.93
129_E132_P0.7750.93
159_A163_G0.7740.93
63_L67_I0.7730.93
313_K316_E0.7720.93
268_H272_L0.7710.93
62_M89_E0.7660.93
148_T155_V0.7650.93
238_E435_T0.7640.93
256_L326_I0.7640.93
384_M427_Q0.7590.93
214_A238_E0.7570.92
364_L377_L0.7560.92
228_F233_V0.7550.92
26_L291_L0.7530.92
140_P143_R0.7480.92
405_P439_F0.7480.92
13_A49_V0.7460.92
24_S344_M0.7460.92
221_T224_G0.7460.92
178_P339_R0.7460.92
8_D109_I0.7390.92
154_L335_F0.7390.92
403_F445_K0.7380.92
181_T214_A0.7360.91
169_K172_R0.7360.91
56_K82_R0.7360.91
201_E225_T0.7330.91
428_I432_Y0.7320.91
184_V215_V0.7310.91
56_K79_Q0.7310.91
27_L31_V0.7310.91
108_K113_K0.7290.91
397_I403_F0.7240.91
59_L82_R0.7220.91
360_Q379_Y0.7190.90
244_A269_I0.7170.90
11_L76_W0.7140.90
280_T305_H0.7120.90
412_R442_S0.7110.90
16_K31_V0.7110.90
187_M273_M0.7110.90
47_E91_L0.7100.90
390_D394_H0.7090.90
74_K114_G0.7070.90
166_A429_L0.7060.90
378_V440_I0.7060.90
420_F424_G0.7060.90
55_N90_Y0.7060.90
368_A371_V0.7040.90
193_E196_D0.7010.89
79_Q83_L0.7000.89
251_S273_M0.7000.89
19_Q75_P0.7000.89
8_D12_E0.6990.89
290_K294_E0.6980.89
52_T82_R0.6980.89
273_M279_V0.6980.89
9_I45_L0.6980.89
211_A245_R0.6910.89
339_R436_D0.6910.89
14_L49_V0.6910.89
270_A279_V0.6900.89
234_S295_A0.6890.88
18_E82_R0.6890.88
279_V301_L0.6850.88
55_N149_S0.6850.88
194_L197_Q0.6850.88
195_L199_A0.6840.88
104_V117_S0.6830.88
248_D253_E0.6820.88
21_Q27_L0.6780.88
78_I82_R0.6780.88
252_D276_K0.6770.88
166_A170_I0.6770.88
353_S385_D0.6760.88
231_G298_R0.6750.87
16_K22_A0.6740.87
170_I431_H0.6740.87
15_I18_E0.6730.87
403_F443_M0.6710.87
74_K112_H0.6710.87
14_L52_T0.6700.87
63_L85_L0.6690.87
47_E51_G0.6690.87
301_L304_I0.6680.87
376_T407_L0.6670.87
397_I400_H0.6670.87
13_A28_L0.6670.87
85_L89_E0.6650.87
10_A49_V0.6640.87
63_L126_I0.6640.87
315_G366_E0.6640.87
88_M100_I0.6630.87
11_L110_R0.6630.87
426_L440_I0.6630.87
183_R271_E0.6620.86
67_I122_V0.6610.86
87_Q91_L0.6600.86
32_I42_R0.6600.86
392_V395_A0.6590.86
191_R194_L0.6580.86
373_K445_K0.6550.86
267_A296_A0.6550.86
56_K59_L0.6540.86
187_M274_K0.6530.86
234_S299_L0.6520.86
14_L79_Q0.6510.86
158_W384_M0.6510.86
157_E161_A0.6470.85
296_A306_A0.6450.85
55_N175_L0.6450.85
167_A170_I0.6450.85
208_G216_K0.6440.85
428_I433_F0.6440.85
391_E395_A0.6440.85
144_L159_A0.6440.85
76_W112_H0.6430.85
249_P376_T0.6430.85
312_R366_E0.6430.85
185_N271_E0.6400.85
286_K293_K0.6400.85
341_K347_T0.6380.84
428_I440_I0.6380.84
394_H425_R0.6370.84
316_E366_E0.6370.84
409_L426_L0.6350.84
368_A400_H0.6340.84
295_A298_R0.6330.84
377_L403_F0.6330.84
335_F338_I0.6330.84
326_I367_I0.6330.84
96_D127_Q0.6320.84
253_E273_M0.6320.84
185_N234_S0.6310.84
265_K329_D0.6300.84
87_Q98_A0.6290.84
355_R359_I0.6280.83
365_R392_V0.6280.83
213_D268_H0.6270.83
326_I369_P0.6270.83
100_I104_V0.6260.83
127_Q131_V0.6240.83
238_E242_L0.6240.83
9_I12_E0.6240.83
62_M85_L0.6240.83
149_S346_Y0.6240.83
63_L81_L0.6230.83
158_W167_A0.6230.83
105_E116_A0.6220.83
56_K346_Y0.6220.83
213_D272_L0.6210.83
185_N188_K0.6200.83
86_Y90_Y0.6200.83
327_L378_V0.6190.83
320_N369_P0.6180.82
43_G47_E0.6170.82
314_A369_P0.6170.82
100_I120_N0.6160.82
15_I76_W0.6150.82
84_S88_M0.6140.82
292_I306_A0.6130.82
421_V425_R0.6110.82
146_T149_S0.6110.82
84_S123_L0.6090.82
291_L294_E0.6090.82
182_L235_I0.6080.81
183_R268_H0.6060.81
143_R146_T0.6040.81
199_A204_E0.6010.81
354_A357_A0.6000.81
282_L311_A0.5980.80
246_A409_L0.5980.80
17_L24_S0.5960.80
287_H291_L0.5960.80
283_D292_I0.5960.80
420_F425_R0.5950.80
357_A387_T0.5950.80
140_P164_F0.5940.80
329_D382_C0.5930.80
124_R128_R0.5910.80
322_Q372_K0.5900.79
392_V399_E0.5900.79
228_F298_R0.5860.79
183_R236_Q0.5830.79
258_A363_I0.5820.79
258_A328_V0.5810.78
335_F353_S0.5790.78
243_V380_S0.5790.78
12_E31_V0.5780.78
183_R234_S0.5780.78
255_V325_R0.5770.78
228_F231_G0.5770.78
258_A326_I0.5760.78
194_L215_V0.5760.78
75_P79_Q0.5750.78
17_L21_Q0.5740.78
244_A272_L0.5730.78
87_Q95_P0.5730.78
58_A147_E0.5730.78
103_A119_V0.5720.77
19_Q79_Q0.5720.77
88_M123_L0.5710.77
52_T59_L0.5700.77
368_A445_K0.5700.77
262_P288_K0.5680.77
351_D355_R0.5670.77
266_S296_A0.5670.77
256_L280_T0.5670.77
209_D238_E0.5660.77
41_N44_L0.5650.77
431_H435_T0.5630.76
368_A402_D0.5630.76
180_Q222_I0.5620.76
48_L94_I0.5620.76
182_L227_F0.5610.76
374_G445_K0.5600.76
75_P78_I0.5580.76
262_P292_I0.5570.76
63_L82_R0.5570.76
279_V304_I0.5560.75
241_M380_S0.5560.75
22_A27_L0.5550.75
334_G344_M0.5550.75
284_L308_T0.5550.75
117_S120_N0.5550.75
77_V115_I0.5540.75
390_D439_F0.5540.75
129_E133_S0.5540.75
149_S171_C0.5540.75
104_V121_G0.5490.74
420_F423_D0.5480.74
56_K60_D0.5480.74
186_Q190_D0.5480.74
389_N427_Q0.5480.74
390_D425_R0.5440.74
393_I441_C0.5440.74
204_E219_K0.5430.74
96_D130_G0.5430.74
41_N91_L0.5420.74
106_I110_R0.5400.73
212_E216_K0.5380.73
104_V108_K0.5380.73
25_N29_K0.5360.73
121_G124_R0.5360.73
7_R10_A0.5340.72
197_Q201_E0.5330.72
192_A207_K0.5330.72
24_S343_D0.5320.72
328_V361_L0.5310.72
66_F125_S0.5310.72
115_I118_F0.5310.72
32_I45_L0.5300.72
197_Q227_F0.5290.72
44_L47_E0.5280.72
153_W350_P0.5270.71
265_K382_C0.5270.71
31_V34_S0.5260.71
83_L106_I0.5250.71
103_A106_I0.5240.71
164_F168_E0.5230.71
47_E94_I0.5230.71
148_T168_E0.5230.71
99_A103_A0.5210.71
369_P373_K0.5200.70
98_A102_E0.5200.70
170_I429_L0.5190.70
380_S440_I0.5170.70
282_L314_A0.5160.70
147_E172_R0.5160.70
424_G427_Q0.5150.70
253_E324_D0.5140.70
169_K431_H0.5140.70
176_I434_G0.5130.69
240_S438_F0.5130.69
350_P354_A0.5120.69
247_L327_L0.5120.69
183_R241_M0.5110.69
237_D436_D0.5100.69
199_A203_I0.5090.69
283_D308_T0.5080.69
61_Y146_T0.5080.69
154_L338_I0.5070.69
397_I401_P0.5070.69
14_L83_L0.5070.69
28_L45_L0.5060.68
150_H154_L0.5060.68
408_S424_G0.5050.68
12_E35_N0.5050.68
39_D42_R0.5050.68
173_I176_I0.5040.68
91_L95_P0.5030.68
340_R436_D0.5030.68
249_P325_R0.5010.68
245_R268_H0.5000.68
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2yxlA 1 0.9642 100 0.279 Contact Map
1sqgA 1 0.9441 100 0.297 Contact Map
2frxA 1 0.651 100 0.444 Contact Map
1ixkA 1 0.6644 100 0.462 Contact Map
3m4xA 1 0.6443 100 0.473 Contact Map
3m6wA 2 0.6532 100 0.481 Contact Map
2b9eA 1 0.5638 100 0.506 Contact Map
3ajdA 1 0.5548 100 0.557 Contact Map
4fzvA 1 0.6689 100 0.609 Contact Map
2vdvE 2 0.443 99.9 0.802 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0124 seconds.