GREMLIN Database
FMT - Methionyl-tRNA formyltransferase
UniProt: P94463 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (300)
Sequences: 5538 (4018)
Seq/√Len: 232.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_K153_E4.1051.00
94_K141_E3.6411.00
94_K98_D3.4201.00
195_D198_K3.3501.00
294_K297_D3.0861.00
216_R220_E2.8991.00
152_V179_E2.7411.00
21_I56_H2.6451.00
140_V145_A2.6351.00
135_T148_M2.5731.00
160_D168_K2.5391.00
160_D164_T2.4801.00
142_K145_A2.4041.00
212_L221_L2.3971.00
222_Y248_S2.2951.00
225_I248_S2.2371.00
3_R26_E2.2191.00
249_K281_L2.2121.00
18_R52_E2.1851.00
136_I180_T2.1821.00
249_K283_T2.1691.00
183_N188_S2.1351.00
114_E129_K2.1181.00
247_A284_E2.1141.00
115_L129_K2.1031.00
284_E292_R2.0921.00
115_L127_Q2.0341.00
18_R22_E2.0251.00
216_R224_Q2.0001.00
29_G78_L1.9951.00
73_E77_A1.9821.00
122_H162_V1.9471.00
163_G230_P1.9421.00
52_E56_H1.9421.00
271_I279_A1.9271.00
82_L181_V1.8971.00
247_A283_T1.8931.00
126_L227_G1.8741.00
271_I281_L1.8581.00
217_T220_E1.8361.00
258_E261_T1.7991.00
241_Q288_A1.7561.00
154_V172_A1.7321.00
131_K155_D1.7231.00
138_Y191_P1.7221.00
147_D193_K1.7141.00
196_E199_A1.7101.00
59_P74_K1.7021.00
296_E300_R1.6921.00
16_V107_V1.6881.00
282_L285_L1.6841.00
297_D300_R1.6821.00
154_V168_K1.6651.00
246_W292_R1.6521.00
123_Y209_Q1.6171.00
5_V80_P1.5781.00
214_W236_T1.5761.00
269_G281_L1.5481.00
152_V175_K1.5401.00
21_I52_E1.5351.00
212_L245_I1.5231.00
157_E160_D1.5231.00
35_D50_K1.5231.00
128_G223_N1.5161.00
52_E55_R1.5121.00
80_P83_I1.5001.00
248_S280_L1.4731.00
221_L280_L1.4671.00
80_P99_S1.4641.00
50_K62_Q1.4631.00
151_K192_E1.4571.00
213_D216_R1.4561.00
74_K77_A1.4501.00
51_E54_L1.4441.00
46_P54_L1.4291.00
111_L133_G1.4291.00
3_R28_V1.4201.00
219_E223_N1.4121.00
135_T151_K1.3911.00
50_K54_L1.3831.00
14_V52_E1.3721.00
19_T175_K1.3701.00
263_V279_A1.3691.00
19_T178_S1.3681.00
161_N229_N1.3461.00
270_I282_L1.3441.00
147_D191_P1.3411.00
284_E294_K1.3371.00
51_E55_R1.3311.00
152_V172_A1.3281.00
222_Y250_K1.3241.00
270_I295_G1.3051.00
126_L228_L1.3021.00
149_I191_P1.2931.00
287_P293_M1.2931.00
148_M151_K1.2931.00
257_A261_T1.2861.00
150_S180_T1.2861.00
126_L224_Q1.2851.00
67_R93_P1.2811.00
9_T47_P1.2791.00
4_I82_L1.2741.00
236_T245_I1.2691.00
138_Y149_I1.2661.00
157_E168_K1.2651.00
16_V177_L1.2641.00
218_G250_K1.2571.00
211_L237_T1.2571.00
5_V29_G1.2501.00
25_Y182_P1.2501.00
107_V177_L1.2471.00
18_R55_R1.2411.00
140_V147_D1.2271.00
211_L235_Y1.2081.00
179_E183_N1.2061.00
222_Y226_R1.1991.00
83_I104_C1.1961.00
91_I143_L1.1951.00
150_S183_N1.1911.00
69_T73_E1.1901.00
217_T276_N1.1871.00
272_V282_L1.1851.00
111_L151_K1.1851.00
123_Y126_L1.1831.00
21_I27_V1.1681.00
38_K41_K1.1671.00
132_T156_I1.1651.00
23_D178_S1.1641.00
183_N189_I1.1491.00
123_Y127_Q1.1491.00
61_L78_L1.1451.00
251_I271_I1.1301.00
16_V86_A1.1251.00
195_D199_A1.1241.00
150_S176_L1.1161.00
218_G276_N1.0961.00
245_I282_L1.0911.00
125_I165_L1.0891.00
118_G204_N1.0891.00
243_L285_L1.0821.00
218_G274_T1.0811.00
251_I281_L1.0791.00
29_G61_L1.0761.00
156_I160_D1.0721.00
266_E269_G1.0681.00
114_E200_T1.0661.00
159_T222_Y1.0651.00
157_E164_T1.0651.00
97_L139_M1.0641.00
286_Q292_R1.0491.00
73_E76_L1.0491.00
38_K45_T1.0441.00
236_T243_L1.0351.00
6_F16_V1.0351.00
119_A123_Y1.0311.00
81_D101_K1.0281.00
32_T47_P1.0271.00
46_P51_E1.0241.00
31_V71_E1.0171.00
150_S179_E1.0121.00
28_V78_L1.0031.00
36_R64_E1.0031.00
136_I150_S1.0011.00
30_V58_I0.9961.00
76_L95_E0.9941.00
237_T240_G0.9941.00
152_V176_L0.9721.00
298_F302_A0.9641.00
105_I149_I0.9611.00
164_T168_K0.9611.00
100_P104_C0.9451.00
7_M31_V0.9441.00
25_Y185_I0.9301.00
107_V136_I0.9291.00
119_A202_A0.9261.00
214_W272_V0.9211.00
104_C139_M0.9211.00
161_N164_T0.9201.00
218_G278_T0.9181.00
66_V71_E0.9111.00
287_P298_F0.9101.00
121_I166_H0.9091.00
7_M83_I0.9020.99
237_T242_N0.9000.99
257_A273_A0.9000.99
208_E211_L0.8990.99
20_L181_V0.8980.99
72_I95_E0.8970.99
229_N246_W0.8940.99
182_P185_I0.8900.99
41_K45_T0.8870.99
76_L99_S0.8860.99
290_K293_M0.8860.99
2_T185_I0.8850.99
159_T249_K0.8800.99
225_I234_A0.8740.99
10_P87_A0.8720.99
223_N226_R0.8710.99
149_I184_V0.8710.99
159_T247_A0.8680.99
221_L274_T0.8680.99
33_Q36_R0.8660.99
114_E198_K0.8660.99
15_P170_S0.8640.99
149_I189_I0.8630.99
107_V134_I0.8620.99
61_L74_K0.8590.99
206_K209_Q0.8590.99
123_Y202_A0.8570.99
130_K155_D0.8540.99
109_A121_I0.8530.99
158_E219_E0.8530.99
222_Y280_L0.8510.99
105_I136_I0.8400.99
160_D165_L0.8370.99
184_V189_I0.8360.99
251_I279_A0.8360.99
224_Q228_L0.8350.99
220_E223_N0.8350.99
261_T273_A0.8320.99
265_V270_I0.8320.99
35_D62_Q0.8320.99
285_L298_F0.8240.99
171_V175_K0.8170.99
245_I248_S0.8090.99
243_L287_P0.8080.99
82_L103_G0.8080.99
23_D182_P0.8010.99
3_R79_K0.7990.99
295_G299_V0.7970.99
19_T23_D0.7910.99
66_V72_I0.7900.99
71_E74_K0.7890.99
266_E271_I0.7870.99
72_I96_L0.7860.99
29_G74_K0.7840.99
18_R56_H0.7830.99
259_P273_A0.7830.99
12_F109_A0.7820.99
215_S275_G0.7820.99
219_E222_Y0.7820.99
176_L180_T0.7780.98
183_N186_A0.7770.98
47_P62_Q0.7760.98
242_N288_A0.7760.98
69_T72_I0.7720.98
210_E235_Y0.7710.98
83_I100_P0.7710.98
158_E222_Y0.7650.98
235_Y242_N0.7640.98
65_K68_L0.7630.98
31_V61_L0.7590.98
15_P18_R0.7560.98
19_T22_E0.7530.98
22_E52_E0.7530.98
273_A279_A0.7490.98
22_E56_H0.7430.98
210_E231_W0.7400.98
80_P100_P0.7380.98
38_K43_V0.7370.98
123_Y203_P0.7360.98
85_T139_M0.7270.98
4_I25_Y0.7260.98
10_P13_S0.7260.98
172_A176_L0.7240.98
220_E224_Q0.7230.98
61_L71_E0.7230.98
246_W286_Q0.7200.98
66_V90_Q0.7170.97
241_Q287_P0.7140.97
244_K286_Q0.7100.97
109_A169_L0.7100.97
68_L71_E0.7100.97
287_P290_K0.7090.97
86_A136_I0.7090.97
154_V160_D0.7080.97
98_D141_E0.7000.97
124_S156_I0.7000.97
122_H227_G0.6960.97
105_I177_L0.6950.97
219_E276_N0.6920.97
70_E73_E0.6920.97
125_I156_I0.6920.97
125_I227_G0.6910.97
233_V246_W0.6870.97
210_E233_V0.6850.97
19_T174_A0.6710.96
182_P186_A0.6670.96
69_T95_E0.6670.96
106_N137_M0.6660.96
5_V83_I0.6650.96
167_D171_V0.6650.96
21_I58_I0.6640.96
127_Q203_P0.6640.96
123_Y204_N0.6610.96
63_P88_F0.6610.96
135_T149_I0.6590.96
13_S16_V0.6580.96
136_I176_L0.6550.96
97_L104_C0.6550.96
121_I162_V0.6530.96
75_V96_L0.6530.96
122_H231_W0.6520.96
238_L243_L0.6510.96
20_L27_V0.6500.95
163_G167_D0.6500.95
255_T273_A0.6440.95
259_P274_T0.6420.95
82_L105_I0.6410.95
252_A278_T0.6410.95
65_K90_Q0.6410.95
255_T279_A0.6410.95
138_Y147_D0.6400.95
76_L79_K0.6400.95
16_V19_T0.6400.95
130_K158_E0.6400.95
33_Q90_Q0.6390.95
161_N247_A0.6360.95
148_M192_E0.6340.95
6_F17_L0.6340.95
72_I76_L0.6330.95
16_V174_A0.6310.95
109_A122_H0.6310.95
24_G182_P0.6250.94
123_Y227_G0.6240.94
107_V173_G0.6230.94
268_E296_E0.6230.94
45_T51_E0.6210.94
79_K101_K0.6200.94
12_F173_G0.6200.94
142_K196_E0.6190.94
293_M297_D0.6180.94
111_L153_E0.6170.94
263_V273_A0.6170.94
134_I172_A0.6160.94
109_A124_S0.6150.94
175_K179_E0.6150.94
90_Q93_P0.6120.94
210_E228_L0.6100.94
105_I191_P0.6100.94
5_V31_V0.6090.94
229_N292_R0.6060.93
74_K78_L0.6050.93
225_I245_I0.6040.93
205_I231_W0.6040.93
257_A263_V0.6030.93
21_I24_G0.6030.93
162_V166_H0.6030.93
270_I281_L0.6020.93
287_P302_A0.6010.93
12_F121_I0.6000.93
132_T165_L0.5990.93
172_A175_K0.5980.93
75_V83_I0.5980.93
65_K72_I0.5950.93
281_L295_G0.5890.93
5_V75_V0.5870.92
95_E98_D0.5840.92
233_V244_K0.5840.92
40_R44_L0.5830.92
64_E68_L0.5830.92
162_V205_I0.5820.92
37_P42_K0.5810.92
124_S129_K0.5800.92
164_T222_Y0.5800.92
103_G138_Y0.5770.92
86_A173_G0.5760.92
168_K172_A0.5750.92
114_E199_A0.5740.92
219_E250_K0.5730.91
130_K219_E0.5720.91
262_V272_V0.5720.91
234_A248_S0.5710.91
274_T279_A0.5700.91
217_T275_G0.5690.91
89_G137_M0.5680.91
110_S120_P0.5670.91
164_T247_A0.5670.91
205_I209_Q0.5660.91
207_R210_E0.5660.91
222_Y225_I0.5630.91
41_K44_L0.5610.91
66_V96_L0.5590.90
229_N233_V0.5590.90
17_L30_V0.5580.90
31_V75_V0.5570.90
2_T81_D0.5570.90
174_A178_S0.5570.90
109_A151_K0.5560.90
163_G229_N0.5550.90
162_V227_G0.5550.90
270_I285_L0.5490.90
140_V143_L0.5490.90
214_W221_L0.5480.90
285_L295_G0.5470.89
5_V28_V0.5470.89
115_L202_A0.5450.89
136_I173_G0.5420.89
269_G295_G0.5420.89
88_F91_I0.5400.89
92_L104_C0.5400.89
37_P44_L0.5390.89
109_A118_G0.5390.89
274_T278_T0.5350.88
32_T49_V0.5330.88
210_E229_N0.5330.88
102_Y185_I0.5320.88
83_I99_S0.5320.88
53_A60_V0.5300.88
65_K71_E0.5290.88
251_I278_T0.5270.88
30_V49_V0.5260.88
135_T140_V0.5260.88
12_F86_A0.5250.88
88_F106_N0.5240.87
125_I162_V0.5230.87
158_E250_K0.5220.87
2_T25_Y0.5190.87
46_P50_K0.5180.87
32_T62_Q0.5180.87
121_I169_L0.5180.87
122_H205_I0.5180.87
248_S283_T0.5170.87
105_I180_T0.5170.87
31_V66_V0.5170.87
143_L199_A0.5160.87
265_V299_V0.5140.86
212_L224_Q0.5120.86
12_F107_V0.5120.86
109_A166_H0.5110.86
291_K297_D0.5110.86
70_E74_K0.5100.86
82_L184_V0.5100.86
15_P52_E0.5090.86
229_N247_A0.5060.86
15_P171_V0.5060.86
276_N279_A0.5050.85
30_V53_A0.5040.85
82_L138_Y0.5030.85
16_V170_S0.5030.85
136_I177_L0.5020.85
179_E182_P0.5020.85
126_L209_Q0.5020.85
122_H166_H0.5010.85
124_S132_T0.5010.85
72_I93_P0.5010.85
250_K280_L0.5010.85
27_V58_I0.5010.85
114_E127_Q0.5000.85
2_T26_E0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4iqfA 1 0.9811 100 0.089 Contact Map
3tqqA 1 0.9495 100 0.091 Contact Map
3q0iA 1 0.9464 100 0.097 Contact Map
1fmtA 1 0.959 100 0.098 Contact Map
2blnA 1 0.9369 100 0.133 Contact Map
4wkgA 5 0.9432 100 0.151 Contact Map
2bw0A 1 0.918 100 0.166 Contact Map
4lxqA 2 0.8454 100 0.277 Contact Map
4xczA 2 0.9211 100 0.302 Contact Map
1zghA 1 0.7003 100 0.358 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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