GREMLIN Database
PRIA - Primosomal protein N'
UniProt: P94461 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 805 (784)
Sequences: 1412 (1139)
Seq/√Len: 40.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
485_L495_A7.3331.00
343_Q369_R5.9111.00
605_G624_N4.9691.00
580_R608_D4.9511.00
493_E664_K4.8661.00
273_R277_E4.8581.00
601_A606_K4.5851.00
271_E450_H4.4861.00
687_D690_T4.2351.00
317_K386_G4.1051.00
201_K204_A4.0751.00
487_E491_K4.0301.00
310_E314_A3.9971.00
521_H757_D3.9481.00
271_E449_K3.9271.00
484_K667_H3.8721.00
31_I50_V3.7551.00
579_A609_I3.6551.00
416_A423_V3.6151.00
488_T495_A3.4901.00
22_K66_E3.4421.00
461_S480_E3.1821.00
488_T667_H3.1611.00
480_E484_K3.1531.00
484_K669_I3.1121.00
294_H435_Y3.0981.00
715_V730_I3.0821.00
486_E490_A3.0611.00
198_Q201_K3.0601.00
19_F41_F3.0451.00
5_E54_K3.0411.00
296_V457_M3.0331.00
582_I607_A3.0291.00
199_A202_Q2.9981.00
572_L581_V2.9981.00
84_L411_V2.9971.00
463_V669_I2.9821.00
291_F446_L2.9611.00
321_V336_F2.9441.00
447_S689_E2.9321.00
413_I423_V2.9221.00
252_R358_D2.8971.00
309_I319_A2.8841.00
452_V455_R2.8561.00
717_H723_A2.7501.00
275_A446_L2.7381.00
484_K487_E2.7061.00
3_F20_D2.6761.00
23_I53_V2.6661.00
345_A368_V2.6541.00
656_S668_V2.6501.00
471_N479_V2.6441.00
311_K314_A2.6161.00
489_I576_L2.5971.00
485_L576_L2.5801.00
235_K239_Q2.5721.00
692_Y696_M2.5711.00
526_M542_H2.5701.00
437_R442_V2.5591.00
682_L690_T2.5391.00
319_A387_M2.5281.00
579_A608_D2.5221.00
715_V723_A2.4801.00
276_F308_S2.4671.00
318_E382_F2.4651.00
280_R311_K2.4501.00
600_S604_E2.4371.00
517_P535_L2.4341.00
468_E479_V2.4231.00
3_F64_V2.4191.00
433_E642_F2.4141.00
304_I448_L2.4131.00
630_V670_I2.4001.00
180_Q244_K2.3901.00
486_E578_S2.3331.00
5_E52_A2.3001.00
269_T452_V2.2951.00
752_I755_I2.2891.00
36_R72_D2.2531.00
229_T233_T2.2451.00
414_K417_E2.2351.00
399_K798_D2.2171.00
305_Y426_G2.2041.00
461_S667_H2.1991.00
715_V727_A2.1981.00
489_I579_A2.1860.99
382_F385_L2.1620.99
220_A234_I2.1510.99
731_A735_K2.1380.99
37_V50_V2.1290.99
263_T338_G2.1110.99
306_L339_R2.0880.99
279_I424_V2.0430.99
488_T627_L2.0410.99
630_V652_L2.0410.99
520_P542_H2.0400.99
238_I245_E2.0280.99
354_G358_D1.9890.99
252_R354_G1.9800.99
249_E361_R1.9790.99
709_Y800_N1.9760.99
313_L369_R1.9720.99
278_P444_E1.9690.99
433_E643_R1.9650.99
431_T434_S1.9610.99
582_I598_L1.9610.99
347_M380_A1.9460.99
711_A799_M1.9420.99
85_S100_L1.9420.99
308_S387_M1.9390.99
278_P446_L1.9100.99
279_I308_S1.9050.99
202_Q206_L1.9010.99
265_P310_E1.9000.99
460_V683_T1.9000.99
435_Y689_E1.8510.98
696_M707_Y1.8430.98
197_R201_K1.8400.98
25_D28_K1.8400.98
432_L696_M1.8200.98
486_E576_L1.8190.98
462_L680_I1.8120.98
439_Q693_Q1.8000.98
468_E473_N1.7970.98
284_D311_K1.7780.98
481_L629_G1.7770.98
571_E575_V1.7750.98
496_V625_V1.7610.98
293_L446_L1.7590.98
217_K248_E1.7530.97
459_E665_P1.7450.97
290_V413_I1.7330.97
716_S758_R1.7300.97
129_E132_F1.7250.97
24_P27_L1.7250.97
33_T53_V1.7140.97
467_E470_R1.7080.97
363_I371_V1.7050.97
561_F632_S1.6870.97
4_A23_I1.6760.97
290_V443_Y1.6700.97
450_H454_H1.6630.97
318_E369_R1.6570.96
489_I609_I1.6470.96
345_A359_E1.6190.96
224_C234_I1.6170.96
128_V132_F1.6060.96
177_R245_E1.6040.96
310_E339_R1.5860.95
236_T239_Q1.5770.95
294_H689_E1.5560.95
524_I539_Y1.5560.95
672_T675_P1.5460.95
434_S443_Y1.5450.95
275_A424_V1.5410.95
294_H447_S1.5370.95
724_A728_E1.5210.94
482_M486_E1.5170.94
413_I443_Y1.5120.94
268_L276_F1.5090.94
485_L572_L1.5070.94
488_T493_E1.5030.94
515_Y552_E1.5030.94
218_I223_L1.5030.94
449_K689_E1.5020.94
602_F607_A1.5020.94
649_F687_D1.4960.94
251_Y367_E1.4940.94
624_N664_K1.4890.94
31_I70_L1.4830.93
289_K444_E1.4830.93
530_R570_E1.4800.93
86_S96_K1.4790.93
468_E478_S1.4750.93
249_E365_R1.4740.93
309_I321_V1.4730.93
569_E573_T1.4730.93
231_S235_K1.4690.93
266_L307_Q1.4690.93
596_E600_S1.4600.93
206_L242_L1.4520.93
539_Y766_K1.4420.92
378_I415_R1.4410.92
352_S592_K1.4380.92
6_V48_G1.4320.92
311_K315_K1.4310.92
435_Y447_S1.4230.92
492_G495_A1.4230.92
198_Q202_Q1.4230.92
271_E448_L1.4170.92
589_T598_L1.4160.92
88_L411_V1.4140.92
116_L152_I1.4140.92
723_A727_A1.4120.92
222_E226_K1.4020.91
501_K506_S1.4020.91
220_A224_C1.3980.91
236_T240_K1.3960.91
200_A203_Q1.3950.91
290_V425_L1.3930.91
477_F482_M1.3890.91
487_E490_A1.3890.91
488_T626_T1.3880.91
85_S103_M1.3740.90
37_V48_G1.3510.90
152_I161_I1.3500.90
320_I378_I1.3500.90
35_M70_L1.3410.89
529_H538_H1.3340.89
469_L473_N1.3260.89
347_M363_I1.3250.89
511_R561_F1.3230.89
355_E592_K1.3180.89
209_L243_L1.3120.88
602_F610_L1.3090.88
436_A440_K1.3090.88
202_Q209_L1.3050.88
177_R247_Y1.2960.88
177_R220_A1.2920.88
436_A707_Y1.2900.87
492_G608_D1.2880.87
395_E620_L1.2870.87
205_I229_T1.2870.87
179_I245_E1.2870.87
682_L686_H1.2800.87
434_S445_L1.2750.87
296_V455_R1.2750.87
308_S424_V1.2750.87
203_Q207_H1.2740.87
119_A122_A1.2740.87
439_Q692_Y1.2730.87
238_I243_L1.2700.87
497_L629_G1.2670.86
692_Y707_Y1.2650.86
452_V456_V1.2630.86
352_S355_E1.2630.86
465_M478_S1.2540.86
290_V423_V1.2520.86
638_H674_T1.2520.86
274_A277_E1.2480.86
497_L572_L1.2480.86
438_A441_G1.2430.85
354_G592_K1.2410.85
176_V221_A1.2360.85
359_E362_K1.2350.85
720_V749_A1.2300.85
465_M468_E1.2270.85
117_K162_D1.2210.84
85_S96_K1.2070.84
94_S99_A1.2030.83
352_S358_D1.1990.83
523_D754_R1.1990.83
516_V525_S1.1980.83
4_A53_V1.1890.83
276_F304_I1.1880.83
199_A206_L1.1840.82
400_Q640_P1.1830.82
620_L655_V1.1780.82
521_H542_H1.1750.82
493_E626_T1.1720.82
772_Q775_A1.1710.82
749_A761_Y1.1660.81
777_L797_I1.1610.81
726_T793_V1.1590.81
140_Y152_I1.1480.80
461_S669_I1.1460.80
303_E307_Q1.1430.80
362_K367_E1.1420.80
589_T592_K1.1410.80
589_T594_A1.1410.80
296_V452_V1.1390.80
4_A48_G1.1330.80
482_M576_L1.1330.80
437_R443_Y1.1330.80
584_M595_H1.1310.79
535_L546_V1.1300.79
481_L497_L1.1300.79
31_I53_V1.1300.79
652_L683_T1.1270.79
294_H445_L1.1250.79
632_S635_T1.1240.79
234_I243_L1.1230.79
496_V616_I1.1210.79
738_C742_T1.1210.79
235_K238_I1.1190.79
686_H690_T1.1170.79
413_I437_R1.1160.79
485_L492_G1.1150.78
573_T581_V1.1140.78
4_A50_V1.1130.78
602_F625_V1.1120.78
275_A279_I1.1100.78
722_K725_V1.1100.78
576_L609_I1.1090.78
138_L143_I1.1080.78
488_T491_K1.1080.78
332_M398_Y1.1050.78
584_M588_T1.1050.78
327_S395_E1.0930.77
3_F57_S1.0920.77
436_A696_M1.0870.77
23_I31_I1.0840.76
460_V686_H1.0830.76
718_E758_R1.0810.76
507_F511_R1.0800.76
18_P51_T1.0790.76
435_Y445_L1.0750.76
731_A763_C1.0750.76
267_P273_R1.0700.75
469_L511_R1.0690.75
505_S560_F1.0680.75
320_I332_M1.0670.75
523_D590_S1.0670.75
202_Q240_K1.0660.75
773_L777_L1.0660.75
307_Q310_E1.0640.75
190_K194_G1.0640.75
507_F561_F1.0630.75
404_P602_F1.0620.75
33_T52_A1.0580.75
469_L472_G1.0560.75
459_E667_H1.0530.74
681_Q684_K1.0510.74
312_V319_A1.0490.74
415_R419_H1.0490.74
180_Q246_S1.0480.74
27_L31_I1.0450.74
593_G597_K1.0450.74
4_A67_V1.0440.74
9_D97_I1.0400.73
251_Y254_P1.0400.73
320_I382_F1.0400.73
278_P291_F1.0390.73
221_A225_K1.0380.73
274_A434_S1.0370.73
695_E698_H1.0360.73
371_V382_F1.0340.73
252_R352_S1.0340.73
124_L129_E1.0340.73
80_E418_H1.0290.73
45_K68_E1.0270.72
263_T266_L1.0240.72
781_L797_I1.0240.72
475_S571_E1.0240.72
373_G377_A1.0230.72
626_T664_K1.0230.72
36_R75_P1.0230.72
327_S330_P1.0210.72
703_S708_Y1.0160.72
4_A24_P1.0140.71
468_E475_S1.0130.71
539_Y704_Y1.0060.71
83_I86_S1.0060.71
304_I424_V1.0050.71
549_T554_A1.0050.71
712_L762_Q1.0030.71
539_Y755_I1.0000.70
518_Q523_D0.9990.70
498_F617_A0.9990.70
54_K58_D0.9960.70
265_P307_Q0.9950.70
372_V653_T0.9950.70
139_L142_D0.9940.70
72_D75_P0.9930.70
482_M575_V0.9930.70
223_L227_T0.9900.70
653_T683_T0.9900.70
724_A761_Y0.9850.69
199_A203_Q0.9810.69
410_E437_R0.9800.69
689_E693_Q0.9780.69
744_I763_C0.9780.69
156_V161_I0.9780.69
547_P551_P0.9780.69
682_L694_H0.9770.69
133_S136_K0.9760.69
652_L670_I0.9750.68
195_L199_A0.9740.68
232_A236_T0.9700.68
468_E477_F0.9660.68
649_F653_T0.9640.68
414_K418_H0.9570.67
469_L475_S0.9570.67
438_A445_L0.9570.67
511_R673_Y0.9560.67
347_M359_E0.9550.67
534_R543_E0.9530.67
26_H66_E0.9520.67
128_V131_L0.9510.66
136_K139_L0.9510.66
344_V370_L0.9490.66
508_V511_R0.9470.66
456_V665_P0.9460.66
723_A761_Y0.9450.66
557_H561_F0.9420.66
644_S659_A0.9400.66
506_S560_F0.9380.65
16_D89_S0.9350.65
551_P554_A0.9320.65
84_L330_P0.9220.64
31_I54_K0.9220.64
255_Y337_K0.9190.64
520_P544_E0.9180.64
435_Y439_Q0.9130.63
561_F673_Y0.9110.63
204_A209_L0.9070.63
507_F558_I0.9050.63
88_L99_A0.9020.62
483_E486_E0.9020.62
321_V389_I0.9010.62
443_Y609_I0.9010.62
425_L434_S0.9000.62
512_D557_H0.8970.62
511_R555_S0.8970.62
777_L780_I0.8940.62
649_F683_T0.8880.61
136_K141_S0.8870.61
502_R587_D0.8870.61
435_Y692_Y0.8840.61
234_I245_E0.8830.61
410_E413_I0.8830.61
497_L620_L0.8820.61
341_G539_Y0.8820.61
205_I237_L0.8810.60
335_R621_D0.8790.60
524_I766_K0.8760.60
182_N244_K0.8740.60
465_M469_L0.8720.60
101_Q109_K0.8710.60
199_A204_A0.8700.60
380_A415_R0.8680.59
230_S233_T0.8680.59
469_L561_F0.8670.59
254_P358_D0.8650.59
207_H210_I0.8640.59
774_S777_L0.8610.59
589_T607_A0.8610.59
277_E281_E0.8540.58
657_G661_R0.8540.58
15_I626_T0.8540.58
22_K64_V0.8530.58
201_K211_S0.8520.58
416_A421_C0.8470.57
566_Q570_E0.8460.57
252_R255_Y0.8460.57
323_V332_M0.8440.57
468_E480_E0.8420.57
394_H668_V0.8420.57
286_D317_K0.8410.57
317_K384_N0.8390.57
466_R673_Y0.8390.57
31_I35_M0.8380.57
270_D389_I0.8380.57
719_E722_K0.8360.56
480_E483_E0.8340.56
730_I780_I0.8340.56
697_A700_R0.8330.56
480_E669_I0.8330.56
326_I349_S0.8330.56
591_R594_A0.8320.56
363_I380_A0.8310.56
330_P655_V0.8310.56
276_F280_R0.8290.56
179_I238_I0.8280.56
232_A370_L0.8280.56
95_F98_T0.8270.56
547_P562_G0.8270.56
469_L673_Y0.8260.56
200_A204_A0.8250.55
10_V15_I0.8240.55
511_R558_I0.8240.55
777_L784_Y0.8240.55
483_E504_Y0.8240.55
335_R394_H0.8220.55
27_L69_D0.8220.55
315_K370_L0.8210.55
208_F212_E0.8210.55
352_S507_F0.8160.55
288_H416_A0.8130.54
55_E449_K0.8120.54
584_M598_L0.8120.54
374_A499_L0.8110.54
206_L209_L0.8110.54
484_K491_K0.8100.54
366_K383_E0.8100.54
33_T82_M0.8090.54
536_K543_E0.8090.54
490_A576_L0.8070.54
139_L143_I0.8060.54
234_I568_V0.8040.54
357_Y595_H0.8040.54
360_W620_L0.8020.53
422_P446_L0.8010.53
524_I704_Y0.8010.53
187_E190_K0.7970.53
395_E586_V0.7960.53
219_P222_E0.7950.53
116_L143_I0.7930.53
359_E380_A0.7910.52
96_K100_L0.7900.52
51_T96_K0.7900.52
728_E732_H0.7880.52
117_K164_T0.7870.52
195_L198_Q0.7860.52
345_A371_V0.7850.52
137_T143_I0.7810.51
359_E368_V0.7800.51
715_V795_I0.7780.51
262_K265_P0.7780.51
279_I422_P0.7780.51
201_K208_F0.7770.51
112_Y165_Y0.7770.51
593_G607_A0.7760.51
619_G660_G0.7760.51
119_A162_D0.7760.51
507_F592_K0.7750.51
202_Q208_F0.7750.51
253_D256_Q0.7740.51
152_I676_S0.7740.51
300_G657_G0.7730.51
35_M76_V0.7730.51
681_Q685_T0.7730.51
344_V625_V0.7730.51
465_M673_Y0.7720.51
372_V443_Y0.7710.50
15_I19_F0.7700.50
27_L79_E0.7700.50
524_I755_I0.7700.50
235_K631_L0.7690.50
416_A656_S0.7680.50
619_G657_G0.7670.50
691_F695_E0.7670.50
274_A278_P0.7650.50
572_L589_T0.7640.50
571_E574_K0.7630.50
50_V344_V0.7630.50
390_I414_K0.7600.49
266_L310_E0.7590.49
202_Q205_I0.7580.49
270_D450_H0.7560.49
52_A86_S0.7520.49
393_E409_K0.7510.49
743_K768_K0.7490.48
715_V763_C0.7490.48
276_F311_K0.7480.48
300_G428_A0.7480.48
459_E686_H0.7470.48
776_L780_I0.7460.48
203_Q707_Y0.7450.48
155_H160_D0.7450.48
436_A692_Y0.7440.48
303_E335_R0.7430.48
678_Y698_H0.7420.48
555_S673_Y0.7420.48
275_A293_L0.7410.48
273_R491_K0.7410.48
619_G661_R0.7400.48
648_T652_L0.7400.48
201_K210_I0.7400.48
251_Y365_R0.7380.47
720_V753_A0.7370.47
567_R729_K0.7360.47
237_L760_R0.7350.47
11_S409_K0.7350.47
496_V620_L0.7330.47
657_G660_G0.7330.47
70_L572_L0.7320.47
528_Y546_V0.7320.47
568_V574_K0.7320.47
291_F444_E0.7300.47
631_L635_T0.7280.47
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78_T371_V0.5050.28
121_G156_V0.5050.28
725_V729_K0.5050.28
605_G608_D0.5050.28
762_Q767_Y0.5040.28
448_L683_T0.5040.28
94_S404_P0.5040.28
411_V528_Y0.5030.27
707_Y737_N0.5030.27
424_V659_A0.5030.27
254_P600_S0.5030.27
615_M619_G0.5030.27
552_E685_T0.5020.27
376_S379_F0.5020.27
330_P360_W0.5020.27
363_I368_V0.5020.27
390_I624_N0.5010.27
530_R750_S0.5010.27
567_R584_M0.5010.27
505_S555_S0.5010.27
728_E731_A0.5010.27
115_E139_L0.5010.27
385_L623_P0.5010.27
400_Q709_Y0.5010.27
347_M499_L0.5000.27
307_Q311_K0.5000.27
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4nl4H 1 0.8646 100 0.41 Contact Map
3o8bA 1 0.6832 100 0.817 Contact Map
1gm5A 1 0.7093 100 0.824 Contact Map
2eyqA 1 0.8497 100 0.832 Contact Map
4f92B 1 0.6708 100 0.862 Contact Map
2ocaA 1 0.5602 100 0.872 Contact Map
3fhoA 2 0.3565 100 0.876 Contact Map
4gl2A 1 0.5329 100 0.879 Contact Map
2fwrA 1 0.5031 100 0.882 Contact Map
4q48A 1 0.5416 100 0.882 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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