GREMLIN Database
YFIN - Putative transport permease YfiN
UniProt: P94442 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 385 (351)
Sequences: 11536 (9437)
Seq/√Len: 503.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
279_L347_G4.9191.00
50_A93_I4.5361.00
84_A96_I4.3021.00
80_S83_K3.7101.00
102_S106_Q3.5131.00
87_K93_I3.3931.00
7_I242_G3.2361.00
106_Q111_K3.0141.00
9_G13_S3.0131.00
86_E90_Q2.8871.00
330_K334_S2.6881.00
78_N87_K2.5581.00
81_E85_S2.5341.00
87_K92_K2.4421.00
85_S89_K2.4391.00
180_Q183_S2.4311.00
256_G277_I2.4161.00
280_V344_A2.3971.00
8_C245_L2.3771.00
8_C249_V2.3721.00
235_S238_E2.3711.00
88_L96_I2.3471.00
362_L366_G2.2611.00
141_N145_T2.2561.00
54_Q81_E2.2031.00
293_M378_A2.1661.00
285_L372_A2.1501.00
11_E243_Y2.1251.00
282_L369_L2.0691.00
99_I103_F2.0561.00
366_G370_A2.0551.00
51_I64_I2.0001.00
13_S16_F1.9961.00
5_L9_G1.9841.00
50_A78_N1.9421.00
83_K87_K1.9191.00
260_L264_W1.9161.00
370_A374_I1.8841.00
180_Q184_D1.8641.00
98_V118_R1.8631.00
54_Q98_V1.8601.00
185_K189_A1.8571.00
81_E98_V1.8391.00
53_D60_S1.8081.00
283_F344_A1.7971.00
79_M83_K1.7951.00
286_T372_A1.7661.00
289_G372_A1.7611.00
192_S195_A1.7221.00
357_R360_D1.7141.00
55_D104_Q1.6981.00
46_K74_Y1.6751.00
86_E89_K1.6391.00
176_A179_R1.6211.00
132_Y136_A1.6171.00
53_D57_T1.6151.00
337_E343_W1.6061.00
136_A140_L1.6011.00
10_I220_A1.6001.00
29_P39_M1.6001.00
346_S364_I1.5681.00
29_P32_L1.5611.00
283_F287_V1.5601.00
209_T213_A1.5601.00
181_T184_D1.5561.00
336_A342_K1.5521.00
337_E342_K1.5331.00
255_F280_V1.5251.00
210_M213_A1.5231.00
274_A278_V1.5211.00
251_G284_L1.5161.00
355_G358_V1.5151.00
132_Y137_L1.5091.00
325_I336_A1.5061.00
140_L144_V1.4761.00
218_L221_R1.4741.00
171_E174_V1.4711.00
53_D56_D1.4701.00
371_F375_T1.4581.00
57_T60_S1.4581.00
126_A130_K1.4521.00
83_K86_E1.4511.00
16_F19_P1.4471.00
275_A351_I1.4461.00
129_V132_Y1.4411.00
126_A132_Y1.4411.00
48_R74_Y1.4401.00
142_I146_A1.4391.00
279_L365_C1.4371.00
248_F285_L1.4291.00
177_V180_Q1.4181.00
143_Q146_A1.4001.00
350_E356_A1.4001.00
130_K134_E1.3981.00
248_F281_S1.3951.00
141_N144_V1.3711.00
174_V179_R1.3641.00
252_W281_S1.3531.00
180_Q185_K1.3451.00
52_V84_A1.3291.00
296_A382_A1.3231.00
279_L351_I1.3211.00
57_T104_Q1.3171.00
282_L365_C1.3131.00
179_R183_S1.3081.00
363_G367_I1.2961.00
62_H65_R1.2921.00
29_P35_V1.2901.00
127_P130_K1.2781.00
282_L372_A1.2771.00
210_M214_A1.2731.00
65_R68_K1.2681.00
272_N275_A1.2631.00
300_T303_Q1.2561.00
333_Q337_E1.2521.00
134_E138_A1.2431.00
175_P179_R1.2401.00
104_Q108_E1.2371.00
131_Q135_S1.2311.00
59_L104_Q1.2291.00
82_S85_S1.2231.00
367_I371_F1.2221.00
54_Q101_R1.2181.00
93_I96_I1.2121.00
60_S104_Q1.2051.00
218_L304_Q1.2051.00
339_L342_K1.2031.00
350_E354_N1.1831.00
220_A243_Y1.1651.00
290_I311_F1.1561.00
331_F334_S1.1501.00
179_R184_D1.1501.00
12_L253_I1.1501.00
367_I370_A1.1461.00
237_A241_A1.1381.00
179_R182_L1.1331.00
130_K136_A1.1301.00
293_M379_G1.1291.00
377_A381_K1.1111.00
334_S337_E1.1021.00
102_S105_T1.0991.00
140_L143_Q1.0911.00
138_A141_N1.0881.00
259_L280_V1.0871.00
13_S17_K1.0871.00
59_L107_L1.0831.00
313_I316_C1.0831.00
182_L185_K1.0801.00
35_V39_M1.0801.00
137_L141_N1.0791.00
32_L36_F1.0761.00
286_T371_F1.0721.00
66_Q69_A1.0721.00
126_A136_A1.0631.00
79_M87_K1.0611.00
23_L27_A1.0531.00
50_A87_K1.0491.00
330_K333_Q1.0481.00
88_L93_I1.0471.00
211_M214_A1.0451.00
209_T212_G1.0421.00
127_P131_Q1.0391.00
342_K346_S1.0331.00
237_A380_L1.0241.00
55_D102_S1.0171.00
139_T142_I1.0171.00
58_I61_Q1.0131.00
82_S86_E1.0131.00
356_A360_D1.0061.00
131_Q134_E1.0061.00
238_E242_G1.0041.00
129_V136_A1.0021.00
34_F38_S1.0001.00
178_T181_T1.0001.00
218_L222_K0.9981.00
136_A141_N0.9961.00
286_T375_T0.9951.00
81_E84_A0.9931.00
181_T185_K0.9891.00
209_T214_A0.9891.00
249_V253_I0.9861.00
334_S338_F0.9841.00
81_E96_I0.9801.00
365_C369_L0.9741.00
346_S350_E0.9731.00
113_P117_F0.9661.00
116_I119_H0.9621.00
36_F39_M0.9581.00
173_I177_V0.9541.00
127_P132_Y0.9541.00
343_W367_I0.9531.00
191_A194_T0.9521.00
142_I145_T0.9511.00
329_P333_Q0.9511.00
133_A136_A0.9511.00
8_C242_G0.9501.00
343_W364_I0.9441.00
135_S139_T0.9431.00
115_L118_R0.9361.00
296_A379_G0.9311.00
286_T368_L0.9301.00
203_I344_A0.9281.00
369_L373_A0.9271.00
79_M84_A0.9201.00
248_F288_V0.9201.00
374_I378_A0.9151.00
289_G376_F0.9141.00
196_S200_G0.9111.00
206_V210_M0.9101.00
293_M375_T0.9091.00
325_I328_E0.9081.00
240_G380_L0.9031.00
292_L379_G0.9001.00
10_I13_S0.8981.00
132_Y140_L0.8921.00
115_L119_H0.8901.00
242_G246_S0.8881.00
309_N313_I0.8881.00
312_V315_T0.8871.00
261_S265_L0.8871.00
128_M131_Q0.8861.00
133_A137_L0.8861.00
129_V133_A0.8851.00
198_A201_F0.8721.00
129_V137_L0.8701.00
260_L263_H0.8701.00
289_G375_T0.8651.00
344_A347_G0.8631.00
7_I234_V0.8601.00
306_A309_N0.8591.00
120_G123_L0.8561.00
12_L249_V0.8521.00
12_L16_F0.8501.00
11_E15_I0.8491.00
29_P33_T0.8471.00
298_V303_Q0.8461.00
192_S196_S0.8441.00
177_V181_T0.8431.00
174_V180_Q0.8411.00
376_F380_L0.8381.00
12_L246_S0.8381.00
331_F335_I0.8371.00
191_A195_A0.8371.00
289_G379_G0.8331.00
190_E194_T0.8291.00
252_W256_G0.8271.00
358_V362_L0.8271.00
329_P332_M0.8261.00
177_V183_S0.8241.00
316_C319_S0.8241.00
98_V116_I0.8201.00
5_L8_C0.8191.00
132_Y135_S0.8151.00
56_D101_R0.8131.00
199_A203_I0.8121.00
30_L34_F0.8121.00
359_T363_G0.8101.00
193_D197_R0.8091.00
293_M297_N0.8091.00
244_V288_V0.8071.00
190_E195_A0.8021.00
85_S118_R0.8021.00
207_M211_M0.8011.00
178_T183_S0.8001.00
32_L39_M0.7991.00
144_V147_A0.7981.00
275_A278_V0.7961.00
32_L35_V0.7941.00
58_I62_H0.7921.00
10_I14_L0.7921.00
78_N93_I0.7921.00
220_A225_V0.7891.00
72_D75_V0.7891.00
66_Q143_Q0.7871.00
276_V348_L0.7861.00
204_L208_L0.7861.00
284_L288_V0.7851.00
128_M132_Y0.7841.00
202_S210_M0.7841.00
328_E333_Q0.7831.00
131_Q140_L0.7811.00
50_A96_I0.7781.00
49_L97_I0.7761.00
215_G218_L0.7751.00
234_V239_I0.7741.00
96_I118_R0.7741.00
240_G292_L0.7731.00
48_R94_A0.7731.00
203_I206_V0.7731.00
18_K21_N0.7711.00
97_I117_F0.7701.00
143_Q147_A0.7691.00
53_D64_I0.7641.00
273_P277_I0.7631.00
78_N84_A0.7621.00
298_V307_F0.7621.00
135_S138_A0.7581.00
225_V228_R0.7551.00
360_D363_G0.7551.00
291_G295_A0.7541.00
311_F315_T0.7521.00
193_D196_S0.7481.00
131_Q136_A0.7431.00
274_A277_I0.7421.00
270_W273_P0.7421.00
175_P183_S0.7411.00
32_L40_L0.7411.00
174_V178_T0.7411.00
189_A193_D0.7371.00
230_L239_I0.7281.00
219_E223_N0.7281.00
350_E364_I0.7271.00
134_E137_L0.7251.00
336_A339_L0.7231.00
184_D189_A0.7211.00
293_M296_A0.7191.00
372_A376_F0.7191.00
8_C246_S0.7181.00
131_Q138_A0.7171.00
320_G324_P0.7161.00
139_T143_Q0.7121.00
131_Q141_N0.7101.00
293_M382_A0.7101.00
173_I181_T0.7101.00
36_F40_L0.7081.00
49_L53_D0.7081.00
29_P34_F0.7071.00
317_M323_W0.7071.00
176_A180_Q0.7061.00
60_S99_I0.7041.00
115_L120_G0.7031.00
29_P36_F0.7001.00
128_M136_A0.6981.00
275_A361_I0.6971.00
34_F37_G0.6961.00
312_V316_C0.6951.00
78_N81_E0.6931.00
126_A131_Q0.6931.00
60_S63_Y0.6921.00
294_I298_V0.6901.00
126_A129_V0.6891.00
203_I207_M0.6891.00
222_K301_P0.6881.00
369_L372_A0.6871.00
259_L276_V0.6871.00
173_I179_R0.6871.00
63_Y99_I0.6861.00
177_V182_L0.6861.00
59_L64_I0.6861.00
84_A87_K0.6861.00
113_P119_H0.6841.00
282_L368_L0.6841.00
343_W346_S0.6831.00
244_V289_G0.6821.00
310_L314_A0.6811.00
175_P180_Q0.6791.00
174_V183_S0.6721.00
217_I220_A0.6711.00
244_V285_L0.6711.00
256_G273_P0.6701.00
61_Q65_R0.6681.00
127_P136_A0.6671.00
74_Y77_E0.6671.00
33_T262_T0.6651.00
110_G113_P0.6641.00
68_K75_V0.6641.00
113_P120_G0.6631.00
277_I280_V0.6621.00
341_Q345_M0.6601.00
361_I365_C0.6601.00
19_P22_Y0.6591.00
29_P41_S0.6581.00
113_P118_R0.6541.00
343_W371_F0.6511.00
280_V348_L0.6511.00
279_L361_I0.6511.00
33_T36_F0.6501.00
35_V38_S0.6501.00
134_E146_A0.6481.00
25_M28_A0.6481.00
30_L33_T0.6471.00
87_K90_Q0.6451.00
315_T339_L0.6431.00
375_T379_G0.6411.00
172_D175_P0.6411.00
366_G369_L0.6401.00
229_L239_I0.6391.00
15_I25_M0.6391.00
8_C12_L0.6391.00
245_L249_V0.6371.00
130_K133_A0.6361.00
204_L207_M0.6341.00
324_P328_E0.6321.00
64_I68_K0.6321.00
340_P343_W0.6311.00
37_G40_L0.6301.00
220_A239_I0.6301.00
200_G205_F0.6301.00
363_G366_G0.6291.00
39_M42_G0.6281.00
263_H267_G0.6281.00
130_K139_T0.6251.00
287_V291_G0.6251.00
199_A202_S0.6251.00
52_V78_N0.6241.00
356_A359_T0.6211.00
62_H66_Q0.6191.00
179_R185_K0.6181.00
137_L140_L0.6181.00
132_Y141_N0.6161.00
138_A142_I0.6141.00
241_A245_L0.6101.00
318_V323_W0.6101.00
347_G364_I0.6091.00
115_L122_E0.6060.99
307_F311_F0.6040.99
132_Y139_T0.6040.99
226_W239_I0.6040.99
199_A208_L0.6010.99
52_V96_I0.6000.99
100_S116_I0.5990.99
321_M345_M0.5980.99
126_A134_E0.5930.99
191_A196_S0.5880.99
127_P141_N0.5860.99
349_T353_A0.5860.99
53_D61_Q0.5850.99
174_V177_V0.5820.99
176_A184_D0.5820.99
373_A377_A0.5790.99
199_A206_V0.5790.99
106_Q113_P0.5780.99
37_G266_F0.5780.99
19_P23_L0.5780.99
114_E117_F0.5760.99
255_F259_L0.5750.99
78_N83_K0.5740.99
34_F261_S0.5730.99
198_A202_S0.5730.99
290_I375_T0.5730.99
325_I342_K0.5730.99
337_E340_P0.5700.99
218_L224_G0.5700.99
11_E246_S0.5690.99
275_A365_C0.5690.99
53_D104_Q0.5680.99
200_G209_T0.5680.99
55_D60_S0.5660.99
214_A304_Q0.5660.99
175_P182_L0.5640.99
56_D60_S0.5640.99
200_G203_I0.5630.99
229_L243_Y0.5610.99
254_Q258_L0.5600.99
80_S84_A0.5590.99
25_M29_P0.5590.99
208_L211_M0.5580.99
128_M137_L0.5570.99
27_A31_L0.5560.99
364_I368_L0.5550.99
140_L145_T0.5510.99
220_A224_G0.5510.99
77_E81_E0.5480.99
190_E193_D0.5470.99
221_R224_G0.5460.99
6_A9_G0.5460.99
136_A139_T0.5460.99
198_A204_L0.5450.99
175_P181_T0.5450.99
61_Q64_I0.5440.99
7_I239_I0.5440.99
173_I176_A0.5440.99
63_Y103_F0.5440.99
44_D47_V0.5440.99
221_R226_W0.5430.99
130_K135_S0.5420.99
177_V184_D0.5410.99
196_S207_M0.5400.99
259_L273_P0.5380.99
141_N146_A0.5380.99
131_Q137_L0.5370.99
254_Q257_I0.5360.99
133_A139_T0.5360.99
32_L41_S0.5350.99
174_V182_L0.5330.99
43_N46_K0.5320.99
49_L95_G0.5310.99
340_P344_A0.5310.99
226_W240_G0.5300.99
355_G359_T0.5300.99
28_A36_F0.5290.99
68_K71_D0.5280.99
57_T102_S0.5280.99
280_V284_L0.5270.99
200_G208_L0.5260.99
278_V282_L0.5260.99
350_E360_D0.5250.99
198_A211_M0.5240.99
215_G295_A0.5240.99
203_I341_Q0.5230.98
194_T197_R0.5210.98
27_A32_L0.5200.98
190_E196_S0.5200.98
306_A315_T0.5200.98
368_L371_F0.5170.98
117_F121_P0.5170.98
275_A279_L0.5170.98
233_S239_I0.5160.98
15_I246_S0.5150.98
253_I256_G0.5150.98
106_Q114_E0.5140.98
315_T341_Q0.5140.98
347_G361_I0.5120.98
371_F374_I0.5080.98
113_P116_I0.5070.98
14_L220_A0.5070.98
51_I75_V0.5060.98
219_E222_K0.5060.98
127_P135_S0.5050.98
364_I367_I0.5050.98
53_D99_I0.5050.98
131_Q139_T0.5040.98
38_S41_S0.5040.98
128_M133_A0.5040.98
29_P42_G0.5010.98
262_T266_F0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cniA 2 0.3636 99.3 0.75 Contact Map
2p0sA 2 0.3299 97.8 0.849 Contact Map
4n6hA 1 0.7351 18.8 0.948 Contact Map
3hdgA 2 0.3065 14.9 0.95 Contact Map
3ktoA 3 0.2935 13.4 0.951 Contact Map
3hdvA 3 0.3039 12.1 0.952 Contact Map
3b2nA 1 0.2909 11.9 0.952 Contact Map
3cg4A 1 0.3039 11.5 0.953 Contact Map
4yayA 1 0.7247 11.2 0.953 Contact Map
3cnbA 1 0.2987 10.4 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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