GREMLIN Database
YFIM - Putative transport permease YfiM
UniProt: P94441 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 396 (350)
Sequences: 10850 (8951)
Seq/√Len: 478.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_G100_I5.2261.00
290_L358_G4.6591.00
91_M103_G4.6061.00
94_L100_I3.5081.00
9_W13_K3.3331.00
7_I252_G3.3261.00
93_K97_E3.3161.00
8_A259_L3.0651.00
85_V94_L3.0641.00
88_K92_K2.9341.00
8_A255_L2.9291.00
4_S255_L2.7741.00
94_L99_K2.6691.00
245_Q248_V2.5281.00
11_D253_K2.4891.00
296_A382_G2.4841.00
92_K96_D2.4311.00
372_Q376_L2.3861.00
376_L380_A2.3741.00
291_G355_A2.3731.00
4_S8_A2.3451.00
106_I110_W2.3301.00
341_D345_S2.3121.00
95_I103_G2.2581.00
266_F288_S2.2551.00
304_L388_I2.2401.00
105_V120_N2.2231.00
90_K94_L2.2131.00
293_S379_A2.1831.00
56_G85_V2.1481.00
57_Y70_T2.0941.00
270_I274_N2.0361.00
60_S88_K1.9711.00
300_G382_G1.9491.00
88_K105_V1.9351.00
60_S105_V1.9281.00
86_G90_K1.9191.00
380_A384_C1.9091.00
13_K16_I1.9051.00
367_G370_D1.8951.00
381_I385_S1.8871.00
5_I9_W1.8571.00
297_A382_G1.8501.00
294_Y355_A1.8251.00
348_K353_R1.8031.00
10_K230_E1.7981.00
285_L289_V1.7621.00
59_Q66_A1.7581.00
12_V263_I1.7581.00
54_K81_K1.7451.00
347_S353_R1.7351.00
58_I91_M1.7231.00
348_K354_W1.7201.00
54_K83_T1.7121.00
357_D374_P1.6941.00
59_Q63_S1.6871.00
258_Y296_A1.6861.00
258_Y292_L1.6781.00
294_Y298_V1.6511.00
52_D81_K1.6501.00
61_D111_E1.6481.00
286_L362_L1.6371.00
63_S66_A1.6211.00
144_K147_K1.6171.00
89_D92_K1.6071.00
265_F291_G1.5901.00
29_P39_A1.5871.00
93_K96_D1.5831.00
137_S140_I1.5551.00
59_Q62_Q1.5501.00
230_E253_K1.5471.00
90_K93_K1.5371.00
16_I19_R1.5351.00
293_S382_G1.5241.00
100_I103_G1.5121.00
102_V132_I1.5061.00
307_S392_R1.5061.00
72_D146_V1.5051.00
336_L347_S1.4741.00
68_M71_K1.4721.00
387_V391_R1.4341.00
71_K75_K1.4241.00
361_S366_G1.4211.00
261_A295_A1.4121.00
133_E137_S1.3891.00
290_L362_L1.3871.00
202_T205_Q1.3851.00
290_L375_V1.3851.00
311_D314_T1.3821.00
13_K17_T1.3811.00
350_V353_R1.3671.00
4_S248_V1.3611.00
304_L389_G1.3561.00
65_T111_E1.3491.00
366_G370_D1.3461.00
228_L231_K1.3451.00
8_A252_G1.3441.00
142_Q146_V1.3411.00
342_V345_S1.3331.00
293_S375_V1.3331.00
301_I322_G1.3241.00
341_D344_Q1.3171.00
377_L381_I1.3161.00
283_N286_L1.3111.00
317_A320_G1.2921.00
66_A111_E1.2921.00
217_L221_T1.2841.00
297_A385_S1.2751.00
109_H112_A1.2691.00
373_K377_L1.2651.00
60_S108_N1.2501.00
304_L392_R1.2461.00
95_I100_I1.2401.00
375_V379_A1.2401.00
92_K120_N1.2391.00
73_V136_A1.2341.00
105_V118_V1.2341.00
63_S111_E1.2321.00
344_Q348_K1.2281.00
345_S349_A1.2261.00
250_L390_I1.2231.00
88_K103_G1.2211.00
297_A378_F1.2171.00
377_L380_A1.2161.00
137_S141_E1.2121.00
85_V100_I1.2091.00
270_I273_I1.2031.00
185_T188_K1.2011.00
259_L263_I1.2011.00
81_K84_K1.1901.00
262_I292_L1.1791.00
18_D21_G1.1771.00
5_I8_A1.1741.00
353_R357_D1.1711.00
4_S252_G1.1601.00
361_S364_E1.1601.00
331_G335_P1.1571.00
345_S348_K1.1531.00
61_D109_H1.1521.00
140_I144_K1.1511.00
104_I119_V1.1511.00
247_S251_F1.1511.00
12_V259_L1.1431.00
271_V275_V1.1431.00
140_I143_Y1.1381.00
29_P32_L1.1371.00
342_V346_V1.1371.00
89_D93_K1.1371.00
217_L220_I1.1361.00
324_Q327_A1.1331.00
30_L34_C1.1331.00
247_S390_I1.1301.00
7_I244_A1.1181.00
230_E235_T1.1181.00
54_K101_D1.1091.00
269_L291_G1.0941.00
297_A381_I1.0871.00
321_F325_L1.0831.00
4_S251_F1.0741.00
354_W374_P1.0691.00
136_A139_F1.0681.00
66_A106_I1.0671.00
144_K148_E1.0641.00
135_A140_I1.0461.00
141_E145_A1.0451.00
287_V359_F1.0441.00
143_Y147_K1.0441.00
252_G256_G1.0361.00
56_G94_L1.0321.00
354_W377_L1.0271.00
58_I103_G1.0221.00
295_A299_S1.0221.00
119_V122_A1.0211.00
248_V252_G1.0141.00
224_A315_A1.0101.00
228_L315_A1.0091.00
12_V256_G1.0071.00
340_P344_Q1.0061.00
354_W357_D1.0051.00
8_A256_G0.9941.00
302_S306_A0.9901.00
23_M27_L0.9881.00
258_Y299_S0.9781.00
235_T238_R0.9741.00
355_A358_G0.9721.00
210_A213_C0.9671.00
304_L385_S0.9661.00
336_L339_F0.9621.00
187_D191_I0.9551.00
141_E144_K0.9511.00
323_I327_A0.9481.00
142_Q147_K0.9471.00
361_S374_P0.9471.00
209_A213_C0.9441.00
213_C216_M0.9421.00
300_G386_L0.9391.00
55_V104_I0.9331.00
379_A383_F0.9301.00
286_L289_V0.9231.00
75_K78_K0.9201.00
262_I266_F0.9151.00
300_G385_S0.9111.00
75_K82_V0.9081.00
384_C388_I0.9021.00
208_S211_M0.8991.00
186_G189_L0.8961.00
339_F344_Q0.8961.00
207_Y211_M0.8951.00
239_M249_I0.8911.00
76_K79_S0.8881.00
240_L249_I0.8871.00
254_W299_S0.8821.00
130_S133_E0.8801.00
68_M72_D0.8781.00
190_T193_E0.8771.00
6_W9_W0.8761.00
12_V16_I0.8761.00
143_Y146_V0.8731.00
277_G280_W0.8721.00
228_L232_D0.8681.00
36_L40_L0.8681.00
369_A373_K0.8681.00
88_K91_M0.8671.00
29_P34_C0.8661.00
142_Q145_A0.8651.00
91_M94_L0.8641.00
59_Q67_N0.8591.00
139_F143_Y0.8571.00
212_L220_I0.8541.00
103_G120_N0.8541.00
35_I39_A0.8541.00
67_N71_K0.8471.00
10_K13_K0.8441.00
213_C355_A0.8421.00
58_I85_V0.8421.00
373_K376_L0.8401.00
368_W372_Q0.8391.00
107_P118_V0.8331.00
365_G368_W0.8311.00
59_Q106_I0.8291.00
309_I318_I0.8291.00
59_Q70_T0.8231.00
188_K193_E0.8221.00
34_C271_V0.8211.00
187_D190_T0.8201.00
134_T137_S0.8191.00
328_V334_L0.8181.00
11_D256_G0.8161.00
62_Q108_N0.8151.00
131_I135_A0.8151.00
55_V102_V0.8151.00
117_A120_N0.8151.00
382_G386_L0.8141.00
309_I314_T0.8051.00
277_G281_G0.8051.00
122_A125_Q0.8051.00
320_G324_Q0.8051.00
189_L192_A0.8051.00
104_I117_A0.8031.00
211_M214_M0.7991.00
145_A149_A0.7901.00
266_F284_L0.7891.00
213_C352_N0.7871.00
188_K194_K0.7861.00
285_L288_S0.7751.00
132_I135_A0.7741.00
371_L375_V0.7711.00
361_S370_D0.7711.00
314_T321_F0.7701.00
191_I195_S0.7701.00
348_K351_P0.7681.00
34_C38_A0.7631.00
203_S206_Y0.7611.00
146_V149_A0.7611.00
10_K14_I0.7601.00
284_L288_S0.7571.00
15_R260_F0.7561.00
357_D361_S0.7551.00
232_D312_M0.7501.00
36_L39_A0.7481.00
14_I230_E0.7461.00
56_G103_G0.7451.00
118_V121_A0.7431.00
69_F140_I0.7421.00
326_L350_V0.7421.00
386_L390_I0.7421.00
33_T272_T0.7401.00
307_S389_G0.7401.00
211_M215_F0.7391.00
29_P35_I0.7381.00
69_F106_I0.7381.00
61_D106_I0.7371.00
85_V91_M0.7341.00
145_A148_E0.7291.00
78_K81_K0.7291.00
222_V225_K0.7251.00
255_L259_L0.7241.00
385_S389_G0.7231.00
138_S142_Q0.7231.00
293_S378_F0.7191.00
15_R25_L0.7151.00
192_A195_S0.7151.00
358_G362_L0.7111.00
286_L375_V0.7101.00
244_A249_I0.7091.00
332_S356_L0.7081.00
254_W296_A0.7071.00
69_F110_W0.7071.00
224_A228_L0.7041.00
68_M146_V0.7011.00
378_F381_I0.7001.00
134_T138_S0.6991.00
216_M220_I0.6991.00
279_D282_G0.6991.00
230_E234_E0.6961.00
385_S388_I0.6941.00
136_A140_I0.6921.00
304_L308_C0.6921.00
191_I194_K0.6911.00
32_L40_L0.6901.00
269_L287_V0.6891.00
305_L309_I0.6881.00
229_Q233_T0.6881.00
65_T68_M0.6861.00
354_W358_G0.6851.00
30_L33_T0.6851.00
67_N70_T0.6841.00
218_F221_T0.6841.00
76_K80_I0.6831.00
354_W362_L0.6811.00
188_K191_I0.6811.00
85_V90_K0.6811.00
286_L371_L0.6801.00
374_P377_L0.6801.00
376_L379_A0.6781.00
8_A12_V0.6781.00
339_F342_V0.6771.00
302_S319_G0.6771.00
382_G385_S0.6761.00
134_T141_E0.6761.00
379_A382_G0.6761.00
347_S350_V0.6751.00
28_M32_L0.6751.00
368_W371_L0.6741.00
352_N356_L0.6721.00
77_M80_I0.6691.00
130_S134_T0.6681.00
132_I139_F0.6671.00
35_I38_A0.6661.00
264_Q267_I0.6661.00
184_E187_D0.6631.00
65_T70_T0.6611.00
203_S207_Y0.6611.00
358_G374_P0.6581.00
182_E188_K0.6561.00
327_A330_G0.6541.00
223_G227_F0.6521.00
138_S141_E0.6511.00
7_I249_I0.6511.00
127_L130_S0.6511.00
253_K257_T0.6501.00
77_M82_V0.6501.00
33_T39_A0.6491.00
351_P354_W0.6471.00
358_G378_F0.6461.00
353_R356_L0.6451.00
336_L344_Q0.6441.00
225_K306_A0.6421.00
366_G371_L0.6411.00
98_K122_A0.6401.00
61_D66_A0.6391.00
269_L284_L0.6381.00
324_Q328_V0.6381.00
66_A70_T0.6361.00
336_L353_R0.6361.00
223_G226_S0.6351.00
365_G370_D0.6351.00
238_R242_T0.6331.00
94_L97_E0.6331.00
19_R22_F0.6321.00
250_L303_M0.6321.00
15_R256_G0.6321.00
239_M242_T0.6321.00
31_I35_I0.6281.00
331_G336_L0.6271.00
186_G190_T0.6230.99
236_L249_I0.6230.99
304_L307_S0.6200.99
55_V58_I0.6200.99
50_I53_I0.6200.99
188_K195_S0.6180.99
388_I391_R0.6170.99
254_W300_G0.6160.99
317_A321_F0.6160.99
318_I322_G0.6140.99
30_L35_I0.6100.99
24_M29_P0.6090.99
308_C392_R0.6090.99
371_L374_P0.6080.99
101_D122_A0.6080.99
305_L318_I0.6070.99
91_M95_I0.6060.99
190_T195_S0.6050.99
340_P343_L0.6040.99
235_T243_P0.6020.99
350_V354_W0.6010.99
229_Q232_D0.6010.99
217_L298_V0.5980.99
305_L319_G0.5970.99
131_I140_I0.5960.99
231_K234_E0.5960.99
37_G276_F0.5950.99
62_Q66_A0.5950.99
133_E136_A0.5940.99
95_I98_K0.5940.99
135_A139_F0.5940.99
372_Q375_V0.5920.99
320_G327_A0.5880.99
317_A325_L0.5860.99
290_L355_A0.5860.99
349_A381_I0.5840.99
137_S146_V0.5830.99
264_Q268_F0.5810.99
231_K236_L0.5810.99
59_Q111_E0.5800.99
213_C326_L0.5790.99
75_K81_K0.5780.99
140_I147_K0.5780.99
29_P315_A0.5770.99
303_M389_G0.5770.99
269_L273_I0.5760.99
214_M217_L0.5750.99
292_L296_A0.5750.99
79_S82_V0.5740.99
223_G299_S0.5730.99
209_A216_M0.5710.99
29_P33_T0.5700.99
374_P378_F0.5700.99
11_D249_I0.5690.99
300_G389_G0.5670.99
128_K131_I0.5660.99
38_A275_V0.5640.99
330_G350_V0.5640.99
4_S247_S0.5630.99
6_W10_K0.5630.99
250_L389_G0.5630.99
239_M253_K0.5630.99
69_F143_Y0.5610.99
72_D75_K0.5600.99
210_A333_M0.5600.99
125_Q128_K0.5590.99
201_V205_Q0.5590.99
374_P381_I0.5580.99
319_G323_I0.5580.99
354_W381_I0.5570.99
210_A215_F0.5560.99
27_L32_L0.5560.99
388_I392_R0.5550.99
193_E196_V0.5530.99
314_T317_A0.5530.99
222_V226_S0.5530.99
288_S291_G0.5520.99
369_A372_Q0.5510.99
214_M218_F0.5500.99
290_L371_L0.5490.99
32_L36_L0.5480.99
291_G359_F0.5480.99
88_K120_N0.5460.99
26_I29_P0.5450.99
137_S147_K0.5450.99
102_V105_V0.5410.99
115_T120_N0.5370.98
188_K192_A0.5350.98
231_K237_A0.5340.98
323_I326_L0.5340.98
213_C219_H0.5320.98
300_G307_S0.5320.98
326_L352_N0.5290.98
266_F269_L0.5280.98
70_T75_K0.5280.98
189_L196_V0.5270.98
199_K205_Q0.5270.98
265_F269_L0.5260.98
288_S292_L0.5260.98
33_T36_L0.5250.98
88_K118_V0.5230.98
184_E190_T0.5230.98
58_I105_V0.5210.98
11_D15_R0.5210.98
76_K82_V0.5200.98
301_I385_S0.5190.98
127_L134_T0.5190.98
24_M40_L0.5180.98
31_I34_C0.5180.98
213_C330_G0.5180.98
236_L250_L0.5170.98
183_K186_G0.5160.98
32_L39_A0.5150.98
107_P116_S0.5150.98
358_G361_S0.5140.98
51_D57_Y0.5130.98
189_L193_E0.5120.98
72_D139_F0.5120.98
348_K357_D0.5120.98
352_N355_A0.5110.98
102_V119_V0.5110.98
116_S192_A0.5100.98
66_A69_F0.5090.98
184_E191_I0.5090.98
127_L132_I0.5090.98
11_D257_T0.5090.98
55_V59_Q0.5070.98
280_W287_V0.5070.98
325_L328_V0.5060.98
334_L338_Q0.5050.98
258_Y262_I0.5050.98
228_L234_E0.5050.98
318_I326_L0.5050.98
69_F73_V0.5030.98
322_G326_L0.5030.98
254_W303_M0.5030.98
29_P36_L0.5020.98
38_A41_G0.5020.98
298_V302_S0.5010.98
263_I266_F0.5000.98
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3cniA 2 0.3409 99.2 0.771 Contact Map
2p0sA 2 0.3207 98.2 0.837 Contact Map
4n6hA 1 0.7222 21.4 0.948 Contact Map
4yayA 1 0.7071 15.6 0.951 Contact Map
3i42A 2 0.2879 12.4 0.953 Contact Map
3cfyA 1 0.3232 11.7 0.954 Contact Map
2z73A 2 0.5177 11.6 0.954 Contact Map
3crnA 2 0.3207 11.5 0.954 Contact Map
3vw7A 1 0.4672 11.4 0.954 Contact Map
3ktoA 3 0.3005 11.4 0.954 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0112 seconds.