GREMLIN Database
YFIL - Uncharacterized ABC transporter ATP-binding protein YfiL
UniProt: P94440 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 311 (243)
Sequences: 70672 (42961)
Seq/√Len: 2755.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
28_E201_R3.6911.00
75_K152_E3.2241.00
6_N19_G3.1311.00
3_Q23_S3.0531.00
15_T18_K2.9991.00
5_E57_N2.9481.00
30_F203_G2.9301.00
125_R128_D2.7051.00
31_G199_C2.6671.00
57_N64_V2.5841.00
201_R213_I2.5141.00
9_K46_M2.4841.00
25_K28_E2.4261.00
10_A15_T2.4211.00
3_Q59_T2.3681.00
215_T218_D2.3541.00
18_K209_E2.3251.00
214_G218_D2.2341.00
203_G210_M2.2081.00
61_G152_E2.1731.00
8_K55_S2.1421.00
8_K19_G2.1311.00
105_T108_E2.1091.00
119_Y181_T2.0991.00
26_K152_E2.0571.00
8_K15_T2.0281.00
4_A7_I2.0151.00
177_Q180_E1.9881.00
112_R150_K1.9301.00
5_E59_T1.9171.00
112_R115_E1.8591.00
189_S195_V1.8361.00
44_I188_T1.8221.00
203_G213_I1.8141.00
91_A133_F1.8101.00
114_A126_A1.7981.00
196_E217_T1.7891.00
68_E71_K1.7491.00
92_H126_A1.7411.00
11_Y42_T1.7291.00
92_H127_K1.6761.00
214_G219_L1.6471.00
128_D132_T1.6201.00
176_K197_F1.5901.00
44_I155_I1.5861.00
115_E119_Y1.5511.00
6_N21_S1.5511.00
119_Y180_E1.5461.00
11_Y16_I1.5441.00
116_V148_M1.5301.00
150_K183_M1.5211.00
96_M109_A1.5201.00
64_V67_K1.5201.00
9_K54_D1.5041.00
61_G75_K1.4721.00
92_H96_M1.4551.00
110_K114_A1.4541.00
4_A22_F1.4481.00
63_Y71_K1.4471.00
9_K51_V1.4391.00
28_E200_D1.4191.00
118_E123_T1.4071.00
96_M113_A1.4051.00
117_L126_A1.4051.00
8_K18_K1.3731.00
31_G195_V1.3701.00
119_Y177_Q1.3531.00
30_F213_I1.3411.00
22_F203_G1.3371.00
7_I53_H1.3251.00
125_R133_F1.2911.00
218_D222_R1.2811.00
178_L183_M1.2791.00
150_K181_T1.2761.00
90_T93_E1.2491.00
24_L30_F1.2491.00
17_V46_M1.2391.00
100_K109_A1.2341.00
20_I43_T1.2331.00
89_L93_E1.2031.00
172_L194_E1.2021.00
5_E23_S1.2001.00
4_A47_I1.2001.00
156_M185_V1.1991.00
81_Q135_G1.1931.00
95_L117_L1.1921.00
10_A54_D1.1851.00
59_T64_V1.1831.00
49_G52_P1.1531.00
32_L186_I1.1451.00
29_S179_N1.1381.00
22_F43_T1.1361.00
25_K201_R1.1281.00
111_K115_E1.1181.00
226_D229_I1.1161.00
79_V156_M1.1101.00
30_F201_R1.1091.00
10_A13_K1.1031.00
94_N145_A1.1011.00
92_H110_K1.0941.00
96_M110_K1.0811.00
90_T127_K1.0781.00
176_K179_N1.0761.00
5_E21_S1.0751.00
108_E111_K1.0741.00
114_A118_E1.0641.00
46_M53_H1.0631.00
92_H113_A1.0601.00
217_T221_S1.0531.00
48_S78_I1.0471.00
26_K61_G1.0411.00
116_V144_G1.0401.00
163_I171_I1.0391.00
29_S185_V1.0371.00
32_L43_T1.0361.00
133_F141_I1.0311.00
95_L148_M1.0171.00
154_L183_M1.0151.00
51_V54_D1.0121.00
225_G228_I0.9941.00
112_R116_V0.9941.00
206_D211_I0.9931.00
6_N55_S0.9921.00
107_G111_K0.9881.00
77_G151_P0.9861.00
175_V185_V0.9701.00
120_V144_G0.9701.00
109_A113_A0.9701.00
106_H109_A0.9661.00
45_S51_V0.9541.00
130_I141_I0.9521.00
47_I186_I0.9511.00
202_I216_K0.9511.00
99_G148_M0.9481.00
29_S199_C0.9451.00
218_D221_S0.9451.00
115_E118_E0.9421.00
93_E96_M0.9421.00
179_N185_V0.9391.00
90_T129_K0.9371.00
168_R194_E0.9341.00
114_A122_L0.9341.00
96_M100_K0.9321.00
92_H114_A0.9321.00
4_A58_I0.9321.00
63_Y75_K0.9291.00
121_G170_H0.9101.00
46_M58_I0.9091.00
102_Y149_H0.9071.00
10_A18_K0.8981.00
206_D230_Q0.8981.00
79_V143_I0.8961.00
179_N200_D0.8951.00
105_T109_A0.8931.00
99_G109_A0.8901.00
88_T131_E0.8891.00
156_M175_V0.8861.00
49_G72_A0.8861.00
154_L185_V0.8841.00
211_I225_G0.8841.00
229_I233_V0.8781.00
43_T205_I0.8751.00
26_K182_G0.8741.00
48_S155_I0.8681.00
168_R191_Y0.8631.00
226_D230_Q0.8591.00
169_N173_E0.8561.00
32_L203_G0.8531.00
89_L94_N0.8491.00
20_I210_M0.8481.00
77_G146_A0.8441.00
4_A43_T0.8411.00
106_H110_K0.8321.00
25_K184_T0.8291.00
9_K42_T0.8281.00
116_V120_V0.8271.00
91_A141_I0.8271.00
104_L108_E0.8271.00
98_W145_A0.8241.00
7_I46_M0.8151.00
45_S50_L0.8141.00
110_K126_A0.8121.00
158_E190_H0.8071.00
223_L227_T0.8071.00
38_A205_I0.8061.00
174_T177_Q0.8031.00
85_L138_K0.8011.00
133_F137_M0.7941.00
79_V146_A0.7931.00
125_R137_M0.7901.00
46_M51_V0.7901.00
94_N130_I0.7811.00
110_K113_A0.7811.00
69_T73_K0.7801.00
89_L97_F0.7771.00
17_V20_I0.7761.00
19_G209_E0.7761.00
176_K198_L0.7751.00
17_V43_T0.7721.00
63_Y68_E0.7711.00
129_K132_T0.7711.00
90_T94_N0.7691.00
216_K220_C0.7691.00
69_T72_A0.7651.00
35_P206_D0.7651.00
19_G55_S0.7651.00
121_G177_Q0.7611.00
2_L153_L0.7601.00
173_E176_K0.7561.00
155_I186_I0.7561.00
160_T171_I0.7551.00
29_S176_K0.7531.00
227_T231_L0.7521.00
24_L184_T0.7501.00
116_V119_Y0.7471.00
24_L153_L0.7451.00
29_S198_L0.7381.00
30_F186_I0.7341.00
88_T93_E0.7311.00
99_G103_G0.7261.00
2_L47_I0.7211.00
212_A222_R0.7201.00
173_E177_Q0.7171.00
104_L109_A0.7151.00
113_A116_V0.7131.00
173_E197_F0.7111.00
100_K106_H0.7111.00
108_E112_R0.7101.00
10_A16_I0.7091.00
194_E198_L0.7081.00
33_L195_V0.7051.00
118_E124_E0.7041.00
47_I58_I0.6991.00
192_M220_C0.6961.00
99_G104_L0.6961.00
53_H66_G0.6941.00
187_Y199_C0.6881.00
9_K17_V0.6871.00
123_T126_A0.6861.00
135_G140_R0.6841.00
76_I153_L0.6821.00
204_I219_L0.6821.00
187_Y198_L0.6801.00
230_Q233_V0.6791.00
98_W149_H0.6751.00
210_M213_I0.6741.00
152_E183_M0.6711.00
6_N9_K0.6701.00
196_E216_K0.6671.00
114_A124_E0.6661.00
11_Y51_V0.6651.00
95_L113_A0.6601.00
199_C202_I0.6581.00
33_L204_I0.6581.00
219_L228_I0.6571.00
153_L184_T0.6561.00
57_N66_G0.6551.00
16_I42_T0.6541.00
241_L244_I0.6541.00
15_T19_G0.6521.00
116_V147_L0.6511.00
172_L197_F0.6501.00
24_L186_I0.6491.00
153_L186_I0.6491.00
237_N240_F0.6431.00
113_A126_A0.6391.00
111_K114_A0.6381.00
77_G149_H0.6321.00
29_S187_Y0.6321.00
28_E213_I0.6301.00
115_E150_K0.6261.00
207_Q230_Q0.6241.00
60_V75_K0.6201.00
160_T194_E0.6191.00
10_A55_S0.6181.00
68_E72_A0.6161.00
46_M54_D0.6161.00
110_K127_K0.6111.00
59_T62_G0.6111.00
2_L60_V0.6111.00
199_C216_K0.6091.00
111_K118_E0.6081.00
196_E220_C0.6081.00
228_I232_T0.6061.00
97_F101_M0.6061.00
27_G184_T0.6041.00
228_I231_L0.6031.00
60_V153_L0.6021.00
212_A219_L0.6011.00
230_Q234_S0.6011.00
128_D133_F0.5961.00
240_F243_A0.5961.00
23_S213_I0.5961.00
170_H173_E0.5921.00
61_G153_L0.5911.00
49_G66_G0.5901.00
204_I223_L0.5871.00
52_P66_G0.5871.00
71_K74_Q0.5811.00
83_I138_K0.5791.00
223_L226_D0.5781.00
7_I58_I0.5761.00
206_D225_G0.5761.00
195_V202_I0.5761.00
29_S200_D0.5741.00
206_D209_E0.5731.00
240_F244_I0.5721.00
147_L183_M0.5711.00
49_G69_T0.5711.00
86_Y89_L0.5701.00
121_G124_E0.5631.00
38_A207_Q0.5591.00
45_S78_I0.5571.00
139_R162_G0.5571.00
229_I232_T0.5561.00
117_L122_L0.5541.00
36_N158_E0.5541.00
41_S45_S0.5531.00
57_N67_K0.5531.00
189_S194_E0.5521.00
220_C223_L0.5501.00
211_I226_D0.5491.00
218_D224_G0.5491.00
175_V187_Y0.5461.00
50_L80_P0.5421.00
193_E197_F0.5421.00
225_G229_I0.5421.00
234_S237_N0.5401.00
32_L205_I0.5401.00
224_G229_I0.5401.00
26_K184_T0.5401.00
48_S76_I0.5391.00
143_I171_I0.5351.00
36_N167_S0.5321.00
97_F100_K0.5271.00
79_V142_N0.5271.00
226_D233_V0.5271.00
91_A95_L0.5241.00
86_Y94_N0.5241.00
87_P138_K0.5211.00
47_I155_I0.5211.00
66_G69_T0.5211.00
85_L130_I0.5201.00
122_L125_R0.5191.00
4_A46_M0.5181.00
72_A76_I0.5181.00
3_Q62_G0.5161.00
61_G65_I0.5161.00
87_P131_E0.5161.00
134_S137_M0.5151.00
195_V199_C0.5151.00
107_G110_K0.5141.00
65_I76_I0.5121.00
85_L141_I0.5111.00
82_E138_K0.5111.00
70_A73_K0.5091.00
212_A223_L0.5071.00
62_G65_I0.5051.00
216_K226_D0.5051.00
33_L192_M0.5031.00
104_L112_R0.5021.00
9_K16_I0.5021.00
117_L125_R0.5021.00
239_A242_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4yerA 2 0.8907 100 0.112 Contact Map
3tuiC 2 0.9936 100 0.166 Contact Map
4rvcA 4 0.7685 100 0.186 Contact Map
1vplA 2 0.7621 100 0.188 Contact Map
4u00A 1 0.7621 100 0.192 Contact Map
4ymuJ 2 0.7588 100 0.194 Contact Map
2oljA 2 0.7588 100 0.195 Contact Map
1b0uA 2 0.7749 100 0.197 Contact Map
1v43A 2 0.9614 100 0.199 Contact Map
4mkiB 2 0.8682 100 0.201 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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