YFIJ - BACSU - GREMLIN Contacts

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YFIJ - Sensor histidine kinase YfiJ

UniProt:	P94438	Sequences: MKALFFTRMFTLMVSCLMYLSIVKEDNWFGYVFIAAGAAMYAANHVLLTKETNAIWFCLIDIAIGFSFGFIFPGTGLFIIMLCPVAVAFFLRGFPKRTAWSVLCLSSILFLTVLIRTYAMFGNEFVIDHLTSMTFVVFCGVVGKLIRKLLDAQDTAKQQFQELTESHLALSAAHQELHLYAKQVEELTAIYERNRMAREIHDTVGHKMTALLVQLQLLREWQKRDSQKADETVGVCETLAREALDDVRLSVRTLQTENDPSLIESLKQLTEDFCKNAGVTTEFAVSGDPAIIPLSLHPTLIRTVQEALTNAKRHGGAAACSIQLACTTDSISLVIKDDGKGNPEAALGFGLLNMKKRAAEHGGMIRFESERDQGFTVNAEFSLANKKWSFGPVQQKESLS	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	400 (338)
Sequences:	31016 (27505)
Seq/√Len:	1496.1

ECOLI - UHPB BARA TORS RCSC RCSD GLRK NARX BAES ARCB EVGS ENVZ KDPD PHOQ CPXA NARQ CUSS RSTB CREC ZRAS ATOS YEDV PHOR QSEC DPIB YPDA DCUS BASS
BACSU - YFIJ YXJM YDFH YVFT DESK GLNK KINB COMP LIAS YCLK YVRG YKOH KINE BCES LYTS CSSS YYCG YVCQ KINA YCBM KIND YRKQ YHCY RESE PHOR YXDK CITS DCTS YBDK KINC MALK NATK DEGS
HALSA - Q9HQG5 Q9HQ16 Q9HRG1 Q9HQ15 Q9HQE9 Q9HR10 O51970 Q9HRE4 Q9HNM2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
330_S	380_E	4.254	1.00
336_K	376_T	3.785	1.00
215_L	236_C	3.496	1.00
334_V	376_T	3.306	1.00
334_V	378_N	3.282	1.00
366_R	378_N	3.254	1.00
355_K	359_A	3.046	1.00
219_R	237_E	2.968	1.00
332_S	380_E	2.884	1.00
212_L	240_A	2.797	1.00
219_R	234_G	2.783	1.00
323_Q	334_V	2.708	1.00
282_E	321_S	2.681	1.00
315_G	338_D	2.663	1.00
332_S	378_N	2.585	1.00
307_A	377_V	2.559	1.00
354_M	365_I	2.558	1.00
311_A	320_C	2.555	1.00
319_A	338_D	2.513	1.00
282_E	319_A	2.510	1.00
327_T	332_S	2.500	1.00
260_P	295_S	2.432	1.00
284_A	323_Q	2.394	1.00
303_T	358_A	2.371	1.00
368_E	376_T	2.318	1.00
358_A	363_G	2.304	1.00
358_A	379_A	2.297	1.00
211_L	240_A	2.290	1.00
284_A	321_S	2.267	1.00
326_C	383_L	2.263	1.00
367_F	377_V	2.259	1.00
325_A	332_S	2.251	1.00
212_L	241_R	2.233	1.00
218_L	233_V	2.214	1.00
370_E	373_Q	2.211	1.00
364_M	380_E	2.137	1.00
216_Q	237_E	2.082	1.00
170_L	174_H	2.082	1.00
318_A	338_D	2.071	1.00
321_S	336_K	2.062	1.00
337_D	341_G	2.043	1.00
259_D	294_L	2.025	1.00
368_E	378_N	2.019	1.00
181_A	184_V	2.013	1.00
170_L	173_A	2.009	1.00
181_A	185_E	1.955	1.00
261_S	264_E	1.940	1.00
295_S	361_H	1.895	1.00
268_Q	301_I	1.882	1.00
303_T	379_A	1.874	1.00
325_A	334_V	1.802	1.00
323_Q	336_K	1.790	1.00
303_T	354_M	1.787	1.00
174_H	177_L	1.782	1.00
280_T	319_A	1.776	1.00
304_V	333_L	1.767	1.00
333_L	379_A	1.721	1.00
342_N	375_F	1.716	1.00
303_T	357_R	1.701	1.00
237_E	241_R	1.678	1.00
369_S	375_F	1.661	1.00
337_D	374_G	1.647	1.00
225_D	228_K	1.638	1.00
315_G	320_C	1.628	1.00
226_S	229_A	1.615	1.00
315_G	318_A	1.603	1.00
366_R	380_E	1.600	1.00
244_L	248_R	1.589	1.00
180_Y	183_Q	1.583	1.00
214_Q	232_T	1.578	1.00
358_A	365_I	1.573	1.00
263_I	267_K	1.572	1.00
219_R	230_D	1.570	1.00
309_T	313_R	1.548	1.00
178_H	181_A	1.548	1.00
265_S	268_Q	1.542	1.00
214_Q	235_V	1.514	1.00
211_L	236_C	1.493	1.00
359_A	364_M	1.461	1.00
331_I	383_L	1.457	1.00
190_I	193_R	1.445	1.00
225_D	229_A	1.441	1.00
215_L	240_A	1.429	1.00
279_V	283_F	1.428	1.00
357_R	361_H	1.421	1.00
173_A	176_E	1.419	1.00
191_Y	195_R	1.417	1.00
215_L	237_E	1.412	1.00
190_I	194_N	1.411	1.00
212_L	237_E	1.405	1.00
221_W	229_A	1.398	1.00
258_N	297_H	1.397	1.00
302_R	305_Q	1.380	1.00
171_S	174_H	1.378	1.00
307_A	335_I	1.372	1.00
212_L	244_L	1.366	1.00
210_A	214_Q	1.322	1.00
178_H	182_K	1.320	1.00
167_H	171_S	1.318	1.00
218_L	229_A	1.300	1.00
167_H	170_L	1.298	1.00
296_L	299_T	1.291	1.00
336_K	370_E	1.282	1.00
286_S	325_A	1.280	1.00
293_P	296_L	1.271	1.00
189_A	193_R	1.263	1.00
180_Y	184_V	1.255	1.00
193_R	197_A	1.251	1.00
316_G	340_K	1.237	1.00
327_T	380_E	1.234	1.00
234_G	238_T	1.233	1.00
273_F	305_Q	1.228	1.00
306_E	354_M	1.204	1.00
173_A	177_L	1.192	1.00
295_S	300_L	1.189	1.00
169_A	173_A	1.179	1.00
177_L	180_Y	1.179	1.00
215_L	233_V	1.162	1.00
147_R	151_D	1.162	1.00
322_I	335_I	1.160	1.00
367_F	375_F	1.160	1.00
299_T	302_R	1.157	1.00
285_V	324_L	1.150	1.00
273_F	312_K	1.149	1.00
179_L	183_Q	1.144	1.00
307_A	354_M	1.140	1.00
321_S	338_D	1.139	1.00
222_Q	229_A	1.130	1.00
276_N	279_V	1.130	1.00
171_S	175_Q	1.127	1.00
270_T	283_F	1.122	1.00
212_L	216_Q	1.121	1.00
263_I	324_L	1.120	1.00
300_L	381_F	1.120	1.00
88_A	92_R	1.119	1.00
167_H	174_H	1.119	1.00
174_H	178_H	1.118	1.00
215_L	219_R	1.110	1.00
267_K	271_E	1.109	1.00
204_V	243_A	1.107	1.00
235_V	239_L	1.096	1.00
148_K	152_A	1.096	1.00
301_I	305_Q	1.094	1.00
172_A	176_E	1.093	1.00
352_L	356_K	1.090	1.00
259_D	292_I	1.088	1.00
210_A	239_L	1.079	1.00
203_T	302_R	1.078	1.00
369_S	373_Q	1.072	1.00
205_G	248_R	1.072	1.00
230_D	234_G	1.069	1.00
363_G	381_F	1.063	1.00
87_V	91_L	1.057	1.00
308_L	320_C	1.053	1.00
192_E	195_R	1.052	1.00
330_S	364_M	1.045	1.00
343_P	371_R	1.044	1.00
195_R	199_E	1.042	1.00
299_T	357_R	1.038	1.00
213_V	217_L	1.038	1.00
240_A	244_L	1.032	1.00
369_S	372_D	1.025	1.00
143_G	147_R	1.020	1.00
208_M	243_A	1.003	1.00
327_T	330_S	1.002	1.00
168_L	171_S	0.999	1.00
268_Q	272_D	0.999	1.00
149_L	152_A	0.998	1.00
40_M	44_N	0.988	1.00
297_H	301_I	0.982	1.00
231_E	234_G	0.977	1.00
204_V	247_V	0.972	1.00
307_A	379_A	0.970	1.00
308_L	322_I	0.967	1.00
356_K	360_E	0.961	1.00
265_S	269_L	0.960	1.00
245_D	249_L	0.958	1.00
227_Q	230_D	0.958	1.00
152_A	156_A	0.957	1.00
267_K	270_T	0.956	1.00
232_T	235_V	0.953	1.00
358_A	381_F	0.952	1.00
272_D	301_I	0.950	1.00
177_L	181_A	0.948	1.00
231_E	235_V	0.948	1.00
290_A	326_C	0.947	1.00
176_E	180_Y	0.947	1.00
222_Q	230_D	0.940	1.00
39_A	43_A	0.933	1.00
234_G	237_E	0.930	1.00
150_L	154_D	0.926	1.00
365_I	377_V	0.924	1.00
311_A	315_G	0.923	1.00
272_D	305_Q	0.922	1.00
188_T	192_E	0.922	1.00
269_L	301_I	0.916	1.00
84_P	87_V	0.914	1.00
249_L	299_T	0.912	1.00
340_K	344_E	0.909	1.00
41_Y	45_H	0.903	1.00
304_V	308_L	0.894	1.00
239_L	242_E	0.893	1.00
342_N	377_V	0.890	1.00
269_L	272_D	0.886	1.00
168_L	172_A	0.883	1.00
349_F	353_N	0.877	1.00
337_D	375_F	0.875	1.00
299_T	360_E	0.874	1.00
203_T	246_D	0.872	1.00
149_L	153_Q	0.871	1.00
189_A	192_E	0.870	1.00
287_G	326_C	0.866	1.00
142_V	145_L	0.862	1.00
206_H	210_A	0.860	1.00
196_M	200_I	0.859	1.00
267_K	285_V	0.854	1.00
286_S	323_Q	0.852	1.00
218_L	236_C	0.852	1.00
40_M	43_A	0.849	1.00
299_T	361_H	0.849	1.00
363_G	379_A	0.848	1.00
169_A	172_A	0.845	1.00
260_P	265_S	0.845	1.00
356_K	359_A	0.843	1.00
147_R	150_L	0.837	1.00
269_L	305_Q	0.835	1.00
289_P	326_C	0.834	1.00
179_L	182_K	0.834	1.00
300_L	361_H	0.834	1.00
342_N	369_S	0.832	1.00
203_T	207_K	0.829	1.00
270_T	274_C	0.828	1.00
273_F	308_L	0.826	1.00
370_E	376_T	0.825	1.00
296_L	361_H	0.815	1.00
265_S	301_I	0.813	1.00
304_V	335_I	0.813	1.00
300_L	333_L	0.812	1.00
58_C	61_D	0.810	1.00
238_T	242_E	0.807	1.00
148_K	151_D	0.805	1.00
291_I	326_C	0.803	1.00
205_G	244_L	0.800	1.00
243_A	247_V	0.799	1.00
228_K	231_E	0.797	1.00
146_I	149_L	0.796	1.00
226_S	230_D	0.793	1.00
248_R	252_R	0.793	1.00
214_Q	236_C	0.792	1.00
37_G	40_M	0.787	1.00
188_T	191_Y	0.785	1.00
266_L	324_L	0.783	1.00
233_V	236_C	0.780	1.00
271_E	274_C	0.775	1.00
204_V	207_K	0.773	1.00
182_K	185_E	0.772	1.00
369_S	374_G	0.766	1.00
294_L	384_A	0.763	1.00
329_D	383_L	0.758	1.00
300_L	331_I	0.758	1.00
267_K	283_F	0.757	1.00
308_L	312_K	0.755	1.00
269_L	273_F	0.755	1.00
219_R	233_V	0.750	1.00
202_D	206_H	0.749	1.00
341_G	375_F	0.742	1.00
262_L	265_S	0.739	1.00
330_S	383_L	0.738	1.00
261_S	291_I	0.738	1.00
314_H	344_E	0.730	1.00
291_I	331_I	0.727	1.00
307_A	358_A	0.723	1.00
95_P	99_A	0.722	1.00
266_L	304_V	0.722	1.00
90_F	93_G	0.721	1.00
216_Q	219_R	0.719	1.00
56_W	59_L	0.718	1.00
228_K	232_T	0.718	1.00
354_M	358_A	0.717	1.00
270_T	273_F	0.716	1.00
314_H	340_K	0.715	1.00
351_L	354_M	0.712	1.00
43_A	46_V	0.712	1.00
365_I	379_A	0.711	1.00
245_D	298_P	0.710	1.00
195_R	356_K	0.709	1.00
280_T	283_F	0.708	1.00
240_A	243_A	0.707	1.00
53_N	56_W	0.707	1.00
330_S	382_S	0.707	1.00
175_Q	179_L	0.705	1.00
217_L	232_T	0.704	1.00
96_K	99_A	0.703	1.00
151_D	155_T	0.698	1.00
207_K	243_A	0.698	1.00
229_A	232_T	0.697	1.00
150_L	153_Q	0.696	1.00
353_N	357_R	0.694	1.00
270_T	281_T	0.694	1.00
261_S	290_A	0.692	1.00
264_E	267_K	0.692	1.00
214_Q	239_L	0.691	1.00
304_V	322_I	0.691	1.00
363_G	382_S	0.689	1.00
169_A	174_H	0.688	1.00
200_I	250_S	0.687	1.00
279_V	315_G	0.686	1.00
176_E	179_L	0.685	1.00
116_R	119_A	0.682	1.00
191_Y	194_N	0.682	1.00
61_D	66_F	0.681	1.00
324_L	331_I	0.680	1.00
37_G	41_Y	0.679	1.00
221_W	232_T	0.677	1.00
277_A	312_K	0.676	1.00
253_T	352_L	0.675	1.00
263_I	285_V	0.675	1.00
167_H	173_A	0.675	1.00
235_V	238_T	0.674	1.00
153_Q	156_A	0.671	1.00
201_H	207_K	0.670	1.00
217_L	221_W	0.668	1.00
216_Q	241_R	0.667	1.00
112_T	117_T	0.666	1.00
324_L	333_L	0.666	1.00
243_A	246_D	0.665	1.00
125_F	128_D	0.664	1.00
342_N	367_F	0.663	1.00
211_L	215_L	0.662	1.00
284_A	325_A	0.655	1.00
221_W	224_R	0.655	1.00
255_Q	349_F	0.654	1.00
210_A	213_V	0.650	1.00
42_A	46_V	0.648	1.00
172_A	175_Q	0.648	1.00
279_V	312_K	0.647	1.00
57_F	61_D	0.645	1.00
182_K	188_T	0.643	1.00
91_L	94_F	0.642	1.00
215_L	218_L	0.641	1.00
144_K	147_R	0.641	1.00
237_E	240_A	0.641	1.00
214_Q	217_L	0.639	1.00
59_L	63_A	0.638	1.00
194_N	257_E	0.638	1.00
126_V	129_H	0.637	1.00
260_P	297_H	0.636	1.00
273_F	309_T	0.635	1.00
196_M	199_E	0.633	1.00
224_R	229_A	0.633	1.00
202_D	306_E	0.633	1.00
247_V	250_S	0.633	1.00
209_T	213_V	0.632	1.00
239_L	243_A	0.629	1.00
210_A	235_V	0.628	1.00
334_V	368_E	0.627	1.00
136_V	140_G	0.626	1.00
253_T	257_E	0.625	1.00
61_D	65_G	0.624	1.00
203_T	306_E	0.623	1.00
264_E	268_Q	0.623	1.00
128_D	132_S	0.620	1.00
185_E	188_T	0.619	1.00
151_D	154_D	0.619	1.00
261_S	265_S	0.618	1.00
205_G	251_V	0.618	1.00
98_T	101_S	0.617	1.00
136_V	139_C	0.616	1.00
38_A	42_A	0.615	1.00
197_A	201_H	0.615	1.00
299_T	303_T	0.615	1.00
317_A	338_D	0.614	1.00
242_E	246_D	0.613	1.00
320_C	335_I	0.612	1.00
81_M	85_V	0.612	1.00
67_S	71_I	0.612	1.00
241_R	244_L	0.611	1.00
114_L	117_T	0.611	1.00
275_K	279_V	0.608	1.00
270_T	308_L	0.608	1.00
322_I	333_L	0.606	1.00
73_P	76_G	0.605	1.00
286_S	289_P	0.605	1.00
205_G	243_A	0.602	1.00
275_K	278_G	0.602	1.00
202_D	205_G	0.599	1.00
250_S	254_L	0.599	1.00
183_Q	188_T	0.598	1.00
246_D	249_L	0.598	1.00
229_A	233_V	0.598	1.00
209_T	212_L	0.597	1.00
252_R	302_R	0.597	1.00
66_F	69_G	0.597	1.00
268_Q	271_E	0.596	1.00
87_V	90_F	0.595	1.00
305_Q	309_T	0.595	1.00
49_T	52_T	0.594	1.00
216_Q	220_E	0.593	1.00
93_G	97_R	0.591	1.00
255_Q	306_E	0.590	1.00
303_T	361_H	0.587	1.00
87_V	92_R	0.586	1.00
218_L	232_T	0.584	1.00
144_K	148_K	0.584	1.00
95_P	98_T	0.584	1.00
55_I	59_L	0.583	1.00
55_I	58_C	0.582	1.00
74_G	78_F	0.582	1.00
251_V	255_Q	0.581	1.00
219_R	222_Q	0.581	1.00
339_G	374_G	0.580	1.00
233_V	237_E	0.580	1.00
125_F	129_H	0.579	1.00
366_R	379_A	0.578	1.00
269_L	308_L	0.577	1.00
89_F	93_G	0.576	1.00
355_K	364_M	0.576	1.00
261_S	292_I	0.574	1.00
306_E	313_R	0.573	1.00
298_P	301_I	0.571	1.00
115_I	118_Y	0.569	1.00
320_C	324_L	0.567	1.00
83_C	91_L	0.563	1.00
74_G	77_L	0.563	1.00
102_V	105_L	0.560	1.00
135_F	139_C	0.560	1.00
265_S	270_T	0.560	1.00
238_T	241_R	0.560	1.00
262_L	333_L	0.559	1.00
193_R	198_R	0.559	1.00
88_A	91_L	0.558	1.00
118_Y	121_F	0.558	1.00
311_A	335_I	0.558	1.00
84_P	88_A	0.558	1.00
133_M	137_V	0.554	1.00
132_S	136_V	0.553	1.00
236_C	240_A	0.552	1.00
193_R	206_H	0.551	1.00
306_E	309_T	0.551	1.00
36_A	40_M	0.550	1.00
282_E	285_V	0.550	1.00
206_H	214_Q	0.549	1.00
184_V	189_A	0.547	1.00
69_G	72_F	0.547	1.00
194_N	199_E	0.547	1.00
56_W	60_I	0.546	1.00
170_L	177_L	0.545	1.00
58_C	62_I	0.539	1.00
221_W	228_K	0.537	1.00
89_F	92_R	0.537	1.00
241_R	245_D	0.536	1.00
265_S	295_S	0.535	1.00
119_A	122_G	0.532	1.00
54_A	57_F	0.532	1.00
336_K	374_G	0.531	1.00
201_H	206_H	0.530	1.00
310_N	350_G	0.530	1.00
146_I	152_A	0.530	1.00
39_A	42_A	0.529	1.00
197_A	200_I	0.529	1.00
217_L	220_E	0.529	1.00
60_I	63_A	0.529	1.00
306_E	353_N	0.529	1.00
54_A	58_C	0.527	1.00
358_A	361_H	0.525	1.00
326_C	330_S	0.524	1.00
120_M	123_N	0.524	1.00
206_H	251_V	0.522	1.00
266_L	322_I	0.520	1.00
340_K	375_F	0.520	1.00
139_C	143_G	0.519	1.00
302_R	357_R	0.518	1.00
139_C	147_R	0.518	1.00
243_A	248_R	0.517	1.00
279_V	320_C	0.516	1.00
92_R	95_P	0.516	1.00
248_R	251_V	0.515	1.00
135_F	138_F	0.514	1.00
152_A	155_T	0.513	1.00
96_K	100_W	0.512	1.00
45_H	48_L	0.511	1.00
66_F	70_F	0.511	1.00
265_S	300_L	0.510	1.00
36_A	43_A	0.510	1.00
214_Q	221_W	0.509	1.00
127_I	130_L	0.509	1.00
185_E	189_A	0.509	1.00
326_C	331_I	0.509	1.00
73_P	77_L	0.508	1.00
206_H	213_V	0.508	1.00
94_F	97_R	0.508	1.00
279_V	317_A	0.507	1.00
175_Q	178_H	0.507	1.00
332_S	366_R	0.506	1.00
201_H	306_E	0.506	1.00
42_A	45_H	0.505	1.00
199_E	250_S	0.505	1.00
203_T	206_H	0.504	1.00
227_Q	231_E	0.504	1.00
41_Y	44_N	0.502	1.00
81_M	84_P	0.502	1.00
208_M	247_V	0.501	1.00
127_I	131_T	0.501	1.00
196_M	201_H	0.500	1.00
173_A	178_H	0.500	1.00
193_R	314_H	0.500	1.00
207_K	239_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4i5sA	2	0.6725	100	0.428	Contact Map
4bixA	2	0.515	100	0.451	Contact Map
3ehhA	2	0.485	100	0.463	Contact Map
4r39A	1	0.5025	100	0.465	Contact Map
4ctiA	2	0.5275	100	0.467	Contact Map
2c2aA	2	0.5275	100	0.474	Contact Map
4q20A	2	0.51	100	0.478	Contact Map
3d36A	2	0.4925	100	0.478	Contact Map
3jz3A	2	0.375	100	0.49	Contact Map
4e01A	3	0.645	100	0.492	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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