GREMLIN Database
YFIJ - Sensor histidine kinase YfiJ
UniProt: P94438 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 400 (338)
Sequences: 31016 (27505)
Seq/√Len: 1496.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
330_S380_E4.2541.00
336_K376_T3.7851.00
215_L236_C3.4961.00
334_V376_T3.3061.00
334_V378_N3.2821.00
366_R378_N3.2541.00
355_K359_A3.0461.00
219_R237_E2.9681.00
332_S380_E2.8841.00
212_L240_A2.7971.00
219_R234_G2.7831.00
323_Q334_V2.7081.00
282_E321_S2.6811.00
315_G338_D2.6631.00
332_S378_N2.5851.00
307_A377_V2.5591.00
354_M365_I2.5581.00
311_A320_C2.5551.00
319_A338_D2.5131.00
282_E319_A2.5101.00
327_T332_S2.5001.00
260_P295_S2.4321.00
284_A323_Q2.3941.00
303_T358_A2.3711.00
368_E376_T2.3181.00
358_A363_G2.3041.00
358_A379_A2.2971.00
211_L240_A2.2901.00
284_A321_S2.2671.00
326_C383_L2.2631.00
367_F377_V2.2591.00
325_A332_S2.2511.00
212_L241_R2.2331.00
218_L233_V2.2141.00
370_E373_Q2.2111.00
364_M380_E2.1371.00
216_Q237_E2.0821.00
170_L174_H2.0821.00
318_A338_D2.0711.00
321_S336_K2.0621.00
337_D341_G2.0431.00
259_D294_L2.0251.00
368_E378_N2.0191.00
181_A184_V2.0131.00
170_L173_A2.0091.00
181_A185_E1.9551.00
261_S264_E1.9401.00
295_S361_H1.8951.00
268_Q301_I1.8821.00
303_T379_A1.8741.00
325_A334_V1.8021.00
323_Q336_K1.7901.00
303_T354_M1.7871.00
174_H177_L1.7821.00
280_T319_A1.7761.00
304_V333_L1.7671.00
333_L379_A1.7211.00
342_N375_F1.7161.00
303_T357_R1.7011.00
237_E241_R1.6781.00
369_S375_F1.6611.00
337_D374_G1.6471.00
225_D228_K1.6381.00
315_G320_C1.6281.00
226_S229_A1.6151.00
315_G318_A1.6031.00
366_R380_E1.6001.00
244_L248_R1.5891.00
180_Y183_Q1.5831.00
214_Q232_T1.5781.00
358_A365_I1.5731.00
263_I267_K1.5721.00
219_R230_D1.5701.00
309_T313_R1.5481.00
178_H181_A1.5481.00
265_S268_Q1.5421.00
214_Q235_V1.5141.00
211_L236_C1.4931.00
359_A364_M1.4611.00
331_I383_L1.4571.00
190_I193_R1.4451.00
225_D229_A1.4411.00
215_L240_A1.4291.00
279_V283_F1.4281.00
357_R361_H1.4211.00
173_A176_E1.4191.00
191_Y195_R1.4171.00
215_L237_E1.4121.00
190_I194_N1.4111.00
212_L237_E1.4051.00
221_W229_A1.3981.00
258_N297_H1.3971.00
302_R305_Q1.3801.00
171_S174_H1.3781.00
307_A335_I1.3721.00
212_L244_L1.3661.00
210_A214_Q1.3221.00
178_H182_K1.3201.00
167_H171_S1.3181.00
218_L229_A1.3001.00
167_H170_L1.2981.00
296_L299_T1.2911.00
336_K370_E1.2821.00
286_S325_A1.2801.00
293_P296_L1.2711.00
189_A193_R1.2631.00
180_Y184_V1.2551.00
193_R197_A1.2511.00
316_G340_K1.2371.00
327_T380_E1.2341.00
234_G238_T1.2331.00
273_F305_Q1.2281.00
306_E354_M1.2041.00
173_A177_L1.1921.00
295_S300_L1.1891.00
169_A173_A1.1791.00
177_L180_Y1.1791.00
215_L233_V1.1621.00
147_R151_D1.1621.00
322_I335_I1.1601.00
367_F375_F1.1601.00
299_T302_R1.1571.00
285_V324_L1.1501.00
273_F312_K1.1491.00
179_L183_Q1.1441.00
307_A354_M1.1401.00
321_S338_D1.1391.00
222_Q229_A1.1301.00
276_N279_V1.1301.00
171_S175_Q1.1271.00
270_T283_F1.1221.00
212_L216_Q1.1211.00
263_I324_L1.1201.00
300_L381_F1.1201.00
88_A92_R1.1191.00
167_H174_H1.1191.00
174_H178_H1.1181.00
215_L219_R1.1101.00
267_K271_E1.1091.00
204_V243_A1.1071.00
235_V239_L1.0961.00
148_K152_A1.0961.00
301_I305_Q1.0941.00
172_A176_E1.0931.00
352_L356_K1.0901.00
259_D292_I1.0881.00
210_A239_L1.0791.00
203_T302_R1.0781.00
369_S373_Q1.0721.00
205_G248_R1.0721.00
230_D234_G1.0691.00
363_G381_F1.0631.00
87_V91_L1.0571.00
308_L320_C1.0531.00
192_E195_R1.0521.00
330_S364_M1.0451.00
343_P371_R1.0441.00
195_R199_E1.0421.00
299_T357_R1.0381.00
213_V217_L1.0381.00
240_A244_L1.0321.00
369_S372_D1.0251.00
143_G147_R1.0201.00
208_M243_A1.0031.00
327_T330_S1.0021.00
168_L171_S0.9991.00
268_Q272_D0.9991.00
149_L152_A0.9981.00
40_M44_N0.9881.00
297_H301_I0.9821.00
231_E234_G0.9771.00
204_V247_V0.9721.00
307_A379_A0.9701.00
308_L322_I0.9671.00
356_K360_E0.9611.00
265_S269_L0.9601.00
245_D249_L0.9581.00
227_Q230_D0.9581.00
152_A156_A0.9571.00
267_K270_T0.9561.00
232_T235_V0.9531.00
358_A381_F0.9521.00
272_D301_I0.9501.00
177_L181_A0.9481.00
231_E235_V0.9481.00
290_A326_C0.9471.00
176_E180_Y0.9471.00
222_Q230_D0.9401.00
39_A43_A0.9331.00
234_G237_E0.9301.00
150_L154_D0.9261.00
365_I377_V0.9241.00
311_A315_G0.9231.00
272_D305_Q0.9221.00
188_T192_E0.9221.00
269_L301_I0.9161.00
84_P87_V0.9141.00
249_L299_T0.9121.00
340_K344_E0.9091.00
41_Y45_H0.9031.00
304_V308_L0.8941.00
239_L242_E0.8931.00
342_N377_V0.8901.00
269_L272_D0.8861.00
168_L172_A0.8831.00
349_F353_N0.8771.00
337_D375_F0.8751.00
299_T360_E0.8741.00
203_T246_D0.8721.00
149_L153_Q0.8711.00
189_A192_E0.8701.00
287_G326_C0.8661.00
142_V145_L0.8621.00
206_H210_A0.8601.00
196_M200_I0.8591.00
267_K285_V0.8541.00
286_S323_Q0.8521.00
218_L236_C0.8521.00
40_M43_A0.8491.00
299_T361_H0.8491.00
363_G379_A0.8481.00
169_A172_A0.8451.00
260_P265_S0.8451.00
356_K359_A0.8431.00
147_R150_L0.8371.00
269_L305_Q0.8351.00
289_P326_C0.8341.00
179_L182_K0.8341.00
300_L361_H0.8341.00
342_N369_S0.8321.00
203_T207_K0.8291.00
270_T274_C0.8281.00
273_F308_L0.8261.00
370_E376_T0.8251.00
296_L361_H0.8151.00
265_S301_I0.8131.00
304_V335_I0.8131.00
300_L333_L0.8121.00
58_C61_D0.8101.00
238_T242_E0.8071.00
148_K151_D0.8051.00
291_I326_C0.8031.00
205_G244_L0.8001.00
243_A247_V0.7991.00
228_K231_E0.7971.00
146_I149_L0.7961.00
226_S230_D0.7931.00
248_R252_R0.7931.00
214_Q236_C0.7921.00
37_G40_M0.7871.00
188_T191_Y0.7851.00
266_L324_L0.7831.00
233_V236_C0.7801.00
271_E274_C0.7751.00
204_V207_K0.7731.00
182_K185_E0.7721.00
369_S374_G0.7661.00
294_L384_A0.7631.00
329_D383_L0.7581.00
300_L331_I0.7581.00
267_K283_F0.7571.00
308_L312_K0.7551.00
269_L273_F0.7551.00
219_R233_V0.7501.00
202_D206_H0.7491.00
341_G375_F0.7421.00
262_L265_S0.7391.00
330_S383_L0.7381.00
261_S291_I0.7381.00
314_H344_E0.7301.00
291_I331_I0.7271.00
307_A358_A0.7231.00
95_P99_A0.7221.00
266_L304_V0.7221.00
90_F93_G0.7211.00
216_Q219_R0.7191.00
56_W59_L0.7181.00
228_K232_T0.7181.00
354_M358_A0.7171.00
270_T273_F0.7161.00
314_H340_K0.7151.00
351_L354_M0.7121.00
43_A46_V0.7121.00
365_I379_A0.7111.00
245_D298_P0.7101.00
195_R356_K0.7091.00
280_T283_F0.7081.00
240_A243_A0.7071.00
53_N56_W0.7071.00
330_S382_S0.7071.00
175_Q179_L0.7051.00
217_L232_T0.7041.00
96_K99_A0.7031.00
151_D155_T0.6981.00
207_K243_A0.6981.00
229_A232_T0.6971.00
150_L153_Q0.6961.00
353_N357_R0.6941.00
270_T281_T0.6941.00
261_S290_A0.6921.00
264_E267_K0.6921.00
214_Q239_L0.6911.00
304_V322_I0.6911.00
363_G382_S0.6891.00
169_A174_H0.6881.00
200_I250_S0.6871.00
279_V315_G0.6861.00
176_E179_L0.6851.00
116_R119_A0.6821.00
191_Y194_N0.6821.00
61_D66_F0.6811.00
324_L331_I0.6801.00
37_G41_Y0.6791.00
221_W232_T0.6771.00
277_A312_K0.6761.00
253_T352_L0.6751.00
263_I285_V0.6751.00
167_H173_A0.6751.00
235_V238_T0.6741.00
153_Q156_A0.6711.00
201_H207_K0.6701.00
217_L221_W0.6681.00
216_Q241_R0.6671.00
112_T117_T0.6661.00
324_L333_L0.6661.00
243_A246_D0.6651.00
125_F128_D0.6641.00
342_N367_F0.6631.00
211_L215_L0.6621.00
284_A325_A0.6551.00
221_W224_R0.6551.00
255_Q349_F0.6541.00
210_A213_V0.6501.00
42_A46_V0.6481.00
172_A175_Q0.6481.00
279_V312_K0.6471.00
57_F61_D0.6451.00
182_K188_T0.6431.00
91_L94_F0.6421.00
215_L218_L0.6411.00
144_K147_R0.6411.00
237_E240_A0.6411.00
214_Q217_L0.6391.00
59_L63_A0.6381.00
194_N257_E0.6381.00
126_V129_H0.6371.00
260_P297_H0.6361.00
273_F309_T0.6351.00
196_M199_E0.6331.00
224_R229_A0.6331.00
202_D306_E0.6331.00
247_V250_S0.6331.00
209_T213_V0.6321.00
239_L243_A0.6291.00
210_A235_V0.6281.00
334_V368_E0.6271.00
136_V140_G0.6261.00
253_T257_E0.6251.00
61_D65_G0.6241.00
203_T306_E0.6231.00
264_E268_Q0.6231.00
128_D132_S0.6201.00
185_E188_T0.6191.00
151_D154_D0.6191.00
261_S265_S0.6181.00
205_G251_V0.6181.00
98_T101_S0.6171.00
136_V139_C0.6161.00
38_A42_A0.6151.00
197_A201_H0.6151.00
299_T303_T0.6151.00
317_A338_D0.6141.00
242_E246_D0.6131.00
320_C335_I0.6121.00
81_M85_V0.6121.00
67_S71_I0.6121.00
241_R244_L0.6111.00
114_L117_T0.6111.00
275_K279_V0.6081.00
270_T308_L0.6081.00
322_I333_L0.6061.00
73_P76_G0.6051.00
286_S289_P0.6051.00
205_G243_A0.6021.00
275_K278_G0.6021.00
202_D205_G0.5991.00
250_S254_L0.5991.00
183_Q188_T0.5981.00
246_D249_L0.5981.00
229_A233_V0.5981.00
209_T212_L0.5971.00
252_R302_R0.5971.00
66_F69_G0.5971.00
268_Q271_E0.5961.00
87_V90_F0.5951.00
305_Q309_T0.5951.00
49_T52_T0.5941.00
216_Q220_E0.5931.00
93_G97_R0.5911.00
255_Q306_E0.5901.00
303_T361_H0.5871.00
87_V92_R0.5861.00
218_L232_T0.5841.00
144_K148_K0.5841.00
95_P98_T0.5841.00
55_I59_L0.5831.00
55_I58_C0.5821.00
74_G78_F0.5821.00
251_V255_Q0.5811.00
219_R222_Q0.5811.00
339_G374_G0.5801.00
233_V237_E0.5801.00
125_F129_H0.5791.00
366_R379_A0.5781.00
269_L308_L0.5771.00
89_F93_G0.5761.00
355_K364_M0.5761.00
261_S292_I0.5741.00
306_E313_R0.5731.00
298_P301_I0.5711.00
115_I118_Y0.5691.00
320_C324_L0.5671.00
83_C91_L0.5631.00
74_G77_L0.5631.00
102_V105_L0.5601.00
135_F139_C0.5601.00
265_S270_T0.5601.00
238_T241_R0.5601.00
262_L333_L0.5591.00
193_R198_R0.5591.00
88_A91_L0.5581.00
118_Y121_F0.5581.00
311_A335_I0.5581.00
84_P88_A0.5581.00
133_M137_V0.5541.00
132_S136_V0.5531.00
236_C240_A0.5521.00
193_R206_H0.5511.00
306_E309_T0.5511.00
36_A40_M0.5501.00
282_E285_V0.5501.00
206_H214_Q0.5491.00
184_V189_A0.5471.00
69_G72_F0.5471.00
194_N199_E0.5471.00
56_W60_I0.5461.00
170_L177_L0.5451.00
58_C62_I0.5391.00
221_W228_K0.5371.00
89_F92_R0.5371.00
241_R245_D0.5361.00
265_S295_S0.5351.00
119_A122_G0.5321.00
54_A57_F0.5321.00
336_K374_G0.5311.00
201_H206_H0.5301.00
310_N350_G0.5301.00
146_I152_A0.5301.00
39_A42_A0.5291.00
197_A200_I0.5291.00
217_L220_E0.5291.00
60_I63_A0.5291.00
306_E353_N0.5291.00
54_A58_C0.5271.00
358_A361_H0.5251.00
326_C330_S0.5241.00
120_M123_N0.5241.00
206_H251_V0.5221.00
266_L322_I0.5201.00
340_K375_F0.5201.00
139_C143_G0.5191.00
302_R357_R0.5181.00
139_C147_R0.5181.00
243_A248_R0.5171.00
279_V320_C0.5161.00
92_R95_P0.5161.00
248_R251_V0.5151.00
135_F138_F0.5141.00
152_A155_T0.5131.00
96_K100_W0.5121.00
45_H48_L0.5111.00
66_F70_F0.5111.00
265_S300_L0.5101.00
36_A43_A0.5101.00
214_Q221_W0.5091.00
127_I130_L0.5091.00
185_E189_A0.5091.00
326_C331_I0.5091.00
73_P77_L0.5081.00
206_H213_V0.5081.00
94_F97_R0.5081.00
279_V317_A0.5071.00
175_Q178_H0.5071.00
332_S366_R0.5061.00
201_H306_E0.5061.00
42_A45_H0.5051.00
199_E250_S0.5051.00
203_T206_H0.5041.00
227_Q231_E0.5041.00
41_Y44_N0.5021.00
81_M84_P0.5021.00
208_M247_V0.5011.00
127_I131_T0.5011.00
196_M201_H0.5001.00
173_A178_H0.5001.00
193_R314_H0.5001.00
207_K239_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4i5sA 2 0.6725 100 0.428 Contact Map
4bixA 2 0.515 100 0.451 Contact Map
3ehhA 2 0.485 100 0.463 Contact Map
4r39A 1 0.5025 100 0.465 Contact Map
4ctiA 2 0.5275 100 0.467 Contact Map
2c2aA 2 0.5275 100 0.474 Contact Map
4q20A 2 0.51 100 0.478 Contact Map
3d36A 2 0.4925 100 0.478 Contact Map
3jz3A 2 0.375 100 0.49 Contact Map
4e01A 3 0.645 100 0.492 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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