GREMLIN Database
YFII - Uncharacterized oxidoreductase YfiI
UniProt: P94437 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 393 (321)
Sequences: 24110 (17773)
Seq/√Len: 992.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
74_Q105_A3.0021.00
14_R42_Q2.7971.00
104_K132_L2.7931.00
147_S215_Y2.7931.00
228_E252_H2.7661.00
154_Q157_A2.7031.00
127_Q370_I2.6921.00
166_D281_S2.6781.00
100_Y128_E2.6711.00
52_A56_K2.6711.00
108_E132_L2.5091.00
227_K254_E2.4911.00
156_R160_E2.4071.00
104_K128_E2.3461.00
16_A76_M2.3241.00
100_Y125_E2.2891.00
104_K108_E2.2651.00
112_H139_I2.2641.00
249_V379_C2.2641.00
107_L138_K2.2581.00
94_T102_I2.2541.00
72_N75_T2.1951.00
381_R385_Q2.1601.00
131_A135_K2.1311.00
45_A70_Y2.0961.00
134_E367_D2.0721.00
157_A161_Q2.0701.00
12_P42_Q2.0431.00
98_T102_I2.0251.00
56_K60_V1.9751.00
345_I349_A1.9691.00
127_Q374_R1.9591.00
40_A348_D1.9441.00
89_V343_F1.9251.00
127_Q131_A1.9061.00
100_Y104_K1.8961.00
103_C115_C1.8861.00
107_L133_A1.8851.00
154_Q158_M1.8731.00
68_R84_Q1.8691.00
164_I280_G1.8301.00
132_L136_K1.8061.00
16_A87_I1.7761.00
94_T98_T1.7701.00
101_E105_A1.7611.00
37_D40_A1.7321.00
112_H138_K1.7031.00
51_D54_R1.6961.00
108_E136_K1.6941.00
71_P75_T1.6891.00
34_A91_S1.6801.00
123_S377_E1.6791.00
15_W89_V1.6781.00
87_I111_V1.6731.00
253_Y259_G1.6681.00
90_V106_A1.6331.00
122_T125_E1.6301.00
155_M285_I1.6121.00
103_C129_I1.6051.00
140_V366_I1.6001.00
37_D341_L1.5951.00
41_F344_A1.5841.00
108_E135_K1.5741.00
227_K252_H1.5581.00
139_I350_K1.5581.00
77_F106_A1.5461.00
64_V67_E1.5461.00
78_A109_A1.5351.00
73_Y105_A1.4671.00
371_E374_R1.4621.00
158_M163_M1.4601.00
225_K371_E1.4461.00
233_R383_A1.4461.00
57_D61_N1.4431.00
143_T339_I1.4411.00
130_K370_I1.4411.00
121_F125_E1.4401.00
130_K366_I1.4401.00
156_R219_L1.4371.00
218_Q225_K1.4211.00
100_Y129_I1.4181.00
168_R281_S1.4161.00
225_K254_E1.4131.00
28_Y61_N1.4061.00
75_T78_A1.4031.00
74_Q78_A1.3811.00
55_G69_C1.3661.00
171_D277_R1.3551.00
221_M257_A1.3491.00
70_Y76_M1.3461.00
132_L135_K1.3361.00
70_Y84_Q1.3351.00
107_L136_K1.3331.00
120_F129_I1.3311.00
105_A108_E1.3231.00
345_I351_N1.3221.00
14_R44_T1.3221.00
52_A71_P1.3211.00
14_R88_E1.3121.00
164_I283_A1.3081.00
47_A73_Y1.3041.00
167_I278_I1.3011.00
126_G370_I1.2961.00
20_G46_G1.2931.00
342_K346_A1.2851.00
105_A109_A1.2851.00
226_I253_Y1.2641.00
120_F126_G1.2481.00
214_Y375_W1.2351.00
218_Q371_E1.2341.00
232_D252_H1.2321.00
92_I102_I1.2231.00
85_D111_V1.2231.00
123_S374_R1.2211.00
218_Q253_Y1.2201.00
123_S127_Q1.2181.00
128_E131_A1.2111.00
47_A76_M1.2091.00
277_R286_E1.2011.00
106_A113_V1.1991.00
342_K363_Y1.1971.00
53_E56_K1.1901.00
27_G32_I1.1881.00
86_G111_V1.1871.00
76_M87_I1.1641.00
73_Y102_I1.1621.00
381_R384_N1.1611.00
92_I103_C1.1541.00
365_D368_A1.1461.00
158_M161_Q1.1461.00
59_G69_C1.1461.00
45_A76_M1.1411.00
107_L132_L1.1391.00
112_H350_K1.1391.00
341_L345_I1.1381.00
130_K367_D1.1291.00
57_D60_V1.1291.00
131_A134_E1.1251.00
95_P98_T1.1101.00
110_G136_K1.1051.00
119_L126_G1.0961.00
97_G199_I1.0951.00
40_A341_L1.0941.00
126_G373_I1.0881.00
128_E132_L1.0791.00
342_K351_N1.0751.00
15_W41_F1.0731.00
40_A345_I1.0701.00
170_V221_M1.0691.00
164_I285_I1.0681.00
275_R286_E1.0651.00
378_N381_R1.0611.00
171_D262_W1.0581.00
13_L89_V1.0541.00
104_K129_I1.0481.00
77_F109_A1.0441.00
152_L219_L1.0431.00
164_I167_I1.0431.00
73_Y77_F1.0431.00
377_E381_R1.0351.00
218_Q368_A1.0321.00
217_S259_G1.0301.00
36_R337_A1.0301.00
230_L250_L1.0291.00
77_F105_A1.0271.00
13_L347_I1.0241.00
84_Q111_V1.0221.00
196_D199_I1.0171.00
18_V102_I1.0161.00
125_E128_E1.0151.00
30_H91_S1.0111.00
344_A348_D1.0041.00
63_G67_E1.0021.00
157_A160_E1.0011.00
45_A87_I0.9961.00
112_H347_I0.9941.00
170_V259_G0.9861.00
226_I251_M0.9861.00
148_G342_K0.9851.00
167_I221_M0.9821.00
32_I61_N0.9761.00
129_I140_V0.9751.00
55_G71_P0.9751.00
115_C140_V0.9731.00
124_A127_Q0.9671.00
84_Q87_I0.9651.00
120_F125_E0.9651.00
147_S368_A0.9561.00
114_I143_T0.9561.00
361_L365_D0.9481.00
153_L363_Y0.9461.00
130_K134_E0.9461.00
54_R57_D0.9411.00
342_K345_I0.9371.00
53_E57_D0.9361.00
13_L348_D0.9311.00
155_M287_W0.9301.00
32_I36_R0.9301.00
114_I339_I0.9291.00
119_L366_I0.9251.00
133_A136_K0.9141.00
70_Y75_T0.9131.00
102_I105_A0.9131.00
56_K69_C0.9131.00
124_A128_E0.9111.00
12_P40_A0.9101.00
337_A341_L0.9081.00
103_C113_V0.9081.00
167_I280_G0.9081.00
46_G58_F0.9081.00
170_V278_I0.8991.00
338_N341_L0.8991.00
123_S370_I0.8981.00
145_G335_A0.8911.00
20_G49_D0.8791.00
107_L113_V0.8781.00
119_L140_V0.8771.00
52_A55_G0.8751.00
345_I350_K0.8741.00
232_D258_V0.8731.00
75_T84_Q0.8691.00
141_G343_F0.8661.00
92_I106_A0.8641.00
68_R86_G0.8611.00
14_R87_I0.8601.00
165_G280_G0.8571.00
286_E296_T0.8571.00
55_G59_G0.8571.00
139_I347_I0.8551.00
16_A45_A0.8521.00
115_C119_L0.8441.00
197_P242_P0.8431.00
367_D371_E0.8431.00
103_C107_L0.8401.00
214_Y376_I0.8401.00
15_W34_A0.8391.00
34_A41_F0.8391.00
100_Y120_F0.8391.00
226_I375_W0.8381.00
98_T101_E0.8361.00
56_K59_G0.8321.00
52_A69_C0.8321.00
96_N208_D0.8271.00
231_C379_C0.8271.00
346_A349_A0.8251.00
248_H260_T0.8231.00
49_D55_G0.8201.00
17_M31_R0.8171.00
49_D54_R0.8111.00
133_A140_V0.8081.00
380_V384_N0.8081.00
226_I254_E0.8071.00
171_D260_T0.8071.00
172_L276_I0.8061.00
18_V73_Y0.8061.00
44_T68_R0.8031.00
196_D242_P0.8031.00
230_L382_S0.8021.00
127_Q130_K0.8001.00
204_F244_E0.8001.00
37_D41_F0.7961.00
346_A351_N0.7961.00
44_T86_G0.7951.00
115_C129_I0.7941.00
59_G64_V0.7931.00
165_G283_A0.7921.00
16_A47_A0.7901.00
91_S340_Y0.7901.00
173_Q275_R0.7881.00
346_A362_V0.7861.00
153_L157_A0.7841.00
378_N382_S0.7821.00
170_V217_S0.7791.00
299_V302_E0.7741.00
228_E386_G0.7731.00
107_L140_V0.7721.00
34_A340_Y0.7701.00
351_N361_L0.7681.00
133_A366_I0.7661.00
277_R284_S0.7601.00
64_V68_R0.7591.00
159_I280_G0.7551.00
44_T87_I0.7541.00
141_G346_A0.7531.00
133_A138_K0.7521.00
26_V32_I0.7501.00
217_S253_Y0.7451.00
31_R43_L0.7451.00
244_E380_V0.7441.00
342_K362_V0.7431.00
44_T84_Q0.7431.00
30_H340_Y0.7421.00
250_L258_V0.7411.00
139_I346_A0.7411.00
205_V263_T0.7401.00
166_D282_K0.7391.00
374_R378_N0.7371.00
251_M259_G0.7341.00
210_S263_T0.7301.00
126_G130_K0.7301.00
218_Q372_G0.7281.00
115_C142_V0.7271.00
100_Y132_L0.7251.00
18_V94_T0.7241.00
343_F347_I0.7231.00
89_V112_H0.7221.00
166_D255_N0.7221.00
58_F61_N0.7211.00
197_P384_N0.7181.00
163_M299_V0.7151.00
172_L213_T0.7141.00
173_Q262_W0.7111.00
228_E232_D0.7081.00
336_W339_I0.7081.00
373_I377_E0.7061.00
211_T372_G0.7051.00
370_I374_R0.7041.00
275_R288_W0.7031.00
221_M253_Y0.7031.00
208_D265_S0.7001.00
119_L142_V0.6981.00
104_K107_L0.6971.00
206_L376_I0.6971.00
160_E222_P0.6961.00
232_D250_L0.6951.00
18_V47_A0.6951.00
142_V369_G0.6951.00
20_G55_G0.6921.00
40_A344_A0.6871.00
111_V138_K0.6871.00
282_K300_Q0.6861.00
159_I278_I0.6851.00
16_A90_V0.6801.00
51_D56_K0.6801.00
139_I361_L0.6791.00
175_T262_W0.6781.00
144_Y211_T0.6761.00
107_L129_I0.6721.00
279_V284_S0.6701.00
212_H215_Y0.6681.00
101_E128_E0.6651.00
169_V258_V0.6631.00
147_S219_L0.6631.00
220_I278_I0.6621.00
299_V303_P0.6601.00
70_Y85_D0.6601.00
234_Q252_H0.6591.00
42_Q67_E0.6571.00
14_R86_G0.6561.00
99_H115_C0.6511.00
15_W344_A0.6511.00
146_F149_N0.6501.00
152_L216_M0.6481.00
110_G138_K0.6471.00
73_Y106_A0.6461.00
366_I369_G0.6461.00
26_V30_H0.6431.00
253_Y257_A0.6381.00
351_N362_V0.6371.00
252_H258_V0.6371.00
174_Y209_L0.6351.00
245_D266_I0.6351.00
20_G58_F0.6341.00
218_Q375_W0.6341.00
90_V111_V0.6321.00
159_I220_I0.6321.00
206_L247_A0.6301.00
172_L217_S0.6291.00
368_A371_E0.6281.00
299_V304_G0.6281.00
46_G69_C0.6281.00
27_G58_F0.6281.00
210_S213_T0.6281.00
89_V347_I0.6221.00
144_Y215_Y0.6211.00
231_C249_V0.6201.00
15_W91_S0.6191.00
76_M84_Q0.6151.00
114_I141_G0.6151.00
215_Y372_G0.6141.00
167_I257_A0.6131.00
264_S267_N0.6121.00
153_L338_N0.6111.00
58_F62_L0.6091.00
295_L298_E0.6091.00
144_Y372_G0.6091.00
31_R58_F0.6081.00
236_F245_D0.6071.00
121_F200_A0.6071.00
225_K374_R0.6061.00
145_G336_W0.6051.00
231_C247_A0.6051.00
193_W196_D0.6041.00
27_G31_R0.6011.00
215_Y219_L0.6001.00
249_V261_M0.5971.00
155_M220_I0.5931.00
251_M261_M0.5921.00
74_Q101_E0.5911.00
156_R220_I0.5841.00
91_S114_I0.5831.00
372_G376_I0.5831.00
381_R387_S0.5811.00
214_Y379_C0.5791.00
78_A85_D0.5741.00
299_V305_Q0.5731.00
59_G67_E0.5721.00
41_F89_V0.5711.00
103_C140_V0.5691.00
141_G342_K0.5681.00
108_E128_E0.5661.00
117_K212_H0.5661.00
28_Y32_I0.5651.00
230_L252_H0.5651.00
27_G61_N0.5631.00
230_L387_S0.5621.00
345_I348_D0.5621.00
122_T377_E0.5621.00
162_G280_G0.5601.00
237_V245_D0.5581.00
163_M166_D0.5571.00
250_L260_T0.5541.00
233_R247_A0.5531.00
27_G93_A0.5521.00
130_K133_A0.5521.00
12_P348_D0.5511.00
31_R35_L0.5511.00
117_K208_D0.5511.00
30_H34_A0.5511.00
47_A70_Y0.5491.00
162_G166_D0.5481.00
139_I343_F0.5461.00
116_E143_T0.5461.00
124_A377_E0.5441.00
37_D337_A0.5431.00
46_G55_G0.5421.00
119_L129_I0.5411.00
246_N264_S0.5411.00
141_G339_I0.5401.00
101_E104_K0.5401.00
103_C133_A0.5401.00
207_G377_E0.5391.00
229_L375_W0.5391.00
206_L249_V0.5381.00
302_E305_Q0.5381.00
92_I99_H0.5371.00
45_A68_R0.5371.00
78_A84_Q0.5371.00
148_G364_P0.5371.00
217_S261_M0.5351.00
376_I380_V0.5331.00
142_V212_H0.5331.00
30_H93_A0.5311.00
169_V279_V0.5301.00
17_M43_L0.5291.00
251_M375_W0.5281.00
104_K136_K0.5281.00
18_V92_I0.5281.00
50_I94_T0.5281.00
26_V93_A0.5271.00
37_D344_A0.5261.00
139_I362_V0.5231.00
13_L344_A0.5191.00
18_V90_V0.5191.00
38_N41_F0.5181.00
362_V365_D0.5181.00
176_H209_L0.5171.00
21_G93_A0.5171.00
169_V260_T0.5171.00
88_E348_D0.5151.00
231_C383_A0.5141.00
97_G121_F0.5111.00
92_I113_V0.5101.00
194_R208_D0.5101.00
169_V246_N0.5091.00
170_V276_I0.5091.00
146_F215_Y0.5051.00
334_E337_A0.5041.00
146_F152_L0.5041.00
126_G369_G0.5021.00
54_R58_F0.5001.00
156_R159_I0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dtyA 4 0.8957 100 0.18 Contact Map
3v5nA 4 0.8753 100 0.2 Contact Map
1h6dA 8 0.8753 100 0.222 Contact Map
2nvwA 3 0.8957 100 0.23 Contact Map
4gqaA 4 0.9008 100 0.242 Contact Map
1zh8A 2 0.8142 100 0.242 Contact Map
3btvA 2 0.8728 100 0.244 Contact Map
4fb5A 4 0.8906 100 0.252 Contact Map
3db2A 2 0.8677 100 0.254 Contact Map
3q2iA 4 0.8677 100 0.254 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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