GREMLIN Database
GABD - Succinate-semialdehyde dehydrogenase [NADP(+)]
UniProt: P94428 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 462 (450)
Sequences: 36194 (21860)
Seq/√Len: 1030.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
276_E378_S5.1201.00
220_K224_D3.5731.00
276_E376_T3.1991.00
248_D285_K3.1511.00
279_K376_T2.9621.00
336_T349_N2.7971.00
243_E275_H2.7821.00
357_D360_M2.7501.00
35_H202_K2.7481.00
6_T18_T2.7241.00
311_K315_E2.6301.00
252_E289_Q2.5991.00
168_E171_R2.5611.00
323_D361_N2.5561.00
283_A374_I2.5361.00
322_D326_E2.5041.00
243_E277_S2.4401.00
61_V94_E2.4271.00
63_H66_E2.4051.00
400_T406_G2.3251.00
321_I348_V2.3101.00
35_H204_R2.2521.00
6_T15_E2.2211.00
23_S26_E2.1941.00
174_Y180_K2.1911.00
318_V322_D2.1451.00
64_K87_L2.1441.00
56_W173_A2.1391.00
59_L175_E2.0681.00
380_I405_R2.0621.00
318_V337_Y2.0241.00
330_K355_D2.0151.00
391_P437_E2.0151.00
161_D310_N1.9891.00
122_Q456_K1.9851.00
308_I317_I1.9641.00
323_D327_K1.9641.00
287_S291_S1.9481.00
408_Y412_N1.9211.00
239_L254_A1.9211.00
121_R450_E1.9151.00
318_V348_V1.9071.00
66_E168_E1.9051.00
325_V331_V1.8931.00
332_I354_T1.8891.00
281_E285_K1.8821.00
195_N199_S1.8811.00
52_L178_I1.8801.00
244_D405_R1.8471.00
199_S221_N1.8471.00
217_I220_K1.8201.00
273_I386_L1.7971.00
216_K437_E1.7741.00
65_E83_V1.7701.00
32_E202_K1.7651.00
63_H175_E1.7601.00
121_R453_L1.7591.00
380_I408_Y1.7521.00
59_L62_E1.7351.00
414_E436_K1.7341.00
28_E196_V1.7211.00
363_M375_V1.7091.00
353_L362_I1.7041.00
273_I383_A1.6891.00
275_H377_F1.6841.00
59_L176_A1.6741.00
28_E32_E1.6711.00
290_V352_V1.6511.00
358_T386_L1.6441.00
59_L172_L1.6431.00
287_S332_I1.6321.00
54_K94_E1.6231.00
15_E18_T1.6221.00
170_A185_V1.6211.00
330_K354_T1.6161.00
382_E385_Q1.6151.00
70_L168_E1.6151.00
254_A282_F1.6001.00
279_K283_A1.5771.00
259_Y290_V1.5741.00
189_D192_E1.5701.00
378_S382_E1.5701.00
93_I145_A1.5681.00
284_A288_E1.5601.00
361_N365_E1.5541.00
61_V90_A1.5481.00
38_F42_S1.5451.00
45_S48_E1.5391.00
247_I285_K1.5371.00
153_T182_V1.5321.00
58_E62_E1.5321.00
319_S361_N1.5091.00
272_L372_A1.5031.00
311_K346_Y1.5021.00
285_K288_E1.4931.00
280_D376_T1.4911.00
28_E200_S1.4881.00
331_V353_L1.4751.00
251_V285_K1.4671.00
55_K58_E1.4571.00
171_R175_E1.4541.00
14_E344_G1.4521.00
273_I377_F1.4451.00
242_D405_R1.4451.00
243_E405_R1.4441.00
48_E51_S1.4441.00
54_K101_K1.4441.00
279_K354_T1.4371.00
381_D412_N1.4331.00
13_G344_G1.4331.00
253_Q399_F1.4311.00
69_D73_K1.4181.00
254_A272_L1.4131.00
43_K412_N1.4101.00
396_A415_Y1.4091.00
65_E69_D1.4011.00
289_Q292_K1.3941.00
281_E284_A1.3931.00
274_V282_F1.3891.00
57_Y94_E1.3861.00
294_K302_G1.3781.00
99_E102_R1.3781.00
382_E386_L1.3771.00
58_E94_E1.3771.00
44_T48_E1.3671.00
26_E29_E1.3671.00
120_T411_E1.3651.00
93_I141_T1.3651.00
322_D325_V1.3651.00
129_A154_F1.3551.00
8_Y15_E1.3491.00
219_M440_I1.3491.00
63_H168_E1.3471.00
320_Q367_T1.3261.00
317_I369_G1.3231.00
72_T82_A1.3211.00
69_D299_L1.3181.00
242_D377_F1.3141.00
205_K230_S1.3031.00
140_I156_I1.2911.00
314_F348_V1.2881.00
315_E319_S1.2821.00
377_F386_L1.2751.00
280_D284_A1.2691.00
314_F318_V1.2661.00
327_K361_N1.2631.00
38_F153_T1.2631.00
9_N12_T1.2601.00
170_A183_L1.2591.00
314_F337_Y1.2561.00
291_S333_A1.2551.00
379_D382_E1.2511.00
288_E291_S1.2491.00
242_D409_I1.2431.00
283_A287_S1.2331.00
384_I409_I1.2201.00
294_K304_N1.2131.00
79_Y83_V1.2121.00
57_Y61_V1.2071.00
240_I383_A1.2061.00
311_K314_F1.2061.00
275_H379_D1.1991.00
173_A183_L1.1921.00
31_I200_S1.1871.00
31_I202_K1.1791.00
67_L168_E1.1781.00
275_H278_I1.1761.00
447_E450_E1.1761.00
288_E292_K1.1751.00
359_S364_H1.1751.00
278_I281_E1.1751.00
118_V407_I1.1751.00
181_D184_Q1.1741.00
121_R455_T1.1671.00
32_E36_Q1.1591.00
286_L372_A1.1551.00
72_T298_G1.1521.00
446_S450_E1.1491.00
69_D79_Y1.1481.00
285_K289_Q1.1471.00
329_A353_L1.1401.00
44_T52_L1.1391.00
282_F286_L1.1361.00
324_A353_L1.1351.00
319_S323_D1.1341.00
296_G303_V1.1341.00
396_A418_I1.1311.00
160_P189_D1.1291.00
410_S458_L1.1221.00
31_I203_I1.1181.00
33_R184_Q1.1181.00
56_W172_L1.1181.00
283_A354_T1.1171.00
160_P191_E1.1161.00
283_A332_I1.1161.00
381_D408_Y1.1141.00
358_T389_D1.1101.00
195_N221_N1.1091.00
55_K59_L1.1061.00
195_N217_I1.1031.00
27_V193_I1.1021.00
21_Q189_D1.0991.00
217_I221_N1.0981.00
144_A183_L1.0981.00
56_W178_I1.0971.00
406_G420_W1.0961.00
364_H391_P1.0931.00
17_K164_L1.0911.00
364_H389_D1.0891.00
124_V205_K1.0881.00
214_V217_I1.0841.00
54_K98_E1.0841.00
339_R343_K1.0831.00
433_G442_R1.0801.00
9_N297_N1.0801.00
213_P217_I1.0791.00
293_L305_V1.0761.00
129_A207_T1.0761.00
167_Y187_I1.0721.00
442_R454_E1.0701.00
56_W93_I1.0701.00
239_L269_A1.0671.00
64_K83_V1.0641.00
24_A196_V1.0631.00
106_R446_S1.0621.00
381_D385_Q1.0551.00
219_M229_V1.0501.00
380_I409_I1.0501.00
287_S333_A1.0481.00
384_I412_N1.0441.00
135_F265_T1.0431.00
196_V200_S1.0421.00
338_D349_N1.0421.00
334_G351_T1.0381.00
291_S349_N1.0381.00
240_I409_I1.0371.00
144_A154_F1.0371.00
246_D401_E1.0351.00
106_R447_E1.0351.00
240_I387_A1.0321.00
447_E455_T1.0311.00
128_A203_I1.0291.00
11_A298_G1.0191.00
236_H270_N1.0151.00
402_N405_R1.0111.00
67_L172_L1.0091.00
334_G349_N1.0061.00
314_F346_Y1.0041.00
377_F383_A0.9991.00
63_H172_L0.9961.00
327_K360_M0.9931.00
40_T44_T0.9931.00
297_N300_E0.9891.00
21_Q192_E0.9821.00
62_E175_E0.9801.00
13_G346_Y0.9781.00
216_K226_V0.9781.00
37_A153_T0.9771.00
246_D249_L0.9741.00
160_P190_G0.9731.00
317_I371_V0.9731.00
50_T101_K0.9711.00
238_P396_A0.9711.00
39_K385_Q0.9701.00
89_G141_T0.9671.00
120_T458_L0.9631.00
167_Y185_V0.9621.00
39_K414_E0.9601.00
435_M454_E0.9541.00
219_M223_A0.9481.00
63_H171_R0.9481.00
126_P153_T0.9431.00
356_V360_M0.9411.00
323_D326_E0.9391.00
35_H39_K0.9371.00
124_V228_H0.9371.00
9_N73_K0.9351.00
171_R174_Y0.9331.00
397_Y423_G0.9321.00
249_L253_Q0.9301.00
66_E69_D0.9281.00
100_A149_A0.9261.00
248_D281_E0.9241.00
385_Q389_D0.9231.00
117_I430_A0.9231.00
24_A192_E0.9231.00
320_Q323_D0.9221.00
255_M289_Q0.9221.00
128_A197_F0.9171.00
257_S269_A0.9161.00
54_K97_A0.9121.00
73_K299_L0.9051.00
258_K270_N0.9001.00
204_R414_E0.8991.00
24_A28_E0.8981.00
77_K85_E0.8971.00
280_D283_A0.8961.00
89_G137_N0.8951.00
39_K43_K0.8941.00
242_D380_I0.8881.00
279_K374_I0.8881.00
122_Q411_E0.8881.00
122_Q435_M0.8871.00
239_L399_F0.8861.00
127_V205_K0.8861.00
211_S214_V0.8861.00
199_S224_D0.8861.00
126_P203_I0.8851.00
251_V286_L0.8831.00
51_S55_K0.8821.00
247_I251_V0.8821.00
75_N162_T0.8791.00
320_Q361_N0.8771.00
143_K443_E0.8751.00
9_N14_E0.8731.00
50_T54_K0.8731.00
27_V128_A0.8721.00
42_S414_E0.8701.00
46_A50_T0.8691.00
59_L63_H0.8691.00
375_V386_L0.8681.00
228_H454_E0.8681.00
251_V289_Q0.8651.00
319_S322_D0.8651.00
317_I367_T0.8611.00
329_A360_M0.8591.00
216_K220_K0.8591.00
29_E33_R0.8581.00
407_I411_E0.8571.00
358_T375_V0.8551.00
60_I89_G0.8521.00
315_E318_V0.8491.00
430_A457_Y0.8491.00
161_D312_R0.8451.00
325_V353_L0.8411.00
57_Y97_A0.8391.00
242_D400_T0.8391.00
50_T97_A0.8381.00
219_M222_S0.8371.00
396_A413_L0.8341.00
403_Y406_G0.8321.00
8_Y346_Y0.8321.00
206_I222_S0.8311.00
383_A386_L0.8301.00
170_A174_Y0.8291.00
241_V282_F0.8271.00
43_K411_E0.8251.00
251_V282_F0.8241.00
206_I218_L0.8231.00
219_M226_V0.8221.00
377_F382_E0.8201.00
11_A347_F0.8201.00
398_F409_I0.8201.00
146_P448_G0.8181.00
124_V454_E0.8171.00
328_G360_M0.8171.00
33_R181_D0.8151.00
25_T29_E0.8151.00
384_I388_N0.8141.00
167_Y171_R0.8131.00
37_A182_V0.8121.00
124_V152_C0.8111.00
215_G233_L0.8111.00
250_A254_A0.8101.00
335_G351_T0.8081.00
22_Q26_E0.8071.00
147_A154_F0.8051.00
40_T43_K0.8031.00
156_I166_A0.8001.00
34_S184_Q0.7991.00
25_T28_E0.7991.00
284_A287_S0.7911.00
321_I371_V0.7891.00
29_E32_E0.7861.00
178_I183_L0.7831.00
150_A453_L0.7831.00
354_T376_T0.7831.00
237_A270_N0.7801.00
324_A367_T0.7791.00
415_Y418_I0.7771.00
216_K224_D0.7771.00
158_P187_I0.7771.00
16_I73_K0.7751.00
317_I348_V0.7741.00
36_Q39_K0.7701.00
140_I144_A0.7691.00
279_K355_D0.7681.00
215_G231_M0.7681.00
72_T79_Y0.7641.00
128_A206_I0.7621.00
80_Q304_N0.7611.00
250_A282_F0.7601.00
251_V255_M0.7601.00
54_K58_E0.7591.00
47_N101_K0.7581.00
208_F214_V0.7561.00
75_N309_I0.7551.00
60_I90_A0.7551.00
41_W182_V0.7541.00
68_A83_V0.7541.00
141_T169_L0.7541.00
53_L149_A0.7531.00
22_Q30_A0.7531.00
178_I182_V0.7431.00
193_I196_V0.7421.00
238_P387_A0.7411.00
286_L352_V0.7401.00
68_A72_T0.7401.00
188_G193_I0.7401.00
129_A143_K0.7391.00
339_R344_G0.7381.00
137_N165_S0.7341.00
198_T218_L0.7341.00
73_K164_L0.7321.00
290_V333_A0.7311.00
68_A79_Y0.7311.00
295_V338_D0.7301.00
312_R315_E0.7291.00
191_E195_N0.7291.00
222_S229_V0.7281.00
39_K42_S0.7261.00
61_V64_K0.7241.00
247_I278_I0.7231.00
255_M286_L0.7221.00
194_G198_T0.7211.00
212_T437_E0.7211.00
248_D289_Q0.7211.00
275_H380_I0.7211.00
274_V278_I0.7201.00
55_K176_A0.7181.00
79_Y299_L0.7161.00
320_Q365_E0.7121.00
293_L304_N0.7091.00
61_V87_L0.7081.00
83_V87_L0.7061.00
117_I457_Y0.7031.00
242_D275_H0.7021.00
198_T221_N0.6921.00
8_Y13_G0.6921.00
131_T140_I0.6901.00
300_E303_V0.6891.00
34_S153_T0.6891.00
152_C453_L0.6871.00
379_D385_Q0.6851.00
156_I183_L0.6841.00
401_E404_R0.6841.00
28_E202_K0.6831.00
287_S290_V0.6811.00
140_I166_A0.6811.00
41_W52_L0.6801.00
161_D309_I0.6791.00
124_V204_R0.6781.00
228_H451_P0.6781.00
27_V31_I0.6771.00
192_E195_N0.6761.00
190_G194_G0.6741.00
140_I169_L0.6741.00
410_S420_W0.6721.00
71_I74_E0.6721.00
290_V293_L0.6691.00
325_V336_T0.6691.00
13_G311_K0.6691.00
310_N313_G0.6671.00
273_I363_M0.6661.00
66_E171_R0.6661.00
311_K337_Y0.6661.00
35_H38_F0.6661.00
220_K223_A0.6641.00
358_T363_M0.6641.00
244_D400_T0.6631.00
70_L164_L0.6631.00
20_P187_I0.6621.00
272_L282_F0.6601.00
128_A194_G0.6601.00
27_V196_V0.6581.00
46_A100_A0.6571.00
348_V351_T0.6561.00
37_A40_T0.6551.00
273_I358_T0.6551.00
262_A305_V0.6531.00
67_L137_N0.6521.00
333_A352_V0.6521.00
254_A286_L0.6511.00
58_E61_V0.6491.00
116_R407_I0.6491.00
221_N224_D0.6491.00
313_G316_K0.6491.00
77_K81_E0.6471.00
380_I384_I0.6461.00
42_S123_P0.6461.00
52_L176_A0.6451.00
57_Y90_A0.6451.00
316_K319_S0.6441.00
65_E79_Y0.6441.00
255_M293_L0.6441.00
297_N303_V0.6431.00
403_Y407_I0.6431.00
155_I184_Q0.6421.00
33_R180_K0.6421.00
160_P316_K0.6411.00
9_N299_L0.6401.00
286_L374_I0.6401.00
230_S451_P0.6391.00
241_V250_A0.6381.00
42_S412_N0.6381.00
386_L389_D0.6381.00
318_V321_I0.6361.00
120_T456_K0.6351.00
321_I353_L0.6351.00
168_E172_L0.6341.00
41_W148_L0.6321.00
103_V453_L0.6301.00
314_F338_D0.6301.00
450_E455_T0.6301.00
143_K207_T0.6301.00
173_A178_I0.6291.00
414_E435_M0.6281.00
48_E52_L0.6281.00
327_K359_S0.6271.00
400_T405_R0.6261.00
22_Q186_V0.6251.00
295_V305_V0.6251.00
86_V90_A0.6241.00
77_K135_F0.6211.00
39_K412_N0.6211.00
247_I281_E0.6201.00
117_I459_S0.6161.00
42_S122_Q0.6161.00
72_T299_L0.6161.00
356_V363_M0.6151.00
312_R316_K0.6151.00
188_G194_G0.6131.00
19_I163_P0.6131.00
198_T206_I0.6121.00
160_P217_I0.6121.00
64_K68_A0.6121.00
118_V458_L0.6121.00
450_E453_L0.6111.00
7_V17_K0.6101.00
46_A149_A0.6091.00
406_G410_S0.6081.00
356_V362_I0.6081.00
249_L252_E0.6071.00
30_A186_V0.6071.00
244_D402_N0.6061.00
32_E35_H0.6051.00
71_I85_E0.6041.00
52_L177_G0.6031.00
335_G349_N0.6031.00
338_D343_K0.6021.00
144_A156_I0.6021.00
249_L401_E0.5991.00
71_I82_A0.5981.00
71_I165_S0.5971.00
219_M231_M0.5951.00
153_T184_Q0.5941.00
244_D401_E0.5941.00
308_I313_G0.5941.00
103_V449_I0.5931.00
137_N169_L0.5931.00
69_D72_T0.5921.00
404_R407_I0.5921.00
384_I408_Y0.5921.00
398_F406_G0.5911.00
367_T371_V0.5891.00
353_L356_V0.5881.00
191_E217_I0.5881.00
24_A195_N0.5871.00
60_I137_N0.5871.00
274_V374_I0.5861.00
331_V334_G0.5851.00
331_V351_T0.5831.00
60_I93_I0.5801.00
127_V152_C0.5801.00
60_I169_L0.5791.00
7_V74_E0.5781.00
59_L177_G0.5771.00
295_V304_N0.5761.00
239_L272_L0.5761.00
337_Y349_N0.5761.00
16_I164_L0.5741.00
358_T385_Q0.5731.00
205_K451_P0.5721.00
257_S423_G0.5711.00
265_T268_C0.5701.00
267_V427_A0.5661.00
384_I413_L0.5661.00
398_F420_W0.5641.00
387_A413_L0.5631.00
95_W99_E0.5631.00
355_D376_T0.5621.00
36_Q40_T0.5621.00
57_Y93_I0.5601.00
258_K372_A0.5601.00
83_V301_E0.5601.00
321_I351_T0.5601.00
404_R408_Y0.5601.00
287_S352_V0.5581.00
212_T216_K0.5581.00
86_V137_N0.5571.00
67_L86_V0.5551.00
195_N198_T0.5551.00
24_A199_S0.5541.00
34_S155_I0.5541.00
247_I282_F0.5511.00
56_W59_L0.5501.00
46_A104_Y0.5491.00
417_I426_S0.5491.00
248_D288_E0.5461.00
198_T225_T0.5461.00
169_L173_A0.5461.00
247_I250_A0.5461.00
239_L397_Y0.5451.00
60_I67_L0.5451.00
30_A184_Q0.5451.00
294_K300_E0.5451.00
419_G422_D0.5441.00
318_V325_V0.5441.00
243_E377_F0.5431.00
138_A142_R0.5431.00
245_A250_A0.5421.00
383_A387_A0.5421.00
127_V154_F0.5421.00
362_I367_T0.5411.00
274_V279_K0.5411.00
33_R37_A0.5401.00
129_A144_A0.5391.00
126_P204_R0.5381.00
68_A86_V0.5381.00
52_L56_W0.5371.00
418_I456_K0.5371.00
213_P312_R0.5371.00
237_A395_A0.5351.00
98_E101_K0.5341.00
276_E279_K0.5301.00
148_L183_L0.5301.00
207_T452_Y0.5291.00
272_L374_I0.5291.00
35_H126_P0.5291.00
99_E446_S0.5281.00
160_P213_P0.5281.00
150_A449_I0.5281.00
96_F146_P0.5271.00
34_S126_P0.5261.00
174_Y181_D0.5261.00
87_L90_A0.5251.00
409_I413_L0.5251.00
75_N261_N0.5251.00
7_V163_P0.5241.00
47_N51_S0.5221.00
88_Y138_A0.5221.00
259_Y293_L0.5221.00
269_A397_Y0.5211.00
229_V440_I0.5201.00
327_K357_D0.5201.00
380_I412_N0.5191.00
68_A82_A0.5191.00
85_E135_F0.5191.00
55_K177_G0.5191.00
308_I348_V0.5181.00
414_E454_E0.5181.00
332_I355_D0.5181.00
122_Q414_E0.5171.00
142_R444_G0.5171.00
251_V278_I0.5161.00
40_T153_T0.5161.00
19_I164_L0.5141.00
286_L290_V0.5131.00
64_K90_A0.5111.00
128_A155_I0.5081.00
192_E196_V0.5071.00
51_S54_K0.5061.00
21_Q160_P0.5061.00
22_Q27_V0.5001.00
92_Y444_G0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o5hA 4 0.9935 100 0.007 Contact Map
4yweA 5 0.9957 100 0.008 Contact Map
3ek1A 5 0.9892 100 0.009 Contact Map
4qf6A 4 0.9913 100 0.01 Contact Map
1a4sA 4 0.9957 100 0.011 Contact Map
4pxlA 4 0.9913 100 0.011 Contact Map
4qtoA 4 1 100 0.015 Contact Map
4lihA 5 0.9892 100 0.015 Contact Map
4pz2A 4 0.9957 100 0.016 Contact Map
3u4jA 4 0.9957 100 0.016 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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