GABD - BACSU - GREMLIN Contacts

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GABD - Succinate-semialdehyde dehydrogenase [NADP(+)]

UniProt:	P94428	Sequences: MPDQLTVYNPATGEEIKTIPQQSATEVEEAIERSHQAFKTWSKTSANERTSLLKKWYELIVEHKEELADLITKENGKPYQEAVGEVLYGAGYIEWFAEEAKRVYGRTVPAPTTGKRIVVTRQPVGPVAAITPWNFPNAMITRKAAPALAAGCTFIIKPAPDTPLSAYELARLAYEAGIPKDVLQVVIGDGEEIGNVFTSSPKIRKITFTGSTPVGKILMKNSADTVKHVSMELGGHAPLIVDEDADIDLAVEQAMASKYRNAGQTCVCANRLIVHESIKDEFAAKLSEQVSKLKVGNGLEEGVNVGPIINKRGFEKIVSQIDDAVEKGAKVIAGGTYDRNDDKGCYFVNPTVLTDVDTSMNIMHEETFGPVAPIVTFSDIDEAIQLANDTPYGLAAYFFTENYRRGIYISENLEYGIIGWNDGGPSAVQAPFGGMKESGIGREGGSEGIEPYLETKYLSIGL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	462 (450)
Sequences:	36194 (21860)
Seq/√Len:	1030.5

ECOLI - GABD PUUC BETB FEAB ALDA ABDH ALDB SAD ASTD EUTE PUTA PAAZ PROA ADHE
BACSU - GABD ALDH4 ROCA ROCA2 ALDH1 ALDH5 IOLA BETB ALDY ALDH3 ALDH2 PROA
HALSA - Q9HQZ2 Q9HMJ6 Q9HR91 Q9HRB5
SULSO - Q97XS9 Q97YT9 KGSDH Q97XA5 GAPN

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
276_E	378_S	5.120	1.00
220_K	224_D	3.573	1.00
276_E	376_T	3.199	1.00
248_D	285_K	3.151	1.00
279_K	376_T	2.962	1.00
336_T	349_N	2.797	1.00
243_E	275_H	2.782	1.00
357_D	360_M	2.750	1.00
35_H	202_K	2.748	1.00
6_T	18_T	2.724	1.00
311_K	315_E	2.630	1.00
252_E	289_Q	2.599	1.00
168_E	171_R	2.561	1.00
323_D	361_N	2.556	1.00
283_A	374_I	2.536	1.00
322_D	326_E	2.504	1.00
243_E	277_S	2.440	1.00
61_V	94_E	2.427	1.00
63_H	66_E	2.405	1.00
400_T	406_G	2.325	1.00
321_I	348_V	2.310	1.00
35_H	204_R	2.252	1.00
6_T	15_E	2.221	1.00
23_S	26_E	2.194	1.00
174_Y	180_K	2.191	1.00
318_V	322_D	2.145	1.00
64_K	87_L	2.144	1.00
56_W	173_A	2.139	1.00
59_L	175_E	2.068	1.00
380_I	405_R	2.062	1.00
318_V	337_Y	2.024	1.00
330_K	355_D	2.015	1.00
391_P	437_E	2.015	1.00
161_D	310_N	1.989	1.00
122_Q	456_K	1.985	1.00
308_I	317_I	1.964	1.00
323_D	327_K	1.964	1.00
287_S	291_S	1.948	1.00
408_Y	412_N	1.921	1.00
239_L	254_A	1.921	1.00
121_R	450_E	1.915	1.00
318_V	348_V	1.907	1.00
66_E	168_E	1.905	1.00
325_V	331_V	1.893	1.00
332_I	354_T	1.889	1.00
281_E	285_K	1.882	1.00
195_N	199_S	1.881	1.00
52_L	178_I	1.880	1.00
244_D	405_R	1.847	1.00
199_S	221_N	1.847	1.00
217_I	220_K	1.820	1.00
273_I	386_L	1.797	1.00
216_K	437_E	1.774	1.00
65_E	83_V	1.770	1.00
32_E	202_K	1.765	1.00
63_H	175_E	1.760	1.00
121_R	453_L	1.759	1.00
380_I	408_Y	1.752	1.00
59_L	62_E	1.735	1.00
414_E	436_K	1.734	1.00
28_E	196_V	1.721	1.00
363_M	375_V	1.709	1.00
353_L	362_I	1.704	1.00
273_I	383_A	1.689	1.00
275_H	377_F	1.684	1.00
59_L	176_A	1.674	1.00
28_E	32_E	1.671	1.00
290_V	352_V	1.651	1.00
358_T	386_L	1.644	1.00
59_L	172_L	1.643	1.00
287_S	332_I	1.632	1.00
54_K	94_E	1.623	1.00
15_E	18_T	1.622	1.00
170_A	185_V	1.621	1.00
330_K	354_T	1.616	1.00
382_E	385_Q	1.615	1.00
70_L	168_E	1.615	1.00
254_A	282_F	1.600	1.00
279_K	283_A	1.577	1.00
259_Y	290_V	1.574	1.00
189_D	192_E	1.570	1.00
378_S	382_E	1.570	1.00
93_I	145_A	1.568	1.00
284_A	288_E	1.560	1.00
361_N	365_E	1.554	1.00
61_V	90_A	1.548	1.00
38_F	42_S	1.545	1.00
45_S	48_E	1.539	1.00
247_I	285_K	1.537	1.00
153_T	182_V	1.532	1.00
58_E	62_E	1.532	1.00
319_S	361_N	1.509	1.00
272_L	372_A	1.503	1.00
311_K	346_Y	1.502	1.00
285_K	288_E	1.493	1.00
280_D	376_T	1.491	1.00
28_E	200_S	1.488	1.00
331_V	353_L	1.475	1.00
251_V	285_K	1.467	1.00
55_K	58_E	1.457	1.00
171_R	175_E	1.454	1.00
14_E	344_G	1.452	1.00
273_I	377_F	1.445	1.00
242_D	405_R	1.445	1.00
243_E	405_R	1.444	1.00
48_E	51_S	1.444	1.00
54_K	101_K	1.444	1.00
279_K	354_T	1.437	1.00
381_D	412_N	1.433	1.00
13_G	344_G	1.433	1.00
253_Q	399_F	1.431	1.00
69_D	73_K	1.418	1.00
254_A	272_L	1.413	1.00
43_K	412_N	1.410	1.00
396_A	415_Y	1.409	1.00
65_E	69_D	1.401	1.00
289_Q	292_K	1.394	1.00
281_E	284_A	1.393	1.00
274_V	282_F	1.389	1.00
57_Y	94_E	1.386	1.00
294_K	302_G	1.378	1.00
99_E	102_R	1.378	1.00
382_E	386_L	1.377	1.00
58_E	94_E	1.377	1.00
44_T	48_E	1.367	1.00
26_E	29_E	1.367	1.00
120_T	411_E	1.365	1.00
93_I	141_T	1.365	1.00
322_D	325_V	1.365	1.00
129_A	154_F	1.355	1.00
8_Y	15_E	1.349	1.00
219_M	440_I	1.349	1.00
63_H	168_E	1.347	1.00
320_Q	367_T	1.326	1.00
317_I	369_G	1.323	1.00
72_T	82_A	1.321	1.00
69_D	299_L	1.318	1.00
242_D	377_F	1.314	1.00
205_K	230_S	1.303	1.00
140_I	156_I	1.291	1.00
314_F	348_V	1.288	1.00
315_E	319_S	1.282	1.00
377_F	386_L	1.275	1.00
280_D	284_A	1.269	1.00
314_F	318_V	1.266	1.00
327_K	361_N	1.263	1.00
38_F	153_T	1.263	1.00
9_N	12_T	1.260	1.00
170_A	183_L	1.259	1.00
314_F	337_Y	1.256	1.00
291_S	333_A	1.255	1.00
379_D	382_E	1.251	1.00
288_E	291_S	1.249	1.00
242_D	409_I	1.243	1.00
283_A	287_S	1.233	1.00
384_I	409_I	1.220	1.00
294_K	304_N	1.213	1.00
79_Y	83_V	1.212	1.00
57_Y	61_V	1.207	1.00
240_I	383_A	1.206	1.00
311_K	314_F	1.206	1.00
275_H	379_D	1.199	1.00
173_A	183_L	1.192	1.00
31_I	200_S	1.187	1.00
31_I	202_K	1.179	1.00
67_L	168_E	1.178	1.00
275_H	278_I	1.176	1.00
447_E	450_E	1.176	1.00
288_E	292_K	1.175	1.00
359_S	364_H	1.175	1.00
278_I	281_E	1.175	1.00
118_V	407_I	1.175	1.00
181_D	184_Q	1.174	1.00
121_R	455_T	1.167	1.00
32_E	36_Q	1.159	1.00
286_L	372_A	1.155	1.00
72_T	298_G	1.152	1.00
446_S	450_E	1.149	1.00
69_D	79_Y	1.148	1.00
285_K	289_Q	1.147	1.00
329_A	353_L	1.140	1.00
44_T	52_L	1.139	1.00
282_F	286_L	1.136	1.00
324_A	353_L	1.135	1.00
319_S	323_D	1.134	1.00
296_G	303_V	1.134	1.00
396_A	418_I	1.131	1.00
160_P	189_D	1.129	1.00
410_S	458_L	1.122	1.00
31_I	203_I	1.118	1.00
33_R	184_Q	1.118	1.00
56_W	172_L	1.118	1.00
283_A	354_T	1.117	1.00
160_P	191_E	1.116	1.00
283_A	332_I	1.116	1.00
381_D	408_Y	1.114	1.00
358_T	389_D	1.110	1.00
195_N	221_N	1.109	1.00
55_K	59_L	1.106	1.00
195_N	217_I	1.103	1.00
27_V	193_I	1.102	1.00
21_Q	189_D	1.099	1.00
217_I	221_N	1.098	1.00
144_A	183_L	1.098	1.00
56_W	178_I	1.097	1.00
406_G	420_W	1.096	1.00
364_H	391_P	1.093	1.00
17_K	164_L	1.091	1.00
364_H	389_D	1.089	1.00
124_V	205_K	1.088	1.00
214_V	217_I	1.084	1.00
54_K	98_E	1.084	1.00
339_R	343_K	1.083	1.00
433_G	442_R	1.080	1.00
9_N	297_N	1.080	1.00
213_P	217_I	1.079	1.00
293_L	305_V	1.076	1.00
129_A	207_T	1.076	1.00
167_Y	187_I	1.072	1.00
442_R	454_E	1.070	1.00
56_W	93_I	1.070	1.00
239_L	269_A	1.067	1.00
64_K	83_V	1.064	1.00
24_A	196_V	1.063	1.00
106_R	446_S	1.062	1.00
381_D	385_Q	1.055	1.00
219_M	229_V	1.050	1.00
380_I	409_I	1.050	1.00
287_S	333_A	1.048	1.00
384_I	412_N	1.044	1.00
135_F	265_T	1.043	1.00
196_V	200_S	1.042	1.00
338_D	349_N	1.042	1.00
334_G	351_T	1.038	1.00
291_S	349_N	1.038	1.00
240_I	409_I	1.037	1.00
144_A	154_F	1.037	1.00
246_D	401_E	1.035	1.00
106_R	447_E	1.035	1.00
240_I	387_A	1.032	1.00
447_E	455_T	1.031	1.00
128_A	203_I	1.029	1.00
11_A	298_G	1.019	1.00
236_H	270_N	1.015	1.00
402_N	405_R	1.011	1.00
67_L	172_L	1.009	1.00
334_G	349_N	1.006	1.00
314_F	346_Y	1.004	1.00
377_F	383_A	0.999	1.00
63_H	172_L	0.996	1.00
327_K	360_M	0.993	1.00
40_T	44_T	0.993	1.00
297_N	300_E	0.989	1.00
21_Q	192_E	0.982	1.00
62_E	175_E	0.980	1.00
13_G	346_Y	0.978	1.00
216_K	226_V	0.978	1.00
37_A	153_T	0.977	1.00
246_D	249_L	0.974	1.00
160_P	190_G	0.973	1.00
317_I	371_V	0.973	1.00
50_T	101_K	0.971	1.00
238_P	396_A	0.971	1.00
39_K	385_Q	0.970	1.00
89_G	141_T	0.967	1.00
120_T	458_L	0.963	1.00
167_Y	185_V	0.962	1.00
39_K	414_E	0.960	1.00
435_M	454_E	0.954	1.00
219_M	223_A	0.948	1.00
63_H	171_R	0.948	1.00
126_P	153_T	0.943	1.00
356_V	360_M	0.941	1.00
323_D	326_E	0.939	1.00
35_H	39_K	0.937	1.00
124_V	228_H	0.937	1.00
9_N	73_K	0.935	1.00
171_R	174_Y	0.933	1.00
397_Y	423_G	0.932	1.00
249_L	253_Q	0.930	1.00
66_E	69_D	0.928	1.00
100_A	149_A	0.926	1.00
248_D	281_E	0.924	1.00
385_Q	389_D	0.923	1.00
117_I	430_A	0.923	1.00
24_A	192_E	0.923	1.00
320_Q	323_D	0.922	1.00
255_M	289_Q	0.922	1.00
128_A	197_F	0.917	1.00
257_S	269_A	0.916	1.00
54_K	97_A	0.912	1.00
73_K	299_L	0.905	1.00
258_K	270_N	0.900	1.00
204_R	414_E	0.899	1.00
24_A	28_E	0.898	1.00
77_K	85_E	0.897	1.00
280_D	283_A	0.896	1.00
89_G	137_N	0.895	1.00
39_K	43_K	0.894	1.00
242_D	380_I	0.888	1.00
279_K	374_I	0.888	1.00
122_Q	411_E	0.888	1.00
122_Q	435_M	0.887	1.00
239_L	399_F	0.886	1.00
127_V	205_K	0.886	1.00
211_S	214_V	0.886	1.00
199_S	224_D	0.886	1.00
126_P	203_I	0.885	1.00
251_V	286_L	0.883	1.00
51_S	55_K	0.882	1.00
247_I	251_V	0.882	1.00
75_N	162_T	0.879	1.00
320_Q	361_N	0.877	1.00
143_K	443_E	0.875	1.00
9_N	14_E	0.873	1.00
50_T	54_K	0.873	1.00
27_V	128_A	0.872	1.00
42_S	414_E	0.870	1.00
46_A	50_T	0.869	1.00
59_L	63_H	0.869	1.00
375_V	386_L	0.868	1.00
228_H	454_E	0.868	1.00
251_V	289_Q	0.865	1.00
319_S	322_D	0.865	1.00
317_I	367_T	0.861	1.00
329_A	360_M	0.859	1.00
216_K	220_K	0.859	1.00
29_E	33_R	0.858	1.00
407_I	411_E	0.857	1.00
358_T	375_V	0.855	1.00
60_I	89_G	0.852	1.00
315_E	318_V	0.849	1.00
430_A	457_Y	0.849	1.00
161_D	312_R	0.845	1.00
325_V	353_L	0.841	1.00
57_Y	97_A	0.839	1.00
242_D	400_T	0.839	1.00
50_T	97_A	0.838	1.00
219_M	222_S	0.837	1.00
396_A	413_L	0.834	1.00
403_Y	406_G	0.832	1.00
8_Y	346_Y	0.832	1.00
206_I	222_S	0.831	1.00
383_A	386_L	0.830	1.00
170_A	174_Y	0.829	1.00
241_V	282_F	0.827	1.00
43_K	411_E	0.825	1.00
251_V	282_F	0.824	1.00
206_I	218_L	0.823	1.00
219_M	226_V	0.822	1.00
377_F	382_E	0.820	1.00
11_A	347_F	0.820	1.00
398_F	409_I	0.820	1.00
146_P	448_G	0.818	1.00
124_V	454_E	0.817	1.00
328_G	360_M	0.817	1.00
33_R	181_D	0.815	1.00
25_T	29_E	0.815	1.00
384_I	388_N	0.814	1.00
167_Y	171_R	0.813	1.00
37_A	182_V	0.812	1.00
124_V	152_C	0.811	1.00
215_G	233_L	0.811	1.00
250_A	254_A	0.810	1.00
335_G	351_T	0.808	1.00
22_Q	26_E	0.807	1.00
147_A	154_F	0.805	1.00
40_T	43_K	0.803	1.00
156_I	166_A	0.800	1.00
34_S	184_Q	0.799	1.00
25_T	28_E	0.799	1.00
284_A	287_S	0.791	1.00
321_I	371_V	0.789	1.00
29_E	32_E	0.786	1.00
178_I	183_L	0.783	1.00
150_A	453_L	0.783	1.00
354_T	376_T	0.783	1.00
237_A	270_N	0.780	1.00
324_A	367_T	0.779	1.00
415_Y	418_I	0.777	1.00
216_K	224_D	0.777	1.00
158_P	187_I	0.777	1.00
16_I	73_K	0.775	1.00
317_I	348_V	0.774	1.00
36_Q	39_K	0.770	1.00
140_I	144_A	0.769	1.00
279_K	355_D	0.768	1.00
215_G	231_M	0.768	1.00
72_T	79_Y	0.764	1.00
128_A	206_I	0.762	1.00
80_Q	304_N	0.761	1.00
250_A	282_F	0.760	1.00
251_V	255_M	0.760	1.00
54_K	58_E	0.759	1.00
47_N	101_K	0.758	1.00
208_F	214_V	0.756	1.00
75_N	309_I	0.755	1.00
60_I	90_A	0.755	1.00
41_W	182_V	0.754	1.00
68_A	83_V	0.754	1.00
141_T	169_L	0.754	1.00
53_L	149_A	0.753	1.00
22_Q	30_A	0.753	1.00
178_I	182_V	0.743	1.00
193_I	196_V	0.742	1.00
238_P	387_A	0.741	1.00
286_L	352_V	0.740	1.00
68_A	72_T	0.740	1.00
188_G	193_I	0.740	1.00
129_A	143_K	0.739	1.00
339_R	344_G	0.738	1.00
137_N	165_S	0.734	1.00
198_T	218_L	0.734	1.00
73_K	164_L	0.732	1.00
290_V	333_A	0.731	1.00
68_A	79_Y	0.731	1.00
295_V	338_D	0.730	1.00
312_R	315_E	0.729	1.00
191_E	195_N	0.729	1.00
222_S	229_V	0.728	1.00
39_K	42_S	0.726	1.00
61_V	64_K	0.724	1.00
247_I	278_I	0.723	1.00
255_M	286_L	0.722	1.00
194_G	198_T	0.721	1.00
212_T	437_E	0.721	1.00
248_D	289_Q	0.721	1.00
275_H	380_I	0.721	1.00
274_V	278_I	0.720	1.00
55_K	176_A	0.718	1.00
79_Y	299_L	0.716	1.00
320_Q	365_E	0.712	1.00
293_L	304_N	0.709	1.00
61_V	87_L	0.708	1.00
83_V	87_L	0.706	1.00
117_I	457_Y	0.703	1.00
242_D	275_H	0.702	1.00
198_T	221_N	0.692	1.00
8_Y	13_G	0.692	1.00
131_T	140_I	0.690	1.00
300_E	303_V	0.689	1.00
34_S	153_T	0.689	1.00
152_C	453_L	0.687	1.00
379_D	385_Q	0.685	1.00
156_I	183_L	0.684	1.00
401_E	404_R	0.684	1.00
28_E	202_K	0.683	1.00
287_S	290_V	0.681	1.00
140_I	166_A	0.681	1.00
41_W	52_L	0.680	1.00
161_D	309_I	0.679	1.00
124_V	204_R	0.678	1.00
228_H	451_P	0.678	1.00
27_V	31_I	0.677	1.00
192_E	195_N	0.676	1.00
190_G	194_G	0.674	1.00
140_I	169_L	0.674	1.00
410_S	420_W	0.672	1.00
71_I	74_E	0.672	1.00
290_V	293_L	0.669	1.00
325_V	336_T	0.669	1.00
13_G	311_K	0.669	1.00
310_N	313_G	0.667	1.00
273_I	363_M	0.666	1.00
66_E	171_R	0.666	1.00
311_K	337_Y	0.666	1.00
35_H	38_F	0.666	1.00
220_K	223_A	0.664	1.00
358_T	363_M	0.664	1.00
244_D	400_T	0.663	1.00
70_L	164_L	0.663	1.00
20_P	187_I	0.662	1.00
272_L	282_F	0.660	1.00
128_A	194_G	0.660	1.00
27_V	196_V	0.658	1.00
46_A	100_A	0.657	1.00
348_V	351_T	0.656	1.00
37_A	40_T	0.655	1.00
273_I	358_T	0.655	1.00
262_A	305_V	0.653	1.00
67_L	137_N	0.652	1.00
333_A	352_V	0.652	1.00
254_A	286_L	0.651	1.00
58_E	61_V	0.649	1.00
116_R	407_I	0.649	1.00
221_N	224_D	0.649	1.00
313_G	316_K	0.649	1.00
77_K	81_E	0.647	1.00
380_I	384_I	0.646	1.00
42_S	123_P	0.646	1.00
52_L	176_A	0.645	1.00
57_Y	90_A	0.645	1.00
316_K	319_S	0.644	1.00
65_E	79_Y	0.644	1.00
255_M	293_L	0.644	1.00
297_N	303_V	0.643	1.00
403_Y	407_I	0.643	1.00
155_I	184_Q	0.642	1.00
33_R	180_K	0.642	1.00
160_P	316_K	0.641	1.00
9_N	299_L	0.640	1.00
286_L	374_I	0.640	1.00
230_S	451_P	0.639	1.00
241_V	250_A	0.638	1.00
42_S	412_N	0.638	1.00
386_L	389_D	0.638	1.00
318_V	321_I	0.636	1.00
120_T	456_K	0.635	1.00
321_I	353_L	0.635	1.00
168_E	172_L	0.634	1.00
41_W	148_L	0.632	1.00
103_V	453_L	0.630	1.00
314_F	338_D	0.630	1.00
450_E	455_T	0.630	1.00
143_K	207_T	0.630	1.00
173_A	178_I	0.629	1.00
414_E	435_M	0.628	1.00
48_E	52_L	0.628	1.00
327_K	359_S	0.627	1.00
400_T	405_R	0.626	1.00
22_Q	186_V	0.625	1.00
295_V	305_V	0.625	1.00
86_V	90_A	0.624	1.00
77_K	135_F	0.621	1.00
39_K	412_N	0.621	1.00
247_I	281_E	0.620	1.00
117_I	459_S	0.616	1.00
42_S	122_Q	0.616	1.00
72_T	299_L	0.616	1.00
356_V	363_M	0.615	1.00
312_R	316_K	0.615	1.00
188_G	194_G	0.613	1.00
19_I	163_P	0.613	1.00
198_T	206_I	0.612	1.00
160_P	217_I	0.612	1.00
64_K	68_A	0.612	1.00
118_V	458_L	0.612	1.00
450_E	453_L	0.611	1.00
7_V	17_K	0.610	1.00
46_A	149_A	0.609	1.00
406_G	410_S	0.608	1.00
356_V	362_I	0.608	1.00
249_L	252_E	0.607	1.00
30_A	186_V	0.607	1.00
244_D	402_N	0.606	1.00
32_E	35_H	0.605	1.00
71_I	85_E	0.604	1.00
52_L	177_G	0.603	1.00
335_G	349_N	0.603	1.00
338_D	343_K	0.602	1.00
144_A	156_I	0.602	1.00
249_L	401_E	0.599	1.00
71_I	82_A	0.598	1.00
71_I	165_S	0.597	1.00
219_M	231_M	0.595	1.00
153_T	184_Q	0.594	1.00
244_D	401_E	0.594	1.00
308_I	313_G	0.594	1.00
103_V	449_I	0.593	1.00
137_N	169_L	0.593	1.00
69_D	72_T	0.592	1.00
404_R	407_I	0.592	1.00
384_I	408_Y	0.592	1.00
398_F	406_G	0.591	1.00
367_T	371_V	0.589	1.00
353_L	356_V	0.588	1.00
191_E	217_I	0.588	1.00
24_A	195_N	0.587	1.00
60_I	137_N	0.587	1.00
274_V	374_I	0.586	1.00
331_V	334_G	0.585	1.00
331_V	351_T	0.583	1.00
60_I	93_I	0.580	1.00
127_V	152_C	0.580	1.00
60_I	169_L	0.579	1.00
7_V	74_E	0.578	1.00
59_L	177_G	0.577	1.00
295_V	304_N	0.576	1.00
239_L	272_L	0.576	1.00
337_Y	349_N	0.576	1.00
16_I	164_L	0.574	1.00
358_T	385_Q	0.573	1.00
205_K	451_P	0.572	1.00
257_S	423_G	0.571	1.00
265_T	268_C	0.570	1.00
267_V	427_A	0.566	1.00
384_I	413_L	0.566	1.00
398_F	420_W	0.564	1.00
387_A	413_L	0.563	1.00
95_W	99_E	0.563	1.00
355_D	376_T	0.562	1.00
36_Q	40_T	0.562	1.00
57_Y	93_I	0.560	1.00
258_K	372_A	0.560	1.00
83_V	301_E	0.560	1.00
321_I	351_T	0.560	1.00
404_R	408_Y	0.560	1.00
287_S	352_V	0.558	1.00
212_T	216_K	0.558	1.00
86_V	137_N	0.557	1.00
67_L	86_V	0.555	1.00
195_N	198_T	0.555	1.00
24_A	199_S	0.554	1.00
34_S	155_I	0.554	1.00
247_I	282_F	0.551	1.00
56_W	59_L	0.550	1.00
46_A	104_Y	0.549	1.00
417_I	426_S	0.549	1.00
248_D	288_E	0.546	1.00
198_T	225_T	0.546	1.00
169_L	173_A	0.546	1.00
247_I	250_A	0.546	1.00
239_L	397_Y	0.545	1.00
60_I	67_L	0.545	1.00
30_A	184_Q	0.545	1.00
294_K	300_E	0.545	1.00
419_G	422_D	0.544	1.00
318_V	325_V	0.544	1.00
243_E	377_F	0.543	1.00
138_A	142_R	0.543	1.00
245_A	250_A	0.542	1.00
383_A	387_A	0.542	1.00
127_V	154_F	0.542	1.00
362_I	367_T	0.541	1.00
274_V	279_K	0.541	1.00
33_R	37_A	0.540	1.00
129_A	144_A	0.539	1.00
126_P	204_R	0.538	1.00
68_A	86_V	0.538	1.00
52_L	56_W	0.537	1.00
418_I	456_K	0.537	1.00
213_P	312_R	0.537	1.00
237_A	395_A	0.535	1.00
98_E	101_K	0.534	1.00
276_E	279_K	0.530	1.00
148_L	183_L	0.530	1.00
207_T	452_Y	0.529	1.00
272_L	374_I	0.529	1.00
35_H	126_P	0.529	1.00
99_E	446_S	0.528	1.00
160_P	213_P	0.528	1.00
150_A	449_I	0.528	1.00
96_F	146_P	0.527	1.00
34_S	126_P	0.526	1.00
174_Y	181_D	0.526	1.00
87_L	90_A	0.525	1.00
409_I	413_L	0.525	1.00
75_N	261_N	0.525	1.00
7_V	163_P	0.524	1.00
47_N	51_S	0.522	1.00
88_Y	138_A	0.522	1.00
259_Y	293_L	0.522	1.00
269_A	397_Y	0.521	1.00
229_V	440_I	0.520	1.00
327_K	357_D	0.520	1.00
380_I	412_N	0.519	1.00
68_A	82_A	0.519	1.00
85_E	135_F	0.519	1.00
55_K	177_G	0.519	1.00
308_I	348_V	0.518	1.00
414_E	454_E	0.518	1.00
332_I	355_D	0.518	1.00
122_Q	414_E	0.517	1.00
142_R	444_G	0.517	1.00
251_V	278_I	0.516	1.00
40_T	153_T	0.516	1.00
19_I	164_L	0.514	1.00
286_L	290_V	0.513	1.00
64_K	90_A	0.511	1.00
128_A	155_I	0.508	1.00
192_E	196_V	0.507	1.00
51_S	54_K	0.506	1.00
21_Q	160_P	0.506	1.00
22_Q	27_V	0.500	1.00
92_Y	444_G	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4o5hA	4	0.9935	100	0.007	Contact Map
4yweA	5	0.9957	100	0.008	Contact Map
3ek1A	5	0.9892	100	0.009	Contact Map
4qf6A	4	0.9913	100	0.01	Contact Map
1a4sA	4	0.9957	100	0.011	Contact Map
4pxlA	4	0.9913	100	0.011	Contact Map
4qtoA	4	1	100	0.015	Contact Map
4lihA	5	0.9892	100	0.015	Contact Map
4pz2A	4	0.9957	100	0.016	Contact Map
3u4jA	4	0.9957	100	0.016	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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