GREMLIN Database
GABT - Probable 4-aminobutyrate aminotransferase
UniProt: P94427 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 436 (377)
Sequences: 20901 (12096)
Seq/√Len: 623.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
73_K77_E4.4161.00
239_A243_K3.9261.00
396_N432_A3.8951.00
40_E48_R3.5591.00
343_I424_N3.2271.00
197_I237_H3.2101.00
35_K42_Y3.0861.00
98_K326_D3.0471.00
343_I420_D2.8641.00
263_T269_H2.8241.00
332_G335_E2.7471.00
336_R340_I2.7021.00
419_S422_L2.6411.00
67_K330_E2.6211.00
70_E74_R2.5251.00
354_E431_E2.5171.00
98_K329_E2.4041.00
52_F426_G2.3981.00
323_A326_D2.3761.00
67_K327_I2.3351.00
237_H240_S2.3071.00
40_E422_L2.2891.00
34_V44_L2.2521.00
347_K427_L2.2431.00
240_S244_E2.2061.00
65_H327_I2.1911.00
42_Y48_R2.1221.00
67_K323_A2.1101.00
339_E420_D2.1031.00
347_K424_N2.0821.00
98_K322_L2.0581.00
201_N244_E2.0281.00
392_Y395_Q1.9981.00
176_P199_A1.9571.00
69_V73_K1.9441.00
95_L321_A1.9391.00
425_E429_I1.9361.00
355_F431_E1.9081.00
345_E349_Y1.9071.00
359_G373_V1.8841.00
136_G212_T1.8791.00
110_K296_A1.8731.00
392_Y396_N1.8631.00
342_K346_D1.8511.00
47_R397_G1.8411.00
43_D47_R1.8231.00
398_L429_I1.8131.00
296_A300_D1.7961.00
109_K296_A1.7951.00
327_I331_E1.7871.00
40_E425_E1.7661.00
217_V250_V1.7591.00
90_P94_E1.7541.00
345_E363_R1.7411.00
347_K350_E1.7281.00
102_I329_E1.7161.00
34_V78_E1.7121.00
114_L290_S1.7031.00
97_E101_G1.6921.00
200_F238_V1.6701.00
287_L317_G1.6311.00
121_V278_T1.6261.00
136_G173_Y1.6261.00
72_V320_A1.6131.00
94_E322_L1.5971.00
263_T338_E1.5881.00
345_E368_A1.5871.00
98_K101_G1.5851.00
37_E66_P1.5831.00
72_V76_A1.5741.00
340_I343_I1.5401.00
218_M238_V1.5381.00
216_V242_C1.5321.00
39_A422_L1.5261.00
204_F247_I1.5221.00
141_T176_P1.5191.00
284_A289_L1.5121.00
392_Y433_G1.5071.00
279_V291_G1.5041.00
340_I423_L1.4951.00
251_A267_I1.4951.00
198_Q202_D1.4761.00
233_R236_Q1.4701.00
74_R78_E1.4681.00
103_A293_I1.4541.00
138_V213_V1.4441.00
48_R425_E1.4431.00
131_Y298_M1.4421.00
39_A417_V1.4361.00
279_V293_I1.4361.00
123_N292_V1.4351.00
201_N237_H1.4321.00
137_V215_C1.4151.00
351_W431_E1.4081.00
239_A242_C1.4051.00
336_R339_E1.4031.00
393_A400_L1.4001.00
66_P70_E1.4001.00
96_A113_F1.3941.00
239_A249_F1.3941.00
396_N433_G1.3931.00
100_C111_A1.3801.00
322_L326_D1.3741.00
178_P231_S1.3671.00
111_A293_I1.3641.00
264_Y268_E1.3591.00
340_I420_D1.3521.00
125_V137_V1.3511.00
140_F234_F1.3431.00
323_A327_I1.3421.00
139_S174_Q1.3401.00
131_Y301_A1.3381.00
269_H364_L1.3331.00
263_T268_E1.3261.00
70_E73_K1.3251.00
343_I347_K1.3231.00
347_K428_S1.3221.00
335_E339_E1.3151.00
289_L318_C1.3021.00
351_W427_L1.2991.00
101_G329_E1.2971.00
349_Y352_K1.2891.00
273_V295_R1.2881.00
201_N241_F1.2851.00
43_D49_F1.2841.00
347_K431_E1.2791.00
218_M235_V1.2751.00
37_E64_S1.2731.00
121_V217_V1.2691.00
418_I423_L1.2661.00
110_K300_D1.2641.00
128_A250_V1.2581.00
124_A278_T1.2531.00
267_I277_I1.2501.00
35_K78_E1.2481.00
71_A323_A1.2391.00
216_V238_V1.2341.00
94_E326_D1.2271.00
65_H331_E1.2261.00
33_A41_L1.2251.00
64_S69_V1.2241.00
61_V327_I1.2211.00
422_L425_E1.2191.00
69_V77_E1.2181.00
198_Q201_N1.2101.00
276_L294_G1.2081.00
236_Q240_S1.2071.00
326_D330_E1.2051.00
270_F364_L1.1971.00
289_L321_A1.1961.00
197_I241_F1.1911.00
283_L289_L1.1901.00
338_E342_K1.1861.00
114_L292_V1.1851.00
69_V76_A1.1681.00
233_R270_F1.1571.00
72_V316_L1.1541.00
136_G210_P1.1531.00
283_L291_G1.1481.00
113_F318_C1.1471.00
236_Q271_D1.1401.00
73_K76_A1.1361.00
154_M172_V1.1311.00
396_N429_I1.1301.00
259_A334_N1.1241.00
428_S432_A1.1211.00
349_Y353_Q1.1141.00
154_M217_V1.1121.00
34_V90_P1.1051.00
425_E428_S1.1021.00
265_F279_V1.0991.00
393_A429_I1.0931.00
398_L426_G1.0851.00
32_L44_L1.0811.00
327_I330_E1.0771.00
39_A50_I1.0771.00
251_A272_V1.0751.00
40_E50_I1.0741.00
199_A202_D1.0721.00
420_D424_N1.0551.00
276_L292_V1.0541.00
393_A433_G1.0531.00
37_E48_R1.0511.00
34_V46_G1.0391.00
175_A203_F1.0381.00
346_D350_E1.0381.00
248_V298_M1.0371.00
201_N245_H1.0361.00
134_R246_G1.0291.00
34_V42_Y1.0291.00
242_C247_I1.0261.00
120_A278_T1.0241.00
67_K326_D1.0171.00
424_N428_S1.0161.00
388_A392_Y1.0151.00
118_A151_T1.0151.00
37_E42_Y1.0141.00
393_A398_L1.0131.00
98_K102_I0.9921.00
240_S243_K0.9901.00
102_I264_Y0.9891.00
95_L322_L0.9851.00
127_I292_V0.9821.00
285_A324_V0.9821.00
202_D208_V0.9811.00
232_K236_Q0.9791.00
262_G268_E0.9791.00
335_E338_E0.9771.00
201_N240_S0.9721.00
391_A395_Q0.9691.00
215_C250_V0.9651.00
220_P251_A0.9581.00
359_G371_E0.9531.00
229_I364_L0.9491.00
74_R319_A0.9441.00
258_F328_I0.9421.00
125_V154_M0.9391.00
176_P179_Y0.9381.00
334_N337_S0.9371.00
70_E77_E0.9361.00
50_I422_L0.9361.00
421_S424_N0.9351.00
61_V324_V0.9291.00
135_Q212_T0.9261.00
67_K70_E0.9261.00
352_K358_I0.9201.00
371_E408_N0.9171.00
60_N282_S0.9121.00
139_S217_V0.9121.00
233_R237_H0.9091.00
235_V270_F0.9071.00
61_V68_V0.9071.00
238_V249_F0.9061.00
336_R420_D0.9041.00
124_A250_V0.9031.00
104_P267_I0.9011.00
204_F213_V0.8991.00
32_L93_I0.8991.00
350_E354_E0.8991.00
210_P245_H0.8981.00
131_Y248_V0.8961.00
319_A323_A0.8941.00
127_I294_G0.8931.00
341_G345_E0.8921.00
140_F230_P0.8881.00
50_I425_E0.8871.00
105_G277_I0.8861.00
346_D349_Y0.8831.00
44_L90_P0.8771.00
269_H338_E0.8741.00
328_I333_L0.8741.00
241_F245_H0.8741.00
68_V320_A0.8671.00
369_A409_I0.8661.00
39_A419_S0.8661.00
328_I334_N0.8621.00
94_E98_K0.8591.00
102_I325_L0.8581.00
74_R77_E0.8551.00
153_S169_A0.8521.00
52_F418_I0.8471.00
128_A215_C0.8471.00
118_A148_T0.8451.00
221_V364_L0.8431.00
140_F177_F0.8431.00
91_T319_A0.8381.00
264_Y334_N0.8371.00
360_D371_E0.8351.00
173_Y203_F0.8321.00
128_A248_V0.8321.00
333_L337_S0.8301.00
256_T367_M0.8291.00
334_N338_E0.8251.00
59_L285_A0.8181.00
67_K71_A0.8151.00
387_A391_A0.8141.00
418_I426_G0.8131.00
221_V367_M0.8121.00
243_K273_V0.8021.00
135_Q171_E0.8011.00
343_I346_D0.7941.00
50_I426_G0.7931.00
99_L293_I0.7921.00
347_K423_L0.7891.00
91_T322_L0.7881.00
267_I272_V0.7871.00
130_K306_E0.7831.00
177_F230_P0.7821.00
242_C249_F0.7781.00
339_E343_I0.7771.00
366_A418_I0.7761.00
350_E431_E0.7711.00
199_A203_F0.7701.00
390_A402_T0.7691.00
133_K212_T0.7671.00
237_H241_F0.7661.00
362_R371_E0.7641.00
204_F241_F0.7621.00
105_G109_K0.7611.00
258_F325_L0.7601.00
389_I430_L0.7601.00
220_P235_V0.7591.00
136_G213_V0.7591.00
412_F430_L0.7591.00
361_I368_A0.7581.00
287_L316_L0.7571.00
258_F279_V0.7561.00
367_M413_L0.7531.00
111_A291_G0.7511.00
265_F277_I0.7481.00
38_G417_V0.7461.00
239_A272_V0.7461.00
91_T94_E0.7441.00
91_T318_C0.7421.00
95_L318_C0.7401.00
351_W355_F0.7391.00
246_G297_E0.7381.00
124_A276_L0.7381.00
209_A212_T0.7381.00
128_A276_L0.7361.00
303_A306_E0.7351.00
114_L120_A0.7351.00
107_H293_I0.7341.00
216_V247_I0.7331.00
218_M249_F0.7331.00
297_E300_D0.7311.00
57_G413_L0.7301.00
200_F216_V0.7291.00
350_E353_Q0.7261.00
363_R368_A0.7231.00
261_T269_H0.7221.00
258_F264_Y0.7221.00
340_I366_A0.7221.00
339_E342_K0.7221.00
71_A320_A0.7201.00
213_V247_I0.7191.00
89_Y92_Y0.7151.00
236_Q270_F0.7141.00
52_F398_L0.7141.00
309_G312_A0.7111.00
264_Y329_E0.7111.00
39_A415_P0.7101.00
223_G255_Q0.7071.00
388_A391_A0.7061.00
125_V217_V0.7051.00
79_L82_P0.7031.00
88_M93_I0.7011.00
385_K388_A0.6981.00
175_A200_F0.6961.00
150_M169_A0.6951.00
337_S341_G0.6951.00
50_I398_L0.6941.00
75_Q78_E0.6931.00
221_V261_T0.6921.00
421_S425_E0.6881.00
92_Y96_A0.6831.00
141_T174_Q0.6811.00
259_A328_I0.6801.00
91_T95_L0.6791.00
127_I302_A0.6791.00
279_V283_L0.6751.00
121_V151_T0.6751.00
267_I274_P0.6751.00
47_R395_Q0.6741.00
258_F283_L0.6741.00
105_G273_V0.6731.00
294_G299_L0.6711.00
357_F373_V0.6681.00
343_I423_L0.6671.00
249_F272_V0.6671.00
173_Y176_P0.6671.00
53_A401_L0.6651.00
80_I287_L0.6641.00
78_E91_T0.6621.00
78_E90_P0.6621.00
298_M301_A0.6611.00
39_A418_I0.6601.00
32_L88_M0.6601.00
71_A74_R0.6591.00
93_I97_E0.6581.00
372_I389_I0.6571.00
102_I265_F0.6571.00
116_S119_E0.6561.00
418_I422_L0.6551.00
229_I363_R0.6551.00
336_R419_S0.6541.00
241_F244_E0.6541.00
115_N119_E0.6541.00
371_E409_I0.6541.00
222_Q228_I0.6531.00
426_G429_I0.6521.00
33_A36_G0.6521.00
389_I433_G0.6511.00
232_K270_F0.6501.00
68_V285_A0.6501.00
98_K325_L0.6481.00
76_A316_L0.6481.00
235_V251_A0.6471.00
250_V276_L0.6461.00
341_G363_R0.6461.00
127_I276_L0.6441.00
232_K364_L0.6421.00
41_L399_L0.6421.00
398_L425_E0.6401.00
223_G367_M0.6361.00
254_I278_T0.6361.00
243_K249_F0.6351.00
342_K345_E0.6351.00
204_F245_H0.6351.00
295_R298_M0.6341.00
103_A277_I0.6341.00
131_Y297_E0.6341.00
48_R429_I0.6321.00
393_A430_L0.6321.00
138_V200_F0.6301.00
197_I201_N0.6291.00
100_C107_H0.6271.00
175_A178_P0.6271.00
117_G254_I0.6271.00
54_G415_P0.6261.00
54_G413_L0.6261.00
391_A394_N0.6261.00
104_P107_H0.6241.00
429_I433_G0.6221.00
203_F207_S0.6171.00
427_L431_E0.6171.00
102_I263_T0.6171.00
104_P273_V0.6161.00
66_P77_E0.6161.00
75_Q91_T0.6151.00
230_P233_R0.6141.00
126_K307_L0.6131.00
410_I430_L0.6121.00
61_V333_L0.6111.00
361_I370_I0.6101.00
105_G267_I0.6091.00
412_F426_G0.6081.00
103_A265_F0.6081.00
167_P171_E0.6071.00
280_S290_S0.6061.00
337_S416_L0.6051.00
175_A179_Y0.6041.00
429_I432_A0.6031.00
140_F175_A0.6021.00
337_S366_A0.6021.00
389_I393_A0.6021.00
347_K351_W0.5991.00
64_S76_A0.5981.00
60_N416_L0.5971.00
129_R149_N0.5971.00
372_I434_L0.5961.00
320_A323_A0.5961.00
33_A87_M0.5951.00
344_I427_L0.5941.00
390_A394_N0.5941.00
100_C109_K0.5931.00
71_A326_D0.5911.00
175_A199_A0.5911.00
95_L289_L0.5901.00
36_G41_L0.5901.00
197_I200_F0.5901.00
370_I430_L0.5901.00
129_R167_P0.5891.00
53_A399_L0.5871.00
104_P268_E0.5861.00
338_E341_G0.5851.00
389_I410_I0.5841.00
220_P256_T0.5831.00
37_E40_E0.5821.00
355_F434_L0.5811.00
243_K297_E0.5811.00
222_Q225_G0.5801.00
76_A320_A0.5801.00
386_A402_T0.5791.00
123_N307_L0.5781.00
140_F218_M0.5781.00
125_V150_M0.5761.00
36_G79_L0.5751.00
329_E332_G0.5741.00
344_I423_L0.5741.00
236_Q239_A0.5731.00
134_R212_T0.5731.00
134_R247_I0.5731.00
344_I368_A0.5731.00
94_E97_E0.5721.00
198_Q237_H0.5701.00
340_I418_I0.5691.00
136_G209_A0.5681.00
362_R409_I0.5651.00
60_N328_I0.5641.00
138_V203_F0.5641.00
132_T214_A0.5591.00
300_D304_P0.5581.00
340_I419_S0.5581.00
95_L113_F0.5561.00
139_S172_V0.5541.00
87_M399_L0.5531.00
76_A80_I0.5531.00
352_K361_I0.5521.00
32_L90_P0.5521.00
50_I418_I0.5511.00
200_F241_F0.5501.00
163_F166_G0.5491.00
300_D303_A0.5491.00
201_N207_S0.5491.00
107_H277_I0.5491.00
200_F237_H0.5481.00
351_W428_S0.5471.00
74_R323_A0.5471.00
31_S34_V0.5450.99
424_N427_L0.5440.99
31_S394_N0.5430.99
211_E245_H0.5430.99
136_G171_E0.5430.99
142_R225_G0.5420.99
362_R369_A0.5420.99
68_V324_V0.5410.99
34_V37_E0.5390.99
136_G208_V0.5390.99
258_F265_F0.5390.99
331_E336_R0.5380.99
144_F147_R0.5380.99
343_I427_L0.5380.99
314_S317_G0.5380.99
138_V175_A0.5380.99
156_S174_Q0.5370.99
158_V163_F0.5340.99
218_M251_A0.5340.99
202_D207_S0.5330.99
264_Y328_I0.5320.99
248_V276_L0.5290.99
423_L427_L0.5290.99
33_A79_L0.5290.99
132_T135_Q0.5290.99
100_C293_I0.5270.99
276_L298_M0.5270.99
415_P418_I0.5260.99
374_K385_K0.5240.99
140_F238_V0.5240.99
230_P235_V0.5230.99
358_I434_L0.5210.99
277_I293_I0.5200.99
238_V247_I0.5190.99
426_G430_L0.5190.99
255_Q367_M0.5180.99
425_E432_A0.5140.99
232_K271_D0.5140.99
103_A111_A0.5130.99
264_Y325_L0.5120.99
236_Q272_V0.5120.99
103_A279_V0.5120.99
68_V323_A0.5110.99
229_I270_F0.5110.99
430_L434_L0.5100.99
36_G59_L0.5090.99
239_A251_A0.5070.99
197_I238_V0.5070.99
423_L426_G0.5060.99
325_L329_E0.5050.99
370_I412_F0.5040.99
274_P277_I0.5030.99
239_A273_V0.5030.99
234_F238_V0.5010.99
35_K48_R0.5010.99
394_N399_L0.5010.99
114_L119_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3oksA 2 0.9954 100 0.362 Contact Map
4atqA 7 0.9885 100 0.368 Contact Map
4ffcA 4 0.9817 100 0.377 Contact Map
4uoxA 3 0.9358 100 0.379 Contact Map
4a0gA 2 0.9587 100 0.388 Contact Map
1z7dA 2 0.8463 100 0.389 Contact Map
4e3qA 3 0.9633 100 0.39 Contact Map
1sffA 3 0.9656 100 0.394 Contact Map
3hmuA 2 0.9702 100 0.394 Contact Map
2epjA 2 0.9037 100 0.4 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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