GREMLIN Database
GABR - HTH-type transcriptional regulatory protein GabR
UniProt: P94426 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 479 (368)
Sequences: 18074 (12478)
Seq/√Len: 650.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
235_T270_E3.5121.00
373_E454_E3.2511.00
421_L466_K2.9991.00
372_K376_E2.9951.00
258_V262_I2.9371.00
225_D260_R2.8801.00
391_T404_E2.7281.00
178_G184_L2.6441.00
197_V218_Q2.5431.00
132_Q136_S2.4611.00
196_A240_D2.4211.00
133_K353_E2.4131.00
273_R303_N2.4061.00
159_T172_P2.3931.00
459_E463_R2.3561.00
453_K456_D2.2201.00
186_Q190_E2.2121.00
223_M233_E2.1671.00
151_I349_L2.1131.00
377_R458_Q2.1081.00
163_S169_K2.1021.00
269_A301_F2.0991.00
125_K129_R2.0951.00
268_A276_I2.0771.00
112_F460_G2.0261.00
381_A462_Q2.0201.00
417_H420_G1.9791.00
421_L463_R1.9611.00
157_A356_E1.9431.00
465_F469_Y1.9181.00
459_E462_Q1.9171.00
310_F351_L1.9161.00
152_Y156_A1.8841.00
156_A172_P1.8701.00
417_H467_A1.8681.00
153_E352_Q1.8441.00
188_L305_I1.8321.00
325_L330_L1.8191.00
174_Q327_P1.8131.00
131_E350_T1.7871.00
149_Q155_R1.7871.00
380_T384_A1.7691.00
381_A461_V1.7491.00
233_E236_R1.7351.00
235_T263_Q1.7111.00
156_A160_R1.7101.00
160_R356_E1.7061.00
378_L461_V1.7011.00
231_I267_W1.6991.00
266_N270_E1.6581.00
381_A458_Q1.6431.00
230_S233_E1.6421.00
232_A263_Q1.6351.00
262_I266_N1.6351.00
377_R381_A1.6291.00
281_Y309_T1.6171.00
323_M333_Y1.6131.00
379_I394_G1.5941.00
411_E429_S1.5931.00
344_S347_T1.5791.00
153_E356_E1.5751.00
241_V277_I1.5721.00
378_L401_F1.5701.00
377_R454_E1.5601.00
202_E223_M1.5531.00
404_E444_A1.5461.00
162_I324_V1.5441.00
418_A464_L1.5301.00
384_A458_Q1.5281.00
257_P260_R1.5111.00
358_G362_K1.5111.00
170_C324_V1.5111.00
336_R340_L1.5031.00
258_V293_P1.4941.00
155_R159_T1.4941.00
263_Q266_N1.4931.00
158_I177_I1.4911.00
149_Q334_K1.4901.00
288_D396_N1.4891.00
199_A239_P1.4891.00
425_I445_L1.4841.00
189_T212_L1.4821.00
173_E327_P1.4691.00
294_A297_S1.4691.00
188_L277_I1.4651.00
381_A384_A1.4641.00
375_R379_I1.4611.00
413_D417_H1.4611.00
266_N269_A1.4601.00
197_V220_K1.4571.00
277_I307_M1.4551.00
199_A222_I1.4481.00
130_C353_E1.4291.00
379_I401_F1.4291.00
181_T307_M1.4231.00
227_K257_P1.4191.00
157_A352_Q1.4171.00
379_I383_E1.4171.00
202_E221_T1.4061.00
370_H454_E1.4041.00
227_K260_R1.4001.00
370_H373_E1.3951.00
268_A274_R1.3911.00
198_Y212_L1.3861.00
353_E357_S1.3821.00
258_V298_L1.3781.00
267_W272_P1.3761.00
383_E392_V1.3691.00
376_E380_T1.3661.00
320_I351_L1.3551.00
410_T413_D1.3521.00
462_Q466_K1.3371.00
235_T272_P1.3341.00
415_L425_I1.3331.00
191_L333_Y1.3321.00
379_I392_V1.3311.00
212_L217_K1.3151.00
131_E135_A1.3071.00
179_A183_V1.3041.00
158_I175_M1.3011.00
267_W274_R1.2981.00
231_I263_Q1.2941.00
183_V340_L1.2901.00
456_D459_E1.2901.00
192_L241_V1.2841.00
352_Q356_E1.2841.00
458_Q462_Q1.2811.00
370_H374_K1.2791.00
381_A465_F1.2771.00
383_E394_G1.2701.00
313_S360_Y1.2701.00
380_T458_Q1.2681.00
157_A160_R1.2491.00
171_R327_P1.2491.00
176_I333_Y1.2491.00
130_C134_A1.2471.00
208_M243_V1.2411.00
107_S422_Q1.2391.00
150_G155_R1.2291.00
259_S263_Q1.2291.00
225_D230_S1.2251.00
353_E356_E1.2211.00
229_M242_L1.2181.00
365_K368_K1.2141.00
159_T175_M1.2131.00
336_R343_C1.2111.00
402_V428_M1.2111.00
168_V296_Q1.2071.00
299_D302_Q1.2051.00
259_S262_I1.2041.00
174_Q330_L1.2011.00
198_Y241_V1.1861.00
121_H370_H1.1841.00
413_D416_S1.1811.00
416_S419_A1.1771.00
305_I325_L1.1771.00
152_Y172_P1.1731.00
137_R353_E1.1681.00
133_K137_R1.1681.00
128_F132_Q1.1641.00
197_V238_Q1.1641.00
117_S371_Y1.1571.00
176_I330_L1.1431.00
412_Q429_S1.1411.00
365_K369_Q1.1401.00
260_R263_Q1.1371.00
175_M324_V1.1361.00
454_E458_Q1.1311.00
165_T361_Q1.1291.00
308_G322_Y1.1221.00
152_Y155_R1.1171.00
369_Q373_E1.1171.00
210_Q213_K1.1081.00
184_L307_M1.1071.00
418_A467_A1.1071.00
307_M323_M1.1011.00
222_I229_M1.0981.00
265_L298_L1.0971.00
375_R449_F1.0951.00
194_K216_G1.0881.00
275_Y303_N1.0861.00
415_L427_G1.0841.00
325_L333_Y1.0771.00
242_L274_R1.0771.00
286_T292_I1.0771.00
410_T442_R1.0741.00
265_L295_L1.0731.00
193_P196_A1.0711.00
330_L334_K1.0661.00
423_L464_L1.0651.00
188_L333_Y1.0611.00
414_I467_A1.0601.00
275_Y305_I1.0601.00
199_A234_I1.0571.00
268_A272_P1.0561.00
262_I298_L1.0531.00
154_V177_I1.0511.00
112_F457_I1.0511.00
161_L361_Q1.0451.00
369_Q372_K1.0431.00
201_E249_Q1.0351.00
412_Q416_S1.0291.00
417_H421_L1.0261.00
265_L276_I1.0251.00
134_A350_T1.0241.00
142_L349_L1.0221.00
418_A425_I1.0221.00
331_R335_Q1.0191.00
153_E349_L1.0121.00
183_V336_R1.0111.00
293_P298_L1.0101.00
265_L299_D1.0091.00
411_E415_L1.0071.00
378_L457_I1.0071.00
280_D283_S1.0061.00
184_L323_M1.0061.00
161_L284_E1.0051.00
160_R163_S1.0051.00
230_S260_R1.0001.00
209_Y213_K0.9971.00
151_I352_Q0.9931.00
171_R174_Q0.9911.00
404_E443_P0.9781.00
129_R133_K0.9781.00
391_T406_D0.9751.00
157_A355_I0.9741.00
229_M260_R0.9701.00
288_D375_R0.9701.00
428_M444_A0.9651.00
269_A303_N0.9641.00
190_E215_A0.9601.00
197_V239_P0.9591.00
202_E434_K0.9571.00
231_I260_R0.9541.00
421_L467_A0.9531.00
377_R380_T0.9531.00
265_L304_V0.9501.00
235_T267_W0.9501.00
310_F322_Y0.9491.00
162_I306_Y0.9441.00
384_A465_F0.9421.00
228_G260_R0.9391.00
208_M212_L0.9361.00
386_F465_F0.9321.00
212_L219_V0.9301.00
299_D303_N0.9301.00
126_S353_E0.9261.00
161_L166_R0.9241.00
414_I445_L0.9231.00
158_I322_Y0.9181.00
332_A335_Q0.9171.00
182_Q207_R0.9151.00
101_E105_D0.9121.00
378_L447_I0.9071.00
177_I320_I0.9011.00
295_L304_V0.8921.00
411_E427_G0.8901.00
305_I329_L0.8821.00
386_F390_V0.8821.00
181_T309_T0.8811.00
128_F135_A0.8801.00
186_Q339_D0.8791.00
423_L463_R0.8781.00
305_I323_M0.8741.00
390_V403_T0.8711.00
276_I295_L0.8681.00
125_K128_F0.8661.00
156_A356_E0.8651.00
416_S420_G0.8641.00
162_I322_Y0.8601.00
128_F136_S0.8591.00
224_L249_Q0.8511.00
376_E394_G0.8491.00
118_D374_K0.8481.00
199_A242_L0.8481.00
286_T289_V0.8481.00
423_L460_G0.8411.00
389_E406_D0.8401.00
153_E156_A0.8401.00
269_A300_R0.8401.00
180_G319_R0.8391.00
179_A344_S0.8371.00
269_A299_D0.8341.00
166_R283_S0.8331.00
258_V291_S0.8331.00
463_R466_K0.8221.00
159_T170_C0.8221.00
296_Q299_D0.8211.00
244_T264_L0.8181.00
403_T447_I0.8141.00
232_A236_R0.8091.00
130_C350_T0.8081.00
463_R467_A0.8071.00
314_L351_L0.8061.00
229_M234_I0.8031.00
234_I267_W0.8011.00
248_H397_A0.8011.00
202_E432_N0.7971.00
296_Q306_Y0.7971.00
239_P274_R0.7951.00
129_R132_Q0.7941.00
378_L381_A0.7931.00
133_K357_S0.7931.00
402_V444_A0.7861.00
405_F445_L0.7831.00
183_V187_L0.7821.00
146_S345_S0.7791.00
386_F389_E0.7771.00
414_I468_V0.7721.00
187_L333_Y0.7691.00
367_M371_Y0.7661.00
200_M219_V0.7661.00
409_R414_I0.7651.00
411_E443_P0.7631.00
386_F461_V0.7631.00
181_T281_Y0.7611.00
404_E442_R0.7611.00
224_L254_T0.7591.00
361_Q365_K0.7581.00
390_V405_F0.7581.00
249_Q252_S0.7571.00
182_Q205_Y0.7561.00
242_L267_W0.7541.00
363_H367_M0.7541.00
161_L283_S0.7531.00
130_C133_K0.7521.00
380_T383_E0.7511.00
419_A424_E0.7491.00
161_L165_T0.7491.00
366_K369_Q0.7461.00
108_D456_D0.7461.00
462_Q465_F0.7461.00
155_R172_P0.7461.00
455_E458_Q0.7451.00
198_Y217_K0.7431.00
375_R395_A0.7431.00
299_D304_V0.7421.00
126_S359_E0.7381.00
452_L456_D0.7371.00
176_I325_L0.7321.00
109_W422_Q0.7291.00
406_D443_P0.7281.00
327_P331_R0.7271.00
382_L392_V0.7221.00
466_K469_Y0.7221.00
189_T215_A0.7201.00
320_I343_C0.7201.00
256_M261_R0.7191.00
359_E362_K0.7161.00
375_R394_G0.7121.00
146_S151_I0.7121.00
189_T217_K0.7091.00
373_E377_R0.7091.00
134_A353_E0.7071.00
179_A343_C0.7071.00
223_M230_S0.7021.00
176_I334_K0.7001.00
381_A457_I0.6981.00
129_R136_S0.6961.00
227_K259_S0.6961.00
247_S280_D0.6951.00
130_C359_E0.6941.00
151_I345_S0.6931.00
108_D422_Q0.6931.00
213_K219_V0.6931.00
280_D294_A0.6911.00
188_L307_M0.6911.00
411_E445_L0.6851.00
112_F447_I0.6831.00
312_K319_R0.6821.00
346_L350_T0.6821.00
98_D101_E0.6821.00
131_E346_L0.6811.00
362_K366_K0.6781.00
393_K404_E0.6781.00
178_G321_S0.6771.00
459_E466_K0.6751.00
366_K370_H0.6751.00
204_G209_Y0.6751.00
434_K440_T0.6731.00
177_I343_C0.6721.00
200_M212_L0.6721.00
357_S361_Q0.6681.00
125_K136_S0.6681.00
382_L390_V0.6671.00
412_Q427_G0.6581.00
93_F97_D0.6571.00
221_T433_L0.6561.00
124_I128_F0.6551.00
382_L461_V0.6541.00
232_A235_T0.6521.00
392_V401_F0.6521.00
94_A98_D0.6511.00
151_I348_Q0.6501.00
110_I463_R0.6481.00
368_K372_K0.6461.00
170_C174_Q0.6451.00
294_A306_Y0.6441.00
382_L403_T0.6431.00
159_T171_R0.6431.00
180_G321_S0.6421.00
111_S424_E0.6411.00
296_Q304_V0.6401.00
106_Q422_Q0.6381.00
126_S129_R0.6371.00
177_I348_Q0.6361.00
374_K454_E0.6351.00
165_T284_E0.6341.00
115_M400_H0.6331.00
269_A302_Q0.6311.00
274_R303_N0.6311.00
325_L329_L0.6281.00
248_H286_T0.6271.00
320_I347_T0.6271.00
126_S130_C0.6261.00
286_T291_S0.6261.00
145_M312_K0.6251.00
123_P126_S0.6241.00
382_L386_F0.6241.00
168_V294_A0.6241.00
242_L268_A0.6231.00
185_M277_I0.6231.00
192_L275_Y0.6231.00
98_D416_S0.6211.00
205_Y243_V0.6201.00
234_I242_L0.6191.00
377_R457_I0.6141.00
363_H366_K0.6141.00
182_Q211_L0.6141.00
411_E414_I0.6131.00
265_L300_R0.6101.00
265_L269_A0.6101.00
264_L295_L0.6071.00
293_P297_S0.6051.00
423_L467_A0.6051.00
347_T350_T0.6011.00
432_N441_G0.6001.00
229_M244_T0.5991.00
146_S342_T0.5961.00
279_D312_K0.5931.00
287_Y375_R0.5931.00
378_L449_F0.5921.00
102_I107_S0.5911.00
118_D371_Y0.5901.00
184_L321_S0.5891.00
200_M209_Y0.5881.00
132_Q135_A0.5881.00
302_Q326_P0.5881.00
201_E224_L0.5861.00
278_E295_L0.5861.00
247_S261_R0.5851.00
158_I310_F0.5841.00
265_L268_A0.5841.00
255_I292_I0.5831.00
403_T445_L0.5821.00
287_Y449_F0.5811.00
265_L303_N0.5811.00
457_I460_G0.5811.00
371_Y399_L0.5801.00
187_L336_R0.5801.00
275_Y329_L0.5801.00
256_M264_L0.5791.00
282_D400_H0.5781.00
230_S263_Q0.5771.00
362_K365_K0.5771.00
402_V446_I0.5771.00
461_V464_L0.5771.00
256_M260_R0.5771.00
248_H255_I0.5761.00
118_D121_H0.5751.00
197_V237_Q0.5751.00
159_T163_S0.5741.00
126_S362_K0.5711.00
248_H282_D0.5691.00
280_D306_Y0.5681.00
121_H127_W0.5671.00
189_T211_L0.5651.00
111_S114_H0.5651.00
185_M211_L0.5631.00
229_M264_L0.5611.00
128_F131_E0.5591.00
106_Q109_W0.5581.00
110_I452_L0.5581.00
345_S349_L0.5561.00
108_D463_R0.5551.00
189_T241_V0.5551.00
95_L113_S0.5541.00
231_I264_L0.5541.00
189_T244_T0.5481.00
205_Y279_D0.5481.00
418_A423_L0.5481.00
350_T353_E0.5481.00
155_R173_E0.5471.00
190_E214_N0.5471.00
261_R295_L0.5471.00
432_N444_A0.5451.00
455_E459_E0.5411.00
261_R298_L0.5401.00
154_V352_Q0.5391.00
247_S255_I0.5391.00
117_S316_P0.5381.00
193_P216_G0.5371.00
110_I459_E0.5361.00
409_R417_H0.5340.99
239_P267_W0.5320.99
431_F446_I0.5310.99
197_V240_D0.5290.99
130_C354_F0.5270.99
242_L276_I0.5260.99
110_I460_G0.5260.99
364_I368_K0.5260.99
182_Q341_Q0.5260.99
371_Y450_A0.5260.99
190_E339_D0.5250.99
239_P242_L0.5250.99
244_T256_M0.5250.99
328_E331_R0.5250.99
226_E393_K0.5230.99
288_D372_K0.5230.99
186_Q215_A0.5230.99
399_L450_A0.5230.99
95_L98_D0.5220.99
250_F282_D0.5220.99
278_E306_Y0.5220.99
120_D453_K0.5220.99
284_E313_S0.5200.99
196_A238_Q0.5190.99
376_E379_I0.5190.99
295_L298_L0.5180.99
204_G224_L0.5180.99
121_H367_M0.5170.99
343_C347_T0.5170.99
382_L447_I0.5170.99
168_V306_Y0.5170.99
206_R430_R0.5170.99
126_S363_H0.5150.99
427_G430_R0.5140.99
234_I274_R0.5120.99
158_I308_G0.5120.99
178_G323_M0.5120.99
207_R211_L0.5120.99
264_L268_A0.5120.99
154_V158_I0.5110.99
188_L323_M0.5110.99
201_E229_M0.5050.99
126_S357_S0.5040.99
349_L352_Q0.5030.99
137_R142_L0.5020.99
386_F468_V0.5020.99
306_Y324_V0.5020.99
250_F400_H0.5020.99
145_M316_P0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4tv7A 2 0.9499 100 0.284 Contact Map
3pplA 2 0.8121 100 0.4 Contact Map
3f6tA 2 0.8643 100 0.425 Contact Map
3qguA 2 0.8058 100 0.426 Contact Map
3ez1A 2 0.7954 100 0.438 Contact Map
2r2nA 2 0.8184 100 0.455 Contact Map
3d6kA 2 0.7933 100 0.461 Contact Map
2x5fA 2 0.8246 100 0.461 Contact Map
1vp4A 2 0.8288 100 0.462 Contact Map
4je5A 2 0.8309 100 0.464 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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