GREMLIN Database
YCNE - Putative monooxygenase YcnE
UniProt: P94425 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 95 (86)
Sequences: 1306 (941)
Seq/√Len: 101.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_E63_K3.2111.00
4_L62_M2.5921.00
15_R48_N2.4651.00
34_G61_A2.3421.00
69_A73_G2.2531.00
14_K17_E2.1961.00
58_D61_A2.1831.00
7_Y49_T2.1281.00
10_V18_F1.9531.00
11_K83_S1.9391.00
15_R42_E1.8771.00
67_E72_Q1.8501.00
9_K84_A1.8221.00
19_L42_E1.7451.00
19_L23_Q1.7351.00
25_L74_F1.5591.00
28_H31_A1.5381.00
24_S73_G1.5011.00
62_M66_N1.4441.00
60_A63_K1.3981.00
35_N56_W1.3901.00
74_F78_G1.3801.00
37_Q55_K1.3770.99
33_E57_K1.3650.99
73_G77_K1.3420.99
18_F22_A1.3380.99
60_A64_F1.2870.99
9_K49_T1.2740.99
29_S71_F1.2480.99
21_E24_S1.1840.98
8_I74_F1.1520.98
14_K81_L1.1340.98
5_Q51_V1.1280.98
63_K66_N1.1060.98
68_T71_F1.0950.97
56_W62_M1.0890.97
24_S28_H1.0880.97
3_V53_L1.0790.97
9_K46_E1.0640.97
43_K49_T1.0520.97
46_E49_T1.0310.96
3_V55_K1.0200.96
16_E20_S1.0190.96
8_I18_F1.0140.96
36_A57_K1.0050.96
6_A38_Y0.9810.95
29_S66_N0.9690.95
22_A40_L0.9690.95
33_E64_F0.9680.95
7_Y87_D0.9580.94
10_V28_H0.9550.94
10_V22_A0.9390.94
32_E65_H0.9280.93
84_A87_D0.9250.93
15_R19_L0.9060.93
41_F51_V0.8960.92
37_Q53_L0.8890.92
42_E50_F0.8880.92
11_K14_K0.8860.92
76_A79_K0.8820.92
40_L50_F0.8690.91
25_L38_Y0.8550.90
66_N74_F0.8540.90
23_Q27_Q0.8490.90
40_L52_M0.8470.90
57_K61_A0.8470.90
72_Q76_A0.8410.90
21_E52_M0.8320.89
33_E61_A0.8290.89
77_K80_E0.8120.88
32_E61_A0.8050.88
63_K67_E0.8050.88
71_F75_V0.7880.86
21_E81_L0.7870.86
26_V30_R0.7870.86
21_E77_K0.7700.85
30_R35_N0.7650.85
6_A52_M0.7580.84
18_F40_L0.7540.84
77_K81_L0.7470.83
18_F81_L0.7400.83
13_E83_S0.7390.83
10_V50_F0.7300.82
78_G82_L0.7170.81
6_A25_L0.7100.80
12_P20_S0.7020.79
4_L66_N0.6960.79
42_E47_E0.6960.79
66_N71_F0.6960.79
56_W66_N0.6940.79
5_Q53_L0.6820.77
30_R56_W0.6760.77
29_S40_L0.6560.75
8_I82_L0.6530.74
41_F53_L0.6490.74
17_E81_L0.6440.73
18_F78_G0.6440.73
29_S70_H0.6430.73
44_V57_K0.6340.72
11_K80_E0.6300.72
29_S32_E0.6270.71
25_L53_L0.6200.70
42_E46_E0.6170.70
42_E48_N0.6140.70
43_K46_E0.6120.69
15_R50_F0.6080.69
28_H70_H0.6080.69
32_E70_H0.6010.68
25_L71_F0.5920.67
29_S56_W0.5870.66
8_I79_K0.5830.66
74_F82_L0.5750.65
38_Y62_M0.5720.64
30_R39_D0.5560.62
82_L85_P0.5550.62
16_E23_Q0.5500.61
19_L50_F0.5470.61
17_E21_E0.5440.60
38_Y71_F0.5400.60
35_N38_Y0.5360.59
74_F86_L0.5310.59
30_R38_Y0.5180.57
6_A71_F0.5120.56
8_I88_V0.5120.56
58_D88_V0.5090.55
18_F28_H0.5050.55
36_A39_D0.5040.55
47_E64_F0.5020.54
75_V86_L0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2omoA 2 1 99.9 0.263 Contact Map
3mcsA 1 1 99.9 0.267 Contact Map
2gffA 2 1 99.9 0.274 Contact Map
3e8oA 2 1 99.9 0.28 Contact Map
1tuvA 2 0.9789 99.8 0.282 Contact Map
2pd1A 5 0.9789 99.8 0.29 Contact Map
3bm7A 2 1 99.8 0.291 Contact Map
3gz7A 2 1 99.8 0.295 Contact Map
2fb0A 2 0.9579 99.8 0.301 Contact Map
3f44A 1 1 99.8 0.301 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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