NFRA2 - BACSU - GREMLIN Contacts

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NFRA2 - FMN reductase [NAD(P)H]

UniProt:	P94424	Sequences: MNEVIKSLTDHRSIRSYTDEPVAQEQLDQIIEAVQSAPSSINGQQVTVITVQDKERKKKISELAGGQPWIDQAPVFLLFCADFNRAKIALEDLHDFKMEITNGLESVLVGAVDAGIALGTATAAAESLGLGTVPIGAVRGNPQELIELLELPKYVFPLSGLVIGHPADRSAKKPRLPQEAVNHQETYLNQDELTSHIQAYDEQMSEYMNKRTNGKETRNWSQSIASYYERLYYPHIREMLEKQGFKVEK	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	249 (238)
Sequences:	1453 (1091)
Seq/√Len:	70.7

ECOLI - NFSA NFNB RUTE
BACSU - NFRA2 NFRA1 YODC MHQN YDGI YFHC YFKO
HALSA - Q9HQZ4
SULSO - Q97VQ3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
52_Q	185_E	4.231	1.00
122_T	132_T	3.452	1.00
80_C	155_V	3.355	1.00
60_I	145_L	3.312	1.00
8_L	123_A	3.131	1.00
23_A	26_Q	3.002	1.00
56_R	185_E	2.977	1.00
81_A	110_G	2.889	1.00
20_E	165_H	2.882	1.00
58_K	71_D	2.810	1.00
150_E	186_T	2.800	1.00
78_L	149_L	2.571	1.00
141_N	144_E	2.546	1.00
14_I	170_S	2.509	1.00
237_R	241_E	2.428	1.00
38_P	132_T	2.365	1.00
30_I	121_A	2.360	1.00
143_Q	242_K	2.276	1.00
3_E	6_K	2.267	1.00
122_T	161_L	2.224	1.00
50_T	182_N	2.215	1.00
138_V	145_L	2.204	1.00
26_Q	165_H	2.155	1.00
50_T	75_V	2.152	1.00
17_Y	162_V	2.056	1.00
18_T	167_A	2.015	1.00
54_K	58_K	2.015	1.00
56_R	186_T	1.957	1.00
130_L	165_H	1.942	1.00
79_F	121_A	1.938	1.00
52_Q	184_Q	1.912	1.00
28_D	178_Q	1.857	1.00
24_Q	52_Q	1.842	1.00
118_L	134_P	1.834	1.00
201_D	221_S	1.825	1.00
146_I	243_Q	1.807	1.00
197_I	221_S	1.765	1.00
144_E	147_E	1.752	1.00
63_L	141_N	1.737	1.00
146_I	239_M	1.733	1.00
59_K	62_E	1.733	1.00
55_E	58_K	1.720	1.00
77_L	121_A	1.699	1.00
29_Q	128_L	1.681	1.00
48_V	77_L	1.677	1.00
37_A	116_I	1.677	1.00
26_Q	30_I	1.675	1.00
34_V	121_A	1.674	1.00
62_E	66_G	1.627	0.99
63_L	144_E	1.626	0.99
133_V	162_V	1.620	0.99
16_S	167_A	1.617	0.99
53_D	56_R	1.610	0.99
31_I	182_N	1.605	0.99
84_N	189_N	1.599	0.99
22_V	74_P	1.567	0.99
108_L	111_A	1.562	0.99
18_T	165_H	1.546	0.99
143_Q	147_E	1.537	0.99
48_V	79_F	1.533	0.99
9_T	29_Q	1.502	0.99
59_K	144_E	1.461	0.99
140_G	233_Y	1.435	0.99
65_G	137_A	1.424	0.98
76_F	160_G	1.422	0.98
26_Q	128_L	1.417	0.98
135_I	162_V	1.412	0.98
53_D	185_E	1.393	0.98
76_F	135_I	1.381	0.98
32_E	35_Q	1.342	0.98
28_D	32_E	1.337	0.98
207_Y	211_R	1.335	0.98
77_L	163_I	1.323	0.98
59_K	148_L	1.314	0.97
24_Q	28_D	1.313	0.97
26_Q	130_L	1.267	0.97
27_L	77_L	1.261	0.97
206_E	209_N	1.255	0.97
201_D	204_M	1.239	0.96
56_R	59_K	1.236	0.96
46_V	117_A	1.234	0.96
22_V	25_E	1.227	0.96
6_K	10_D	1.205	0.96
61_S	71_D	1.200	0.96
105_E	139_R	1.194	0.95
194_T	198_Q	1.183	0.95
38_P	122_T	1.173	0.95
87_K	154_Y	1.161	0.95
132_T	163_I	1.158	0.95
35_Q	181_V	1.151	0.94
27_L	31_I	1.127	0.94
202_E	206_E	1.126	0.94
76_F	162_V	1.124	0.94
153_K	243_Q	1.113	0.93
69_W	168_D	1.103	0.93
118_L	159_S	1.098	0.93
56_R	148_L	1.094	0.93
107_V	110_G	1.090	0.93
5_I	124_A	1.089	0.93
84_N	88_I	1.088	0.93
64_A	137_A	1.069	0.92
125_A	132_T	1.069	0.92
30_I	125_A	1.059	0.92
235_H	238_E	1.056	0.91
205_S	219_N	1.048	0.91
180_A	196_H	1.034	0.91
198_Q	201_D	1.032	0.90
36_S	172_K	1.026	0.90
188_L	191_D	1.025	0.90
54_K	186_T	1.022	0.90
198_Q	202_E	1.010	0.89
122_T	134_P	1.009	0.89
11_H	120_T	0.992	0.89
69_W	135_I	0.988	0.88
55_E	59_K	0.987	0.88
206_E	210_K	0.987	0.88
81_A	158_L	0.984	0.88
32_E	178_Q	0.980	0.88
113_D	136_G	0.979	0.88
195_S	198_Q	0.971	0.88
216_E	223_S	0.967	0.87
238_E	242_K	0.966	0.87
48_V	117_A	0.959	0.87
108_L	112_V	0.946	0.86
107_V	240_L	0.944	0.86
179_E	196_H	0.936	0.86
218_R	223_S	0.935	0.85
117_A	121_A	0.933	0.85
48_V	182_N	0.932	0.85
29_Q	33_A	0.924	0.85
56_R	150_E	0.922	0.85
132_T	161_L	0.919	0.84
112_V	159_S	0.915	0.84
9_T	33_A	0.907	0.84
23_A	165_H	0.905	0.84
24_Q	184_Q	0.905	0.84
61_S	64_A	0.903	0.83
4_V	7_S	0.901	0.83
49_I	80_C	0.897	0.83
47_T	183_H	0.887	0.82
28_D	179_E	0.887	0.82
16_S	170_S	0.882	0.82
40_S	105_E	0.882	0.82
4_V	123_A	0.878	0.82
11_H	126_E	0.877	0.82
83_F	110_G	0.876	0.82
50_T	184_Q	0.876	0.82
6_K	9_T	0.875	0.81
9_T	32_E	0.869	0.81
54_K	57_K	0.868	0.81
31_I	50_T	0.859	0.80
42_N	204_M	0.857	0.80
34_V	117_A	0.855	0.80
115_G	159_S	0.851	0.80
68_P	71_D	0.850	0.80
240_L	246_K	0.849	0.79
237_R	246_K	0.847	0.79
46_V	181_V	0.836	0.78
16_S	168_D	0.835	0.78
4_V	127_S	0.833	0.78
134_P	159_S	0.832	0.78
8_L	124_A	0.829	0.78
235_H	239_M	0.825	0.77
119_G	134_P	0.824	0.77
111_A	156_F	0.822	0.77
171_A	212_T	0.821	0.77
21_P	74_P	0.817	0.77
63_L	148_L	0.815	0.77
68_P	72_Q	0.814	0.77
11_H	132_T	0.812	0.76
8_L	33_A	0.811	0.76
198_Q	204_M	0.811	0.76
5_I	29_Q	0.810	0.76
125_A	163_I	0.809	0.76
87_K	153_K	0.809	0.76
142_P	239_M	0.802	0.75
138_V	157_P	0.800	0.75
201_D	219_N	0.798	0.75
238_E	241_E	0.798	0.75
64_A	70_I	0.793	0.75
14_I	168_D	0.790	0.74
78_L	138_V	0.782	0.74
38_P	134_P	0.773	0.73
73_A	162_V	0.761	0.72
22_V	26_Q	0.761	0.72
84_N	155_V	0.759	0.71
76_F	137_A	0.756	0.71
16_S	72_Q	0.754	0.71
124_A	127_S	0.751	0.71
12_R	170_S	0.748	0.70
26_Q	121_A	0.744	0.70
105_E	233_Y	0.741	0.70
75_V	182_N	0.741	0.70
219_N	222_Q	0.740	0.69
200_Y	204_M	0.737	0.69
5_I	128_L	0.737	0.69
111_A	158_L	0.734	0.69
151_L	155_V	0.732	0.69
151_L	187_Y	0.720	0.67
5_I	127_S	0.716	0.67
74_P	130_L	0.716	0.67
241_E	246_K	0.712	0.66
33_A	123_A	0.704	0.66
52_Q	75_V	0.703	0.65
112_V	115_G	0.703	0.65
110_G	156_F	0.702	0.65
57_K	75_V	0.692	0.64
79_F	114_A	0.691	0.64
79_F	118_L	0.689	0.64
150_E	179_E	0.688	0.64
25_E	28_D	0.687	0.64
194_T	202_E	0.685	0.63
57_K	162_V	0.683	0.63
43_G	106_S	0.682	0.63
191_D	195_S	0.675	0.62
22_V	163_I	0.675	0.62
112_V	134_P	0.674	0.62
46_V	115_G	0.672	0.62
235_H	242_K	0.669	0.62
12_R	169_R	0.669	0.62
22_V	28_D	0.666	0.61
88_I	189_N	0.666	0.61
199_A	202_E	0.661	0.61
40_S	140_G	0.661	0.61
50_T	57_K	0.657	0.60
64_A	67_Q	0.656	0.60
77_L	161_L	0.655	0.60
45_Q	109_V	0.654	0.60
209_N	226_S	0.652	0.60
58_K	61_S	0.648	0.59
121_A	161_L	0.648	0.59
50_T	77_L	0.646	0.59
5_I	33_A	0.644	0.59
218_R	222_Q	0.642	0.59
146_I	153_K	0.641	0.58
17_Y	69_W	0.640	0.58
6_K	81_A	0.639	0.58
215_K	218_R	0.637	0.58
216_E	221_S	0.631	0.57
40_S	109_V	0.627	0.57
135_I	220_W	0.627	0.57
30_I	163_I	0.626	0.57
224_I	228_Y	0.625	0.56
99_E	117_A	0.623	0.56
139_R	220_W	0.623	0.56
11_H	38_P	0.622	0.56
70_I	85_R	0.619	0.56
183_H	188_L	0.618	0.56
108_L	236_I	0.615	0.55
42_N	200_Y	0.615	0.55
153_K	244_G	0.613	0.55
209_N	217_T	0.611	0.55
179_E	199_A	0.610	0.55
51_V	78_L	0.607	0.54
19_D	72_Q	0.607	0.54
32_E	58_K	0.607	0.54
38_P	161_L	0.607	0.54
86_A	224_I	0.607	0.54
31_I	37_A	0.602	0.54
31_I	178_Q	0.601	0.54
201_D	211_R	0.599	0.53
178_Q	182_N	0.597	0.53
10_D	169_R	0.596	0.53
67_Q	70_I	0.594	0.53
57_K	73_A	0.593	0.53
75_V	163_I	0.592	0.52
171_A	210_K	0.590	0.52
48_V	121_A	0.590	0.52
26_Q	29_Q	0.589	0.52
233_Y	236_I	0.589	0.52
5_I	9_T	0.587	0.52
40_S	160_G	0.586	0.52
205_S	217_T	0.586	0.52
208_M	211_R	0.585	0.52
212_T	215_K	0.584	0.52
84_N	153_K	0.581	0.51
60_I	138_V	0.581	0.51
34_V	120_T	0.581	0.51
36_S	173_K	0.579	0.51
144_E	148_L	0.576	0.51
63_L	145_L	0.573	0.50
173_K	200_Y	0.572	0.50
208_M	223_S	0.572	0.50
69_W	133_V	0.570	0.50
96_F	226_S	0.568	0.50
63_L	137_A	0.568	0.50
38_P	159_S	0.568	0.50
38_P	126_E	0.568	0.50
210_K	242_K	0.567	0.49
40_S	173_K	0.567	0.49
47_T	136_G	0.566	0.49
32_E	172_K	0.561	0.49
50_T	74_P	0.560	0.49
10_D	172_K	0.560	0.49
51_V	60_I	0.560	0.49
195_S	205_S	0.557	0.48
156_F	239_M	0.556	0.48
56_R	63_L	0.553	0.48
116_I	120_T	0.552	0.48
156_F	245_F	0.550	0.47
33_A	124_A	0.549	0.47
43_G	228_Y	0.548	0.47
39_S	233_Y	0.548	0.47
142_P	236_I	0.547	0.47
61_S	66_G	0.546	0.47
81_A	155_V	0.545	0.47
46_V	114_A	0.545	0.47
142_P	157_P	0.544	0.47
21_P	75_V	0.543	0.47
61_S	137_A	0.543	0.47
51_V	149_L	0.543	0.47
40_S	139_R	0.541	0.46
224_I	230_R	0.540	0.46
40_S	136_G	0.540	0.46
28_D	198_Q	0.539	0.46
7_S	10_D	0.539	0.46
234_P	238_E	0.538	0.46
224_I	232_Y	0.538	0.46
21_P	52_Q	0.535	0.46
208_M	216_E	0.535	0.46
58_K	62_E	0.532	0.45
38_P	173_K	0.530	0.45
105_E	112_V	0.530	0.45
131_G	166_P	0.528	0.45
6_K	32_E	0.527	0.45
69_W	134_P	0.525	0.44
120_T	123_A	0.524	0.44
11_H	123_A	0.524	0.44
22_V	128_L	0.524	0.44
195_S	199_A	0.524	0.44
74_P	165_H	0.523	0.44
25_E	153_K	0.523	0.44
105_E	109_V	0.521	0.44
77_L	182_N	0.521	0.44
30_I	128_L	0.520	0.44
41_I	134_P	0.519	0.44
27_L	182_N	0.519	0.44
150_E	189_N	0.518	0.44
203_Q	226_S	0.518	0.44
44_Q	176_L	0.516	0.43
86_A	142_P	0.516	0.43
224_I	229_E	0.516	0.43
8_L	120_T	0.516	0.43
46_V	75_V	0.515	0.43
112_V	139_R	0.513	0.43
24_Q	27_L	0.512	0.43
116_I	119_G	0.512	0.43
60_I	64_A	0.508	0.42
72_Q	202_E	0.508	0.42
73_A	76_F	0.507	0.42
87_K	98_M	0.507	0.42
44_Q	200_Y	0.506	0.42
43_G	86_A	0.504	0.42
117_A	181_V	0.503	0.42
84_N	154_Y	0.502	0.42
83_F	111_A	0.501	0.41
115_G	220_W	0.500	0.41

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1zchA	2	0.988	100	0.24	Contact Map
3n2sA	2	0.988	100	0.248	Contact Map
1f5vA	2	0.9639	100	0.255	Contact Map
1bkjA	2	0.9237	100	0.256	Contact Map
3eofA	2	0.9398	100	0.338	Contact Map
3gagA	4	0.739	100	0.495	Contact Map
3bemA	2	0.7309	100	0.496	Contact Map
1noxA	2	0.7349	100	0.498	Contact Map
3gbhA	3	0.7309	100	0.5	Contact Map
3ge6A	2	0.7349	100	0.501	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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