GREMLIN Database
YCNC - Uncharacterized HTH-type transcriptional regulator YcnC
UniProt: P94423 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 292 (268)
Sequences: 457 (377)
Seq/√Len: 23.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
137_Y184_N6.4201.00
26_M40_I5.3341.00
19_K28_A4.6911.00
139_E142_L3.7791.00
30_A40_I3.3691.00
78_E184_N3.2151.00
248_A272_Y2.9921.00
37_K41_Y2.8880.99
251_M269_L2.8680.99
229_H253_E2.7840.99
11_A32_E2.7230.99
268_S272_Y2.7000.99
258_K262_R2.6190.99
147_D178_F2.5960.99
72_N83_Q2.5620.99
31_E186_I2.2820.97
254_E258_K2.2590.97
95_N265_L2.2360.97
245_L273_L2.2170.96
255_E262_R2.1720.96
251_M264_F2.1300.95
251_M265_L2.1000.95
82_T177_E2.0920.95
178_F182_T2.0640.95
16_F24_V2.0620.95
42_K268_S2.0250.94
36_S40_I2.0200.94
38_A84_K1.9300.92
248_A268_S1.8830.91
86_K173_D1.8670.91
39_S42_K1.8600.91
26_M38_A1.8460.90
151_I155_M1.8270.90
42_K45_Q1.8040.89
244_E267_K1.7290.87
185_Q189_N1.7280.87
247_S264_F1.6930.86
84_K136_A1.6810.86
4_K36_S1.6650.85
11_A35_M1.6370.84
27_Q36_S1.6180.83
81_L89_L1.6140.83
36_S39_S1.6000.83
277_G280_T1.5530.81
37_K154_G1.5460.81
38_A41_Y1.5440.80
175_I196_L1.5430.80
264_F272_Y1.5400.80
53_E265_L1.5360.80
138_G144_F1.4740.77
102_L105_G1.4600.76
16_F47_K1.4440.76
54_L101_M1.4420.76
38_A42_K1.4330.75
12_A49_D1.4220.75
27_Q37_K1.4180.74
38_A46_S1.3970.73
133_L194_Q1.3900.73
129_H133_L1.3860.73
23_S147_D1.3810.72
218_S222_S1.3790.72
134_I145_V1.3680.72
15_L40_I1.3630.71
203_E227_E1.3610.71
16_F20_D1.3560.71
246_T270_I1.3500.71
43_L136_A1.3400.70
255_E273_L1.3180.69
5_K49_D1.3150.68
50_L95_N1.3050.68
149_V158_E1.3040.68
9_L254_E1.2940.67
247_S251_M1.2920.67
84_K132_S1.2740.66
50_L273_L1.2730.66
8_I272_Y1.2670.66
178_F187_I1.2640.65
23_S266_L1.2380.64
53_E196_L1.2350.63
144_F147_D1.2330.63
49_D146_W1.2260.63
260_E263_A1.2190.62
39_S43_L1.2150.62
8_I43_L1.2140.62
157_R161_M1.2120.62
264_F267_K1.2100.62
27_Q38_A1.2100.62
23_S117_H1.1820.60
46_S147_D1.1680.59
159_F178_F1.1660.59
52_L117_H1.1660.59
69_L75_L1.1580.58
101_M104_Y1.1510.58
95_N259_E1.1450.58
15_L24_V1.1390.57
251_M272_Y1.1390.57
3_D52_L1.1380.57
17_S28_A1.1380.57
159_F175_I1.1350.57
36_S42_K1.1350.57
158_E272_Y1.1280.56
262_R266_L1.1210.56
42_K84_K1.1180.56
27_Q31_E1.1160.56
40_I157_R1.1130.55
49_D70_Q1.1030.55
39_S158_E1.0940.54
30_A48_E1.0930.54
136_A194_Q1.0870.54
12_A34_K1.0870.54
8_I22_T1.0840.53
81_L122_R1.0840.53
72_N77_P1.0830.53
12_A177_E1.0610.52
254_E267_K1.0600.52
99_F185_Q1.0500.51
15_L47_K1.0470.51
81_L117_H1.0460.51
78_E180_I1.0420.50
148_L187_I1.0410.50
128_W132_S1.0340.50
7_D85_V1.0290.50
199_P230_K1.0280.49
6_T152_L1.0230.49
59_Q118_I1.0200.49
246_T263_A1.0190.49
231_G235_L1.0180.49
243_D246_T1.0170.49
66_A97_Q1.0140.48
66_A69_L1.0090.48
155_M179_I0.9990.47
166_E202_I0.9980.47
40_I50_L0.9940.47
26_M30_A0.9920.47
182_T189_N0.9890.47
20_D24_V0.9880.47
33_C40_I0.9850.46
235_L279_L0.9810.46
49_D252_L0.9810.46
84_K96_Q0.9810.46
266_L270_I0.9800.46
122_R125_I0.9790.46
197_L254_E0.9780.46
66_A162_L0.9740.46
228_L249_A0.9730.46
174_P194_Q0.9710.45
17_S105_G0.9680.45
246_T279_L0.9630.45
252_L266_L0.9600.45
253_E261_P0.9550.44
54_L61_Q0.9550.44
45_Q49_D0.9520.44
181_S193_R0.9490.44
21_F48_E0.9480.44
149_V173_D0.9400.43
18_E108_K0.9250.42
182_T187_I0.9220.42
102_L180_I0.9200.42
262_R273_L0.9200.42
22_T114_V0.9200.42
29_I44_F0.9160.42
197_L202_I0.9150.42
94_R259_E0.9140.42
4_K8_I0.9130.42
122_R161_M0.9020.41
88_E155_M0.9010.41
33_C176_A0.8990.41
112_D123_S0.8930.40
42_K272_Y0.8930.40
172_L224_S0.8860.40
74_A129_H0.8820.39
210_S246_T0.8760.39
39_S58_N0.8740.39
25_S96_Q0.8660.38
57_F137_Y0.8520.37
39_S176_A0.8520.37
65_A230_K0.8520.37
144_F157_R0.8510.37
255_E261_P0.8510.37
144_F151_I0.8510.37
114_V251_M0.8470.37
36_S133_L0.8470.37
52_L123_S0.8460.37
83_Q235_L0.8360.36
34_K65_A0.8360.36
249_A253_E0.8310.36
112_D137_Y0.8210.35
25_S29_I0.8200.35
48_E95_N0.8180.35
25_S154_G0.8120.35
253_E275_Q0.8120.35
138_G141_I0.8110.35
4_K62_M0.8090.35
172_L180_I0.8080.35
248_A264_F0.8070.35
38_A54_L0.8060.35
98_F104_Y0.8030.34
269_L272_Y0.8010.34
98_F268_S0.7960.34
81_L141_I0.7870.33
247_S262_R0.7840.33
150_I280_T0.7810.33
148_L190_R0.7800.33
30_A39_S0.7730.32
69_L180_I0.7720.32
17_S99_F0.7710.32
30_A42_K0.7700.32
254_E262_R0.7660.32
17_S26_M0.7650.32
151_I211_S0.7650.32
27_Q84_K0.7630.32
81_L84_K0.7620.32
79_E173_D0.7600.32
17_S184_N0.7560.31
253_E269_L0.7550.31
246_T257_K0.7550.31
276_T280_T0.7510.31
8_I40_I0.7500.31
264_F271_G0.7460.31
131_D180_I0.7450.31
24_V40_I0.7450.31
10_L26_M0.7430.31
50_L54_L0.7400.31
220_L228_L0.7370.30
134_I246_T0.7370.30
81_L161_M0.7360.30
85_V278_V0.7340.30
6_T59_Q0.7340.30
84_K128_W0.7330.30
36_S41_Y0.7330.30
10_L152_L0.7310.30
66_A251_M0.7270.30
69_L202_I0.7260.30
28_A78_E0.7210.29
38_A45_Q0.7210.29
83_Q260_E0.7190.29
224_S277_G0.7190.29
83_Q229_H0.7180.29
183_L246_T0.7180.29
25_S37_K0.7180.29
186_I225_L0.7150.29
8_I273_L0.7120.29
48_E66_A0.7110.29
150_I197_L0.7100.29
24_V34_K0.7100.29
19_K262_R0.7080.29
16_F37_K0.7080.29
159_F248_A0.7070.29
133_L252_L0.7050.28
253_E273_L0.7020.28
79_E160_L0.7010.28
76_T179_I0.7000.28
76_T79_E0.6980.28
24_V46_S0.6970.28
83_Q233_S0.6940.28
113_R177_E0.6930.28
105_G108_K0.6900.28
176_A179_I0.6870.27
154_G182_T0.6850.27
57_F268_S0.6820.27
26_M182_T0.6820.27
261_P265_L0.6790.27
7_D42_K0.6790.27
74_A210_S0.6780.27
14_K78_E0.6770.27
97_Q149_V0.6770.27
41_Y50_L0.6740.27
264_F269_L0.6740.27
81_L134_I0.6730.27
21_F126_I0.6710.27
34_K105_G0.6690.26
12_A138_G0.6690.26
192_T229_H0.6680.26
225_L228_L0.6640.26
28_A117_H0.6600.26
39_S98_F0.6590.26
4_K42_K0.6560.26
117_H121_T0.6510.26
8_I137_Y0.6500.25
74_A250_A0.6500.25
57_F101_M0.6490.25
43_L256_A0.6490.25
251_M268_S0.6480.25
246_T250_A0.6480.25
171_E174_P0.6470.25
37_K50_L0.6460.25
54_L91_G0.6450.25
254_E279_L0.6440.25
235_L254_E0.6440.25
23_S175_I0.6420.25
37_K42_K0.6420.25
33_C130_R0.6390.25
9_L276_T0.6360.25
4_K148_L0.6340.25
158_E268_S0.6330.25
254_E278_V0.6330.25
37_K47_K0.6320.25
53_E86_K0.6320.25
55_L108_K0.6310.24
138_G143_P0.6290.24
142_L235_L0.6290.24
39_S49_D0.6270.24
144_F187_I0.6270.24
80_R230_K0.6260.24
40_I44_F0.6250.24
197_L205_Y0.6250.24
25_S71_E0.6240.24
104_Y109_L0.6240.24
74_A252_L0.6190.24
9_L165_I0.6180.24
236_S277_G0.6180.24
26_M223_E0.6150.24
19_K77_P0.6110.23
158_E265_L0.6100.23
243_D271_G0.6100.23
21_F51_L0.6090.23
41_Y81_L0.6090.23
81_L206_I0.6090.23
4_K268_S0.6080.23
94_R220_L0.6070.23
221_L228_L0.6060.23
41_Y47_K0.6060.23
234_S275_Q0.6050.23
177_E199_P0.6050.23
30_A251_M0.6040.23
90_E179_I0.6000.23
250_A280_T0.6000.23
84_K88_E0.5970.23
143_P229_H0.5960.23
152_L167_E0.5960.23
43_L96_Q0.5940.23
34_K106_N0.5940.23
171_E244_E0.5930.23
151_I182_T0.5920.23
50_L178_F0.5920.23
172_L176_A0.5910.22
116_Q120_Q0.5890.22
136_A140_T0.5890.22
69_L114_V0.5860.22
52_L279_L0.5840.22
228_L279_L0.5840.22
249_A278_V0.5810.22
52_L114_V0.5780.22
107_P156_M0.5740.22
42_K66_A0.5720.22
18_E32_E0.5710.22
96_Q162_L0.5670.21
39_S125_I0.5630.21
48_E111_N0.5620.21
63_V185_Q0.5620.21
152_L262_R0.5610.21
37_K98_F0.5610.21
119_H206_I0.5580.21
138_G142_L0.5580.21
37_K138_G0.5580.21
228_L232_I0.5570.21
58_N155_M0.5560.21
26_M66_A0.5560.21
26_M83_Q0.5550.21
244_E279_L0.5510.21
22_T51_L0.5470.20
26_M221_L0.5460.20
183_L219_V0.5450.20
17_S57_F0.5440.20
32_E51_L0.5440.20
4_K37_K0.5420.20
233_S243_D0.5410.20
65_A68_R0.5410.20
13_R58_N0.5370.20
34_K96_Q0.5360.20
86_K269_L0.5340.20
76_T228_L0.5330.20
60_K155_M0.5320.20
34_K275_Q0.5310.20
217_K232_I0.5300.20
51_L162_L0.5300.20
39_S100_N0.5290.20
78_E95_N0.5260.19
26_M46_S0.5260.19
200_E266_L0.5230.19
232_I280_T0.5180.19
25_S80_R0.5180.19
74_A236_S0.5170.19
9_L266_L0.5150.19
58_N98_F0.5150.19
11_A61_Q0.5150.19
263_A274_E0.5130.19
124_T133_L0.5130.19
102_L192_T0.5120.19
267_K272_Y0.5110.19
28_A104_Y0.5100.19
145_V148_L0.5080.19
151_I178_F0.5070.19
42_K158_E0.5070.19
246_T260_E0.5060.19
36_S154_G0.5060.19
90_E94_R0.5050.19
171_E249_A0.5040.19
25_S52_L0.5020.18
13_R97_Q0.5020.18
82_T176_A0.5010.18
27_Q46_S0.5000.18
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dcfA 2 0.6233 100 0.592 Contact Map
2ibdA 2 0.6438 100 0.594 Contact Map
2g3bA 2 0.6301 100 0.603 Contact Map
4udsA 2 0.6233 100 0.604 Contact Map
2id6A 2 0.6507 100 0.605 Contact Map
1vi0A 2 0.637 100 0.605 Contact Map
4gckA 2 0.637 100 0.606 Contact Map
3bqzB 3 0.6301 100 0.611 Contact Map
2genA 2 0.637 100 0.612 Contact Map
3himA 2 0.6438 100 0.612 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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