GREMLIN Database
YCNB - Uncharacterized MFS-type transporter YcnB
UniProt: P94422 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 472 (413)
Sequences: 70914 (52175)
Seq/√Len: 2567.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
100_P104_V5.5161.00
88_I115_G4.0871.00
90_T178_A4.0231.00
95_V108_A3.6661.00
97_A172_Y3.6511.00
103_P107_T3.5471.00
78_S129_T3.1841.00
61_T110_I3.1781.00
101_N104_V3.1081.00
92_G108_A2.6701.00
276_T406_G2.6601.00
92_G115_G2.6591.00
387_L395_G2.6451.00
300_T303_D2.5831.00
280_A410_G2.5741.00
102_F106_L2.5671.00
348_P364_L2.5341.00
47_D50_Q2.4731.00
12_R135_K2.4611.00
65_L114_A2.4331.00
69_T118_I2.4161.00
314_V366_T2.4091.00
57_S110_I2.3981.00
318_M370_L2.3551.00
443_I447_V2.3481.00
137_G327_D2.3411.00
359_A363_V2.3061.00
20_L146_V2.2661.00
85_A118_I2.2651.00
131_F139_A2.2621.00
92_G111_I2.2381.00
135_K138_Q2.2331.00
83_I186_S2.1971.00
46_V102_F2.1851.00
54_L105_L2.1441.00
99_A104_V2.1111.00
74_E393_P2.0881.00
96_G108_A2.0851.00
388_P391_L2.0701.00
261_R264_T2.0691.00
50_Q102_F2.0551.00
94_V175_L2.0281.00
165_F169_S1.9941.00
183_I187_I1.9851.00
99_A108_A1.9561.00
284_G414_L1.9521.00
132_P135_K1.9451.00
104_V108_A1.9351.00
65_L117_G1.9111.00
201_D204_S1.9031.00
87_S182_L1.8841.00
57_S106_L1.8661.00
83_I182_L1.8611.00
272_T402_I1.8471.00
357_S360_W1.8301.00
324_R328_R1.7961.00
73_I122_L1.7761.00
96_G105_L1.7721.00
261_R391_L1.7581.00
72_L81_L1.7341.00
46_V50_Q1.7051.00
79_R83_I1.6871.00
185_A189_M1.6851.00
281_L449_A1.6641.00
166_S169_S1.6471.00
203_L249_R1.6451.00
345_T364_L1.6301.00
161_A169_S1.6161.00
39_H42_R1.6031.00
283_I407_G1.5971.00
72_L76_F1.5941.00
338_G374_M1.5821.00
323_G327_D1.5761.00
350_M443_I1.5651.00
95_V98_F1.5621.00
90_T182_L1.5581.00
341_I371_G1.5461.00
71_F75_K1.5371.00
345_T371_G1.5341.00
333_G336_I1.5321.00
84_T88_I1.4961.00
90_T175_L1.4751.00
440_A444_V1.4661.00
88_I92_G1.4641.00
294_Q304_T1.4621.00
41_M51_A1.4501.00
163_E302_F1.4491.00
219_F222_V1.4431.00
94_V98_F1.4361.00
314_V318_M1.4361.00
22_G82_L1.4351.00
103_P106_L1.4251.00
222_V227_W1.4101.00
303_D306_L1.4001.00
343_F453_F1.3991.00
36_A162_V1.3991.00
343_F347_L1.3921.00
259_E391_L1.3921.00
244_L248_T1.3881.00
299_V303_D1.3771.00
83_I185_A1.3721.00
322_I374_M1.3681.00
91_A95_V1.3591.00
184_L188_L1.3451.00
343_F450_L1.3421.00
258_L261_R1.3331.00
16_V131_F1.3321.00
80_A84_T1.3301.00
73_I78_S1.3281.00
60_L408_S1.3231.00
61_T65_L1.3181.00
292_Y297_R1.3151.00
90_T179_V1.3141.00
21_A181_D1.3101.00
100_P168_R1.2951.00
345_T368_R1.2941.00
80_A191_N1.2851.00
133_I136_R1.2831.00
70_A74_E1.2821.00
440_A443_I1.2761.00
58_F116_A1.2751.00
128_L136_R1.2711.00
217_Y221_S1.2691.00
160_W164_A1.2671.00
24_F150_A1.2661.00
347_L351_Q1.2661.00
36_A170_L1.2661.00
92_G112_Q1.2661.00
77_T80_A1.2641.00
269_S273_L1.2601.00
32_L170_L1.2541.00
138_Q327_D1.2521.00
29_N32_L1.2511.00
263_F269_S1.2411.00
169_S176_P1.2281.00
325_I329_V1.2271.00
311_G369_L1.2251.00
454_L458_T1.2231.00
299_V307_M1.2151.00
172_Y176_P1.2141.00
321_I324_R1.2131.00
53_W57_S1.2101.00
27_I147_I1.2061.00
359_A362_V1.1901.00
15_I130_I1.1891.00
268_F272_T1.1791.00
76_F81_L1.1751.00
350_M446_A1.1741.00
340_C453_F1.1731.00
330_G333_G1.1651.00
363_V367_V1.1571.00
107_T111_I1.1571.00
43_D168_R1.1551.00
13_S17_G1.1541.00
95_V104_V1.1531.00
193_T196_R1.1501.00
37_L51_A1.1381.00
176_P180_I1.1201.00
221_S225_Y1.1201.00
340_C344_L1.1181.00
348_P351_Q1.1091.00
333_G337_A1.1061.00
339_F452_G1.1061.00
63_G408_S1.1021.00
80_A83_I1.1011.00
421_Q440_A1.0991.00
39_H43_D1.0931.00
83_I87_S1.0881.00
406_G410_G1.0881.00
257_M261_R1.0861.00
363_V366_T1.0851.00
249_R253_L1.0841.00
127_F143_V1.0821.00
57_S61_T1.0801.00
43_D167_W1.0801.00
202_I206_I1.0781.00
78_S191_N1.0771.00
12_R131_F1.0711.00
18_I181_D1.0701.00
358_L362_V1.0621.00
61_T113_A1.0601.00
157_L160_W1.0591.00
74_E394_H1.0591.00
104_V107_T1.0571.00
79_R186_S1.0541.00
169_S172_Y1.0531.00
74_E78_S1.0521.00
347_L446_A1.0521.00
85_A115_G1.0501.00
97_A168_R1.0481.00
14_V188_L1.0471.00
324_R327_D1.0451.00
332_R336_I1.0451.00
93_T174_I1.0431.00
65_L68_I1.0421.00
331_G385_N1.0421.00
96_G171_F1.0381.00
182_L186_S1.0361.00
443_I446_A1.0341.00
54_L102_F1.0321.00
439_N443_I1.0291.00
22_G119_M1.0291.00
257_M260_F1.0281.00
450_L454_L1.0211.00
98_F172_Y1.0161.00
41_M48_A1.0151.00
444_V448_I1.0131.00
277_L452_G1.0101.00
416_S420_N1.0091.00
289_L365_Y1.0051.00
266_G270_L1.0051.00
22_G86_M0.9981.00
336_I453_F0.9971.00
200_I205_V0.9961.00
266_G269_S0.9951.00
383_G399_N0.9891.00
29_N109_R0.9871.00
200_I203_L0.9871.00
18_I188_L0.9871.00
56_T408_S0.9741.00
447_V451_V0.9721.00
77_T81_L0.9701.00
345_T367_V0.9641.00
320_P324_R0.9601.00
275_G399_N0.9581.00
86_M182_L0.9571.00
256_P259_E0.9551.00
82_L126_V0.9521.00
342_I449_A0.9501.00
303_D307_M0.9501.00
138_Q142_M0.9481.00
278_V375_I0.9461.00
191_N195_L0.9461.00
58_F62_N0.9391.00
138_Q324_R0.9361.00
268_F387_L0.9341.00
272_T398_M0.9341.00
129_T392_I0.9331.00
338_G371_G0.9311.00
134_E138_Q0.9291.00
93_T112_Q0.9291.00
36_A40_I0.9281.00
421_Q425_A0.9281.00
265_F391_L0.9241.00
58_F113_A0.9231.00
163_E300_T0.9151.00
294_Q301_A0.9141.00
199_Q203_L0.9131.00
334_L337_A0.9131.00
352_L364_L0.9061.00
156_T309_L0.9031.00
452_G456_S0.9011.00
218_G222_V0.9001.00
325_I334_L0.8961.00
136_R385_N0.8941.00
360_W363_V0.8941.00
175_L179_V0.8941.00
248_T251_M0.8891.00
445_A449_A0.8891.00
28_L174_I0.8861.00
347_L350_M0.8831.00
187_I190_K0.8831.00
337_A341_I0.8811.00
336_I457_F0.8801.00
179_V183_I0.8771.00
161_A165_F0.8761.00
446_A450_L0.8761.00
274_L456_S0.8751.00
343_F446_A0.8751.00
419_S422_A0.8751.00
417_V421_Q0.8731.00
336_I340_C0.8711.00
458_T461_K0.8701.00
421_Q424_H0.8681.00
418_M422_A0.8671.00
318_M321_I0.8671.00
200_I204_S0.8651.00
338_G375_I0.8641.00
293_T361_I0.8641.00
306_L310_P0.8641.00
20_L142_M0.8621.00
307_M362_V0.8611.00
108_A111_I0.8581.00
270_L458_T0.8571.00
90_T94_V0.8561.00
313_V317_F0.8541.00
161_A173_I0.8531.00
79_R191_N0.8531.00
160_W302_F0.8521.00
198_T202_I0.8521.00
248_T252_K0.8491.00
315_M373_A0.8471.00
271_T383_G0.8471.00
247_I251_M0.8441.00
345_T348_P0.8431.00
377_M381_T0.8431.00
251_M261_R0.8421.00
128_L392_I0.8421.00
454_L457_F0.8401.00
279_F403_R0.8361.00
58_F109_R0.8361.00
126_V189_M0.8351.00
84_T87_S0.8351.00
96_G99_A0.8321.00
55_T287_T0.8311.00
381_T385_N0.8291.00
97_A175_L0.8251.00
360_W364_L0.8231.00
164_A302_F0.8211.00
28_L154_G0.8191.00
192_V195_L0.8161.00
82_L185_A0.8161.00
265_F269_S0.8131.00
317_F320_P0.8111.00
16_V139_A0.8091.00
198_T201_D0.8051.00
183_I186_S0.8011.00
70_A393_P0.8001.00
81_L84_T0.8001.00
293_T297_R0.7991.00
145_L148_S0.7971.00
29_N89_F0.7971.00
410_G413_L0.7961.00
288_I415_V0.7951.00
96_G112_Q0.7931.00
65_L69_T0.7931.00
415_V419_S0.7921.00
420_N423_A0.7911.00
66_I400_N0.7911.00
457_F461_K0.7901.00
89_F116_A0.7891.00
346_S350_M0.7871.00
416_S419_S0.7841.00
87_S91_A0.7831.00
218_G221_S0.7821.00
145_L316_G0.7791.00
246_F250_Q0.7771.00
362_V366_T0.7771.00
100_P103_P0.7721.00
63_G401_T0.7681.00
422_A425_A0.7661.00
413_L416_S0.7641.00
292_Y296_V0.7631.00
78_S125_T0.7611.00
36_A171_F0.7591.00
89_F178_A0.7591.00
384_I392_I0.7571.00
18_I184_L0.7551.00
326_F378_P0.7541.00
151_P312_A0.7541.00
444_V447_V0.7531.00
150_A154_G0.7531.00
417_V420_N0.7531.00
249_R252_K0.7511.00
29_N174_I0.7501.00
284_G445_A0.7501.00
33_L54_L0.7481.00
293_T307_M0.7481.00
24_F153_I0.7431.00
159_G301_A0.7421.00
199_Q202_I0.7421.00
342_I345_T0.7421.00
76_F80_A0.7421.00
89_F115_G0.7411.00
125_T393_P0.7381.00
18_I185_A0.7381.00
342_I371_G0.7381.00
199_Q255_K0.7381.00
154_G158_S0.7371.00
245_L248_T0.7361.00
277_L448_I0.7351.00
109_R112_Q0.7341.00
156_T160_W0.7331.00
148_S315_M0.7321.00
40_I105_L0.7321.00
52_Q56_T0.7311.00
340_C343_F0.7301.00
53_W412_A0.7301.00
204_S249_R0.7281.00
339_F375_I0.7271.00
336_I456_S0.7251.00
159_G305_G0.7231.00
24_F146_V0.7211.00
126_V130_I0.7201.00
67_P71_F0.7201.00
247_I260_F0.7161.00
344_L348_P0.7161.00
153_I156_T0.7141.00
162_V170_L0.7131.00
94_V172_Y0.7131.00
318_M322_I0.7111.00
397_A401_T0.7111.00
307_M310_P0.7101.00
71_F394_H0.7101.00
366_T369_L0.7071.00
25_V178_A0.7061.00
92_G95_V0.7061.00
341_I345_T0.7031.00
176_P179_V0.7011.00
420_N425_A0.7001.00
267_V386_A0.7001.00
276_T402_I0.7001.00
123_M143_V0.6981.00
194_T197_K0.6971.00
52_Q288_I0.6961.00
169_S173_I0.6951.00
48_A419_S0.6951.00
100_P108_A0.6941.00
125_T129_T0.6921.00
314_V317_F0.6911.00
455_L459_L0.6911.00
243_L247_I0.6901.00
362_V365_Y0.6901.00
148_S319_S0.6881.00
267_V460_K0.6881.00
60_L63_G0.6861.00
374_M378_P0.6841.00
46_V51_A0.6841.00
293_T299_V0.6821.00
38_P42_R0.6751.00
54_L57_S0.6741.00
177_F180_I0.6731.00
267_V270_L0.6731.00
302_F306_L0.6711.00
418_M421_Q0.6701.00
68_I71_F0.6701.00
291_L295_N0.6691.00
124_Q140_M0.6671.00
203_L206_I0.6671.00
25_V29_N0.6661.00
22_G185_A0.6641.00
321_I325_I0.6641.00
49_N419_S0.6631.00
451_V455_L0.6601.00
15_I18_I0.6551.00
350_M353_T0.6541.00
26_A119_M0.6531.00
449_A453_F0.6531.00
275_G279_F0.6531.00
336_I339_F0.6531.00
318_M373_A0.6521.00
14_V17_G0.6511.00
87_S90_T0.6511.00
186_S190_K0.6501.00
98_F108_A0.6491.00
137_G323_G0.6491.00
69_T85_A0.6481.00
265_F388_P0.6481.00
54_L106_L0.6471.00
317_F321_I0.6461.00
273_L277_L0.6461.00
41_M46_V0.6441.00
23_A147_I0.6431.00
159_G302_F0.6431.00
130_I190_K0.6391.00
127_F139_A0.6381.00
30_Q62_N0.6371.00
272_T276_T0.6361.00
444_V461_K0.6361.00
69_T81_L0.6351.00
128_L384_I0.6351.00
256_P260_F0.6341.00
59_M407_G0.6331.00
202_I205_V0.6321.00
140_M381_T0.6321.00
318_M374_M0.6321.00
32_L158_S0.6311.00
442_F446_A0.6301.00
198_T205_V0.6301.00
44_F167_W0.6291.00
107_T110_I0.6291.00
384_I396_T0.6271.00
79_R190_K0.6261.00
273_L455_L0.6261.00
356_T360_W0.6231.00
161_A170_L0.6221.00
456_S459_L0.6211.00
264_T269_S0.6201.00
19_L123_M0.6161.00
13_S131_F0.6161.00
222_V225_Y0.6151.00
50_Q103_P0.6121.00
56_T412_A0.6121.00
456_S461_K0.6101.00
145_L149_F0.6101.00
74_E77_T0.6071.00
137_G141_G0.6061.00
93_T175_L0.6031.00
346_S368_R0.6031.00
63_G404_Q0.6001.00
262_V265_F0.6001.00
191_N196_R0.5981.00
32_L174_I0.5971.00
220_S223_G0.5971.00
405_V409_I0.5961.00
64_I68_I0.5911.00
128_L140_M0.5901.00
448_I452_G0.5891.00
270_L455_L0.5881.00
190_K193_T0.5861.00
53_W60_L0.5851.00
223_G226_G0.5841.00
343_F449_A0.5841.00
160_W163_E0.5831.00
314_V370_L0.5811.00
391_L394_H0.5801.00
217_Y220_S0.5791.00
332_R460_K0.5791.00
337_A340_C0.5781.00
253_L256_P0.5781.00
148_S316_G0.5771.00
62_N404_Q0.5741.00
40_I44_F0.5741.00
272_T399_N0.5741.00
322_I325_I0.5721.00
389_R392_I0.5701.00
27_I30_Q0.5701.00
160_W306_L0.5701.00
259_E262_V0.5701.00
158_S170_L0.5681.00
418_M423_A0.5681.00
453_F457_F0.5671.00
146_V150_A0.5661.00
168_R172_Y0.5661.00
98_F104_V0.5651.00
352_L360_W0.5641.00
69_T117_G0.5641.00
329_V334_L0.5631.00
255_K259_E0.5621.00
131_F135_K0.5621.00
335_A339_F0.5611.00
350_M439_N0.5601.00
344_L347_L0.5601.00
13_S139_A0.5591.00
313_V316_G0.5581.00
53_W106_L0.5581.00
172_Y175_L0.5581.00
180_I184_L0.5571.00
244_L247_I0.5561.00
307_M358_L0.5561.00
351_Q443_I0.5561.00
369_L373_A0.5551.00
310_P362_V0.5551.00
456_S460_K0.5541.00
457_F460_K0.5531.00
135_K139_A0.5531.00
325_I328_R0.5511.00
441_A445_A0.5501.00
334_L338_G0.5491.00
418_M441_A0.5481.00
275_G403_R0.5461.00
17_G21_A0.5461.00
242_A245_L0.5451.00
331_G461_K0.5431.00
86_M178_A0.5431.00
127_F136_R0.5421.00
270_L460_K0.5421.00
310_P314_V0.5421.00
147_I151_P0.5411.00
119_M185_A0.5411.00
414_L445_A0.5391.00
95_V99_A0.5391.00
412_A416_S0.5391.00
122_L125_T0.5381.00
152_A312_A0.5381.00
184_L187_I0.5381.00
118_I122_L0.5381.00
255_K258_L0.5371.00
311_G365_Y0.5361.00
15_I126_V0.5361.00
50_Q54_L0.5341.00
398_M402_I0.5341.00
441_A444_V0.5321.00
225_Y228_S0.5311.00
256_P261_R0.5301.00
451_V454_L0.5281.00
174_I178_A0.5281.00
406_G409_I0.5281.00
53_W56_T0.5271.00
352_L356_T0.5271.00
50_Q106_L0.5261.00
311_G368_R0.5261.00
25_V177_F0.5251.00
37_L55_T0.5231.00
88_I111_I0.5221.00
262_V395_G0.5201.00
142_M145_L0.5191.00
28_L32_L0.5191.00
152_A313_V0.5171.00
329_V333_G0.5171.00
339_F453_F0.5171.00
22_G181_D0.5161.00
20_L145_L0.5141.00
332_R461_K0.5141.00
109_R113_A0.5131.00
73_I125_T0.5131.00
299_V358_L0.5131.00
404_Q407_G0.5131.00
91_A94_V0.5121.00
320_P323_G0.5121.00
364_L367_V0.5111.00
198_T203_L0.5111.00
96_G109_R0.5101.00
30_Q59_M0.5101.00
92_G99_A0.5101.00
63_G405_V0.5091.00
56_T60_L0.5081.00
41_M47_D0.5071.00
455_L458_T0.5071.00
400_N403_R0.5071.00
260_F264_T0.5071.00
222_V226_G0.5061.00
321_I370_L0.5061.00
342_I346_S0.5041.00
106_L110_I0.5041.00
380_T384_I0.5021.00
64_I67_P0.5021.00
138_Q141_G0.5011.00
180_I183_I0.5011.00
330_G334_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1pw4A 1 0.8686 100 0.272 Contact Map
4j05A 3 0.7945 100 0.291 Contact Map
4pypA 1 0.8814 100 0.293 Contact Map
3wdoA 1 0.8411 100 0.317 Contact Map
2gfpA 2 0.7945 100 0.333 Contact Map
3o7qA 1 0.8136 100 0.337 Contact Map
4ldsA 2 0.8686 100 0.337 Contact Map
4gc0A 1 0.9153 100 0.338 Contact Map
4zw9A 1 0.9089 100 0.34 Contact Map
2cfqA 1 0.8453 100 0.36 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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