GREMLIN Database
YCLQ - Uncharacterized ABC transporter solute-binding protein YclQ
UniProt: P94421 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 317 (280)
Sequences: 14089 (11195)
Seq/√Len: 669.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
157_E170_K4.1241.00
247_N279_N4.1081.00
160_G169_V4.0641.00
153_K177_D3.9481.00
165_K168_K3.4271.00
179_S309_K3.2841.00
161_K166_E3.1051.00
279_N283_N3.0611.00
59_V65_L2.9251.00
40_K47_G2.8971.00
157_E173_L2.7991.00
168_K171_D2.6881.00
181_A185_K2.5971.00
217_H222_V2.5971.00
170_K174_A2.5301.00
174_A178_H2.5171.00
38_T47_G2.4841.00
110_K113_E2.4691.00
242_Y245_K2.3551.00
58_V111_V2.2951.00
41_H48_T2.1371.00
57_V163_F2.1311.00
68_L163_F2.1091.00
177_D181_A2.1031.00
179_S305_T2.0721.00
178_H182_D1.9991.00
214_G218_D1.9941.00
73_L165_K1.9771.00
73_L163_F1.9581.00
249_D279_N1.9421.00
182_D186_T1.9261.00
67_T156_A1.9251.00
193_N223_A1.9061.00
129_Y133_S1.8411.00
171_D175_N1.8361.00
270_V284_G1.8291.00
36_Q49_K1.8281.00
131_E134_K1.8041.00
278_V281_V1.7981.00
38_T49_K1.7661.00
120_I159_I1.7451.00
250_Y287_I1.7441.00
151_S154_S1.6741.00
181_A184_K1.6721.00
167_D171_D1.6701.00
279_N282_K1.6361.00
250_Y285_H1.6331.00
130_K134_K1.5951.00
154_S157_E1.5841.00
86_P89_L1.5761.00
168_K172_E1.5691.00
267_K271_E1.5561.00
37_I161_K1.5521.00
175_N179_S1.5331.00
106_P111_V1.5301.00
267_K270_V1.5281.00
277_N282_K1.5251.00
266_T270_V1.5251.00
58_V114_L1.5101.00
98_A110_K1.5011.00
195_L198_M1.4711.00
107_D110_K1.4551.00
154_S158_T1.4061.00
240_Y272_N1.3971.00
56_K78_A1.3951.00
112_A135_I1.3781.00
275_V281_V1.3741.00
12_V15_V1.3711.00
166_E170_K1.3571.00
59_V68_L1.3561.00
153_K173_L1.3481.00
185_K188_E1.3461.00
109_D241_E1.3371.00
242_Y246_T1.3331.00
183_V312_K1.3211.00
157_E177_D1.3201.00
174_A177_D1.2971.00
251_L280_A1.2941.00
178_H181_A1.2871.00
50_V53_N1.2781.00
203_K237_S1.2661.00
192_K250_Y1.2621.00
13_T16_V1.2621.00
179_S182_D1.2521.00
126_S130_K1.2451.00
108_F131_E1.2411.00
194_G222_V1.2381.00
172_E175_N1.2371.00
180_I308_I1.2331.00
55_K76_I1.2281.00
310_E313_D1.2261.00
71_L165_K1.2221.00
130_K133_S1.2171.00
68_L73_L1.2101.00
55_K117_D1.2071.00
167_D170_K1.2031.00
158_T161_K1.2031.00
156_A169_V1.2001.00
85_L88_Y1.1991.00
228_N246_T1.1981.00
225_A228_N1.1781.00
182_D185_K1.1711.00
225_A246_T1.1681.00
184_K219_V1.1611.00
183_V308_I1.1601.00
56_K115_D1.1591.00
69_D74_D1.1571.00
54_P117_D1.1511.00
226_D246_T1.1491.00
125_Q128_S1.1421.00
209_P218_D1.1351.00
187_A190_L1.1181.00
173_L177_D1.1071.00
41_H129_Y1.0901.00
175_N178_H1.0871.00
70_K172_E1.0821.00
223_A227_Q1.0821.00
36_Q53_N1.0801.00
196_V217_H1.0661.00
186_T312_K1.0631.00
87_K90_S1.0551.00
76_I165_K1.0541.00
268_Q271_E1.0481.00
57_V118_L1.0461.00
184_K188_E1.0411.00
191_N223_A1.0411.00
77_V114_L1.0411.00
83_Q86_P1.0381.00
73_L76_I1.0311.00
36_Q51_P1.0271.00
302_E305_T1.0181.00
36_Q52_K1.0171.00
195_L199_A1.0091.00
309_K313_D1.0061.00
85_L89_L1.0021.00
180_I184_K0.9981.00
128_S131_E0.9761.00
290_D293_T0.9741.00
41_H47_G0.9731.00
89_L92_F0.9711.00
88_Y91_K0.9691.00
160_G173_L0.9681.00
197_I200_N0.9651.00
69_D92_F0.9641.00
157_E161_K0.9631.00
68_L77_V0.9611.00
275_V278_V0.9501.00
158_T162_I0.9501.00
86_P90_S0.9481.00
79_G114_L0.9461.00
57_V68_L0.9451.00
147_K150_E0.9441.00
43_L133_S0.9421.00
82_K99_D0.9421.00
53_N165_K0.9411.00
279_N285_H0.9381.00
56_K76_I0.9361.00
77_V80_L0.9351.00
193_N249_D0.9281.00
176_I219_V0.9251.00
140_Y162_I0.9221.00
67_T159_I0.9171.00
84_V88_Y0.9161.00
15_V18_S0.9111.00
179_S183_V0.9091.00
264_S267_K0.9091.00
169_V173_L0.9091.00
66_D302_E0.9071.00
68_L120_I0.9061.00
71_L172_E0.9051.00
247_N251_L0.8981.00
20_C23_Q0.8961.00
211_S214_G0.8941.00
59_V77_V0.8941.00
281_V286_V0.8921.00
119_I136_A0.8861.00
226_D242_Y0.8801.00
148_Y151_S0.8751.00
273_D276_K0.8691.00
159_I163_F0.8661.00
194_G197_I0.8631.00
64_S120_I0.8621.00
50_V54_P0.8521.00
215_L219_V0.8461.00
215_L218_D0.8381.00
120_I162_I0.8371.00
78_A114_L0.8361.00
77_V97_Y0.8321.00
248_P251_L0.8301.00
54_P118_L0.8291.00
90_S95_D0.8291.00
80_L99_D0.8281.00
13_T17_I0.8261.00
243_I278_V0.8261.00
265_S268_Q0.8251.00
155_D158_T0.8231.00
74_D77_V0.8221.00
194_G198_M0.8211.00
14_A17_I0.8191.00
305_T309_K0.8151.00
276_K281_V0.8101.00
50_V138_T0.8091.00
84_V87_K0.8091.00
170_K173_L0.8081.00
252_F311_V0.8071.00
157_E160_G0.8051.00
53_N164_D0.8041.00
119_I137_P0.8031.00
61_D122_S0.8031.00
85_L90_S0.8001.00
118_L162_I0.7991.00
69_D91_K0.7991.00
58_V79_G0.7971.00
194_G217_H0.7971.00
20_C24_S0.7971.00
60_F119_I0.7951.00
140_Y158_T0.7941.00
66_D300_G0.7941.00
176_I180_I0.7891.00
35_E52_K0.7881.00
84_V89_L0.7871.00
195_L248_P0.7851.00
35_E164_D0.7851.00
192_K285_H0.7851.00
244_S278_V0.7851.00
226_D229_I0.7841.00
37_I50_V0.7831.00
171_D174_A0.7821.00
244_S277_N0.7801.00
194_G199_A0.7791.00
207_F235_G0.7791.00
192_K222_V0.7751.00
300_G303_S0.7691.00
290_D310_E0.7651.00
111_V132_F0.7651.00
159_I162_I0.7641.00
253_V288_Y0.7641.00
150_E154_S0.7631.00
70_K156_A0.7611.00
209_P227_Q0.7571.00
116_P119_I0.7541.00
52_K55_K0.7531.00
112_A137_P0.7521.00
98_A101_G0.7521.00
206_A226_D0.7501.00
253_V286_V0.7441.00
195_L206_A0.7421.00
224_P228_N0.7411.00
252_F287_I0.7411.00
41_H44_D0.7361.00
153_K157_E0.7361.00
71_L163_F0.7311.00
187_A312_K0.7311.00
272_N276_K0.7301.00
80_L97_Y0.7291.00
179_S312_K0.7231.00
195_L243_I0.7211.00
149_M152_F0.7181.00
270_V286_V0.7121.00
16_V19_A0.7101.00
180_I219_V0.7091.00
83_Q88_Y0.7081.00
127_E130_K0.7071.00
238_V246_T0.7031.00
75_D79_G0.7011.00
131_E135_I0.6981.00
20_C25_T0.6971.00
156_A172_E0.6971.00
299_G307_M0.6911.00
118_L140_Y0.6911.00
172_E176_I0.6911.00
71_L168_K0.6901.00
183_V187_A0.6881.00
309_K312_K0.6841.00
56_K117_D0.6831.00
150_E153_K0.6801.00
86_P91_K0.6801.00
163_F166_E0.6791.00
216_I308_I0.6741.00
298_G303_S0.6711.00
74_D91_K0.6691.00
72_G168_K0.6671.00
153_K180_I0.6641.00
191_N194_G0.6641.00
298_G301_L0.6631.00
74_D96_K0.6621.00
71_L156_A0.6621.00
256_R291_S0.6601.00
255_D288_Y0.6571.00
121_I140_Y0.6561.00
76_I163_F0.6561.00
39_V50_V0.6561.00
136_A139_I0.6511.00
254_I289_L0.6511.00
119_I135_I0.6471.00
14_A18_S0.6451.00
69_D77_V0.6431.00
18_S21_G0.6401.00
251_L275_V0.6381.00
176_I179_S0.6361.00
186_T189_K0.6361.00
264_S268_Q0.6331.00
102_S105_E0.6321.00
133_S138_T0.6291.00
42_Q158_T0.6281.00
239_S242_Y0.6281.00
71_L160_G0.6281.00
152_F176_I0.6281.00
83_Q87_K0.6261.00
244_S248_P0.6261.00
266_T269_V0.6241.00
157_E166_E0.6231.00
153_K176_I0.6221.00
184_K220_F0.6201.00
54_P163_F0.6181.00
197_I206_A0.6181.00
59_V64_S0.6171.00
19_A23_Q0.6131.00
224_P227_Q0.6121.00
108_F135_I0.6101.00
50_V118_L0.6081.00
64_S159_I0.6081.00
119_I132_F0.6071.00
197_I251_L0.6061.00
23_Q26_S0.6061.00
37_I52_K0.6051.00
108_F128_S0.6041.00
58_V119_I0.6041.00
88_Y92_F0.6011.00
57_V76_I0.5991.00
109_D112_A0.5991.00
58_V100_V0.5951.00
58_V116_P0.5951.00
68_L159_I0.5951.00
70_K302_E0.5941.00
61_D64_S0.5941.00
53_N117_D0.5941.00
191_N195_L0.5921.00
87_K92_F0.5911.00
208_G214_G0.5901.00
12_V18_S0.5901.00
72_G75_D0.5891.00
222_V250_Y0.5881.00
293_T310_E0.5881.00
196_V213_Y0.5841.00
173_L176_I0.5821.00
50_V162_I0.5811.00
156_A173_L0.5801.00
272_N275_V0.5791.00
209_P228_N0.5771.00
207_F211_S0.5741.00
308_I312_K0.5741.00
71_L169_V0.5721.00
210_K233_T0.5711.00
212_R215_L0.5681.00
251_L254_I0.5661.00
240_Y275_V0.5651.00
177_D180_I0.5641.00
176_I304_M0.5631.00
108_F111_V0.5621.00
43_L126_S0.5611.00
247_N278_V0.5601.00
67_T70_K0.5581.00
112_A241_E0.5561.00
195_L251_L0.5561.00
73_L77_V0.5551.00
183_V186_T0.5521.00
152_F156_A0.5511.00
183_V220_F0.5501.00
238_V243_I0.5501.00
209_P229_I0.5491.00
217_H220_F0.5471.00
214_G227_Q0.5471.00
109_D239_S0.5471.00
243_I246_T0.5461.00
72_G165_K0.5461.00
187_A220_F0.5451.00
266_T288_Y0.5451.00
12_V16_V0.5441.00
226_D238_V0.5421.00
303_S307_M0.5411.00
250_Y254_I0.5411.00
244_S274_Y0.5381.00
304_M307_M0.5381.00
84_V90_S0.5351.00
58_V78_A0.5341.00
160_G165_K0.5341.00
110_K114_L0.5321.00
100_V114_L0.5321.00
129_Y139_I0.5311.00
294_W307_M0.5301.00
86_P92_F0.5291.00
83_Q89_L0.5281.00
98_A114_L0.5281.00
119_I139_I0.5281.00
132_F138_T0.5260.99
301_L305_T0.5260.99
128_S132_F0.5210.99
185_K189_K0.5200.99
193_N250_Y0.5170.99
19_A22_N0.5170.99
127_E131_E0.5170.99
205_S235_G0.5170.99
195_L200_N0.5150.99
85_L91_K0.5150.99
35_E53_N0.5100.99
150_E177_D0.5090.99
184_K187_A0.5070.99
20_C26_S0.5070.99
153_K219_V0.5060.99
60_F121_I0.5050.99
113_E245_K0.5040.99
60_F106_P0.5040.99
157_E169_V0.5030.99
229_I236_Q0.5030.99
36_Q50_V0.5020.99
220_F308_I0.5020.99
194_G252_F0.5010.99
132_F135_I0.5010.99
69_D97_Y0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n01A 1 0.8738 100 0.214 Contact Map
3gfvA 1 0.8927 100 0.234 Contact Map
4mlzA 1 0.8612 100 0.244 Contact Map
4hn9A 1 0.8738 100 0.258 Contact Map
4ovkA 1 0.8644 100 0.269 Contact Map
4mo9A 1 0.858 100 0.269 Contact Map
5a1jA 1 0.9054 100 0.27 Contact Map
4jccA 1 0.8864 100 0.272 Contact Map
4mx8A 1 0.8959 100 0.273 Contact Map
3tlkA 1 0.8517 100 0.277 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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