GREMLIN Database
YCLO - Uncharacterized ABC transporter permease protein YclO
UniProt: P94419 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (295)
Sequences: 13409 (9543)
Seq/√Len: 555.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_D259_K4.8391.00
48_G268_V3.9441.00
84_I104_I3.7591.00
56_I191_V3.6681.00
214_D217_K3.3641.00
44_V272_I3.2941.00
56_I222_M3.2511.00
49_A184_F3.2431.00
12_G15_I3.0491.00
43_I169_F2.9981.00
251_A270_I2.9571.00
42_A172_I2.7841.00
49_A233_S2.6501.00
49_A229_L2.6341.00
52_F268_V2.5981.00
79_L145_L2.4551.00
205_R219_V2.4541.00
46_T233_S2.3651.00
255_L266_G2.3211.00
44_V276_V2.3061.00
55_M267_S2.2841.00
52_F188_G2.2811.00
25_D28_N2.1951.00
15_I18_I2.1911.00
79_L142_F2.1501.00
39_K279_Q2.1181.00
46_T237_V2.1121.00
197_F218_V2.0941.00
45_L181_F2.0901.00
199_D260_H2.0731.00
183_I232_V2.0061.00
59_T260_H2.0011.00
57_F226_V1.9381.00
83_G87_L1.9371.00
19_G22_L1.9171.00
194_F197_F1.9121.00
200_V213_I1.8881.00
82_T146_S1.8341.00
172_I176_L1.8241.00
190_Y225_V1.7971.00
187_T229_L1.7621.00
19_G23_F1.7511.00
15_I28_N1.7361.00
26_L29_W1.6981.00
281_V285_V1.6911.00
29_W33_L1.6851.00
194_F221_Q1.6591.00
109_M231_S1.6511.00
55_M263_L1.6361.00
18_I22_L1.6331.00
243_L275_L1.6191.00
217_K221_Q1.6051.00
178_W182_I1.6041.00
41_A177_L1.5891.00
18_I23_F1.5871.00
81_Q105_S1.5751.00
194_F218_V1.5691.00
113_S227_A1.5681.00
187_T228_I1.5631.00
17_C21_F1.5611.00
173_N176_L1.5511.00
282_V292_L1.5421.00
80_I104_I1.5281.00
187_T225_V1.4571.00
251_A266_G1.4471.00
169_F275_L1.4421.00
281_V295_I1.4331.00
262_Y265_A1.4281.00
53_S229_L1.3901.00
78_M146_S1.3861.00
112_F142_F1.3701.00
251_A263_L1.3691.00
141_L301_G1.3611.00
42_A236_L1.3391.00
51_A247_V1.3331.00
190_Y194_F1.3231.00
12_G18_I1.3171.00
178_W181_F1.3121.00
74_D230_V1.3101.00
194_F222_M1.3061.00
45_L177_L1.3011.00
182_I186_L1.2961.00
209_V216_D1.2751.00
247_V274_A1.2741.00
283_E289_S1.2661.00
247_V270_I1.2571.00
60_I222_M1.2431.00
180_A236_L1.2371.00
217_K220_K1.2351.00
80_I108_L1.2281.00
207_H210_N1.2221.00
30_D34_P1.2171.00
218_V221_Q1.2061.00
55_M264_I1.2011.00
23_F29_W1.1991.00
200_V211_L1.1901.00
260_H263_L1.1891.00
27_G30_D1.1851.00
216_D219_V1.1821.00
43_I276_V1.1791.00
190_Y221_Q1.1781.00
82_T161_V1.1781.00
237_V240_I1.1781.00
40_V280_F1.1751.00
106_V228_I1.1751.00
78_M165_M1.1721.00
79_L83_G1.1561.00
55_M260_H1.1521.00
273_I277_G1.1511.00
279_Q283_E1.1511.00
19_G24_Y1.1491.00
191_V225_V1.1441.00
14_A18_I1.1421.00
204_G208_A1.1401.00
42_A177_L1.1371.00
76_L112_F1.1291.00
118_Q121_F1.1281.00
103_I107_L1.1151.00
45_L180_A1.1141.00
116_L138_F1.1131.00
265_A268_V1.1031.00
43_I275_L1.1011.00
155_P159_Q1.0871.00
48_G272_I1.0831.00
41_A174_T1.0801.00
86_F149_M1.0791.00
19_G33_L1.0771.00
104_I108_L1.0761.00
48_G51_A1.0741.00
76_L108_L1.0721.00
262_Y266_G1.0691.00
139_G143_S1.0631.00
216_D220_K1.0591.00
189_V193_R1.0481.00
247_V251_A1.0441.00
255_L262_Y1.0421.00
240_I275_L1.0401.00
75_S142_F1.0371.00
180_A184_F1.0351.00
187_T232_V1.0341.00
281_V284_K1.0341.00
83_G149_M1.0191.00
33_L37_I1.0131.00
218_V222_M1.0101.00
206_E209_V1.0101.00
297_N302_I1.0091.00
282_V295_I1.0041.00
186_L189_V0.9991.00
233_S237_V0.9951.00
154_D157_E0.9921.00
198_F222_M0.9841.00
284_K287_T0.9841.00
74_D239_P0.9831.00
79_L146_S0.9761.00
182_I185_L0.9731.00
174_T177_L0.9721.00
15_I22_L0.9721.00
179_L182_I0.9641.00
40_V276_V0.9641.00
79_L149_M0.9481.00
254_F270_I0.9481.00
213_I218_V0.9451.00
302_I306_Y0.9441.00
48_G188_G0.9441.00
73_L109_M0.9401.00
45_L184_F0.9401.00
19_G29_W0.9331.00
49_A53_S0.9311.00
18_I24_Y0.9281.00
18_I21_F0.9251.00
263_L267_S0.9251.00
277_G281_V0.9191.00
303_Y306_Y0.9111.00
111_L115_V0.9081.00
15_I23_F0.9061.00
148_F152_L0.9011.00
12_G19_G0.8971.00
69_S74_D0.8961.00
77_Y109_M0.8931.00
29_W34_P0.8901.00
260_H265_A0.8891.00
12_G20_L0.8841.00
54_T248_V0.8811.00
205_R209_V0.8751.00
117_Y216_D0.8741.00
155_P158_F0.8731.00
53_S226_V0.8731.00
282_V291_T0.8691.00
259_K262_Y0.8681.00
161_V165_M0.8541.00
20_L23_F0.8541.00
39_K283_E0.8541.00
183_I187_T0.8541.00
194_F225_V0.8511.00
199_D261_S0.8511.00
92_N100_I0.8481.00
12_G16_V0.8471.00
39_K289_S0.8431.00
277_G280_F0.8421.00
107_L111_L0.8411.00
117_Y220_K0.8391.00
208_A215_Y0.8361.00
15_I19_G0.8351.00
81_Q101_N0.8351.00
190_Y193_R0.8341.00
195_T261_S0.8321.00
205_R215_Y0.8291.00
51_A55_M0.8291.00
114_L118_Q0.8281.00
12_G22_L0.8251.00
220_K224_I0.8241.00
159_Q162_Q0.8231.00
176_L236_L0.8201.00
251_A255_L0.8191.00
48_G184_F0.8181.00
243_L296_I0.8171.00
12_G23_F0.8171.00
185_L189_V0.8151.00
255_L258_Y0.8111.00
156_N160_V0.8111.00
110_I231_S0.8041.00
109_M227_A0.8021.00
14_A17_C0.8011.00
37_I174_T0.7941.00
175_D178_W0.7901.00
57_F71_L0.7891.00
251_A254_F0.7891.00
191_V222_M0.7891.00
85_I101_N0.7881.00
67_T70_I0.7841.00
223_L227_A0.7811.00
106_V110_I0.7781.00
252_R263_L0.7741.00
286_F290_T0.7731.00
298_F302_I0.7651.00
76_L142_F0.7621.00
26_L30_D0.7621.00
83_G145_L0.7611.00
73_L113_S0.7591.00
75_S78_M0.7591.00
215_Y219_V0.7581.00
50_I243_L0.7581.00
25_D29_W0.7551.00
13_L17_C0.7491.00
275_L296_I0.7471.00
52_F191_V0.7461.00
180_A232_V0.7451.00
250_L270_I0.7371.00
199_D265_A0.7361.00
274_A278_G0.7351.00
30_D33_L0.7311.00
269_F273_I0.7301.00
52_F264_I0.7271.00
197_F213_I0.7241.00
83_G88_F0.7231.00
13_L20_L0.7231.00
82_T150_Q0.7221.00
15_I24_Y0.7221.00
184_F233_S0.7171.00
86_F153_I0.7151.00
16_V19_G0.7121.00
209_V215_Y0.7091.00
193_R197_F0.7081.00
51_A268_V0.7071.00
113_S223_L0.7071.00
120_M124_E0.7071.00
279_Q289_S0.7061.00
61_T132_L0.7061.00
13_L18_I0.7051.00
85_I160_V0.7011.00
84_I101_N0.7011.00
30_D35_R0.6971.00
306_Y310_K0.6951.00
180_A183_I0.6951.00
174_T178_W0.6921.00
232_V236_L0.6911.00
201_L215_Y0.6861.00
41_A45_L0.6841.00
59_T202_S0.6811.00
187_T191_V0.6801.00
42_A180_A0.6801.00
48_G52_F0.6791.00
181_F185_L0.6771.00
272_I276_V0.6761.00
240_I292_L0.6721.00
275_L292_L0.6701.00
78_M239_P0.6681.00
53_S230_V0.6681.00
192_W195_T0.6681.00
268_V272_I0.6671.00
162_Q165_M0.6651.00
250_L253_E0.6641.00
56_I225_V0.6631.00
276_V280_F0.6621.00
248_V267_S0.6621.00
232_V235_A0.6601.00
278_G295_I0.6601.00
67_T244_G0.6571.00
253_E307_L0.6531.00
74_D77_Y0.6521.00
85_I161_V0.6521.00
110_I227_A0.6521.00
129_F132_L0.6521.00
150_Q162_Q0.6511.00
46_T169_F0.6501.00
37_I41_A0.6491.00
243_L274_A0.6491.00
282_V289_S0.6461.00
183_I228_I0.6441.00
157_E160_V0.6441.00
250_L274_A0.6421.00
265_A269_F0.6401.00
188_G192_W0.6391.00
147_S164_K0.6391.00
80_I84_I0.6391.00
227_A231_S0.6371.00
14_A23_F0.6371.00
127_N130_F0.6371.00
112_F116_L0.6361.00
245_L307_L0.6321.00
246_L304_F0.6281.00
108_L112_F0.6281.00
112_F138_F0.6261.00
32_T37_I0.6231.00
120_M134_I0.6231.00
57_F66_L0.6231.00
19_G28_N0.6221.00
153_I158_F0.6211.00
61_T64_R0.6191.00
274_A299_A0.6171.00
122_K216_D0.6141.00
12_G24_Y0.6121.00
280_F284_K0.6111.00
309_L312_N0.6101.00
184_F188_G0.6101.00
256_K265_A0.6091.00
87_L90_S0.6091.00
197_F200_V0.6091.00
84_I88_F0.6081.00
169_F237_V0.6071.00
17_C22_L0.6071.00
122_K126_R0.6041.00
270_I273_I0.6041.00
151_M154_D0.6031.00
150_Q165_M0.6001.00
143_S147_S0.6001.00
221_Q224_I0.6001.00
122_K125_G0.5961.00
57_F73_L0.5951.00
214_D221_Q0.5951.00
143_S165_M0.5911.00
134_I137_V0.5911.00
75_S139_G0.5911.00
186_L190_Y0.5901.00
193_R196_K0.5891.00
42_A46_T0.5891.00
111_L114_L0.5881.00
246_L303_Y0.5811.00
177_L181_F0.5791.00
169_F292_L0.5791.00
199_D202_S0.5791.00
153_I157_E0.5780.99
221_Q225_V0.5760.99
231_S235_A0.5750.99
88_F91_A0.5750.99
175_D179_L0.5740.99
24_Y29_W0.5730.99
230_V234_T0.5720.99
147_S151_M0.5720.99
261_S265_A0.5720.99
199_D263_L0.5710.99
107_L110_I0.5710.99
115_V118_Q0.5700.99
201_L218_V0.5700.99
73_L116_L0.5690.99
43_I292_L0.5690.99
13_L16_V0.5680.99
246_L250_L0.5670.99
222_M226_V0.5630.99
179_L232_V0.5600.99
15_I20_L0.5600.99
191_V264_I0.5600.99
250_L303_Y0.5590.99
150_Q158_F0.5540.99
84_I100_I0.5520.99
241_M246_L0.5520.99
266_G269_F0.5490.99
193_R221_Q0.5490.99
198_F260_H0.5480.99
62_N205_R0.5450.99
55_M251_A0.5450.99
179_L183_I0.5450.99
184_F189_V0.5430.99
81_Q104_I0.5430.99
214_D220_K0.5430.99
66_L73_L0.5430.99
51_A271_S0.5430.99
75_S143_S0.5420.99
150_Q161_V0.5420.99
16_V32_T0.5420.99
27_G31_Y0.5400.99
42_A237_V0.5390.99
126_R130_F0.5380.99
250_L254_F0.5380.99
159_Q165_M0.5380.99
251_A267_S0.5370.99
123_G126_R0.5350.99
52_F184_F0.5340.99
158_F161_V0.5320.99
44_V169_F0.5310.99
120_M123_G0.5300.99
60_I226_V0.5300.99
196_K199_D0.5300.99
55_M59_T0.5270.99
134_I138_F0.5260.99
163_D168_S0.5260.99
226_V231_S0.5250.99
86_F151_M0.5250.99
57_F227_A0.5240.99
188_G268_V0.5240.99
101_N104_I0.5230.99
249_N252_R0.5220.99
177_L180_A0.5200.99
148_F294_V0.5190.99
41_A181_F0.5190.99
198_F264_I0.5180.99
93_M100_I0.5160.99
62_N204_G0.5160.99
142_F145_L0.5150.99
59_T263_L0.5150.99
56_I226_V0.5140.99
247_V278_G0.5140.99
61_T130_F0.5090.99
67_T239_P0.5090.99
306_Y309_L0.5060.99
44_V273_I0.5050.99
23_F33_L0.5050.99
115_V138_F0.5050.99
15_I21_F0.5030.99
76_L138_F0.5010.99
12_G28_N0.5010.99
67_T296_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9111 100 0.193 Contact Map
2qi9A 2 0.9619 100 0.203 Contact Map
4g1uA 2 0.8984 100 0.205 Contact Map
3o7qA 1 0.3492 9 0.968 Contact Map
1pw4A 1 0.8857 7.9 0.969 Contact Map
2l9uA 2 0.0921 7.8 0.969 Contact Map
2cfqA 1 0.4 5.3 0.972 Contact Map
3l1lA 2 0.854 4.9 0.972 Contact Map
1u7gA 3 0.6 4.5 0.972 Contact Map
4ikvA 1 0.9048 4.4 0.972 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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