GREMLIN Database
YCLN - Uncharacterized ABC transporter permease protein YclN
UniProt: P94418 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 316 (308)
Sequences: 13692 (9708)
Seq/√Len: 553.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
200_T259_N4.2771.00
57_L268_V3.7171.00
93_S108_V3.5821.00
13_L277_F3.4631.00
65_I192_A3.4551.00
14_A49_L3.2591.00
215_K218_R3.2081.00
65_I223_G3.0251.00
53_V272_A2.9491.00
58_S186_I2.9051.00
52_I171_F2.8341.00
252_V270_L2.7901.00
29_D37_E2.7001.00
51_S174_V2.5881.00
58_S230_I2.5231.00
61_I268_V2.5111.00
58_S234_V2.4251.00
88_L149_I2.4201.00
14_A53_V2.3941.00
29_D32_D2.3831.00
206_E220_V2.3701.00
10_L273_V2.3141.00
55_A234_V2.2471.00
64_L267_T2.2311.00
9_L273_V2.2221.00
61_I189_V2.2221.00
256_R266_H2.1901.00
53_V276_L2.0971.00
19_F27_P2.0911.00
198_K219_V2.0601.00
55_A238_V2.0471.00
185_S233_L2.0251.00
34_S37_E2.0231.00
88_L146_V1.9961.00
26_S29_D1.9781.00
10_L53_V1.9611.00
54_I183_Y1.9431.00
92_I96_L1.9301.00
195_Y198_K1.8951.00
48_R279_D1.8881.00
66_M227_V1.8541.00
68_Q260_L1.8481.00
201_L214_L1.8271.00
200_T260_L1.8251.00
17_S49_L1.8061.00
28_L32_D1.8031.00
35_K38_A1.8001.00
191_I226_I1.7961.00
91_L150_A1.7771.00
38_A42_F1.7651.00
13_L273_V1.7441.00
174_V178_R1.6621.00
195_Y222_I1.6571.00
64_L263_S1.5871.00
50_I179_Y1.5751.00
244_L275_V1.5541.00
175_V178_R1.5501.00
180_E184_L1.5481.00
218_R222_I1.5411.00
195_Y219_V1.5381.00
281_L285_I1.5261.00
113_A232_S1.5141.00
90_I109_A1.5111.00
33_L42_F1.5111.00
6_L269_L1.5101.00
117_N228_S1.4931.00
10_L269_L1.4741.00
16_T20_I1.4691.00
89_G108_V1.4691.00
16_T19_F1.4671.00
282_G293_I1.4491.00
17_S280_I1.4181.00
262_S265_P1.4171.00
171_F275_V1.3981.00
252_V266_H1.3901.00
281_L296_M1.3751.00
6_L266_H1.3751.00
13_L276_L1.3581.00
191_I195_Y1.3401.00
62_C230_I1.3231.00
195_Y223_G1.3071.00
6_L270_L1.3031.00
51_S237_T1.2771.00
180_E183_Y1.2711.00
210_V217_K1.2661.00
184_L188_L1.2641.00
116_G146_V1.2581.00
33_L38_A1.2511.00
145_I302_S1.2471.00
248_I270_L1.2461.00
87_R150_A1.2461.00
252_V263_S1.2431.00
54_I179_Y1.2341.00
36_Q39_S1.2331.00
39_S43_A1.2281.00
208_F211_N1.2251.00
89_G112_F1.2241.00
248_I274_F1.2201.00
24_D27_P1.2201.00
83_M231_T1.2201.00
10_L272_A1.2021.00
201_L212_L1.1961.00
33_L41_L1.1871.00
218_R221_N1.1851.00
238_V241_L1.1791.00
69_I223_G1.1781.00
60_S248_I1.1701.00
85_W116_G1.1601.00
260_L263_S1.1581.00
101_S104_I1.1571.00
107_L111_V1.1531.00
219_V222_I1.1501.00
6_L273_V1.1451.00
91_L163_V1.1431.00
52_I276_L1.1351.00
87_R167_L1.1341.00
190_I194_V1.1321.00
57_L272_A1.1311.00
182_L237_T1.1271.00
64_L264_L1.1241.00
52_I275_V1.1101.00
95_L153_I1.1081.00
217_K220_V1.1071.00
23_E40_T1.1071.00
192_A226_I1.1061.00
143_G147_S1.1021.00
191_I222_I1.0971.00
88_L92_I1.0961.00
51_S179_Y1.0941.00
57_L60_S1.0831.00
118_F122_K1.0811.00
283_R290_E1.0801.00
85_W112_F1.0731.00
265_P268_V1.0731.00
205_G209_S1.0671.00
217_K221_N1.0591.00
110_F229_L1.0501.00
184_L187_P1.0491.00
15_V19_F1.0461.00
84_D146_V1.0461.00
54_I182_L1.0391.00
120_F142_L1.0381.00
20_I284_I1.0361.00
64_L260_L1.0351.00
262_S266_H1.0341.00
182_L186_I1.0331.00
108_V112_F1.0251.00
152_F156_K1.0221.00
256_R262_S1.0201.00
50_I176_K1.0171.00
42_F46_L1.0171.00
8_I12_I1.0111.00
199_F223_G1.0061.00
219_V223_G0.9981.00
282_G296_M0.9971.00
30_L41_L0.9971.00
92_I153_I0.9961.00
281_L284_I0.9941.00
125_E217_K0.9931.00
30_L33_L0.9901.00
273_V277_F0.9831.00
279_D283_R0.9711.00
115_A119_L0.9701.00
18_V49_L0.9661.00
7_F11_I0.9661.00
303_G307_F0.9611.00
248_I252_V0.9611.00
83_M240_M0.9601.00
14_A276_L0.9591.00
241_L275_V0.9551.00
49_L280_I0.9501.00
33_L37_E0.9451.00
19_F30_L0.9441.00
95_L157_Y0.9421.00
13_L280_I0.9321.00
255_Y270_L0.9311.00
181_L184_L0.9261.00
263_S267_T0.9261.00
88_L150_A0.9231.00
286_I289_Y0.9161.00
234_V238_V0.9121.00
38_A43_A0.9051.00
298_G303_G0.9031.00
207_S210_V0.9031.00
82_T113_A0.9031.00
214_L219_V0.8951.00
304_I307_F0.8941.00
176_K179_Y0.8881.00
221_N225_I0.8861.00
206_E210_V0.8831.00
259_N262_S0.8771.00
15_V27_P0.8751.00
277_F281_L0.8711.00
19_F24_D0.8641.00
88_L153_I0.8611.00
200_T261_K0.8601.00
191_I194_V0.8581.00
94_L105_K0.8551.00
62_C227_V0.8551.00
125_E128_K0.8471.00
7_F269_L0.8461.00
57_L189_V0.8451.00
25_L41_L0.8451.00
86_A113_A0.8441.00
178_R237_T0.8431.00
177_G180_E0.8421.00
78_T83_M0.8391.00
58_S62_C0.8361.00
282_G292_S0.8341.00
90_I105_K0.8321.00
163_V167_L0.8321.00
11_I14_A0.8301.00
63_G249_P0.8281.00
46_L176_K0.8251.00
49_L276_L0.8221.00
195_Y226_I0.8221.00
111_V115_A0.8181.00
196_A261_K0.8171.00
206_E216_Y0.8171.00
121_M221_N0.8171.00
161_Q164_S0.8161.00
11_I15_V0.8131.00
35_K39_S0.8111.00
21_G45_R0.8111.00
57_L186_I0.8071.00
216_Y220_V0.7991.00
104_I107_L0.7991.00
252_V256_R0.7991.00
54_I186_I0.7931.00
253_S263_S0.7871.00
183_Y187_P0.7861.00
269_L273_V0.7851.00
12_I15_V0.7831.00
110_F114_L0.7821.00
299_I303_G0.7811.00
20_I24_D0.7791.00
93_S105_K0.7791.00
224_L228_S0.7781.00
284_I287_F0.7751.00
122_K125_E0.7721.00
192_A223_G0.7711.00
260_L265_P0.7701.00
84_D87_R0.7691.00
286_I291_I0.7681.00
114_L232_S0.7671.00
182_L233_L0.7661.00
39_S42_F0.7641.00
60_S64_L0.7621.00
85_W146_V0.7611.00
82_T117_N0.7581.00
92_I149_I0.7551.00
76_S79_T0.7551.00
209_S216_Y0.7541.00
244_L297_V0.7531.00
275_V297_V0.7521.00
194_V198_K0.7501.00
50_I54_I0.7481.00
193_Y196_A0.7451.00
252_V255_Y0.7451.00
120_F124_L0.7441.00
34_S38_A0.7431.00
48_R283_R0.7431.00
285_I288_P0.7411.00
51_S182_L0.7401.00
6_L10_L0.7381.00
25_L37_E0.7361.00
187_P190_I0.7361.00
198_K214_L0.7341.00
66_M80_A0.7331.00
23_E27_P0.7321.00
307_F311_R0.7261.00
92_I97_F0.7231.00
48_R290_E0.7191.00
189_V193_Y0.7171.00
91_L154_A0.7141.00
233_L236_L0.7131.00
17_S283_R0.7131.00
60_S268_V0.7121.00
59_M244_L0.7121.00
10_L14_A0.7111.00
117_N224_L0.7101.00
254_I308_M0.7081.00
272_A276_L0.7071.00
61_I192_A0.7061.00
186_I234_V0.7051.00
200_T265_P0.7031.00
27_P30_L0.7011.00
275_V293_I0.7001.00
182_L185_S0.6991.00
125_E130_N0.6991.00
29_D33_L0.6991.00
87_R240_M0.6981.00
10_L276_L0.6971.00
113_A228_S0.6961.00
233_L237_T0.6951.00
202_A216_Y0.6921.00
105_K108_V0.6901.00
18_V41_L0.6901.00
114_L228_S0.6901.00
62_C231_T0.6891.00
70_S136_P0.6891.00
121_M217_K0.6851.00
94_L162_N0.6851.00
210_V216_Y0.6831.00
18_V46_L0.6801.00
251_I270_L0.6781.00
123_I138_V0.6761.00
154_A164_S0.6761.00
127_I134_F0.6751.00
61_I264_L0.6751.00
41_L46_L0.6741.00
103_L107_L0.6741.00
171_F293_I0.6731.00
116_G120_F0.6701.00
251_I254_I0.6681.00
278_C296_M0.6611.00
244_L274_F0.6601.00
93_S104_I0.6591.00
151_T155_Y0.6551.00
147_S167_L0.6551.00
185_S229_L0.6541.00
39_S44_S0.6541.00
241_L293_I0.6531.00
65_I226_I0.6521.00
68_Q203_G0.6511.00
157_Y160_I0.6461.00
20_I280_I0.6441.00
164_S167_L0.6411.00
274_F278_C0.6401.00
249_P267_T0.6391.00
12_I16_T0.6371.00
84_D143_G0.6351.00
57_L61_I0.6321.00
222_I226_I0.6321.00
151_T166_W0.6311.00
198_K201_L0.6311.00
223_G227_V0.6291.00
46_L50_I0.6291.00
176_K180_E0.6281.00
247_I305_F0.6281.00
159_L162_N0.6271.00
133_I136_P0.6271.00
247_I251_I0.6261.00
265_P269_L0.6241.00
89_G93_S0.6241.00
274_F300_I0.6241.00
28_L31_F0.6241.00
17_S276_L0.6231.00
122_K126_R0.6231.00
15_V31_F0.6201.00
55_A171_F0.6191.00
76_S245_G0.6171.00
251_I274_F0.6161.00
66_M75_V0.6151.00
94_L163_V0.6151.00
23_E26_S0.6141.00
268_V272_A0.6121.00
147_S151_T0.6111.00
83_M86_A0.6111.00
119_L122_K0.6101.00
5_Y9_L0.6091.00
138_V141_M0.6081.00
171_F238_V0.6081.00
27_P31_F0.6081.00
222_I225_I0.6061.00
277_F280_I0.6051.00
66_M82_T0.6031.00
179_Y182_L0.6031.00
115_A118_F0.6031.00
197_D200_T0.6021.00
251_I304_I0.6021.00
282_G290_E0.5971.00
131_D134_F0.5961.00
177_G181_L0.5961.00
310_L313_K0.5951.00
202_A219_V0.5951.00
13_L16_T0.5951.00
93_S97_F0.5921.00
111_V114_L0.5921.00
231_T235_I0.5921.00
26_S37_E0.5911.00
194_V197_D0.5901.00
247_I304_I0.5891.00
186_I190_I0.5891.00
246_L308_M0.5881.00
112_F116_G0.5831.00
282_G285_I0.5821.00
52_I293_I0.5800.99
121_M125_E0.5800.99
84_D147_S0.5790.99
25_L40_T0.5790.99
124_L138_V0.5780.99
116_G142_L0.5770.99
200_T203_G0.5760.99
19_F31_F0.5740.99
51_S55_A0.5740.99
186_I189_V0.5710.99
117_N121_M0.5710.99
70_S73_K0.5690.99
228_S232_S0.5690.99
71_R206_E0.5690.99
51_S238_V0.5660.99
64_L252_V0.5660.99
215_K222_I0.5640.99
261_K265_P0.5630.99
270_L273_V0.5630.99
16_T280_I0.5610.99
192_A264_L0.5590.99
65_I227_V0.5590.99
232_S236_L0.5580.99
17_S21_G0.5580.99
154_A160_I0.5550.99
279_D290_E0.5540.99
276_L280_I0.5520.99
148_S298_G0.5510.99
25_L33_L0.5500.99
179_Y183_Y0.5450.99
181_L185_S0.5440.99
199_F264_L0.5430.99
257_G265_P0.5430.99
280_I284_I0.5430.99
24_D28_L0.5430.99
5_Y8_I0.5420.99
162_N165_S0.5410.99
60_S271_G0.5400.99
124_L130_N0.5400.99
102_P106_M0.5370.99
82_T120_F0.5370.99
154_A163_V0.5340.99
215_K221_N0.5330.99
14_A50_I0.5320.99
181_L233_L0.5290.99
96_L99_S0.5290.99
161_Q167_L0.5260.99
307_F310_L0.5260.99
90_I108_V0.5260.99
124_L135_I0.5250.99
145_I149_I0.5250.99
165_S170_D0.5240.99
251_I255_Y0.5220.99
36_Q40_T0.5220.99
82_T170_D0.5220.99
155_Y168_Q0.5210.99
85_W142_L0.5200.99
189_V268_V0.5180.99
119_L142_L0.5150.99
22_V288_P0.5150.99
188_L191_I0.5150.99
75_V82_T0.5150.99
138_V142_L0.5140.99
126_R134_F0.5130.99
66_M228_S0.5090.99
252_V267_T0.5090.99
248_I278_C0.5080.99
250_N253_S0.5080.99
7_F10_L0.5060.99
105_K109_A0.5060.99
199_F260_L0.5060.99
61_I230_I0.5050.99
7_F266_H0.5010.99
14_A18_V0.5000.99
23_E37_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2nq2A 2 0.9557 100 0.166 Contact Map
2qi9A 2 0.9747 100 0.168 Contact Map
4g1uA 2 0.9114 100 0.169 Contact Map
4f35D 2 0.6361 10.1 0.967 Contact Map
2l9uA 2 0.0918 6.4 0.97 Contact Map
2m20A 2 0.0918 6.3 0.97 Contact Map
3wdoA 1 0.8987 5.9 0.97 Contact Map
2kluA 1 0.1266 3.6 0.973 Contact Map
4gxbB 1 0.0032 3.2 0.974 Contact Map
2l2tA 2 0.1171 3.2 0.974 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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