GREMLIN Database
AK3 - Aspartokinase 3
UniProt: P94417 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 454 (353)
Sequences: 4297 (2434)
Seq/√Len: 129.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_V176_L4.7781.00
137_K175_G4.2761.00
186_S190_D4.2691.00
403_R446_E4.2691.00
179_F206_L4.0631.00
435_E438_K3.9721.00
207_A215_Y3.8531.00
249_L390_V3.1221.00
240_E288_V3.0731.00
214_L273_Q3.0181.00
273_Q286_R3.0071.00
406_K410_E2.9961.00
279_N282_A2.9391.00
141_V170_L2.9131.00
128_A138_A2.8591.00
222_D279_N2.7741.00
383_H433_E2.7491.00
303_S436_E2.7371.00
139_E175_G2.6501.00
387_I443_L2.6181.00
329_Q333_E2.4211.00
363_R367_K2.4101.00
152_N186_S2.3481.00
124_A180_P2.3291.00
132_R137_K2.3131.00
305_T437_R2.2851.00
239_S283_E2.2801.00
211_Q268_A2.2331.00
222_D282_A2.2251.00
165_Q169_R2.2171.00
326_R372_D2.1841.00
216_E273_Q2.1781.00
394_M399_G2.1601.00
359_A380_V2.1581.00
150_V192_I2.0661.00
113_D155_G2.0371.00
305_T433_E2.0181.00
244_R266_F1.9721.00
238_I241_L1.9471.00
234_N445_Q1.9301.00
438_K441_Q1.9261.00
112_L116_K1.9231.00
206_L210_L1.9041.00
367_K370_E1.9011.00
93_I96_D1.8931.00
411_A438_K1.8861.00
325_R332_E1.8681.00
164_Y168_Y1.8581.00
265_A272_V1.8351.00
408_L439_A1.8281.00
130_Y134_K1.7861.00
144_K191_V1.7461.00
432_K435_E1.7071.00
269_G289_S1.6591.00
143_P146_A1.6231.00
204_S215_Y1.6121.00
139_E177_I1.6101.00
131_F136_V1.5761.00
227_V303_S1.5471.00
360_A382_H1.5431.00
387_I439_A1.5361.00
340_H430_G1.5311.00
105_K108_P1.5301.00
219_T274_I1.5301.00
404_A429_F1.5221.00
308_C354_Q1.5221.00
317_M322_G1.5211.00
301_I440_V1.5191.00
118_S122_N1.5001.00
404_A443_L1.4841.00
410_E446_E1.4811.00
150_V184_G1.4811.00
117_A191_V1.4331.00
334_H361_T1.4301.00
166_N170_L1.4181.00
381_E416_E1.4081.00
94_R97_L1.4061.00
169_R173_R1.4031.00
411_A442_A1.4011.00
216_E275_K1.3811.00
413_V439_A1.3751.00
387_I440_V1.3731.00
115_V125_K1.3671.00
151_T157_A1.3601.00
407_A446_E1.3601.00
414_N418_I1.3431.00
101_L115_V1.3411.00
159_V205_I1.3371.00
385_A436_E1.3351.00
129_A132_R1.3251.00
110_Q190_D1.3231.00
162_E166_N1.3091.00
375_A378_V1.3051.00
222_D225_Y1.3011.00
99_T103_G1.2971.00
214_L286_R1.2931.00
94_R98_F1.2891.00
312_I327_A1.2861.00
141_V177_I1.2781.00
149_F187_K1.2731.00
333_E368_R1.2711.00
169_R172_E1.2681.00
154_P157_A1.2601.00
416_E432_K1.2591.00
399_G424_E1.2581.00
327_A366_I1.2541.00
167_L177_I1.2521.00
215_Y265_A1.2471.00
308_C382_H1.2461.00
226_S444_Y1.2391.00
370_E375_A1.2341.00
445_Q449_A1.2191.00
143_P180_P1.2171.00
208_N270_I1.2140.99
240_E286_R1.2140.99
222_D276_N1.2080.99
322_G414_N1.2080.99
363_R380_V1.2060.99
137_K174_D1.1970.99
149_F185_F1.1940.99
383_H432_K1.1900.99
336_L365_V1.1870.99
202_T206_L1.1840.99
303_S440_V1.1800.99
167_L206_L1.1800.99
308_C356_Q1.1790.99
324_G350_I1.1640.99
364_S368_R1.1600.99
157_A192_I1.1560.99
99_T102_E1.1540.99
437_R441_Q1.1520.99
324_G348_M1.1490.99
128_A140_Y1.1400.99
240_E292_D1.1380.99
127_I131_F1.1270.99
95_D99_T1.1270.99
334_H368_R1.1210.99
131_F178_I1.1200.99
310_I362_E1.1160.99
109_E155_G1.1120.99
186_S192_I1.1120.99
330_I334_H1.1110.99
168_Y172_E1.1110.99
117_A121_D1.1080.99
313_S377_E1.1010.99
144_K185_F1.0960.99
420_Q424_E1.0910.99
221_V256_V1.0830.99
241_L299_V1.0790.99
389_V404_A1.0780.99
413_V438_K1.0750.99
367_K371_E1.0740.99
113_D193_T1.0720.99
93_I125_K1.0660.99
95_D98_F1.0660.99
407_A442_A1.0560.99
387_I431_V1.0550.99
150_V154_P1.0510.99
324_G338_Y1.0510.99
168_Y211_Q1.0500.99
98_F102_E1.0440.98
330_I369_I1.0390.98
154_P186_S1.0370.98
358_D361_T1.0320.98
399_G414_N1.0290.98
257_F287_V1.0270.98
148_L202_T1.0260.98
333_E372_D1.0240.98
149_F163_S1.0190.98
231_F303_S1.0160.98
309_S416_E1.0100.98
128_A132_R1.0060.98
160_L187_K1.0010.98
305_T436_E0.9930.98
401_T405_A0.9880.98
388_M428_M0.9830.98
200_D220_D0.9830.98
227_V440_V0.9810.98
389_V427_M0.9770.98
331_L350_I0.9760.98
328_L350_I0.9720.98
231_F440_V0.9700.98
306_G433_E0.9700.98
385_A433_E0.9690.97
317_M323_F0.9650.97
151_T154_P0.9630.97
127_I178_I0.9610.97
151_T156_N0.9580.97
356_Q382_H0.9540.97
150_V157_A0.9540.97
308_C359_A0.9530.97
125_K129_A0.9520.97
407_A411_A0.9500.97
96_D100_L0.9490.97
364_S367_K0.9480.97
149_F189_G0.9430.97
262_L272_V0.9430.97
227_V232_V0.9380.97
340_H428_M0.9360.97
143_P179_F0.9320.97
324_G343_S0.9230.97
356_Q433_E0.9200.97
370_E374_H0.9190.97
149_F166_N0.9180.97
314_K376_D0.9140.96
257_F272_V0.9110.96
177_I180_P0.9090.96
342_P419_N0.9090.96
138_A176_L0.9080.96
152_N188_D0.9040.96
411_A435_E0.8980.96
113_D184_G0.8960.96
402_A409_S0.8950.96
381_E384_L0.8930.96
384_L416_E0.8930.96
406_K446_E0.8910.96
152_N157_A0.8900.96
304_D307_F0.8900.96
386_L430_G0.8860.96
142_N191_V0.8860.96
324_G341_V0.8790.96
156_N358_D0.8790.96
151_T158_Q0.8720.95
331_L338_Y0.8720.95
384_L430_G0.8680.95
327_A378_V0.8660.95
233_E441_Q0.8640.95
445_Q448_F0.8620.95
322_G343_S0.8570.95
311_Y351_I0.8560.95
395_R424_E0.8550.95
334_H365_V0.8520.95
360_A363_R0.8500.95
225_Y257_F0.8480.95
344_G351_I0.8460.95
328_L338_Y0.8450.94
237_E282_A0.8440.94
310_I336_L0.8440.94
132_R138_A0.8400.94
232_V440_V0.8380.94
369_I373_L0.8350.94
124_A178_I0.8340.94
198_G220_D0.8330.94
234_N449_A0.8330.94
219_T277_T0.8320.94
404_A427_M0.8320.94
401_T418_I0.8300.94
225_Y235_P0.8290.94
163_S168_Y0.8280.94
249_L302_A0.8270.94
394_M424_E0.8240.94
240_E290_K0.8230.94
339_E386_L0.8220.94
124_A140_Y0.8220.94
262_L287_V0.8210.94
231_F305_T0.8200.94
408_L413_V0.8170.93
140_Y180_P0.8170.93
141_V146_A0.8150.93
371_E374_H0.8150.93
166_N169_R0.8140.93
227_V301_I0.8090.93
441_Q445_Q0.8010.93
305_T385_A0.8010.93
202_T264_P0.7980.93
128_A178_I0.7970.93
331_L336_L0.7920.92
219_T256_V0.7920.92
97_L101_L0.7920.92
145_D170_L0.7900.92
252_A388_M0.7830.92
100_L104_D0.7820.92
139_E170_L0.7800.92
170_L175_G0.7770.92
217_N255_S0.7760.92
276_N279_N0.7720.91
143_P183_F0.7690.91
145_D185_F0.7630.91
366_I378_V0.7630.91
367_K377_E0.7620.91
383_H434_A0.7610.91
224_V256_V0.7570.91
136_V178_I0.7520.90
365_V369_I0.7510.90
413_V442_A0.7500.90
142_N146_A0.7490.90
345_I348_M0.7480.90
336_L361_T0.7470.90
394_M400_T0.7470.90
310_I363_R0.7430.90
314_K345_I0.7410.90
113_D192_I0.7390.89
417_M430_G0.7370.89
260_E263_I0.7340.89
331_L362_E0.7320.89
402_A406_K0.7260.89
324_G418_I0.7230.88
329_Q406_K0.7200.88
399_G402_A0.7190.88
118_S121_D0.7180.88
131_F176_L0.7170.88
149_F160_L0.7170.88
306_G355_G0.7160.88
325_R329_Q0.7160.88
259_D264_P0.7120.88
321_I324_G0.7110.88
157_A160_L0.7110.88
138_A178_I0.7100.88
328_L337_T0.7060.87
94_R101_L0.7060.87
324_G346_D0.7040.87
401_T424_E0.7030.87
406_K409_S0.7000.87
330_I365_V0.7000.87
197_S261_A0.6960.87
114_A140_Y0.6960.87
182_F199_S0.6950.86
340_H419_N0.6950.86
306_G357_M0.6940.86
93_I101_L0.6920.86
194_F220_D0.6890.86
297_P400_T0.6880.86
165_Q168_Y0.6870.86
395_R398_V0.6870.86
119_G196_R0.6860.86
405_A414_N0.6840.86
122_N125_K0.6840.86
258_H264_P0.6840.86
121_D140_Y0.6820.85
131_F138_A0.6820.85
307_F339_E0.6810.85
322_G337_T0.6800.85
112_L155_G0.6800.85
400_T427_M0.6800.85
194_F198_G0.6800.85
442_A446_E0.6760.85
309_S381_E0.6760.85
242_T245_E0.6740.85
104_D133_Y0.6740.85
263_I267_R0.6730.85
368_R372_D0.6710.84
195_S444_Y0.6710.84
434_A438_K0.6700.84
161_P164_Y0.6690.84
401_T414_N0.6680.84
310_I378_V0.6670.84
226_S236_K0.6650.84
96_D99_T0.6630.84
273_Q282_A0.6610.84
105_K133_Y0.6610.84
248_E405_A0.6600.83
203_G215_Y0.6590.83
93_I122_N0.6580.83
142_N180_P0.6570.83
323_F348_M0.6560.83
343_S346_D0.6540.83
182_F196_R0.6530.83
168_Y171_R0.6530.83
389_V447_F0.6520.83
121_D191_V0.6490.82
201_I261_A0.6480.82
120_E196_R0.6460.82
130_Y133_Y0.6450.82
265_A268_A0.6450.82
361_T364_S0.6440.82
242_T289_S0.6440.82
224_V246_M0.6430.82
92_K95_D0.6420.82
219_T300_G0.6410.82
344_G349_T0.6370.81
288_V291_R0.6360.81
359_A363_R0.6360.81
439_A442_A0.6350.81
170_L177_I0.6340.81
351_I417_M0.6330.81
258_H272_V0.6310.81
227_V444_Y0.6280.80
218_F246_M0.6250.80
261_A264_P0.6240.80
313_S379_I0.6230.80
240_E291_R0.6230.80
275_K280_P0.6220.80
360_A367_K0.6210.80
124_A142_N0.6190.79
204_S261_A0.6180.79
314_K346_D0.6180.79
301_I443_L0.6160.79
100_L103_G0.6140.79
310_I352_L0.6140.79
324_G414_N0.6140.79
338_Y354_Q0.6130.79
438_K442_A0.6120.79
161_P187_K0.6090.78
336_L362_E0.6090.78
225_Y237_E0.6070.78
391_G394_M0.6060.78
236_K240_E0.6050.78
398_V449_A0.6040.78
113_D154_P0.6030.78
258_H417_M0.6030.78
409_S414_N0.6010.77
386_L428_M0.6000.77
369_I375_A0.6000.77
148_L151_T0.5980.77
201_I208_N0.5980.77
410_E445_Q0.5970.77
92_K96_D0.5970.77
257_F261_A0.5960.77
254_F257_F0.5950.77
180_P202_T0.5940.77
385_A431_V0.5920.76
420_Q425_V0.5920.76
424_E427_M0.5920.76
309_S417_M0.5910.76
303_S385_A0.5910.76
432_K442_A0.5900.76
97_L118_S0.5900.76
93_I97_L0.5890.76
191_V208_N0.5890.76
246_M252_A0.5880.76
381_E432_K0.5880.76
114_A191_V0.5870.76
169_R333_E0.5860.76
113_D150_V0.5860.76
247_R343_S0.5860.76
106_S360_A0.5850.75
319_R324_G0.5820.75
392_E425_V0.5810.75
121_D124_A0.5800.75
355_G358_D0.5800.75
405_A418_I0.5800.75
328_L339_E0.5800.75
243_Y287_V0.5780.75
248_E251_Y0.5780.75
142_N185_F0.5770.75
261_A401_T0.5760.74
223_A237_E0.5760.74
411_A434_A0.5750.74
320_E323_F0.5750.74
324_G339_E0.5740.74
121_D144_K0.5730.74
261_A268_A0.5710.74
366_I375_A0.5700.74
157_A184_G0.5690.73
225_Y228_N0.5680.73
153_E156_N0.5680.73
131_F134_K0.5660.73
328_L341_V0.5650.73
314_K317_M0.5650.73
319_R414_N0.5650.73
226_S235_P0.5640.73
330_I372_D0.5630.73
109_E361_T0.5630.73
143_P194_F0.5610.72
304_D347_D0.5610.72
368_R371_E0.5610.72
261_A265_A0.5600.72
414_N432_K0.5600.72
289_S389_V0.5600.72
311_Y379_I0.5580.72
394_M414_N0.5570.72
154_P173_R0.5570.72
309_S349_T0.5570.72
323_F350_I0.5570.72
431_V436_E0.5540.72
113_D195_S0.5540.72
193_T198_G0.5520.71
252_A261_A0.5510.71
394_M409_S0.5500.71
321_I414_N0.5500.71
249_L440_V0.5500.71
224_V241_L0.5480.71
304_D419_N0.5480.71
201_I252_A0.5470.71
121_D142_N0.5470.71
408_L429_F0.5450.70
199_S220_D0.5430.70
121_D183_F0.5430.70
153_E335_G0.5430.70
250_S286_R0.5390.69
117_A412_Q0.5380.69
313_S346_D0.5370.69
268_A271_P0.5370.69
217_N224_V0.5370.69
364_S374_H0.5360.69
312_I378_V0.5340.69
326_R329_Q0.5300.68
193_T199_S0.5300.68
197_S255_S0.5290.68
343_S354_Q0.5270.68
99_T105_K0.5250.67
328_L343_S0.5240.67
205_I260_E0.5240.67
195_S223_A0.5220.67
364_S377_E0.5220.67
217_N256_V0.5220.67
327_A348_M0.5210.67
252_A342_P0.5200.67
299_V381_E0.5190.67
360_A364_S0.5180.66
106_S109_E0.5170.66
154_P192_I0.5170.66
93_I100_L0.5150.66
313_S376_D0.5150.66
164_Y206_L0.5140.66
156_N335_G0.5120.66
223_A228_N0.5120.66
216_E276_N0.5110.65
370_E378_V0.5110.65
361_T365_V0.5080.65
101_L111_Y0.5080.65
97_L100_L0.5080.65
120_E200_D0.5070.65
187_K281_S0.5070.65
405_A415_I0.5060.65
298_V447_F0.5050.64
317_M349_T0.5050.64
223_A254_F0.5050.64
310_I359_A0.5030.64
319_R346_D0.5030.64
375_A379_I0.5020.64
170_L224_V0.5020.64
411_A439_A0.5020.64
148_L159_V0.5020.64
217_N220_D0.5020.64
124_A128_A0.5010.64
146_A167_L0.5010.64
364_S412_Q0.5010.64
220_D256_V0.5000.64
387_I429_F0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2j0wA 2 0.9537 100 0.244 Contact Map
2cdqA 2 0.9824 100 0.247 Contact Map
3c1mA 3 0.9758 100 0.267 Contact Map
3tviA 2 0.9559 100 0.267 Contact Map
3ab4A 7 0.8282 100 0.333 Contact Map
3l76A 2 0.8568 100 0.336 Contact Map
4ab7A 3 0.7907 100 0.684 Contact Map
2j4jA 5 0.4493 100 0.747 Contact Map
3d2mA 5 0.7533 100 0.749 Contact Map
1ybdA 5 0.467 100 0.754 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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