GREMLIN Database
RAPC - Response regulator aspartate phosphatase C
UniProt: P94415 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 382 (324)
Sequences: 1054 (923)
Seq/√Len: 51.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
278_K281_K4.7051.00
238_L241_P4.6121.00
194_M206_F4.0941.00
353_W356_L3.9201.00
230_G246_F3.9171.00
270_T286_H3.8501.00
190_G206_F3.8381.00
198_N201_Q3.4461.00
109_G125_Y3.1891.00
345_A361_F2.9621.00
117_E120_S2.6071.00
105_N124_Y2.5941.00
243_I272_I2.5471.00
246_F268_L2.4971.00
233_Y241_P2.4901.00
273_Y281_K2.4721.00
273_Y278_K2.4231.00
329_K363_Q2.3351.00
186_H205_H2.3161.00
241_P244_D2.2691.00
171_I175_Q2.2661.00
281_K284_E2.2491.00
203_A229_L2.1601.00
327_Y330_N2.1301.00
272_I276_Q2.1091.00
164_N167_N2.0761.00
321_I324_C2.0461.00
191_V206_F2.0341.00
29_D32_V2.0331.00
34_K38_Q2.0241.00
304_K336_D1.9601.00
226_Y245_Y1.9541.00
189_F193_L1.9470.99
48_S51_L1.9450.99
145_Y164_N1.9430.99
26_S39_Q1.9380.99
30_A37_I1.9340.99
122_I152_Y1.9090.99
289_G305_F1.8930.99
167_N170_E1.8410.99
108_R112_E1.8370.99
102_Y109_G1.8270.99
239_L272_I1.8170.99
203_A233_Y1.8130.99
28_P32_V1.8100.99
26_S29_D1.7970.99
223_G249_A1.7720.99
266_Y285_Y1.7710.99
50_L89_I1.7400.99
230_G242_A1.7350.99
354_F357_S1.7300.99
358_A362_L1.6540.98
308_L312_Y1.6520.98
53_Y57_M1.6450.98
187_F228_N1.6370.98
109_G113_F1.6350.98
127_Q130_K1.6280.98
149_A165_I1.6210.98
210_L222_V1.6130.98
105_N127_Q1.6120.98
269_I273_Y1.6090.98
190_G209_A1.6060.98
32_V35_A1.6040.98
183_I209_A1.6010.98
243_I247_E1.5950.98
214_Q222_V1.5850.98
349_Y362_L1.5530.97
175_Q178_Y1.5520.97
35_A39_Q1.5490.97
106_F110_M1.5480.97
267_F289_G1.5460.97
243_I273_Y1.5410.97
113_F125_Y1.5300.97
359_S363_Q1.5260.97
28_P39_Q1.5100.97
243_I276_Q1.5070.97
27_V37_I1.4980.97
121_A282_A1.4870.97
106_F125_Y1.4710.96
27_V45_Q1.4680.96
356_L360_Y1.4590.96
237_D275_K1.4280.96
226_Y248_K1.4190.96
112_E124_Y1.4060.95
246_F289_G1.4030.95
262_L265_A1.4020.95
230_G245_Y1.4020.95
305_F316_P1.4010.95
341_A360_Y1.3930.95
244_D248_K1.3860.95
324_C331_K1.3850.95
143_E147_K1.3830.95
102_Y128_A1.3820.95
302_A305_F1.3820.95
347_Y350_E1.3620.94
26_S32_V1.3450.94
357_S364_V1.3390.94
345_A357_S1.3150.93
203_A236_Q1.3140.93
357_S361_F1.2970.93
203_A232_C1.2720.92
191_V228_N1.2680.92
302_A306_E1.2660.92
109_G124_Y1.2570.92
208_L211_N1.2450.91
243_I269_I1.2420.91
129_E145_Y1.2300.91
282_A364_V1.2190.90
156_K161_S1.2150.90
340_L344_V1.2120.90
169_Y192_N1.2060.90
268_L271_L1.2040.90
247_E281_K1.1960.90
226_Y249_A1.1850.89
306_E313_L1.1530.88
192_N286_H1.1440.87
33_L44_M1.1430.87
283_S287_K1.1410.87
190_G342_L1.1320.87
148_I152_Y1.1320.87
240_D276_Q1.1270.87
249_A252_T1.1260.87
116_R154_Y1.1190.86
102_Y144_F1.1150.86
31_E38_Q1.1130.86
287_K291_E1.1120.86
303_V306_E1.1070.86
112_E120_S1.1040.85
301_Y304_K1.1000.85
356_L359_S1.0960.85
345_A360_Y1.0920.85
62_Q69_E1.0910.85
62_Q71_L1.0870.85
128_A228_N1.0870.85
26_S35_A1.0820.84
233_Y238_L1.0800.84
133_S141_R1.0770.84
190_G205_H1.0770.84
101_D109_G1.0750.84
62_Q65_L1.0640.83
35_A38_Q1.0620.83
355_K362_L1.0560.83
188_V206_F1.0540.83
188_V268_L1.0480.82
263_P266_Y1.0450.82
309_Q312_Y1.0430.82
51_L55_S1.0420.82
227_Y268_L1.0280.81
219_A252_T1.0170.80
27_V38_Q1.0120.80
250_V266_Y1.0080.80
38_Q42_K1.0060.80
40_E44_M1.0010.79
118_F151_A0.9980.79
122_I147_K0.9930.79
29_D36_E0.9920.79
106_F128_A0.9910.79
158_T161_S0.9870.78
142_A145_Y0.9860.78
190_G225_A0.9850.78
362_L365_E0.9820.78
179_N215_A0.9780.78
234_Y239_L0.9770.78
38_Q41_L0.9730.77
210_L269_I0.9730.77
319_E325_F0.9690.77
250_V269_I0.9680.77
128_A131_K0.9680.77
120_S123_T0.9660.77
67_Y70_P0.9620.77
63_L67_Y0.9610.76
312_Y316_P0.9600.76
132_L135_V0.9580.76
125_Y147_K0.9550.76
309_Q316_P0.9550.76
249_A265_A0.9470.75
145_Y226_Y0.9430.75
174_E177_T0.9430.75
56_L168_A0.9400.75
29_D42_K0.9370.75
229_L245_Y0.9280.74
161_S164_N0.9220.73
176_E272_I0.9200.73
230_G249_A0.9170.73
304_K311_L0.9160.73
37_I40_E0.9130.73
225_A273_Y0.9110.72
210_L245_Y0.9090.72
80_P84_E0.9070.72
149_A266_Y0.9020.72
190_G228_N0.8980.71
329_K337_I0.8980.71
29_D39_Q0.8950.71
344_V348_Y0.8950.71
58_E230_G0.8930.71
155_M158_T0.8910.71
27_V31_E0.8870.70
32_V40_E0.8870.70
168_A172_Y0.8840.70
247_E269_I0.8820.70
300_D356_L0.8810.70
358_A361_F0.8800.70
305_F308_L0.8760.70
56_L60_R0.8720.69
234_Y272_I0.8680.69
270_T300_D0.8670.69
288_R337_I0.8650.69
341_A348_Y0.8640.68
304_K312_Y0.8630.68
313_L317_N0.8630.68
159_Y193_L0.8600.68
325_F344_V0.8600.68
353_W360_Y0.8580.68
146_F187_F0.8550.68
253_F262_L0.8550.68
37_I41_L0.8550.68
26_S38_Q0.8500.67
213_A225_A0.8490.67
321_I357_S0.8490.67
61_H65_L0.8470.67
125_Y357_S0.8460.67
353_W359_S0.8400.66
301_Y314_D0.8290.65
348_Y356_L0.8270.65
262_L266_Y0.8260.65
341_A363_Q0.8230.65
279_H330_N0.8210.64
31_E44_M0.8180.64
32_V38_Q0.8130.64
85_L88_N0.8120.64
334_Y337_I0.8100.63
206_F229_L0.8040.63
207_K229_L0.8010.63
357_S365_E0.7990.62
144_F147_K0.7980.62
69_E352_K0.7920.62
311_L352_K0.7900.61
107_F228_N0.7890.61
251_S269_I0.7880.61
193_L201_Q0.7860.61
169_Y173_V0.7860.61
37_I242_A0.7830.61
142_A146_F0.7830.61
186_H226_Y0.7820.61
26_S43_H0.7810.61
262_L282_A0.7800.60
333_M336_D0.7790.60
235_N275_K0.7780.60
229_L260_N0.7770.60
112_E117_E0.7760.60
206_F237_D0.7750.60
227_Y230_G0.7730.60
348_Y352_K0.7730.60
279_H283_S0.7720.60
28_P45_Q0.7710.60
166_K196_E0.7710.60
103_Y107_F0.7700.59
80_P89_I0.7680.59
226_Y266_Y0.7670.59
47_D50_L0.7660.59
30_A45_Q0.7630.59
355_K359_S0.7620.59
157_Q161_S0.7610.59
105_N172_Y0.7570.58
189_F195_D0.7550.58
201_Q204_R0.7550.58
199_F203_A0.7540.58
34_K50_L0.7530.58
121_A168_A0.7510.58
352_K357_S0.7510.58
157_Q160_F0.7450.57
49_N55_S0.7410.57
341_A357_S0.7400.56
229_L233_Y0.7390.56
36_E40_E0.7340.56
59_F66_D0.7280.55
314_D317_N0.7280.55
177_T211_N0.7250.55
304_K307_F0.7240.55
117_E237_D0.7240.55
149_A190_G0.7230.55
271_L307_F0.7220.55
237_D352_K0.7200.54
48_S139_I0.7170.54
82_L85_L0.7160.54
177_T275_K0.7120.54
35_A45_Q0.7110.53
39_Q42_K0.7090.53
337_I357_S0.7070.53
147_K150_E0.7050.53
33_L39_Q0.7030.53
113_F150_E0.7020.53
269_I285_Y0.7020.53
193_L204_R0.7000.52
125_Y129_E0.6980.52
172_Y189_F0.6980.52
323_R327_Y0.6970.52
249_A284_E0.6970.52
150_E190_G0.6970.52
360_Y364_V0.6960.52
27_V39_Q0.6960.52
114_D118_F0.6940.52
143_E146_F0.6930.52
118_F295_E0.6930.52
48_S55_S0.6930.52
326_Q329_K0.6920.51
44_M48_S0.6890.51
110_M125_Y0.6880.51
345_A365_E0.6840.51
131_K190_G0.6830.51
329_K365_E0.6810.50
286_H290_Y0.6810.50
303_V316_P0.6770.50
139_I167_N0.6760.50
231_L286_H0.6750.50
102_Y106_F0.6730.50
29_D33_L0.6730.50
50_L54_Y0.6710.49
354_F358_A0.6710.49
176_E186_H0.6710.49
274_Y286_H0.6680.49
302_A321_I0.6670.49
129_E144_F0.6650.49
29_D34_K0.6650.49
158_T192_N0.6600.48
52_L70_P0.6600.48
228_N268_L0.6590.48
277_G350_E0.6550.48
186_H266_Y0.6530.47
53_Y56_L0.6520.47
38_Q43_H0.6510.47
290_Y337_I0.6480.47
67_Y71_L0.6470.47
346_K350_E0.6450.47
302_A316_P0.6400.46
311_L314_D0.6400.46
113_F153_Y0.6400.46
127_Q198_N0.6390.46
97_K103_Y0.6380.46
332_N356_L0.6380.46
206_F228_N0.6370.46
81_S91_S0.6350.46
80_P85_L0.6350.46
231_L234_Y0.6350.46
199_F239_L0.6340.45
191_V195_D0.6330.45
45_Q55_S0.6320.45
189_F201_Q0.6320.45
58_E62_Q0.6300.45
35_A42_K0.6260.45
39_Q43_H0.6240.44
351_Q361_F0.6240.44
309_Q313_L0.6230.44
231_L246_F0.6230.44
41_L51_L0.6220.44
169_Y186_H0.6210.44
80_P86_S0.6210.44
170_E173_V0.6210.44
44_M47_D0.6190.44
189_F203_A0.6190.44
243_I281_K0.6180.44
223_G252_T0.6170.44
27_V32_V0.6150.44
155_M164_N0.6140.43
165_I169_Y0.6130.43
48_S82_L0.6120.43
313_L316_P0.6120.43
63_L280_D0.6100.43
52_L60_R0.6060.43
52_L58_E0.6060.43
145_Y171_I0.6060.43
189_F205_H0.6030.42
89_I249_A0.6010.42
230_G293_A0.6000.42
238_L292_Y0.6000.42
322_E355_K0.5970.42
312_Y326_Q0.5940.41
337_I360_Y0.5930.41
316_P319_E0.5920.41
172_Y179_N0.5910.41
194_M231_L0.5890.41
109_G158_T0.5840.40
152_Y181_R0.5830.40
106_F153_Y0.5820.40
306_E312_Y0.5810.40
182_I212_M0.5810.40
161_S270_T0.5800.40
116_R122_I0.5800.40
270_T289_G0.5770.40
201_Q241_P0.5760.40
81_S90_D0.5750.40
28_P58_E0.5750.40
121_A236_Q0.5730.39
109_G269_I0.5720.39
179_N182_I0.5690.39
352_K355_K0.5690.39
109_G195_D0.5650.39
325_F332_N0.5640.38
340_L345_A0.5630.38
37_I45_Q0.5630.38
60_R129_E0.5630.38
143_E185_C0.5620.38
69_E177_T0.5620.38
108_R124_Y0.5600.38
155_M159_Y0.5590.38
27_V30_A0.5580.38
288_R291_E0.5570.38
180_V185_C0.5560.38
350_E365_E0.5540.37
36_E67_Y0.5540.37
306_E315_Q0.5530.37
230_G265_A0.5520.37
207_K241_P0.5500.37
286_H304_K0.5480.37
133_S136_A0.5480.37
35_A357_S0.5470.37
31_E40_E0.5470.37
347_Y351_Q0.5450.37
290_Y300_D0.5450.37
225_A293_A0.5440.36
32_V49_N0.5430.36
89_I311_L0.5410.36
235_N268_L0.5400.36
35_A49_N0.5390.36
27_V43_H0.5380.36
333_M356_L0.5380.36
52_L63_L0.5380.36
28_P189_F0.5370.36
361_F365_E0.5370.36
68_L72_E0.5360.36
227_Y232_C0.5360.36
128_A209_A0.5340.36
34_K37_I0.5340.36
209_A249_A0.5340.36
318_E328_L0.5320.35
161_S165_I0.5320.35
142_A153_Y0.5320.35
106_F143_E0.5290.35
339_D343_E0.5250.35
117_E317_N0.5250.35
121_A129_E0.5250.35
234_Y289_G0.5240.35
356_L365_E0.5220.34
63_L184_Q0.5220.34
30_A33_L0.5220.34
56_L62_Q0.5210.34
226_Y244_D0.5200.34
329_K334_Y0.5190.34
45_Q120_S0.5190.34
106_F172_Y0.5190.34
45_Q53_Y0.5180.34
200_E240_D0.5170.34
105_N128_A0.5170.34
48_S99_L0.5160.34
187_F227_Y0.5150.34
177_T317_N0.5150.34
32_V42_K0.5140.34
106_F149_A0.5140.34
199_F236_Q0.5130.34
109_G213_A0.5120.33
57_M86_S0.5120.33
213_A222_V0.5110.33
125_Y157_Q0.5100.33
66_D278_K0.5100.33
121_A147_K0.5100.33
183_I202_A0.5090.33
114_D117_E0.5080.33
316_P321_I0.5080.33
56_L103_Y0.5080.33
104_V108_R0.5070.33
261_S264_Q0.5060.33
250_V265_A0.5060.33
64_M143_E0.5050.33
185_C188_V0.5050.33
337_I341_A0.5040.33
129_E229_L0.5040.33
146_F185_C0.5040.33
38_Q190_G0.5040.33
149_A199_F0.5040.33
54_Y61_H0.5030.33
190_G260_N0.5030.33
286_H349_Y0.5010.32
118_F197_R0.5010.32
165_I200_E0.5000.32
149_A163_I0.5000.32
233_Y249_A0.5000.32
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ulqA 1 0.9843 100 0.308 Contact Map
4i1aA 2 0.9372 100 0.312 Contact Map
4gyoA 2 0.9424 100 0.32 Contact Map
3q15A 2 0.9555 100 0.32 Contact Map
4gpkA 3 0.9031 100 0.388 Contact Map
4l9pA 1 0.7435 100 0.463 Contact Map
3q7aA 1 0.7251 100 0.47 Contact Map
3dssA 1 0.712 100 0.479 Contact Map
1w3bA 2 0.7644 100 0.481 Contact Map
4jhrA 2 0.5995 100 0.483 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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