RAPC - BACSU - GREMLIN Contacts

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RAPC - Response regulator aspartate phosphatase C

UniProt:	P94415	Sequences: MKSGVIPSSAVGQKINEWYRYIRTFSVPDAEVLKAEIQQELKHMQHDSNLLLYYSLMEFRHQLMLDYLEPLEKLNIEDQPSLSELSRNIDSNQADLKGLLDYYVNFFRGMYEFDKREFISAITYYKQAEKKLSFVADHIERAEFYFKIAEAYYYMKQTYFSLINIKNAYEIYVEQETYNVRIIQCHFVFGVNLMDERNFEQAARHFKLALNMAQAEQKAQLVGRAYYNLGLCYYNQDLLDPAIDYFEKAVSTFESSRIVNSLPQAYFLITLIYYKQGKHDKASEYHKRGYEYAKETDDADYAVKFEFLQSLYLDQPNEEGIERCFQYLKNKNMYADIEDLALEVAKYYYEQKWFKLSASYFLQVEEARKQIQRSEGLYEIEI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	382 (324)
Sequences:	1054 (923)
Seq/√Len:	51.3

ECOLI - LPSRP
BACSU - RAPC RAPF RAPA RAPB RAPH RAPI RAPJ RAPK RAPD RAPG RAPE YVCD

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
278_K	281_K	4.705	1.00
238_L	241_P	4.612	1.00
194_M	206_F	4.094	1.00
353_W	356_L	3.920	1.00
230_G	246_F	3.917	1.00
270_T	286_H	3.850	1.00
190_G	206_F	3.838	1.00
198_N	201_Q	3.446	1.00
109_G	125_Y	3.189	1.00
345_A	361_F	2.962	1.00
117_E	120_S	2.607	1.00
105_N	124_Y	2.594	1.00
243_I	272_I	2.547	1.00
246_F	268_L	2.497	1.00
233_Y	241_P	2.490	1.00
273_Y	281_K	2.472	1.00
273_Y	278_K	2.423	1.00
329_K	363_Q	2.335	1.00
186_H	205_H	2.316	1.00
241_P	244_D	2.269	1.00
171_I	175_Q	2.266	1.00
281_K	284_E	2.249	1.00
203_A	229_L	2.160	1.00
327_Y	330_N	2.130	1.00
272_I	276_Q	2.109	1.00
164_N	167_N	2.076	1.00
321_I	324_C	2.046	1.00
191_V	206_F	2.034	1.00
29_D	32_V	2.033	1.00
34_K	38_Q	2.024	1.00
304_K	336_D	1.960	1.00
226_Y	245_Y	1.954	1.00
189_F	193_L	1.947	0.99
48_S	51_L	1.945	0.99
145_Y	164_N	1.943	0.99
26_S	39_Q	1.938	0.99
30_A	37_I	1.934	0.99
122_I	152_Y	1.909	0.99
289_G	305_F	1.893	0.99
167_N	170_E	1.841	0.99
108_R	112_E	1.837	0.99
102_Y	109_G	1.827	0.99
239_L	272_I	1.817	0.99
203_A	233_Y	1.813	0.99
28_P	32_V	1.810	0.99
26_S	29_D	1.797	0.99
223_G	249_A	1.772	0.99
266_Y	285_Y	1.771	0.99
50_L	89_I	1.740	0.99
230_G	242_A	1.735	0.99
354_F	357_S	1.730	0.99
358_A	362_L	1.654	0.98
308_L	312_Y	1.652	0.98
53_Y	57_M	1.645	0.98
187_F	228_N	1.637	0.98
109_G	113_F	1.635	0.98
127_Q	130_K	1.628	0.98
149_A	165_I	1.621	0.98
210_L	222_V	1.613	0.98
105_N	127_Q	1.612	0.98
269_I	273_Y	1.609	0.98
190_G	209_A	1.606	0.98
32_V	35_A	1.604	0.98
183_I	209_A	1.601	0.98
243_I	247_E	1.595	0.98
214_Q	222_V	1.585	0.98
349_Y	362_L	1.553	0.97
175_Q	178_Y	1.552	0.97
35_A	39_Q	1.549	0.97
106_F	110_M	1.548	0.97
267_F	289_G	1.546	0.97
243_I	273_Y	1.541	0.97
113_F	125_Y	1.530	0.97
359_S	363_Q	1.526	0.97
28_P	39_Q	1.510	0.97
243_I	276_Q	1.507	0.97
27_V	37_I	1.498	0.97
121_A	282_A	1.487	0.97
106_F	125_Y	1.471	0.96
27_V	45_Q	1.468	0.96
356_L	360_Y	1.459	0.96
237_D	275_K	1.428	0.96
226_Y	248_K	1.419	0.96
112_E	124_Y	1.406	0.95
246_F	289_G	1.403	0.95
262_L	265_A	1.402	0.95
230_G	245_Y	1.402	0.95
305_F	316_P	1.401	0.95
341_A	360_Y	1.393	0.95
244_D	248_K	1.386	0.95
324_C	331_K	1.385	0.95
143_E	147_K	1.383	0.95
102_Y	128_A	1.382	0.95
302_A	305_F	1.382	0.95
347_Y	350_E	1.362	0.94
26_S	32_V	1.345	0.94
357_S	364_V	1.339	0.94
345_A	357_S	1.315	0.93
203_A	236_Q	1.314	0.93
357_S	361_F	1.297	0.93
203_A	232_C	1.272	0.92
191_V	228_N	1.268	0.92
302_A	306_E	1.266	0.92
109_G	124_Y	1.257	0.92
208_L	211_N	1.245	0.91
243_I	269_I	1.242	0.91
129_E	145_Y	1.230	0.91
282_A	364_V	1.219	0.90
156_K	161_S	1.215	0.90
340_L	344_V	1.212	0.90
169_Y	192_N	1.206	0.90
268_L	271_L	1.204	0.90
247_E	281_K	1.196	0.90
226_Y	249_A	1.185	0.89
306_E	313_L	1.153	0.88
192_N	286_H	1.144	0.87
33_L	44_M	1.143	0.87
283_S	287_K	1.141	0.87
190_G	342_L	1.132	0.87
148_I	152_Y	1.132	0.87
240_D	276_Q	1.127	0.87
249_A	252_T	1.126	0.87
116_R	154_Y	1.119	0.86
102_Y	144_F	1.115	0.86
31_E	38_Q	1.113	0.86
287_K	291_E	1.112	0.86
303_V	306_E	1.107	0.86
112_E	120_S	1.104	0.85
301_Y	304_K	1.100	0.85
356_L	359_S	1.096	0.85
345_A	360_Y	1.092	0.85
62_Q	69_E	1.091	0.85
62_Q	71_L	1.087	0.85
128_A	228_N	1.087	0.85
26_S	35_A	1.082	0.84
233_Y	238_L	1.080	0.84
133_S	141_R	1.077	0.84
190_G	205_H	1.077	0.84
101_D	109_G	1.075	0.84
62_Q	65_L	1.064	0.83
35_A	38_Q	1.062	0.83
355_K	362_L	1.056	0.83
188_V	206_F	1.054	0.83
188_V	268_L	1.048	0.82
263_P	266_Y	1.045	0.82
309_Q	312_Y	1.043	0.82
51_L	55_S	1.042	0.82
227_Y	268_L	1.028	0.81
219_A	252_T	1.017	0.80
27_V	38_Q	1.012	0.80
250_V	266_Y	1.008	0.80
38_Q	42_K	1.006	0.80
40_E	44_M	1.001	0.79
118_F	151_A	0.998	0.79
122_I	147_K	0.993	0.79
29_D	36_E	0.992	0.79
106_F	128_A	0.991	0.79
158_T	161_S	0.987	0.78
142_A	145_Y	0.986	0.78
190_G	225_A	0.985	0.78
362_L	365_E	0.982	0.78
179_N	215_A	0.978	0.78
234_Y	239_L	0.977	0.78
38_Q	41_L	0.973	0.77
210_L	269_I	0.973	0.77
319_E	325_F	0.969	0.77
250_V	269_I	0.968	0.77
128_A	131_K	0.968	0.77
120_S	123_T	0.966	0.77
67_Y	70_P	0.962	0.77
63_L	67_Y	0.961	0.76
312_Y	316_P	0.960	0.76
132_L	135_V	0.958	0.76
125_Y	147_K	0.955	0.76
309_Q	316_P	0.955	0.76
249_A	265_A	0.947	0.75
145_Y	226_Y	0.943	0.75
174_E	177_T	0.943	0.75
56_L	168_A	0.940	0.75
29_D	42_K	0.937	0.75
229_L	245_Y	0.928	0.74
161_S	164_N	0.922	0.73
176_E	272_I	0.920	0.73
230_G	249_A	0.917	0.73
304_K	311_L	0.916	0.73
37_I	40_E	0.913	0.73
225_A	273_Y	0.911	0.72
210_L	245_Y	0.909	0.72
80_P	84_E	0.907	0.72
149_A	266_Y	0.902	0.72
190_G	228_N	0.898	0.71
329_K	337_I	0.898	0.71
29_D	39_Q	0.895	0.71
344_V	348_Y	0.895	0.71
58_E	230_G	0.893	0.71
155_M	158_T	0.891	0.71
27_V	31_E	0.887	0.70
32_V	40_E	0.887	0.70
168_A	172_Y	0.884	0.70
247_E	269_I	0.882	0.70
300_D	356_L	0.881	0.70
358_A	361_F	0.880	0.70
305_F	308_L	0.876	0.70
56_L	60_R	0.872	0.69
234_Y	272_I	0.868	0.69
270_T	300_D	0.867	0.69
288_R	337_I	0.865	0.69
341_A	348_Y	0.864	0.68
304_K	312_Y	0.863	0.68
313_L	317_N	0.863	0.68
159_Y	193_L	0.860	0.68
325_F	344_V	0.860	0.68
353_W	360_Y	0.858	0.68
146_F	187_F	0.855	0.68
253_F	262_L	0.855	0.68
37_I	41_L	0.855	0.68
26_S	38_Q	0.850	0.67
213_A	225_A	0.849	0.67
321_I	357_S	0.849	0.67
61_H	65_L	0.847	0.67
125_Y	357_S	0.846	0.67
353_W	359_S	0.840	0.66
301_Y	314_D	0.829	0.65
348_Y	356_L	0.827	0.65
262_L	266_Y	0.826	0.65
341_A	363_Q	0.823	0.65
279_H	330_N	0.821	0.64
31_E	44_M	0.818	0.64
32_V	38_Q	0.813	0.64
85_L	88_N	0.812	0.64
334_Y	337_I	0.810	0.63
206_F	229_L	0.804	0.63
207_K	229_L	0.801	0.63
357_S	365_E	0.799	0.62
144_F	147_K	0.798	0.62
69_E	352_K	0.792	0.62
311_L	352_K	0.790	0.61
107_F	228_N	0.789	0.61
251_S	269_I	0.788	0.61
193_L	201_Q	0.786	0.61
169_Y	173_V	0.786	0.61
37_I	242_A	0.783	0.61
142_A	146_F	0.783	0.61
186_H	226_Y	0.782	0.61
26_S	43_H	0.781	0.61
262_L	282_A	0.780	0.60
333_M	336_D	0.779	0.60
235_N	275_K	0.778	0.60
229_L	260_N	0.777	0.60
112_E	117_E	0.776	0.60
206_F	237_D	0.775	0.60
227_Y	230_G	0.773	0.60
348_Y	352_K	0.773	0.60
279_H	283_S	0.772	0.60
28_P	45_Q	0.771	0.60
166_K	196_E	0.771	0.60
103_Y	107_F	0.770	0.59
80_P	89_I	0.768	0.59
226_Y	266_Y	0.767	0.59
47_D	50_L	0.766	0.59
30_A	45_Q	0.763	0.59
355_K	359_S	0.762	0.59
157_Q	161_S	0.761	0.59
105_N	172_Y	0.757	0.58
189_F	195_D	0.755	0.58
201_Q	204_R	0.755	0.58
199_F	203_A	0.754	0.58
34_K	50_L	0.753	0.58
121_A	168_A	0.751	0.58
352_K	357_S	0.751	0.58
157_Q	160_F	0.745	0.57
49_N	55_S	0.741	0.57
341_A	357_S	0.740	0.56
229_L	233_Y	0.739	0.56
36_E	40_E	0.734	0.56
59_F	66_D	0.728	0.55
314_D	317_N	0.728	0.55
177_T	211_N	0.725	0.55
304_K	307_F	0.724	0.55
117_E	237_D	0.724	0.55
149_A	190_G	0.723	0.55
271_L	307_F	0.722	0.55
237_D	352_K	0.720	0.54
48_S	139_I	0.717	0.54
82_L	85_L	0.716	0.54
177_T	275_K	0.712	0.54
35_A	45_Q	0.711	0.53
39_Q	42_K	0.709	0.53
337_I	357_S	0.707	0.53
147_K	150_E	0.705	0.53
33_L	39_Q	0.703	0.53
113_F	150_E	0.702	0.53
269_I	285_Y	0.702	0.53
193_L	204_R	0.700	0.52
125_Y	129_E	0.698	0.52
172_Y	189_F	0.698	0.52
323_R	327_Y	0.697	0.52
249_A	284_E	0.697	0.52
150_E	190_G	0.697	0.52
360_Y	364_V	0.696	0.52
27_V	39_Q	0.696	0.52
114_D	118_F	0.694	0.52
143_E	146_F	0.693	0.52
118_F	295_E	0.693	0.52
48_S	55_S	0.693	0.52
326_Q	329_K	0.692	0.51
44_M	48_S	0.689	0.51
110_M	125_Y	0.688	0.51
345_A	365_E	0.684	0.51
131_K	190_G	0.683	0.51
329_K	365_E	0.681	0.50
286_H	290_Y	0.681	0.50
303_V	316_P	0.677	0.50
139_I	167_N	0.676	0.50
231_L	286_H	0.675	0.50
102_Y	106_F	0.673	0.50
29_D	33_L	0.673	0.50
50_L	54_Y	0.671	0.49
354_F	358_A	0.671	0.49
176_E	186_H	0.671	0.49
274_Y	286_H	0.668	0.49
302_A	321_I	0.667	0.49
129_E	144_F	0.665	0.49
29_D	34_K	0.665	0.49
158_T	192_N	0.660	0.48
52_L	70_P	0.660	0.48
228_N	268_L	0.659	0.48
277_G	350_E	0.655	0.48
186_H	266_Y	0.653	0.47
53_Y	56_L	0.652	0.47
38_Q	43_H	0.651	0.47
290_Y	337_I	0.648	0.47
67_Y	71_L	0.647	0.47
346_K	350_E	0.645	0.47
302_A	316_P	0.640	0.46
311_L	314_D	0.640	0.46
113_F	153_Y	0.640	0.46
127_Q	198_N	0.639	0.46
97_K	103_Y	0.638	0.46
332_N	356_L	0.638	0.46
206_F	228_N	0.637	0.46
81_S	91_S	0.635	0.46
80_P	85_L	0.635	0.46
231_L	234_Y	0.635	0.46
199_F	239_L	0.634	0.45
191_V	195_D	0.633	0.45
45_Q	55_S	0.632	0.45
189_F	201_Q	0.632	0.45
58_E	62_Q	0.630	0.45
35_A	42_K	0.626	0.45
39_Q	43_H	0.624	0.44
351_Q	361_F	0.624	0.44
309_Q	313_L	0.623	0.44
231_L	246_F	0.623	0.44
41_L	51_L	0.622	0.44
169_Y	186_H	0.621	0.44
80_P	86_S	0.621	0.44
170_E	173_V	0.621	0.44
44_M	47_D	0.619	0.44
189_F	203_A	0.619	0.44
243_I	281_K	0.618	0.44
223_G	252_T	0.617	0.44
27_V	32_V	0.615	0.44
155_M	164_N	0.614	0.43
165_I	169_Y	0.613	0.43
48_S	82_L	0.612	0.43
313_L	316_P	0.612	0.43
63_L	280_D	0.610	0.43
52_L	60_R	0.606	0.43
52_L	58_E	0.606	0.43
145_Y	171_I	0.606	0.43
189_F	205_H	0.603	0.42
89_I	249_A	0.601	0.42
230_G	293_A	0.600	0.42
238_L	292_Y	0.600	0.42
322_E	355_K	0.597	0.42
312_Y	326_Q	0.594	0.41
337_I	360_Y	0.593	0.41
316_P	319_E	0.592	0.41
172_Y	179_N	0.591	0.41
194_M	231_L	0.589	0.41
109_G	158_T	0.584	0.40
152_Y	181_R	0.583	0.40
106_F	153_Y	0.582	0.40
306_E	312_Y	0.581	0.40
182_I	212_M	0.581	0.40
161_S	270_T	0.580	0.40
116_R	122_I	0.580	0.40
270_T	289_G	0.577	0.40
201_Q	241_P	0.576	0.40
81_S	90_D	0.575	0.40
28_P	58_E	0.575	0.40
121_A	236_Q	0.573	0.39
109_G	269_I	0.572	0.39
179_N	182_I	0.569	0.39
352_K	355_K	0.569	0.39
109_G	195_D	0.565	0.39
325_F	332_N	0.564	0.38
340_L	345_A	0.563	0.38
37_I	45_Q	0.563	0.38
60_R	129_E	0.563	0.38
143_E	185_C	0.562	0.38
69_E	177_T	0.562	0.38
108_R	124_Y	0.560	0.38
155_M	159_Y	0.559	0.38
27_V	30_A	0.558	0.38
288_R	291_E	0.557	0.38
180_V	185_C	0.556	0.38
350_E	365_E	0.554	0.37
36_E	67_Y	0.554	0.37
306_E	315_Q	0.553	0.37
230_G	265_A	0.552	0.37
207_K	241_P	0.550	0.37
286_H	304_K	0.548	0.37
133_S	136_A	0.548	0.37
35_A	357_S	0.547	0.37
31_E	40_E	0.547	0.37
347_Y	351_Q	0.545	0.37
290_Y	300_D	0.545	0.37
225_A	293_A	0.544	0.36
32_V	49_N	0.543	0.36
89_I	311_L	0.541	0.36
235_N	268_L	0.540	0.36
35_A	49_N	0.539	0.36
27_V	43_H	0.538	0.36
333_M	356_L	0.538	0.36
52_L	63_L	0.538	0.36
28_P	189_F	0.537	0.36
361_F	365_E	0.537	0.36
68_L	72_E	0.536	0.36
227_Y	232_C	0.536	0.36
128_A	209_A	0.534	0.36
34_K	37_I	0.534	0.36
209_A	249_A	0.534	0.36
318_E	328_L	0.532	0.35
161_S	165_I	0.532	0.35
142_A	153_Y	0.532	0.35
106_F	143_E	0.529	0.35
339_D	343_E	0.525	0.35
117_E	317_N	0.525	0.35
121_A	129_E	0.525	0.35
234_Y	289_G	0.524	0.35
356_L	365_E	0.522	0.34
63_L	184_Q	0.522	0.34
30_A	33_L	0.522	0.34
56_L	62_Q	0.521	0.34
226_Y	244_D	0.520	0.34
329_K	334_Y	0.519	0.34
45_Q	120_S	0.519	0.34
106_F	172_Y	0.519	0.34
45_Q	53_Y	0.518	0.34
200_E	240_D	0.517	0.34
105_N	128_A	0.517	0.34
48_S	99_L	0.516	0.34
187_F	227_Y	0.515	0.34
177_T	317_N	0.515	0.34
32_V	42_K	0.514	0.34
106_F	149_A	0.514	0.34
199_F	236_Q	0.513	0.34
109_G	213_A	0.512	0.33
57_M	86_S	0.512	0.33
213_A	222_V	0.511	0.33
125_Y	157_Q	0.510	0.33
66_D	278_K	0.510	0.33
121_A	147_K	0.510	0.33
183_I	202_A	0.509	0.33
114_D	117_E	0.508	0.33
316_P	321_I	0.508	0.33
56_L	103_Y	0.508	0.33
104_V	108_R	0.507	0.33
261_S	264_Q	0.506	0.33
250_V	265_A	0.506	0.33
64_M	143_E	0.505	0.33
185_C	188_V	0.505	0.33
337_I	341_A	0.504	0.33
129_E	229_L	0.504	0.33
146_F	185_C	0.504	0.33
38_Q	190_G	0.504	0.33
149_A	199_F	0.504	0.33
54_Y	61_H	0.503	0.33
190_G	260_N	0.503	0.33
286_H	349_Y	0.501	0.32
118_F	197_R	0.501	0.32
165_I	200_E	0.500	0.32
149_A	163_I	0.500	0.32
233_Y	249_A	0.500	0.32

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ulqA	1	0.9843	100	0.308	Contact Map
4i1aA	2	0.9372	100	0.312	Contact Map
4gyoA	2	0.9424	100	0.32	Contact Map
3q15A	2	0.9555	100	0.32	Contact Map
4gpkA	3	0.9031	100	0.388	Contact Map
4l9pA	1	0.7435	100	0.463	Contact Map
3q7aA	1	0.7251	100	0.47	Contact Map
3dssA	1	0.712	100	0.479	Contact Map
1w3bA	2	0.7644	100	0.481	Contact Map
4jhrA	2	0.5995	100	0.483	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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